Abstract:
:Despite years of research into its pathobiology and continuing clinical trials for novel therapies, the prognosis for patients with glioblastoma (GBM) remains dismal. An important obstacle against treatment efficacy may be a high degree of intra- and inter-tumoral heterogeneity within GBMs, which may be caused by the presence of self-renewing GBM stem cells (GSCs). Recent advances in multi-omics technology introduce new possibilities for applying personalized strategies to GBM therapy. As drug discovery is accelerating with the transition from non-selective, cytotoxic therapy to a precision, targeted approach, the appropriate in vivo platform for GBM is critical for validating drug targets and prioritizing candidates for clinical studies, for co-development of companion diagnostics and, ultimately, for drug approval. Here we will describe GBM orthotopic patient-derived xenografts (PDXs) as more useful, clinically relevant resources for individually tailored strategies for GBM.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Lee HW,Lee K,Kim DG,Yang H,Nam DHdoi
10.14670/HH-11-695subject
Has Abstractpub_date
2016-03-01 00:00:00pages
269-83issue
3eissn
0213-3911issn
1699-5848pii
HH-11-695journal_volume
31pub_type
杂志文章,评审abstract::Thyroid glands from 7 marmosets (Callithrix jacchus) of different age groups (newborn, 2 weeks, 2, 7, 8 and 11 months, and 8 years) were grown as organ culture according to Trowell at the medium/air interphase for 3 to 30 days. The morphology of thyroid tissue was well preserved until the end of the culture period. Ne...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1995-10-01 00:00:00
abstract::A proportion of anaplastic large cell tumours is difficult to classify on sections of routinely processed, paraffin-embedded tissue. Differentiation into large cell lymphoma, carcinoma, melanoma or sarcoma is important in order to assess prognosis and proper treatment. Although the use of immunohistochemistry has been...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1987-04-01 00:00:00
abstract::Bone marrow features in stable-phase chronic myelogenous leukemia (CML) are characterized by a striking heterogeneity which is determinable by appropriate means including representative pre-treatment trephine biopsies, immunohistochemistry and morphometry. Cell lineages involved to a variable extent consist not only o...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-14.1241
更新日期:1999-10-01 00:00:00
abstract::Emperipolesis has recently been described as a constant feature of "biphasic squamoid" papillary renal cell carcinoma (BPRCC). We also noticed this in some high-grade (HG) RCC, which promoted the present study to estimate the incidence of emperipolesis in RCCs and to describe them in further detail. 14 cases of HGRCC ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-11-925
更新日期:2018-03-01 00:00:00
abstract::An ultrastructural and histological study was made to analyse the structural and cellular features of the pulmonary lesions produced in Wistar rats by intraperitoneal (i.p.) administration of cyclophosphamide (two i.p. doses of 150 mg CP/1 kg bw/1 ml PBS). Rats exposed to cyclophosphamide (CP) developed a condition wh...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-14.1145
更新日期:1999-10-01 00:00:00
abstract::The lower respiratory tract of the sheep was studied by light-microscopical immunocytochemistry for serotonin, cholecystokinin, somatostatin, bombesin and calcitonin during different periods of lung development; embryonic, foetal and postnatal. At embryonic period only intraepithelial serotonin-containing cells as sol...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1992-10-01 00:00:00
abstract::The ultrastructure of the atrial myocardium in the monkey (Macaca fascicularis) was studied after bilateral cervical vagotomy and survival times of 100, 175 and 367 days. Changes were observed in the nucleus and the cytoplasm of the myocyte. Sequestered within the nuclei of the affected myocytes were cytoplasmic organ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1989-07-01 00:00:00
abstract::The present study analyzed the temporal and spatial expression of TGF-beta isoforms and activated pSmad2 and p38MAPK during epithelial debridement wound repair, using chick cornea by immunohistochemistry. Normal corneas showed low-level TGF-betas staining. Following wounding, TGF-beta1 expression was strong in the Bow...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-24.1405
更新日期:2009-11-01 00:00:00
abstract::Complex carbohydrate structures are essential molecules of infectious microbes and host cells, and are involved in cell signaling associated with inflammatory and immune responses. The uptake of mannose-tailed glycans is usually carried out by macrophages, dendritic cells (DCs), and other professional phagocytes to tr...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-24.1029
更新日期:2009-08-01 00:00:00
abstract::To understand the role of microtubules and microfilaments in regulating endothelial monolayer integrity and repair, and since microtubules and microfilaments show some co-alignment in endothelial cells, we tested the hypothesis that microtubules organize microfilament distribution. Disruption of microtubules with colc...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-20.455
更新日期:2005-04-01 00:00:00
abstract::Primordial germ cells (PGCs) are the founder cells of all gametes. PGCs differentiate from pluripotent epiblasts cells by mesodermal induction signals during gastrulation. Although PGCs are unipotent cells that eventually differentiate into only sperm or oocytes, they dedifferentitate to pluripotent stem cells known a...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-26.643
更新日期:2011-05-01 00:00:00
abstract::Systematic studies on hepatic stellate cells and myofibroblasts have so far mainly focused on cells located in the perisinusoidal space of Disse, the so-called littoral compartment. Here, these cells play a key role for intralobular fibrogenesis and sinusoidal capillarization. However, advanced hepatic fibrosis and ci...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-14.719
更新日期:1999-07-01 00:00:00
abstract::The presence of synaptophysin, a presynaptic Ca2+ binding glycoprotein, has been analyzed in the cochlear nucleus complex of the adult cat using an antisynaptophysin monoclonal antibody. Synaptophysin immunoreactivity was differently distributed between regions of cochlear nuclei. Terminal boutons contacting directly ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-13.415
更新日期:1998-04-01 00:00:00
abstract::HNK-1 positive (HNK-1+) cells in human peripheral blood and lymph nodes were comparatively analysed by means of immunohistochemistry and immunoelectron microscopy. In peripheral blood, the HNK-1+ cells were grouped into large granular lymphocytes (LGLs), small lymphocytes and intermediate forms, all of which had many ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1989-04-01 00:00:00
