Nitric oxide synthase in the pineal gland.

Abstract:

:The recent discovery of nitric oxide (NO) as a biological messenger molecule with unique characteristics has opened a new field in pineal research. This free radical gas is synthesized by the enzyme nitric oxide synthase (NOS) from L-arginine. The activation of adrenoreceptors in the membrane of the pinealocytes mediates the increase in NO through a mechanism that involves G proteins. In the pinealocyte, NO stimulates guanylyl cyclase resulting in an increased intracellular content of cGMP. The role of cGMP in pineal metabolism, however, is still enigmatic. Using enzyme histochemistry and immunohistochemistry, the presence of NOS has been confirmed in the pineal gland of some species. In the rat and especially in the sheep, NOS is located in nerve fibres innervating the gland. These nerve fibres also contain the neuropeptides vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI), and are probably of parasympathetic origin. In cell cultures and tissue sections NOS immunoreactivity has been shown to be present in pinealocytes of the rat and bovine but not in the sheep. Finally, NOS is also present in the endothelial cells of the blood vessels of the pineal gland. Accordingly, in the mammalian pineal gland, NO is synthesized in both presynaptic nerve fibers and pinealocytes, as well as in blood vessels. However, the anatomical location of NO synthesis varies considerably among species. NO released in the pineal gland, might influence both the pineal metabolism and the blood flow of the gland.

journal_name

Histol Histopathol

authors

López-Figueroa MO,Møller M

subject

Has Abstract

pub_date

1996-10-01 00:00:00

pages

1089-100

issue

4

eissn

0213-3911

issn

1699-5848

journal_volume

11

pub_type

杂志文章,评审
  • Multilocular cystic renal cell carcinoma with focus on clinical and pathobiological aspects.

    abstract::Multilocular cystic renal cell carcinoma (MCRCC) accounts for approximately 1 to 2% of all renal tumors. This tumor is currently classified as a subtype of clear cell RCC. Clinically, the majority of these tumors are incidentally found. Macroscopically, the tumor is well demarcated and consists of various-sized cysts....

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-27.969

    authors: Kuroda N,Ohe C,Mikami S,Inoue K,Nagashima Y,Cohen RJ,Pan CC,Michal M,Hes O

    更新日期:2012-08-01 00:00:00

  • Microvascular changes in relation to inflammation and epidermal hyperplasia in chronic cutaneous lesions of psoriasis vulgaris.

    abstract::Epidermal proliferation, inflammatory changes and microvascular augmentation are prominent features of chronic cutaneous psoriatic lesions. The objective of this study was the investigation of blood and lymphatic microvascular changes in relation to epidermal changes and inflammatory infiltration in dermis. Immunohist...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-11-811

    authors: Výbohová D,Adamicová K,Mellová Y,Hešková G

    更新日期:2017-05-01 00:00:00

  • Recent development of in vivo cryotechnique to cryobiopsy for living animals.

    abstract::Various microscopic methods have been used to analyze the morphology and molecular distribution of cells and tissues. Using conventional procedures, however, ischemic or anoxic artifacts are inevitably caused by tissue-resection or perfusion-fixation. The in vivo cryotechnique (IVCT) was developed to overcome these pr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-22.1281

    authors: Ohno N,Terada N,Saitoh S,Zhou H,Fujii Y,Ohno S

    更新日期:2007-11-01 00:00:00

  • Control of the cell cycle by neurotrophins: lessons from the p75 neurotrophin receptor.

    abstract::Although traditionally little attention has been paid to the interplay between neurotrophins and the cell cycle, a number of recent findings suggest an important role for these growth factors in the regulation of this aspect of the cellular physiology. In this article, we review the evidence from a number of studies t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-17.1227

    authors: López-Sánchez N,Frade JM

    更新日期:2002-10-01 00:00:00

  • MMP-2 and TIMP-2 in the prostates of male and female mongolian gerbils: effects of hormonal manipulation.

    abstract::TIMPs in the prostates of male and female gerbils and evaluated the effects of testosterone on the expression of these enzymes. Ventral prostates from male gerbils that were either intact or had been castrated for 7 or 21 days, along with prostates from female gerbils that were either intact or had been treated with t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-26.1423

    authors: Rochel-Maia SS,Santos FC,Vilamaior PS,Justulin LA Jr,Felisbino SL,Góes RM,Taboga SR

    更新日期:2011-11-01 00:00:00

  • The combined effect of honey and olive oil against methotrexate mediated hepatotoxicity in rats: A biochemical, histological and immunohistological study.

