Abstract:
:The ultrastructure of four aldosterone secreting adenomas and of the adjacent zona glomerulosa has been described by the use of stereological techniques. Adenomatous cells (about 2800 microns 3 in volume) invariably displayed a striking abundance of lipid droplets, which occupied about 30% of the cytoplasm. Mitochondria prevalently contained tubulo-lamellar or lamellar cristae, but some cells exhibited organelles with vesicular cristae. Smooth endoplasmic reticulum (SER) was not very abundant. Small lipofuscin-pigment granules were frequently seen and in a few cells they were exceedingly numerous. Zona glomerulosa cells were smaller (about 950 microns 3 in volume) and possessed mitochondria with typical tubulo-lamellar cristae, a plentiful SER and few lipid droplets. They showed the ultrastructural features of elements actively engaged in steroid synthesis. The possible origin of aldosteronoma cells from the zona glomerulosa is discussed.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Belloni AS,Mantero F,Rocco S,Gottardo G,Mazzocchi G,Nussdorfer GGsubject
Has Abstractpub_date
1988-07-01 00:00:00pages
241-7issue
3eissn
0213-3911issn
1699-5848journal_volume
3pub_type
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