Abstract：
:In this article we review immunocytochemical localization studies using a monoclonal antibody raised against the 31 kD subunit of bovine H(+)-ATPase, and indirect immunofluorescent staining. In the proximal tubules there is intense H(+)-ATPase staining along the brush borders of S1 and S2, and linear subvillar invagination staining in S1, S2, and S3 segments. In the thick ascending limb of the loop of Henle there is a mild to moderate degree apical cytoplasmic vesicular staining. In distal convoluted tubule there is mild to moderate degree of H(+)-ATPase staining which is sharply delineated along the luminal plasma membrane. In the connecting tubule, the connecting tubule cells show mild to moderate luminal membrane and apical cytoplasmic vesicular staining, and the intercalated cells demonstrate prominent H(+)-ATPase staining which is polarized to either apical or basolateral pole or distributed diffusely throughout the cell. In the cortical collecting duct the principal cells show minimal or no staining while the intercalated cells show very bright H(+)-ATPase staining with 6 identifiable morphologic subtypes based on polarization of the pump to apical or basolateral poles, and the degree of polarization (well polarized or poorly polarized). In the medullary collecting duct the principal cells show no staining and the intercalated cells show prominent H(+)-ATPase staining only in the apical pole. We also describe adaptive responses to different physiologic manipulations e.g., chronic oral acid loads, chronic respiratory acidosis, remnant kidney model, chronic desoxycorticosterone (DOCA) administration, and chronic potassium depletion diet. Moreover, we compare the immunocytochemical localization of the H(+)-ATPase pump of rabbit and kidneys.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Bastani Bsubject
Has Abstractpub_date
1997-07-01 00:00:00pages
769-79issue
3eissn
0213-3911issn
1699-5848journal_volume
12pub_type
杂志文章,评审abstract：:Macrophages play important roles in host defense mechanisms. In the brain, besides microglial cells, meningeal macrophages are present. However, the pathobiological characteristics of meningeal macrophages in rats remain to be investigated. In normal meninx, immunohistochemically, macrophages reacting to CD163 (macrop...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-24.13
更新日期：2009-01-01 00:00:00
abstract：:One hundred and eleven pituitary glands of patients (93 males, 18 females; mean age 32 years, 5 months) who died of fully developed AIDS or ARC were examined under light microscopy with the aid of immunohistochemistry. On post mortem (p.m.) examination a wide series of multiorgan alterations was noticed. Microscopical...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：:To determine the appropriate time for bone reconstruction after irradiation, the healing process after autogenous iliac bone transplantation in the irradiated parietal bone was examined by scanning electron microscopy and light microscopy. Bone transplantation was carried out at the second and the fourth weeks after C...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-15.7
更新日期：2000-01-01 00:00:00
abstract：:Smads are signal transducers for the members of the TGF-beta superfamily. Of these Smads, Smad4 is essential for TGF-beta signaling. The purpose of this study was to elucidate Smad4 expression and localization in 65 gastric adenomas, 49 intestinal-type and 39 diffuse type of gastric adenocarcinomas (including 12 cases...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-20.543
更新日期：2005-04-01 00:00:00
abstract：:The anti-oxidant food additive, butylated hydroxytoluene (BHT), was fed to Sprague-Dawley rats at three concentrations: 0.2%, 0.4% and 0.8% for periods of 6, 12, 18 and 24 weeks, and the results were compared with corresponding groups treated with a potent carcinogen, 7,12-dimethylbenz[a]anthracene (DMBA) groups, with...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-14.391
更新日期：1999-04-01 00:00:00
abstract：:Ischemic heart disease is a widespread cause of death. During infarction, myocardial injury is mediated by release of several pro-inflammatory cytokines including multifunctional interleukin-1 (IL-1). In various tissues, IL-1-mediated deleterious effects are known to be attenuated via the over-expression of natural an...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-23.1093
更新日期：2008-09-01 00:00:00
abstract：:There is scarce information on the possible effects of chronic exposure to mercury on skeletal muscle. Dental personnel are frequently exposed to inhalation of metallic mercury vapours. The skeletal muscle of five technicians and one dentist (females, age 36-55) was studied. All of them presented symptoms of chronic m...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-15.673