    abstract:BACKGROUND:Honey and olive oil are natural products that have high nutritional values, and therapeutic properties. Cytotoxic drugs, like methotrexate (MTX) are used to treat malignancies in tumour cells; however, these drugs also have serious side effects that could threaten the patient's life. AIM:To evaluate the pot...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-18-126

    authors: Alturkistani HA,Abuzinadah OAH,Kelany AM,Abd El-Aziz GS,Alrafiah AR

    更新日期:2019-12-01 00:00:00

  • Liver growth factor antifibrotic activity in vivo is associated with a decrease in activation of hepatic stellate cells.

    abstract::The antifibrotic activity of Liver Growth Factor (LGF), a liver mitogen, was previously demonstrated in several models of rat liver fibrosis and even in extrahepatic sites, such as carotid artery in hypertensive rats and rat CdCl2-induced lung fibrosis. In the present study, we have attempted to examine in depth its m...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-24.473

    authors: Díaz-Gil JJ,García-Monzón C,Rúa C,Martín-Sanz P,Cereceda RM,Miquilena-Colina ME,Machín C,Fernández-Martínez A,García-Cañero R

    更新日期:2009-04-01 00:00:00

  • Selective immunolabeling of early gestational cytotrophoblast and its neoplastic counterpart by the monoclonal antibody Ber-EP4.

    abstract::This report presents preliminary observations on the distribution of an epithelial surface antigen in human trophoblastic cells studied with the monoclonal antibody Ber-EP4 by means of an immunoperoxidase technique. Three cases of gestational choriocarcinoma and 20 cases of both villous and extravillous trophoblast, i...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Babury RA,Moscovic EA

    更新日期:1993-04-01 00:00:00

  • Treatment and new progress of neonatal hypoxic-ischemic brain damage.

    abstract::Neonatal hypoxic ischemia (HI) results in different extents of brain damage, and immature brain tissue is particularly sensitive to the stimulation of HI. Hypoxic-ischemic brain damage (HIBD) is a common and serious nervous system disease in neonates, for both full-term infants and preterm infants, and is one of the m...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-18-214

    authors: Yang L,Zhao H,Cui H

    更新日期:2020-09-01 00:00:00

  • Retinal afferents on Golgi-identified vertical neurons in the superior colliculus of the rabbit. A Golgi-EM, degenerative and autoradiographic study.

    abstract::The characteristics and distribution pattern of retinal afferent terminals making synaptic contacts on narrow field vertical neurons in the stratum griseum superficiale of the rabbit superior colliculus were studied using the Golgi-gold substitution technique in combination with either autoradiographic or degenerative...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Ortega F,Doñate-Oliver F,Grandes P

    更新日期:1993-01-01 00:00:00

  • Immunocytohistochemical characterization of pituitary cells of the bluefin tuna, Thunnus thynnus L.

    abstract::In this paper we report the first complete mapping of the pituitary in a tuna species. The various different adenohypophysis cell types of the bluefin tuna, Thunnus thynnus L. have been identified and located using different antisera against mammalian and piscine hormones and various histochemical techniques: PAS, Alc...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-16.443

    authors: Rodríguez-Gómez FJ,Rendón-Unceta MC,Piñuela C,Muñoz-Cueto JA,Jiménez-Tenorio N,Sarasquete C

    更新日期:2001-04-01 00:00:00

  • Aberrant expression and association of VEGF and Dll4/Notch pathway molecules under hypoxia in patients with lung cancer.

    abstract::Tumor angiogenesis plays important roles in the pathogenesis and prognosis of lung cancer. Both vascular endothelial growth factor (VEGF) and Dll4/Notch pathways are critical for angiogenesis, whereas their relationship under hypoxia in lung cancer remains unknown. Thus, in the present study, we evaluated the expressi...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-28.277

    authors: Yu S,Sun J,Zhang J,Xu X,Li H,Shan B,Tian T,Wang H,Ma D,Ji C

    更新日期:2013-02-01 00:00:00

  • Advances in the knowledge of breast cancer stem cells. A review.

    abstract::Much effort has been made by researchers to elucidate the complex biology of breast cancer stem cells (BCSCs), a small subset of breast tumor cells that display stem cell properties, drive tumor initiation, and growth. In recent years, it has been suggested that BCSCs could be responsible for the process of metastasis...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-11-718

    authors: Schwarz-Cruz Y Celis A,Espinosa M,Maldonado V,Melendez-Zajgla J

    更新日期:2016-06-01 00:00:00

  • Collagen-platelet interaction: platelet non-integrin receptors.

