Abstract：
BACKGROUND:Lipopolysaccharide (LPS) induced inflammation often leads to lung injury, in which pulmonary recruitment of neutrophils plays a pivotal role. Inflammatory processes are influenced by CD26/DPP4, highly expressed in lungs. Asthma induced CD26/DPP4 deficient (CD26/DPP4⁻) Fischer (F) 344 rats suffering from a transport block in the rER caused by a point mutation showed reduced pulmonary inflammation and reduced expression of immunomodulating surfactant proteins (SP). The degree of LPS induced lung injury in CD26/DPP4 deficient rats has not been investigated so far. OBJECTIVE:We hypothesize that LPS induced lung injury leads not only to an attenuated inflammation but also to a reduced SP expression and decreased structural damage in CD26/DPP4⁻ rats. METHODS:Both genotypes were intratracheally instilled with 250 µl LPS or with 250 µl 0.9% NaCl. Nine hours later animals were killed and either bronchoalveolar lavage was carried out to determine inflammatory cells and surface tension or lung blocks were removed and processed for histology, immunohistochemistry, electron microscopy or qRt-PCR analyses and Western Blot analyses. RESULTS:Signs of acute lung injury, such as structural damage of the blood gas barrier occurred only sporadically in both genotypes. LPS-induced CD26/DPP4⁻ rats showed decreased gene expression of SP-A and SP-D and reduced signs of lung inflammation associated with a reduced alveolar influx of macrophages and neutrophils. CONCLUSIONS:Less pulmonary inflammation combined with less structural alterations and minor expression of immunomodulating SP may be an indication of the critical role of CD26/DPP4 in regulating lung inflammation.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Zientara A,Stephan M,von Hörsten S,Schmiedl Adoi
10.14670/HH-18-117subject
Has Abstractpub_date
2019-10-01 00:00:00pages
1151-1171issue
10eissn
0213-3911issn
1699-5848pii
HH-18-117journal_volume
34pub_type
杂志文章abstract：:Platelet-collagen interaction is a complex event that involves ligand-receptor interaction. There are many adhesive non-integrin receptors for platelets to interact with various types of collagens. These non-integrin receptors also serve as signal transducers both from the outside of platelets to the inside and possib...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-14.579
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journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
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journal_title：Histology and histopathology
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doi：
更新日期：1988-07-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-24.1515
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journal_title：Histology and histopathology
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doi：10.14670/HH-14.151
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journal_title：Histology and histopathology
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journal_title：Histology and histopathology
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更新日期：1993-04-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
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更新日期：2009-03-01 00:00:00
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journal_title：Histology and histopathology
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更新日期：2011-02-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
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更新日期：1988-01-01 00:00:00
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journal_title：Histology and histopathology
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journal_title：Histology and histopathology
pub_type： 杂志文章,评审
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更新日期：2007-11-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章,评审
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更新日期：2017-03-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-18-025
更新日期：2019-01-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-21.503
更新日期：2006-05-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1993-01-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-21.157
更新日期：2006-02-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-18-205
更新日期：2020-08-01 00:00:00
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journal_title：Histology and histopathology
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journal_title：Histology and histopathology
pub_type： 杂志文章
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更新日期：2012-07-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
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journal_title：Histology and histopathology
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journal_title：Histology and histopathology
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doi：
更新日期：2013-04-01 00:00:00
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journal_title：Histology and histopathology
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更新日期：1992-07-01 00:00:00
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journal_title：Histology and histopathology
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-26.1265
更新日期：2011-10-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：:The corneal structure of three deep-sea species of teleosts (Gadiformes, Teleostei) from different depths (250-4000 m) and photic zones are examined at the level of the light and electron microscopes. Each species shows a similar but complex arrangement of layers with a cornea split into dermal and scleral components....
journal_title：Histology and histopathology
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更新日期：1998-04-01 00:00:00
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journal_title：Histology and histopathology
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更新日期：2015-11-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章,评审
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更新日期：2000-10-01 00:00:00
