Abnormal distribution of CD45 isoforms expressed by CD4+ and CD8+ T cells in rheumatoid arthritis.


:CD45RO+ T cells are referred to as memory or helper-inducer while CD45RA+ T cells are regarded as naive or suppressor-inducer T cells. The former population predominates in the peripheral blood and even more in the synovial fluid of patients with rheumatoid arthritis, to the expense of the latter population. Within the CD45RB+ compartment, there appears to be more of the fully-differentiated than of the early-differentiated CD4+ T cells. In spite of the fact that these lymphocytes are close to undergoing apoptosis, this programmed cell death is inhibited in the rheumatoid synovium.


Histol Histopathol


Mamoune A,Durand V,Le Goff P,Pennec YL,Youinou P,Le Corre R




Has Abstract


2000-04-01 00:00:00












  • Novel polyvinyl alcohol (PVA) based cryoprotection method that facilitates cutting frozen sections of decalcified human trabecular bone.

    abstract::Processing adult human trabecular bone to obtain tissue sections suitable for research or diagnostic purposes has always been challenging, particularly in the preparation of adult bone specimens for advanced immunohistochemistry applications. In contrast to the majority of soft tissues, decalcified bone samples perfor...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Maly IP,Rahner C,Nowakowski AM,Müller-Gerbl M

    更新日期:2013-12-01 00:00:00

  • Ultrastructure and organisation of the cornea, lens and iris in the pipefish, Corythoichthyes paxtoni (Syngnathidae, Teleostei).

    abstract::The corneas of nine pipefish, Corythoichthyes paxtoni (Syngnathidae, Teleostei), five freshly fixed and four museum specimens, were examined using light and electron microscopy. In transverse section, the surface of the corneal epithelium is covered by a complex series of ridges or microplicae which extends over the c...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Collin HB,Collin SP

    更新日期:1995-04-01 00:00:00

  • Cadmium toxicity on cultured neonatal rat hepatocytes: biochemical and ultrastructural analyses.

    abstract::The effects of cadmium exposure on the protein secretory functions of cultured neonatal rat hepatocytes were analyzed by both two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) and electron microscopy. [35S]Methionine-labelled protein secretion was significantly depressed by cadmium exposure in a dose-depend...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Hirano T,Ueda H,Kawahara A,Fujimoto S

    更新日期:1991-01-01 00:00:00

  • Anti-platelet agents reduce morphological changes of chronic hypoxic pulmonary hypertension.

    abstract::The pathophysiologic mechanism by which chronic hypoxia causes pulmonary hypertension is unknown. If anti-platelet agents, or other pharmacologic interventions, altered the pulmonary vascular changes induced by hypoxia, information concerning the pathogenesis of the pulmonary hypertension or the potential therapeutic ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Keith IM,Will JA,Huxtable RJ,Weir K

    更新日期:1987-04-01 00:00:00

  • Decalcification by perfusion. A new method for rapid softening of temporal bones.

    abstract::We describe a new technique, decalcification by perfusion, for the softening of bony tissue. The blood circulatory system was perfused in 16 rats via a cannula through the left heart ventricle with a fixative followed by New Decalc (an acidic demineralizer) for 30-240 minutes. Perfusion decalcification for 120 minutes...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Nilsson M,Hellström S,Albiin N

    更新日期:1991-07-01 00:00:00

  • Induction system of neural and muscle lineage cells from bone marrow stromal cells; a new strategy for tissue reconstruction in degenerative diseases.

    abstract::Since bone marrow stromal cells (MSCs) are easily accessible both from healthy donors and patients, and can be expanded on a therapeutic scale, they have attracted attention for cell-based therapy. MSCs contribute to the protection of host tissue after transplantation by Immune modulation and trophic effect. They also...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Kitada M,Dezawa M

    更新日期:2009-05-01 00:00:00

  • Immunohistochemical expression and localization of MMP-9, MMP-13, E-Cadherin and Ki-67 in road pavers' skin chronically exposed to bitumen products.

    abstract::To investigate the matrix metalloproteinase (MMP)-9, (MMP)-13, E-Cadherin and Ki-67 expressions in road pavers' skin chronically exposed to bitumen products in order to contribute to a better understanding of the earlier tissue alteration. Skin punch biopsies from 16 daily exposed workers and a control group were stud...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Loreto C,Lombardo C,Caltabiano R,Filetti V,Vitale E,Seminara D,Castorina S,Fenga C,Ledda C,Rapisarda V

