Abstract:
:In the present study we examined prognostic value of immunohistochemical estimation of topoisomerase 1A (TOP 1A) and HER-2/neu expression in ovarian cancers treated with platinum-based drugs but not with topotecan and the relation between expression of these proteins on the one hand and intensity of proliferation (Ki67) on the other. The analyses were performed on 73 samples of ovarian carcinoma originating from 43 first-look laparotomies (FLL) and, in 30 cases, from secondary cytoreductions (SCR)(after chemotherapy) from the same patients. In paraffin sections immunohistochemical reactions were performed using antibodies directed to HER-2/neu, TOP 1A and Ki67. Kaplan-Meier's analysis disclosed a shorter overall survival time in cases with augmented expression of TOP 1A at FLL and with higher expression of Ki67 at SCR. A shorter progression-free time was detected in cases with higher proportion of Ki67 positive cells at FLL. No relationship could be disclosed between HER-2/neu expression and the studied clinicopathological parameters. The studies confirmed high value of Ki67 estimation. The augmented expression of TOP 1A was demonstrated to represent an unfavourable prognostic factor. Thus, in cases with elevated expression of TOP 1A application of topotecan-based therapeutic schemes should be considered.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Surowiak P,Materna V,Kaplenko I,Spaczynski M,Dietel M,Lage H,Zabel Mdoi
10.14670/HH-21.713subject
Has Abstractpub_date
2006-07-01 00:00:00pages
713-20issue
7eissn
0213-3911issn
1699-5848journal_volume
21pub_type
杂志文章abstract:BACKGROUND:Lipopolysaccharide (LPS) induced inflammation often leads to lung injury, in which pulmonary recruitment of neutrophils plays a pivotal role. Inflammatory processes are influenced by CD26/DPP4, highly expressed in lungs. Asthma induced CD26/DPP4 deficient (CD26/DPP4⁻) Fischer (F) 344 rats suffering from a tr...
journal_title:Histology and histopathology
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doi:10.14670/HH-18-117
更新日期:2019-10-01 00:00:00
abstract::Oligodendrocytes are the myelinating cells of the central nervous system. Since many studies of demyelinating diseases focus their research on this cell type, there is growing interest for obtaining reliable markers that can specifically recognize oligodendroglia. Established markers are the myelin-associated neurite ...
journal_title:Histology and histopathology
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doi:10.14670/HH-11-640
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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doi:10.14670/HH-28.61
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journal_title:Histology and histopathology
pub_type: 杂志文章
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更新日期:2020-05-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
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journal_title:Histology and histopathology
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更新日期:2005-10-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
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journal_title:Histology and histopathology
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更新日期:2017-11-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2006-08-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-22.399
更新日期:2007-04-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
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更新日期:2020-10-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-18-088
更新日期:2019-07-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-14.805
更新日期:1999-07-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
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更新日期:2017-03-01 00:00:00
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journal_title:Histology and histopathology
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更新日期:2019-01-01 00:00:00
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
pub_type: 杂志文章,meta分析
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更新日期:2018-04-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
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更新日期:1999-04-01 00:00:00
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journal_title:Histology and histopathology
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更新日期:2009-05-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
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更新日期:1997-04-01 00:00:00
abstract::F10, a subline of the B16 mouse melanoma cell line, is itself the parent of the more metastatic BL6 line. BL6 cells differ from F10 cells by an alteration of the gene encoding the B56gamma regulatory subunit of protein phosphatase 2A (PP2A), which results in mRNA encoding a truncated variant of the subunit (deltagamma...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-19.391
更新日期:2004-04-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
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更新日期:2010-08-01 00:00:00
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journal_title:Histology and histopathology
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更新日期:2005-01-01 00:00:00