Extrahepatic production of acute phase serum amyloid A.


:Amyloidosis is a group of diseases characterized by the extracellular deposition of protein that contains non-branching, straight fibrils on electron microscopy (amyloid fibrils) that have a high content of beta-pleated sheet conformation. Various biochemically distinct proteins can undergo transformation into amyloid fibrils. The precursor protein of amyloid protein A (AA) is the acute phase protein serum amyloid A (SAA). The concentration of SAA in plasma increases up to 1000-fold within 24 to 48 h after trauma, inflammation or infection. Individuals with chronically increased SAA levels may develop AA amyloidosis. SAA has been divided into two groups according to the encoding genes and the source of protein production. These two groups are acute phase SAA (A-SAA) and constitutive SAA (C-SAA). Although the liver is the primary site of the synthesis of A-SAA and C-SAA, extrahepatic production of both SAAs has been observed in animal models and cell culture experiments of several mammalian species and chicken. The functions of A-SAA are thought to involve lipid metabolism, lipid transport, chemotaxis and regulation of the inflammatory process. There is growing evidence that extrahepatic A-SAA formation may play a crucial role in amyloidogenesis and enhances amyloid formation at the site of SAA production.


Histol Histopathol


Upragarin N,Landman WJ,Gaastra W,Gruys E




Has Abstract


2005-10-01 00:00:00












  • Neutrophil extracellular traps in tissue pathology.

    abstract::Neutrophil extracellular traps (NETs) are innate immune systems against invading pathogens. NETs are characterized as released DNA mixed with cytoplasmic antimicrobial proteins such as myeloperoxidase, proteinase3 and neutrophil elastase. While NETs are thought to have an important role in host defense, recent work ha...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Nakazawa D,Kumar S,Desai J,Anders HJ

    更新日期:2017-03-01 00:00:00

  • Aberrant expression and association of VEGF and Dll4/Notch pathway molecules under hypoxia in patients with lung cancer.

    abstract::Tumor angiogenesis plays important roles in the pathogenesis and prognosis of lung cancer. Both vascular endothelial growth factor (VEGF) and Dll4/Notch pathways are critical for angiogenesis, whereas their relationship under hypoxia in lung cancer remains unknown. Thus, in the present study, we evaluated the expressi...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Yu S,Sun J,Zhang J,Xu X,Li H,Shan B,Tian T,Wang H,Ma D,Ji C

    更新日期:2013-02-01 00:00:00

  • Primordial germ cell specification: the importance of being 'blimped'.

    abstract::In mouse embryos, the expression of Blimp1 has recently revealed a population of allocated primordial germ cell precursors 24 hours earlier than previously thought. Those 'blimped' precursors have been shown to give rise, by mitotic division, to germ cells only and no other cell lineages. Here, we try to understand th...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Chuva de Sousa Lopes SM,Roelen BA

    更新日期:2008-12-01 00:00:00

  • Immunoexpression of gelatinase (MMP-2 and MMP-9) in the seminal vesicles and ventral prostate of Libyan jird (Meriones libycus) during the seasonal cycle of reproduction.

    abstract::An immunohistochemical study of matrix metalloproteinases (MMP-2 and MMP-9) or gelatinase (gelatinase A and gelatinase B) was performed on the seminal vesicles and ventral prostate of the Libyan jird (Meriones libycus) collected in the Beni-Abbes area during breeding period (spring and early summer), during resting ph...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Belhocine M,Gernigon-Spychalowicz T,Jacob MP,Benazzoug Y,Exbrayat JM

    更新日期:2010-05-01 00:00:00

  • Histochemical study of skin and gills of Senegal sole, Solea senegalensis larvae and adults.

    abstract::A battery of horseradish peroxidase-conjugated lectins (Con A, WGA and DBA), as well as conventional histochemical techniques (PAS, saponification, Alcian Blue pH 0.1, 1, 2.5, chlorhydric hydrolisis, neuraminidase, Bromophenol blue, Tioglycollate reduction and Ferric-ferricyanide-FeIII) were used to study the content ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Sarasquete C,González de Canales ML,Arellano J,Muñoz Cueto JA,Ribeiro L,Dinis MT

