Monoclonal antibody against histiocytosis X cells.

Abstract:

:Monoclonal antibody against histiocytosis X cells (HXCs) was established. The antigen was the cell membrane of HXCs from the submandibular lesion of a 63-year-old man who had been diagnosed as an adult type of histiocytosis X (HX) and whose HXCs had numerous Birbeck granules (BGs). The obtained monoclonal antibody, named MI1, reacted with the antigenic cell membrane of HXC. Immunoblotting showed that MI1 bound to the cell membrane of 28500 mw. MI1 also reacted with interdigitating reticulum cells (IDCs) in the tonsil and Langerhans cells (LCs) in the epidermis. MI1 reacted with the BGs which connected to the cell membrane, but not with those located near the nucleus.

journal_name

Histol Histopathol

authors

Ishikawa M,Matsuda M,Imai Y

subject

Has Abstract

pub_date

1992-07-01 00:00:00

pages

405-13

issue

3

eissn

0213-3911

issn

1699-5848

journal_volume

7

pub_type

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