    更新日期:2019-10-01 00:00:00

  • Nitric oxide, a biological double-faced janus--is this good or bad?

    abstract::Nitric oxide (NO) is a biological messenger molecule produced by one of the essential amino acids L-arginine by the catalytic action of the enzyme NO synthase (NOS). The dual role of NO as a protective or toxic molecule is due to several factors, such as; the isoform of NOS involved, concentration of NO and the type o...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Thippeswamy T,McKay JS,Quinn JP,Morris R

    更新日期:2006-04-01 00:00:00

  • Immunohistochemistry of connexin43 and zonula occludens-1 in the myocardium as markers of early ischemia in autopsy material.

    abstract::Immunohistochemistry of the terminal complement complex (C5b-9) and fibronectin (FN) is useful to detect myocardial ischemia preceding necrosis in the postmortem diagnosis of sudden cardiac death. The present immunohistochemical study examined connexin43 (Cx43) and zonula occludens-1 (ZO-1) as markers of early myocard...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Kawamoto O,Michiue T,Ishikawa T,Maeda H

    更新日期:2014-06-01 00:00:00

  • Aluminium exposure induces Alzheimer's disease-like histopathological alterations in mouse brain.

    abstract::Aluminium (Al) is a neurotoxic metal and Al exposure may be a factor in the aetiology of various neurodegenerative diseases such as Alzheimer's disease (AD). The major pathohistological findings in the AD brain are the presence of neuritic plaques containing beta-amyloid (Abeta) which may interfere with neuronal commu...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Rodella LF,Ricci F,Borsani E,Stacchiotti A,Foglio E,Favero G,Rezzani R,Mariani C,Bianchi R

    更新日期:2008-04-01 00:00:00

  • Daunorubicin does not induce immunohistochemically detectable endothelial dysfunction in rabbit aorta and femoral artery.

    abstract::Anthracyclines are one of the most effective anticancer drugs ever developed, but their clinical use has been hampered by the risk of severe cardiotoxicity. In this study, we investigated whether rabbits exposed to a different cumulative dose of anthracycline suffer from immunohistochemically detectable vascular toxic...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Nachtigal P,Sterba M,Popelová O,Večeřová L,Kudláčková Z,Jirkovský E,Geršl V

    更新日期:2011-05-01 00:00:00

  • Perspectives of SLIT/ROBO signaling in placental angiogenesis.

    abstract::A novel family of evolutionally conserved neuronal guidance cues, including ligands (i.e., Slit, netrin, epherin, and semaphorin) and their corresponding receptors (i.e., Robo, DCC/Unc5, Eph and plexin/ neuropilin), has been identified to play a crucial role in axon pathfinding and branching as well as neuronal cell m...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Liao WX,Wing DA,Geng JG,Chen DB

    更新日期:2010-09-01 00:00:00

  • Telocytes form networks in normal cardiac tissues.

    abstract::Telocytes (TC) are a class of interstitial cells present in heart. Their characteristic feature is the presence of extremely long and thin prolongations (called telopodes). Therefore, we were interested to see whether or not TCs form networks in normal cardiac tissues, as previously suggested. Autopsy samples of card...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Rusu MC,Pop F,Hostiuc S,Curca GC,Jianu AM,Paduraru D

    更新日期:2012-06-01 00:00:00

  • Role of angiogenesis on bone formation.

    abstract::Angiogenesis and bone formation are coupled during skeletal development and fracture healing. This relationship, although known for some time, has not been properly explored. Advances in the discovery of how angiogenesis is regulated in physiological processes like embryogenesis, endometrial regeneration and wound hea...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Portal-Núñez S,Lozano D,Esbrit P

    更新日期:2012-05-01 00:00:00

  • Immunocytochemical localization of the vacuolar H(+)-ATPase pump in the kidney.

    abstract::In this article we review immunocytochemical localization studies using a monoclonal antibody raised against the 31 kD subunit of bovine H(+)-ATPase, and indirect immunofluorescent staining. In the proximal tubules there is intense H(+)-ATPase staining along the brush borders of S1 and S2, and linear subvillar invagin...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Bastani B

    更新日期:1997-07-01 00:00:00

  • Pancreas is a preeminent source of ghrelin after sleeve gastrectomy in Wistar rats.