    更新日期:1998-07-01 00:00:00

  • Myofibroblasts and myoepithelial cells in the chicken harderian gland.

    abstract::An electron microscopic study of the myoepithelial cells in the chicken Harderian gland provides evidence that these cells can be transformed into myofibroblasts. After the application of a Brucella ovis suspension in sterile saline onto the eyeball, every 5 minutes for half an hour, myoepithelial cells gradually deve...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: del Cacho E,Gallego M,Felices C,Bascuas JA

    更新日期:1991-07-01 00:00:00

  • Implications of androgen receptor and FUS expression on tumor progression in urothelial carcinoma.

    abstract::Androgen receptor (AR) interact with many pathways involved in bladder cancer development and progression. FUS (fused in liposarcoma), a multifunctional protein essential for different cellular processes, has been demonstrated as a key link between androgen receptor signaling and cell-cycle progression in prostate can...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Abd Raboh NM,Hakim SA,Abd El Atti RM

    更新日期:2020-12-23 00:00:00

  • Telocytes form networks in normal cardiac tissues.

    abstract::Telocytes (TC) are a class of interstitial cells present in heart. Their characteristic feature is the presence of extremely long and thin prolongations (called telopodes). Therefore, we were interested to see whether or not TCs form networks in normal cardiac tissues, as previously suggested. Autopsy samples of card...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Rusu MC,Pop F,Hostiuc S,Curca GC,Jianu AM,Paduraru D

    更新日期:2012-06-01 00:00:00

  • Apoptosis in dopaminergic neurons of the human substantia nigra during normal aging.

    abstract::Morphological and biochemical alterations have been described in neurons of the aged human brain. However, the cell death process associated with neuronal senescence remains to be elucidated. Apoptosis and autophagic degeneration, two modes of programmed cell death described in embryogenesis and tissue renewal in adul...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Anglade P,Vyas S,Hirsch EC,Agid Y

    更新日期:1997-07-01 00:00:00

  • Might the Masson trichrome stain be considered a useful method for categorizing experimental tendon lesions?

    abstract::Strain injuries of tendons are the most common orthopedic injuries in athletic subjects, be they equine or human. When the tendon is suddenly damaged, an acute inflammatory phase occurs whereas its repetitive overloading may cause chronic injuries. Currently the criteria used for grading injuries are general and subje...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Martinello T,Pascoli F,Caporale G,Perazzi A,Iacopetti I,Patruno M

    更新日期:2015-08-01 00:00:00

  • An immunohistochemical study on the distribution of endocrine cells in the gastrointestinal tract of the musk shrew, Suncus murinus.

    abstract::The endocrine cells in the gastrointestinal tract of the musk shrew were studied immunohistochemically. Eleven kinds of endocrine cells, immunoreactive for serotonin, somatostatin, gastrin, cholecistokinin, gastric inhibitory polypeptide, motilin, secretin, neurotensin, pancreatic glucagon, enteroglucagon and bovine p...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Kitamura N,Yamada J,Watanabe T,Yamashita T

    更新日期:1990-01-01 00:00:00

  • Chaperone-mediated autophagy in cancer: Advances from bench to bedside.

    abstract::Chaperone-mediated autophagy (CMA), a selective form of autophagy, where cellular proteins with KFERQ-like motif are targeted to the lysosome for degradation, is necessary to maintain cellular homeostasis. The role of CMA in neurodegenerative diseases has been extensively studied in the past decades, with defects in t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Hou T,Fan Y,Dan W,Liu B,Wang Z,Zeng J,Li L

    更新日期:2020-07-01 00:00:00

  • Gene therapy strategies in neurodegenerative diseases.

    abstract::Treatment of neurodegenerative diseases by classical pharmacotherapy is restricted by blood-brain barrier which prevents access to the brain of potentially therapeutic molecules. Recent progress in the knowledge of pathophysiological molecular processes, and in the development of molecular biotechnology have opened th...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Giménez y Ribotta M

    更新日期:2001-07-01 00:00:00

  • Eosinophils and airway nerves in asthma.

    abstract::In the lungs, neuronal M2 muscarinic receptors limit the release of acetylcholine from postganglionic cholinergic nerves. However, these receptors are not functional under certain circumstances in animal models of hyperreactivity such as occurs after exposure of sensitised animals to an allergen or during a respirator...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Costello RW,Jacoby DB,Gleich GJ,Fryer AD

