Renal clear-cell carcinoma: an ultrastructural study on the junctional complexes.

Abstract:

:Junctional complexes such as tight junctions, adherens junctions, and desmosomes play crucial roles in the structure and function of epithelial cells. These junctions are involved in increasing cell-cell contact and as well serve as signaling centers regulating multiple functions in epithelial cells. Carcinoma cell lines cultured in the laboratory generally lack junctional complexes. However, studies directed towards understanding the distribution of junctional complexes in human cancer tissues are lacking. In this study, we analyzed by electron microscopy the distribution of junctional complexes in patients diagnosed with renal clear-cell carcinoma. We found that both tight junctions and adherens junctions were drastically reduced in patients with cancer compared to normal tissues. Desmosomes were not detected in normal proximal tubules while distinctly present in cancer tissues. These results suggest that analysis of junctional complexes in human tumors should provide valuable information that might have prognostic and diagnostic value.

journal_name

Histol Histopathol

authors

Kim G,Rajasekaran SA,Thomas G,Rosen EA,Landaw EM,Shintaku P,Lassman C,Said J,Rajasekaran AK

doi

10.14670/HH-20.35

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

35-44

issue

1

eissn

0213-3911

issn

1699-5848

journal_volume

20

pub_type

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