    abstract::Platelet-collagen interaction is a complex event that involves ligand-receptor interaction. There are many adhesive non-integrin receptors for platelets to interact with various types of collagens. These non-integrin receptors also serve as signal transducers both from the outside of platelets to the inside and possib...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-14.579

    authors: Chiang TM

    更新日期:1999-04-01 00:00:00

  • Rab GTPases in the differential processing of phagocytosed pathogens versus efferocytosed apoptotic cells.

    abstract::Phagocytosis is an important feature of innate immunity in which invading microorganisms are engulfed, killed and degraded - and in some immune cells, their antigens presented to adaptive immune system. A closely related process, efferocytosis, removes apoptotic cells, and is essential for the maintenance of homeostas...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-18-252

    authors: Taefehshokr N,Yin C,Heit B

    更新日期:2020-09-29 00:00:00

  • The dynamic stem cell microenvironment is orchestrated by microvesicle-mediated transfer of genetic information.

    abstract::It has been commonly supposed that adult stem cells co-localize with supporting cells within specific regions or specialized microenvironment in each tissue/organ, called stem cell niche. This concept was based on the assumption that stem cells are intrinsically hierarchical in nature. However, recent data indicate th...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-25.397

    authors: Deregibus MC,Tetta C,Camussi G

    更新日期:2010-03-01 00:00:00

  • Fine structure of the retinal photoreceptors of the barred owl (Strix varia).

    abstract::The photoreceptors of the barred owl (Strix varia) consist of rods, single cones and unequal double cones present in a ratio of about 35:1:3. In the light-adapted condition the rods are of uniform diameter along their entire length and are therefore not felt to undergo photomechanical changes. The rod outer segment co...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Braekevelt CR,Smith SA,Smith BJ

    更新日期:1996-01-01 00:00:00

  • Temporal and spatial distribution of TGF-beta isoforms and signaling intermediates in corneal regenerative wound repair.

    abstract::The present study analyzed the temporal and spatial expression of TGF-beta isoforms and activated pSmad2 and p38MAPK during epithelial debridement wound repair, using chick cornea by immunohistochemistry. Normal corneas showed low-level TGF-betas staining. Following wounding, TGF-beta1 expression was strong in the Bow...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-24.1405

    authors: Huh MI,Chang Y,Jung JC

    更新日期:2009-11-01 00:00:00

  • Gli-similar (Glis) Krüppel-like zinc finger proteins: insights into their physiological functions and critical roles in neonatal diabetes and cystic renal disease.

    abstract::GLI-similar (Glis) 1-3 proteins constitute a subfamily of the Krüppel-like zinc finger transcription factors that are closely related to the Gli family. Glis1-3 play critical roles in the regulation of a number of physiological processes and have been implicated in several pathologies. Mutations in GLIS2 have been lin...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-25.1481

    authors: Kang HS,ZeRuth G,Lichti-Kaiser K,Vasanth S,Yin Z,Kim YS,Jetten AM

    更新日期:2010-11-01 00:00:00

  • Clinical significance of Src expression and activity in human neoplasia.

    abstract::Src, a 60 kDa non-receptor tyrosine kinase, is the product of normal c-src of the human genome and member of the Src protein tyrosine kinases family (SFK). As described by Martin and Rous, a genetic recombination between c-src and the RSV oncogene of Rous sarcoma virus results in a modified Src protein, with increased...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-27.677

    authors: Chatzizacharias NA,Kouraklis GP,Giaginis CT,Theocharis SE

    更新日期:2012-06-01 00:00:00

  • Glomerular filtration barrier in experimental endotoxin shock: a histopathological and physiopathological study.

    abstract::In the present work a morphopathological study is carried out of the glomerular filtration barrier in 20 Large-White pigs weighing 20 kg, subjected to experimental intravenous inoculations of endotoxin from Salmonella enteritidis. The study is completed with the determination of protein plasmatic levels, through urine...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Redondo E,Roncero V,Durán E,Gázquez A

    更新日期:1989-10-01 00:00:00

  • New models towards assessing anti-cancer therapeutics.

    abstract::Cancer is the subject of intense research around the world, but many questions about how the disease works remain unanswered. How exactly does cancer start and how do tumours grow? In fact, at present there are ten times more anticancer drugs being tested in clinical trials than there were 15 years ago. However, many ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-27.157

    authors: Romero-Camarero I,Barajas-Diego M,Castellanos-Martín A,García-Martín Á,Varela G,Abad M,Ludeña MD,Pérez-Losada J,Sánchez-García I

