Abstract:
:Amyloidosis is a group of diseases characterized by the extracellular deposition of protein that contains non-branching, straight fibrils on electron microscopy (amyloid fibrils) that have a high content of beta-pleated sheet conformation. Various biochemically distinct proteins can undergo transformation into amyloid fibrils. The precursor protein of amyloid protein A (AA) is the acute phase protein serum amyloid A (SAA). The concentration of SAA in plasma increases up to 1000-fold within 24 to 48 h after trauma, inflammation or infection. Individuals with chronically increased SAA levels may develop AA amyloidosis. SAA has been divided into two groups according to the encoding genes and the source of protein production. These two groups are acute phase SAA (A-SAA) and constitutive SAA (C-SAA). Although the liver is the primary site of the synthesis of A-SAA and C-SAA, extrahepatic production of both SAAs has been observed in animal models and cell culture experiments of several mammalian species and chicken. The functions of A-SAA are thought to involve lipid metabolism, lipid transport, chemotaxis and regulation of the inflammatory process. There is growing evidence that extrahepatic A-SAA formation may play a crucial role in amyloidogenesis and enhances amyloid formation at the site of SAA production.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Upragarin N,Landman WJ,Gaastra W,Gruys Edoi
10.14670/HH-20.1295subject
Has Abstractpub_date
2005-10-01 00:00:00pages
1295-307issue
4eissn
0213-3911issn
1699-5848journal_volume
20pub_type
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
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更新日期:2001-04-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
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更新日期:2018-05-01 00:00:00
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journal_title:Histology and histopathology
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doi:
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-13.21
更新日期:1998-01-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-23.717
更新日期:2008-06-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-15.95
更新日期:2000-01-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:
更新日期:1995-04-01 00:00:00
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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pub_type: 杂志文章,评审
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更新日期:2007-10-01 00:00:00
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更新日期:2012-06-01 00:00:00
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journal_title:Histology and histopathology
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更新日期:1997-01-01 00:00:00
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更新日期:2000-04-01 00:00:00