    abstract::Many surgical techniques are employed in the treatment of severe obesity. A main consequence of these techniques is the improvement of type 2 Diabetes mellitus. Ghrelin is a gut hormone released in the gastric fundus and corpus, which has been related to diabetic improvement as mentioned in these papers. Sleeve gastre...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Camacho-Ramírez A,Mayo-Ossorio MÁ,Pacheco-García JM,Almorza-Gomar D,Ribelles-García A,Belmonte-Núñez A,Prada-Oliveira JA,Pérez-Arana GM

    更新日期:2020-08-01 00:00:00

  • Ultrastructural substrates for increased lung water content in experimental pulmonary edema.

    abstract::We examined the relationship between the incidence of ultrastructural changes in the alveolar septum and the extravascular lung water content. Pulmonary edema was induced in 18 mongrel dogs by either dextran (n = 12) or alloxan (n = 6) administration. Six other dogs served as controls. Extravascular lung water content...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Oda H,Arakawa M,Kambara K,Nakahara K,Segawa T,Ando F,Kawada T,Hirakawa S,Shoumura S,Isono H

    更新日期:1993-01-01 00:00:00

  • Commonly used mesenchymal stem cell markers and tracking labels: Limitations and challenges.

    abstract::Early observations that cultured mesenchymal stem cells (MSCs) could be induced to exhibit certain characteristics of osteocytes and chondrocytes led to the proposal that they could be transplanted for tissue repair through cellular differentiation. Therefore, many subsequent preclinical studies with transplanted MSCs...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Lin CS,Xin ZC,Dai J,Lue TF

    更新日期:2013-09-01 00:00:00

  • Involvement of endogenous prostaglandin E2 in tubular epithelial regeneration through inhibition of apoptosis and epithelial-mesenchymal transition in cisplatin-induced rat renal lesions.

    abstract::In the kidney, prostaglandin (PG) E2 is the main PG, playing important roles in maintaining homeostasis or development of pathological settings. Roles of PGE2 in renal lesions remain to be clarified. The expression patterns of PGE2 synthesis enzymes such as cyclooxygenase (COX)-1, COX-2 and microsomal PGE synthase (mP...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Yamamoto E,Izawa T,Juniantito V,Kuwamura M,Sugiura K,Takeuchi T,Yamate J

    更新日期:2010-08-01 00:00:00

  • Topographical difference of cytoskeletal organization in smooth muscle cells of rat duodenum revealed by quick-freezing and deep-etching method.

    abstract::The sarcolemmal domain of rat duodenal smooth muscle cells includes caveolae and associated cytoskeletal or filamentous elements. We have used the quick-freezing, deep-etching method to examine the three dimensional relationships between these components. Replica membranes for separated strips of rat duodenal muscle l...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Takayama I,Fujii Y,Terada N,Baba T,Kato Y,Fujino MA,Ohno S

    更新日期:2000-10-01 00:00:00

  • Pax genes in development and maturation of the vertebrate visual system: implications for optic nerve regeneration.

    abstract::Pax genes play a pivotal role in development of the vertebrate visual system. Pax6 is the master control gene for eye development: ectopic expression of Pax6 in Xenopus laevis and Drosphila melanogaster leads to the formation of differentiated eyes on the legs or wings. Pax6 is involved in formation of ganglion cells ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Ziman MR,Rodger J,Chen P,Papadimitriou JM,Dunlop SA,Beazley LD

    更新日期:2001-01-01 00:00:00

  • Comparison of the dysadherin and E-cadherin expression in primary lung cancer and metastatic sites.

    abstract::Dysadherin, a cancer associated cell membrane glycoprotein, has been reported to downregulate E-cadherin. Aberrant expression of E-cadherin has been associated with the development of metastases in patients with cancer. Even though the expression of dysadherin and E-cadherin has been studied in primary non-small cell ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Mitselou A,Batistatou A,Nakanishi Y,Hirohashi S,Vougiouklakis T,Charalabopoulos K

    更新日期:2010-10-01 00:00:00

  • Topoisomerase 1A, HER/2neu and Ki67 expression in paired primary and relapse ovarian cancer tissue samples.