    更新日期:2012-02-01 00:00:00

  • Localization of androgen and estrogen receptors in rat and primate tissues.

    abstract::There is now evidence that estrogens and androgens are exerting their effects in different tissues throughout the body. In order to determine the sites of action of these steroids, studies have been performed to identify at the cellular level the localization of androgen receptor (AR) and the two estrogen receptor (ER...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-15.1261

    authors: Pelletier G

    更新日期:2000-10-01 00:00:00

  • Vacuolar-type proton pump ATPases: roles of subunit isoforms in physiology and pathology.

    abstract::The vacuolar-type H(+)-ATPases (V-ATPases) are a family of multi-subunit ATP-dependent proton pumps involved in diverse cellular processes, including acid/base homeostasis, receptor-mediated endocytosis, processing of proteins and signaling molecules, targeting of lysosomal enzymes, and activation of various degradati...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-25.1611

    authors: Sun-Wada GH,Wada Y

    更新日期:2010-12-01 00:00:00

  • Fine reconstruction of the pancreatic ductular system at the onset of pancreatitis.

    abstract::The three-dimensional structure of the pancreatic ductular system (from the intercalated duct to the intercellular secretory canaliculus) is controversial and unclear. The aim of this study is to reveal the three-dimensional structure of the pancreatic ductular sysytem at the onset of pancreatitis. One day following r...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-17.107

    authors: Endo H,Ashizawa N,Niigaki M,Hamamoto N,Niigaki M,Kaji T,Katsube T,Watanabe M,Naora H,Otani H,Kinoshita Y

    更新日期:2002-01-01 00:00:00

  • Ultrastructural characterization of calcification onset and progression in subdermally implanted aortic valves. Histochemical and spectrometric data.

    abstract::Detailed characterization of the subdermal model is a significant tool for better understanding of calcification mechanisms occurring in heart valves. In previous ultrastructural investigation on six-week-implantated aortic valve leaflets, modified pre-embedding glutaraldehyde-cuprolinic-blue reactions (GA-CB) enabled...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-22.261

    authors: Ortolani F,Bonetti A,Tubaro F,Petrelli L,Contin M,Nori SL,Spina M,Marchini M

    更新日期:2007-03-01 00:00:00

  • Effects of Helicobacter pylori on biological characteristics of gastric epithelial cells.

    abstract::Infection with Helicobacter pylori (H. pylori) strains is linked to an increased risk of inflammation and gastric cancer. To investigate the effects of H. pylori on biological characteristics of gastric epithelial cells SGC-7901, derived from human adenocarcinoma, morphological appearances of both the pathogen and the...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-27.1079

    authors: Wang P,Mei J,Tao J,Zhang N,Tian H,Fu GH

    更新日期:2012-08-01 00:00:00

  • Structure and function of melanocytes: microscopic morphology and cell biology of mouse melanocytes in the epidermis and hair follicle.

    abstract::Melanocytes characterized by their tyrosinase activity, melanosomes and dendrites locate in the basal layer of epidermis and hair bulb in the skin of mice. Melanocytes differentiate from undifferentiated melanoblasts derived from embryonic neural crest. Melanocyte-stimulating hormone plays an important role in the reg...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:

    authors: Hirobe T

    更新日期:1995-01-01 00:00:00

  • Immunocytochemical localization of the vacuolar H(+)-ATPase pump in the kidney.

    abstract::In this article we review immunocytochemical localization studies using a monoclonal antibody raised against the 31 kD subunit of bovine H(+)-ATPase, and indirect immunofluorescent staining. In the proximal tubules there is intense H(+)-ATPase staining along the brush borders of S1 and S2, and linear subvillar invagin...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:

    authors: Bastani B

    更新日期:1997-07-01 00:00:00

  • Cisplatin treatment of NIH/3T3 cultures induces a form of autophagic death in polyploid cells.

    abstract::The effects induced by different concentrations (50, 75, 100 microM) of the cytostatic drug cisplatin (cDDP) in NIH/3T3 cells were analyzed. Sub-confluent cultures of this mouse fibroblast line, obtained after serum deprivation, showed the presence of aneuploid/polyploid cells with ploidy values ranging from 4c to 24c...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-23.717

    authors: Spano A,Monaco G,Barni S,Sciola L

    更新日期:2008-06-01 00:00:00