abstract::Experimental Doxorubicin-exposure in utero is correlated with foetal oesophageal atresia, tracheo-oesophageal fistula, axial alterations. While gastrointestinal and respiratory defects have been largely investigated, only sporadic data have been published to date on notochordal and vertebral defects. The aim of this w...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-17.31
更新日期:2002-01-01 00:00:00
abstract::Targeting essential cellular pathways that determine neuronal and vascular survival can foster a successful therapeutic platform for the treatment of a wide variety of degenerative disorders in the central nervous system. In particular, oxidative cellular injury can precipitate several nervous system disorders that ma...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-19.495
更新日期:2004-04-01 00:00:00
abstract::Chronic lung allograft dysfunction (CLAD) still remains a major drawback in the outcome following lung transplantation (LTx). New therapeutic strategies are warranted. Growth factors and their receptors like platelet-derived growth factor-receptor (PDGFR) and vascular endothelial growth factor-receptor (VEGFR), may pl...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-18-088
更新日期:2019-07-01 00:00:00
abstract::Pax genes play a pivotal role in development of the vertebrate visual system. Pax6 is the master control gene for eye development: ectopic expression of Pax6 in Xenopus laevis and Drosphila melanogaster leads to the formation of differentiated eyes on the legs or wings. Pax6 is involved in formation of ganglion cells ...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-16.239
更新日期:2001-01-01 00:00:00
abstract::Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity with a poor 5-year survival rate, due in large part to the presence of metastatic disease at initial diagnosis. In recent years, a number of studies have examined the oral tumor microenvironment to asses the potential dynamic balance ...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-25.917
更新日期:2010-07-01 00:00:00
abstract::CD45RO+ T cells are referred to as memory or helper-inducer while CD45RA+ T cells are regarded as naive or suppressor-inducer T cells. The former population predominates in the peripheral blood and even more in the synovial fluid of patients with rheumatoid arthritis, to the expense of the latter population. Within th...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-15.587
更新日期:2000-04-01 00:00:00
abstract::CD24 is known to be an important diagnostic and prognostic marker of several major cancers affecting females. We aimed to determine CD24 expression in normal, hyperplastic, and carcinomatous endometrium and its correlation with estrogen and progesterone receptor expression. A total of 271 cases including 62 normal/atr...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-24.309
更新日期:2009-03-01 00:00:00
abstract::The integrity of the thymus during early life is necessary for a proper maturation of the neuroendocrine system, including the adrenal axis. The thymic metallopeptide thymulin seems to be a central physiologic mediator of thymus-pituitary communication. Furthermore, neonatal thymulin gene therapy has been shown to pre...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-26.471
更新日期:2011-04-01 00:00:00
abstract::Neurotrophins are substances that have been shown to be important in growth and remodelling phases in different types of tissue. There is no information concerning the possible occurrences of neurotrophins and their receptors in tendons. In this study, sections of both chronic painful (tendinosis) and pain-free (non-t...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-24.839
更新日期:2009-07-01 00:00:00
abstract::Chronic liver diseases are commonly associated with tissue hypoxia that may cause inflammation, oxidative stress, liver cell injury and increased nuclear transcriptional regulation. The hepatic response to chronic hypoxia at the molecular level has not yet been clearly understood until now. The aim of this study is to...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:2013-04-01 00:00:00
abstract::Oligodendrocytes are the myelinating cells of the central nervous system. Since many studies of demyelinating diseases focus their research on this cell type, there is growing interest for obtaining reliable markers that can specifically recognize oligodendroglia. Established markers are the myelin-associated neurite ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-11-640
更新日期:2015-12-01 00:00:00
abstract::The low density lipoprotein receptor-related protein (LRP) 1 is a ubiquitously expressed, versatile cell surface transmembrane receptor involved in embryonic development and adult tissue homeostasis. LRP1 binds and endocytoses a broad spectrum of over 40 ligands identified thus far, including lipoproteins, extracellul...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-11-746
更新日期:2016-07-01 00:00:00
abstract::Peritumoral brain edema (PTBE) is considered to be one of the main biological behaviors of brain glioma. However, the histopathological features of PTBE remain imprecisely defined. We analyzed the histopathological characteristics in the PTBE area of 22 cases of glioma. Microscopically, the pre-existing basic structur...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-11-607
更新日期:2015-09-01 00:00:00
abstract::Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the purpose of anti-inflammation, antipyretic, and analgesia. For this aim, they are used for the alleviation of pain, fever, and inflammation associated with rheumatoid arthritis, sports injuries, and temporary pain. However, treatment with NSAIDs may ...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-27.417
更新日期:2012-04-01 00:00:00
abstract::Cerebral cavernous malformations (CCMs) are described as vascular lesions consisting of endothelial-lined dilated vessels embedded in a connective tissue sheath without intervening parenchyma between them. Their anatomical connections with the normal blood vessels are still enigmatic and the fine three-dimensional (3-...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-29.1071
更新日期:2014-08-01 00:00:00
abstract::The anti-oxidant food additive, butylated hydroxytoluene (BHT), was fed to Sprague-Dawley rats at three concentrations: 0.2%, 0.4% and 0.8% for periods of 6, 12, 18 and 24 weeks, and the results were compared with corresponding groups treated with a potent carcinogen, 7,12-dimethylbenz[a]anthracene (DMBA) groups, with...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-14.391
更新日期:1999-04-01 00:00:00