    更新日期:2000-07-01 00:00:00

  • Advances in the knowledge of breast cancer stem cells. A review.

    abstract::Much effort has been made by researchers to elucidate the complex biology of breast cancer stem cells (BCSCs), a small subset of breast tumor cells that display stem cell properties, drive tumor initiation, and growth. In recent years, it has been suggested that BCSCs could be responsible for the process of metastasis...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Schwarz-Cruz Y Celis A,Espinosa M,Maldonado V,Melendez-Zajgla J

    更新日期:2016-06-01 00:00:00

  • Localization of blood coagulation factors in the germinal centers of human Peyer's patches.

    abstract::The immunohistochemical distribution of 15 blood coagulation factors in the germinal centers (GCs) of human Peyer's patches (PPs) was studied. Although factor VIII, active alpha-thrombin, and fibrinogen were hardly evident in the GCs, the majority of coagulation factors, such as kallikrein, high-molecular-weight kinin...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Kudo S,Yamakawa M,Imai Y,Tsukamoto M

    更新日期:1992-04-01 00:00:00

  • The thyroid gland of Callithrix jacchus in organ culture.

    abstract::Thyroid glands from 7 marmosets (Callithrix jacchus) of different age groups (newborn, 2 weeks, 2, 7, 8 and 11 months, and 8 years) were grown as organ culture according to Trowell at the medium/air interphase for 3 to 30 days. The morphology of thyroid tissue was well preserved until the end of the culture period. Ne...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Maile S,Merker HJ

    更新日期:1995-10-01 00:00:00

  • Killing two birds with one stone: The multifunctional roles of mesenchymal stem cells in the treatment of neurodegenerative and muscle diseases.

    abstract::Neurodegenerative and muscle diseases bear both complex and multifactorial pathologies. An efficacious and robust therapeutic option to treat these diseases is yet to be elucidated. At such a time, mesenchymal stem cells have drawn significant attention due to their immunomodulatory and regenerative properties. Accumu...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Lee NK,Na DL,Chang JW

    更新日期:2018-07-01 00:00:00

  • Pathophysiology of stem cells in restenosis.

    abstract::Recent evidence has shown that vascular function depends not only on cells within the vessels, but is also significantly modulated by circulating cells derived from the bone marrow. A number of studies indicate that an early reendothelialization by circulating endothelial precursors after vascular injury prevents exce...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Forte A,Cipollaro M,Cascino A,Galderisi U

    更新日期:2007-05-01 00:00:00

  • Anti-apoptotic activity in deep pelvic endometriosis.

    abstract::Since endometriosis is a proliferative disease we evaluated the presence of anti-apoptotic factor (Bcl-2) and pro-apoptotic factor (Bax) in deep pelvic endometriosis. A Cross-sectional observational study was performed at Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil. Forty women aged 26 to 46 years with ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Abdalla Ribeiro HS,Galvāo MA,Aoki T,Aldrighi JM,Ribeiro PA

    更新日期:2014-09-01 00:00:00

  • Immunocytochemical localization of the vacuolar H(+)-ATPase pump in the kidney.

    abstract::In this article we review immunocytochemical localization studies using a monoclonal antibody raised against the 31 kD subunit of bovine H(+)-ATPase, and indirect immunofluorescent staining. In the proximal tubules there is intense H(+)-ATPase staining along the brush borders of S1 and S2, and linear subvillar invagin...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Bastani B

    更新日期:1997-07-01 00:00:00

  • Immunohistochemical characterisation of dorsal root ganglia neurons supplying the porcine mammary gland.

    abstract::The present study investigated the chemical coding of mammary gland-projecting dorsal root ganglia (DRG) neurons using double-labelling immunohistochemistry. Earlier investigations revealed the presence of Fast blue - positive (FB+) neurons in Th9-Th12 DRG after injection of the tracer into the second, right thoracic ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Franke-Radowiecka A

    更新日期:2011-12-01 00:00:00

  • Suppression of growth of tumour cell lines in vitro and tumours in vivo by mistletoe lectins.

