Abnormal distribution of CD45 isoforms expressed by CD4+ and CD8+ T cells in rheumatoid arthritis.

Abstract:

:CD45RO+ T cells are referred to as memory or helper-inducer while CD45RA+ T cells are regarded as naive or suppressor-inducer T cells. The former population predominates in the peripheral blood and even more in the synovial fluid of patients with rheumatoid arthritis, to the expense of the latter population. Within the CD45RB+ compartment, there appears to be more of the fully-differentiated than of the early-differentiated CD4+ T cells. In spite of the fact that these lymphocytes are close to undergoing apoptosis, this programmed cell death is inhibited in the rheumatoid synovium.

journal_name

Histol Histopathol

authors

Mamoune A,Durand V,Le Goff P,Pennec YL,Youinou P,Le Corre R

doi

10.14670/HH-15.587

subject

Has Abstract

pub_date

2000-04-01 00:00:00

pages

587-91

issue

2

eissn

0213-3911

issn

1699-5848

journal_volume

15

pub_type

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