更新日期：2000-07-01 00:00:00
abstract：:The vacuolar-type H(+)-ATPases (V-ATPases) are a family of multi-subunit ATP-dependent proton pumps involved in diverse cellular processes, including acid/base homeostasis, receptor-mediated endocytosis, processing of proteins and signaling molecules, targeting of lysosomal enzymes, and activation of various degradati...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-25.1611
更新日期：2010-12-01 00:00:00
abstract：:Systematic studies on hepatic stellate cells and myofibroblasts have so far mainly focused on cells located in the perisinusoidal space of Disse, the so-called littoral compartment. Here, these cells play a key role for intralobular fibrogenesis and sinusoidal capillarization. However, advanced hepatic fibrosis and ci...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-14.719
更新日期：1999-07-01 00:00:00
abstract：:Since bone marrow stromal cells (MSCs) are easily accessible both from healthy donors and patients, and can be expanded on a therapeutic scale, they have attracted attention for cell-based therapy. MSCs contribute to the protection of host tissue after transplantation by Immune modulation and trophic effect. They also...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-24.631
更新日期：2009-05-01 00:00:00
abstract：:We compared characteristic lesions occurring in chickens and domestic ducks naturally infected with H5N1 HPAI virus in April and May 2008. Infected chickens generally exhibited pale-green, watery diarrhoea, depression, neurological signs and cyanosis of wattles and combs, and infected ducks generally exhibited neurolo...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-26.167
更新日期：2011-02-01 00:00:00
abstract：:To clarify the role of REG IV, a new member of the regenerating gene (REG) family, in tumorigenesis and progression of colorectal carcinoma (CRC), 320 CRC specimens, 123 corresponding adjacent non-cancerous mucosa (ANCMs), 46 corresponding non-adjacent non-cancerous mucosa (NANCMs) and 86 adenomas were investigated im...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-25.473
更新日期：2010-04-01 00:00:00
abstract：:Gp96 is the endoplasmic reticulum (ER)-resident molecular chaperone, which is involved in the correction of unfolded proteins, in the activation of proteasome-dependent ER-associated degradation of the misfolded proteins, and in activation of the protein translation that modulates polypeptide traffic into the ER. Furt...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-28.61
更新日期：2013-01-01 00:00:00
abstract：:Sample preparation of dental tissues for quantitative electron microprobe analysis has not been critically examined because of the highly mineralized nature of these structures. The present study was designed to establish the most suitable method for the electron probe quantitative determination of calcium in human pe...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-13.109
更新日期：1998-01-01 00:00:00
abstract：:The techniques for light and electron microscopic radioautography developed in our laboratory are described. The outlines of the applications to various tissues and organs are also briefly summarized. First, the techniques are explained in detail. These techniques can be divided into two categories, i.e., chemical fix...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1997-10-01 00:00:00
abstract：:Laminin (LAM) and fibronectin (FI) are regarded as major components of the glomerular extracellular matrix. The aim of this study was to define the distribution of LAM and FI in primary glomerulonephritis (GN) and GN of systemic lupus erythematosus (SLE) and to correlate the type of glomerular disorders with possible ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
abstract：:Differentiating nonspecific interstitial pneumonia (NSIP) from usual interstitial pneumonia (UIP) is important for the determination of both treatment and prognosis. Using two-dimensional fluorescence difference gel electrophoresis (2D-DIGE), we examined 8 UIPs, 8 NSIPs, and 30 normal lung tissues. Comparisons with co...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-29.377
更新日期：2014-03-01 00:00:00
abstract：:Complex carbohydrate structures are essential molecules of infectious microbes and host cells, and are involved in cell signaling associated with inflammatory and immune responses. The uptake of mannose-tailed glycans is usually carried out by macrophages, dendritic cells (DCs), and other professional phagocytes to tr...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-24.1029
更新日期：2009-08-01 00:00:00