    abstract::A variety of studies have shown that incubation of different tumour cell lines with mistletoe lectins (MLs) in vitro has a marked cytotoxic effect. In the concentration range of low cytotoxicity cell death induced by ML-I is quantitatively due to apoptotic processes. The first events observed being membrane perforatio...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Pryme IF,Bardocz S,Pusztai A,Ewen SW

    更新日期:2006-03-01 00:00:00

  • Commonly used mesenchymal stem cell markers and tracking labels: Limitations and challenges.

    abstract::Early observations that cultured mesenchymal stem cells (MSCs) could be induced to exhibit certain characteristics of osteocytes and chondrocytes led to the proposal that they could be transplanted for tissue repair through cellular differentiation. Therefore, many subsequent preclinical studies with transplanted MSCs...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Lin CS,Xin ZC,Dai J,Lue TF

    更新日期:2013-09-01 00:00:00

  • Smad4 expression in gastric adenoma and adenocarcinoma: frequent loss of expression in diffuse type of gastric adenocarcinoma.

    abstract::Smads are signal transducers for the members of the TGF-beta superfamily. Of these Smads, Smad4 is essential for TGF-beta signaling. The purpose of this study was to elucidate Smad4 expression and localization in 65 gastric adenomas, 49 intestinal-type and 39 diffuse type of gastric adenocarcinomas (including 12 cases...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Kim JY,Park DY,Kim GH,Choi KU,Lee CH,Huh GY,Sol MY,Song GA,Jeon TY,Kim DH,Sim MS

    更新日期:2005-04-01 00:00:00

  • Ultrastructure of the chronically vagotomised atrial myocardium in the monkey (Macaca fascicularis).

    abstract::The ultrastructure of the atrial myocardium in the monkey (Macaca fascicularis) was studied after bilateral cervical vagotomy and survival times of 100, 175 and 367 days. Changes were observed in the nucleus and the cytoplasm of the myocyte. Sequestered within the nuclei of the affected myocytes were cytoplasmic organ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Wong WC,Yick TY,Ling EA

    更新日期:1989-07-01 00:00:00

  • Immunohistochemical analyses on albumin and immunoglobulin in acute hypertensive mouse kidneys by "in vivo cryotechnique".

    abstract::The purpose of this study is to visualize topographical changes of serum proteins, albumin and immunoglobulin, passing through mouse glomerular capillary loops and their reabsorption in renal proximal tubules by immunohistochemistry in combination with our "in vivo cryotechnique". The "in vivo cryotechnique" was perfo...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Li Z,Terada N,Ohno N,Ohno S

    更新日期:2005-07-01 00:00:00

  • How galectins have become multifunctional proteins.

    abstract::Having identified glycans of cellular glycoconjugates as versatile molecular messages, their recognition by sugar receptors (lectins) is a fundamental mechanism within the flow of biological information. This type of molecular interplay is increasingly revealed to be involved in a wide range of (patho)physiological pr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: García Caballero G,Kaltner H,Kutzner TJ,Ludwig AK,Manning JC,Schmidt S,Sinowatz F,Gabius HJ

    更新日期:2020-06-01 00:00:00

  • Topoisomerase 1A, HER/2neu and Ki67 expression in paired primary and relapse ovarian cancer tissue samples.

    abstract::In the present study we examined prognostic value of immunohistochemical estimation of topoisomerase 1A (TOP 1A) and HER-2/neu expression in ovarian cancers treated with platinum-based drugs but not with topotecan and the relation between expression of these proteins on the one hand and intensity of proliferation (Ki6...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Surowiak P,Materna V,Kaplenko I,Spaczynski M,Dietel M,Lage H,Zabel M

    更新日期:2006-07-01 00:00:00

  • Validation of an original incubator set-up for the exposure of human astrocyte cells to X-band microwaves in a GTEM-chamber.

    abstract::A current concern about the biological effects of electromagnetic fields (EMF) is increasing with the wide spread use of X-band microwaves (MW, 8-10 GHz range). Gigahertz transverse electromagnetic (GTEM) field flat transmission lines are currently being used for experimental exposure of biological samples to high fre...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Pérez-Bruzón RN,Del Moral A,Pérez-Castejón C,Llorente M,Vera A,Azanza MJ

    更新日期:2011-09-01 00:00:00