    abstract::In the present study we examined prognostic value of immunohistochemical estimation of topoisomerase 1A (TOP 1A) and HER-2/neu expression in ovarian cancers treated with platinum-based drugs but not with topotecan and the relation between expression of these proteins on the one hand and intensity of proliferation (Ki6...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Surowiak P,Materna V,Kaplenko I,Spaczynski M,Dietel M,Lage H,Zabel M

    更新日期:2006-07-01 00:00:00

  • Aberrant expression and association of VEGF and Dll4/Notch pathway molecules under hypoxia in patients with lung cancer.

    abstract::Tumor angiogenesis plays important roles in the pathogenesis and prognosis of lung cancer. Both vascular endothelial growth factor (VEGF) and Dll4/Notch pathways are critical for angiogenesis, whereas their relationship under hypoxia in lung cancer remains unknown. Thus, in the present study, we evaluated the expressi...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Yu S,Sun J,Zhang J,Xu X,Li H,Shan B,Tian T,Wang H,Ma D,Ji C

    更新日期:2013-02-01 00:00:00

  • Immunolocalization of serum proteins in xenografted mouse model of human tumor cells by various cryotechniques.

    abstract::The transport mechanism of soluble molecules throughout the interstitial matrix is closely associated with human tumor behavior in vivo. However, the examination of soluble components in histological architectures has been hampered by artifacts caused during conventional tissue preparation. In this study, the immunodi...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Bai Y,Ohno N,Terada N,Saitoh S,Nakazawa T,Nakamura N,Katoh R,Ohno S

    更新日期:2009-06-01 00:00:00

  • Fine reconstruction of the pancreatic ductular system at the onset of pancreatitis.

    abstract::The three-dimensional structure of the pancreatic ductular system (from the intercalated duct to the intercellular secretory canaliculus) is controversial and unclear. The aim of this study is to reveal the three-dimensional structure of the pancreatic ductular sysytem at the onset of pancreatitis. One day following r...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Endo H,Ashizawa N,Niigaki M,Hamamoto N,Niigaki M,Kaji T,Katsube T,Watanabe M,Naora H,Otani H,Kinoshita Y

    更新日期:2002-01-01 00:00:00

  • Microglia and prion disease: a review.

    abstract::Prion diseases are characterized by the accumulation of PrPSc, an altered isoform of a normal cellular protein, PrPc. The prion hypothesis holds that the process of conformational change from PrPc to PrPSc under the influence of PrPSc constitutes the basic infectious mechanism in prion diseases. It is still unknown wh...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Brown DR,Kretzschmar HA

    更新日期:1997-07-01 00:00:00

  • Immunohistological signposts in central nervous system tumours with neuronal differentiation.

    abstract::25 neuronal tumours with a panel of antibodies were studied and it was found that vimentin was present in 15 tumours. It was also found in a few cells within rosettes. PGP 9.5 showed a somatic pattern of staining with nuclear and perinuclear positivity in 23. Neurofilament reactivity was found in 14. Retinal S-antigen...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Cruz-Sánchez FF,Rossi ML,Rodríguez-Prados S,Cusi V,Coakham HB

    更新日期:1991-10-01 00:00:00

  • The presence of the mu-opioid receptor in the isthmus of mare oviduct.

    abstract::The presence of the mu-opioid receptor and the type of glycosylation in the third extra-cellular loop of this receptor was investigated in the isthmus of mare oviduct during oestrus by means of immunoblotting and immunohistochemistry combined with enzymatic (N-glycosidase F and O-glycosidase) and chemical (beta-elimin...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Desantis S,Albrizio M,Ventriglia G,Deflorio M,Guaricci AC,Minoia R,De Metrio G

    更新日期:2008-05-01 00:00:00

  • The combination of strong immunohistochemical mtTFA expression and a high survivin index predicts a shorter disease-specific survival in pancreatic ductal adenocarcinoma.

    abstract::Mitochondrial transcription factor A (mtTFA) plays a crucial role in both the transcription and maintenance of mitochondrial DNA. A high expression of mtTFA has been demonstrated in several solid tumors, and is closely associated with cancer cell survival/apoptosis and growth. However, its expression pattern in pancre...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Kimura T,Kitada S,Uramoto H,Zhi L,Kawatsu Y,Takeda T,Horie S,Nabeshima A,Noguchi H,Sasaguri Y,Izumi H,Kohno K,Yamada S

    更新日期:2015-02-01 00:00:00