abstract：:This study explores the possibility of a regulatory role for cytokine IL-10 in platelet aggregation as an active vascular repair mechanism. Endothelial cells from human umbilical cord vein were cultured in the presence of different IL-10 concentrations (0-100 ng/ml). Platelet-rich plasma was then added to these cultur...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-18.695
更新日期：2003-07-01 00:00:00
abstract：:We report a case of subcutaneous fat necrosis of a newborn child which appeared 9 days after birth and was cured without any complications. We propose the reclassification of the etiological factors accompanying this lesion by classifying them in a plurietiological syndrome with some basic or essential factors and oth...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Sulfur dioxide (SO₂) is a toxic gas and air pollutant. The toxic effects of SO₂ have been extensively studied. Oxidative damage due to SO₂ can occur in multiple organs. Inhaled SO₂ can also cause chromosomal aberrations, DNA damage and gene mutations in mammals. However, SO₂ can also be generated from the sulfur-conta...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-11-904
更新日期：2017-12-01 00:00:00
abstract：:Much effort has been made by researchers to elucidate the complex biology of breast cancer stem cells (BCSCs), a small subset of breast tumor cells that display stem cell properties, drive tumor initiation, and growth. In recent years, it has been suggested that BCSCs could be responsible for the process of metastasis...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-11-718
更新日期：2016-06-01 00:00:00
abstract：:Ultrastructural changes of the parathyroid glands of pinealectomized golden hamsters were investigated. The main changes in the parathyroid glands 1 hour and 1 day after pinealectomy compared with the control and sham-operated groups were an increase of the Golgi complexes, cisternae of the granular endoplasmic reticu...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：:Neurodegenerative and muscle diseases bear both complex and multifactorial pathologies. An efficacious and robust therapeutic option to treat these diseases is yet to be elucidated. At such a time, mesenchymal stem cells have drawn significant attention due to their immunomodulatory and regenerative properties. Accumu...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-11-951
更新日期：2018-07-01 00:00:00
abstract：:Cyclin A, cyclin E, BUBR1, MAD2 and Aurora A are all cell-cycle regulatory proteins and have been proven to play crucial roles in carcinogenesis. However, their expression patterns in invasive ductal breast carcinoma (IDBC) are controversial and unclear. In this study, we examined the expression status of these candid...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-26.761
更新日期：2011-06-01 00:00:00
abstract：:The immunohistochemical distribution of 15 blood coagulation factors in the germinal centers (GCs) of human Peyer's patches (PPs) was studied. Although factor VIII, active alpha-thrombin, and fibrinogen were hardly evident in the GCs, the majority of coagulation factors, such as kallikrein, high-molecular-weight kinin...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：:In view of the limitations of conventional prognostic factors such as differentiation degree, metastatic lymph nodes, hormonal receptors and others, especially when early lesions are found, additional new markers have been studied, such as gene amplification and cell proliferation index, in order to choose the appropr...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
abstract：:Bacillus subtilis has been used as a classic model to study biofilm formation and sporulation process. Colonies of wild-type strains usually have a complex external morphology, but the details of their internal architecture are still undisclosed. Since bacterial biofilms fulfill the criteria to be considered tissues, ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-28.1351
更新日期：2013-10-01 00:00:00
abstract：:In this paper we report the first complete mapping of the pituitary in a tuna species. The various different adenohypophysis cell types of the bluefin tuna, Thunnus thynnus L. have been identified and located using different antisera against mammalian and piscine hormones and various histochemical techniques: PAS, Alc...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-16.443
更新日期：2001-04-01 00:00:00
abstract：:Peritumoral brain edema (PTBE) is considered to be one of the main biological behaviors of brain glioma. However, the histopathological features of PTBE remain imprecisely defined. We analyzed the histopathological characteristics in the PTBE area of 22 cases of glioma. Microscopically, the pre-existing basic structur...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-11-607
更新日期：2015-09-01 00:00:00
