Abstract：
:Having identified glycans of cellular glycoconjugates as versatile molecular messages, their recognition by sugar receptors (lectins) is a fundamental mechanism within the flow of biological information. This type of molecular interplay is increasingly revealed to be involved in a wide range of (patho)physiological processes. To do so, it is a vital prerequisite that a lectin (and its expression) can develop more than a single skill, that is the general ability to bind glycans. By studying the example of vertebrate galectins as a model, a total of five relevant characteristics is disclosed: i) access to intra- and extracellular sites, ii) fine-tuned gene regulation (with evidence for co-regulation of counterreceptors) including the existence of variants due to alternative splicing or single nucleotide polymorphisms, iii) specificity to distinct glycans from the glycome with different molecular meaning, iv) binding capacity also to peptide motifs at different sites on the protein and v) diversity of modular architecture. They combine to endow these lectins with the capacity to serve as multi-purpose tools. Underscoring the arising broad-scale significance of tissue lectins, their numbers in terms of known families and group members have steadily grown by respective research that therefore unveiled a well-stocked toolbox. The generation of a network of (ga)lectins by evolutionary diversification affords the opportunity for additive/synergistic or antagonistic interplay in situ, an emerging aspect of (ga)lectin functionality. It warrants close scrutiny. The realization of the enormous potential of combinatorial permutations using the five listed features gives further efforts to understand the rules of functional glycomics/lectinomics a clear direction.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
García Caballero G,Kaltner H,Kutzner TJ,Ludwig AK,Manning JC,Schmidt S,Sinowatz F,Gabius HJdoi
10.14670/HH-18-199subject
Has Abstractpub_date
2020-06-01 00:00:00pages
509-539issue
6eissn
0213-3911issn
1699-5848pii
HH-18-199journal_volume
35pub_type
杂志文章,评审abstract：:"Classically activated macrophages (M1)" and "alternatively activated macrophages (M2)", which appear in injured tissues, control either inflammation or remodeling. The mechanism remains unclear. To clarify the M1-/M2-macrophage polarization in acute liver injury, M1- and M2-related factors were analysed in F344 rats ...
journal_title：Histology and histopathology
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journal_title：Histology and histopathology
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journal_title：Histology and histopathology
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更新日期：1994-01-01 00:00:00
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journal_title：Histology and histopathology
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更新日期：1997-07-01 00:00:00
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更新日期：2010-11-01 00:00:00
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journal_title：Histology and histopathology
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更新日期：2016-08-01 00:00:00
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更新日期：2000-01-01 00:00:00
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更新日期：2000-04-01 00:00:00
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更新日期：1986-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2011-08-01 00:00:00
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更新日期：2002-01-01 00:00:00
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journal_title：Histology and histopathology
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更新日期：2014-06-01 00:00:00
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journal_title：Histology and histopathology
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更新日期：2012-07-01 00:00:00
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更新日期：1989-01-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1997-04-01 00:00:00
