Histopathological findings in the peritumoral edema area of human glioma.


:Peritumoral brain edema (PTBE) is considered to be one of the main biological behaviors of brain glioma. However, the histopathological features of PTBE remain imprecisely defined. We analyzed the histopathological characteristics in the PTBE area of 22 cases of glioma. Microscopically, the pre-existing basic structure in the edema area was still preserved but there were varying degrees of loose tissue. The main components of the edema tissue were scattered invasive tumor cells, reactive cells, and various blood vessel patterns. Invasive tumor cell density was significantly higher in high-grade glioma than in low-grade glioma, and the density was significantly higher in the area near compared to the area far from the glioma. The Ki-67 proliferative index of the invasive tumor cells was higher in high-grade glioma than in low-grade glioma, but the index was not different in the area near compared to the area far from the glioma. The microvessel pattern in PTBE was primarily branching capillary. The microvessel densities (MVDs) of CD34⁺ and CD105⁺ were higher in high-grade glioma and the area near the glioma than in low-grade glioma and the area far from the glioma. Compared to CD34⁺, the MVD of CD105⁺ exhibited a more significant downward trend in terms of distance from the glioma. The most obvious types of reactive cells were reactive astrocytes and activated microglia. The reactive astrocytes were positive for nestin. The activated microglia emerged in the area near the glioma in most cases and in the area far from the glioma in more than half of the cases. In addition, several cases displayed focal collections of small lymphocytes around small blood vessels and tumor cells arranged around a neuronal cell, and a limited number of cases displayed giant dysmorphic neurons in an edematous cortex. Our data indicate that PTBE is a consequence of tissue reconstruction resulting from tumor cell invasion and is an appropriate niche for the growth and spread of glioma cells.


Histol Histopathol


Wang X,Liu X,Chen Y,Lin G,Mei W,Chen J,Liu Y,Lin Z,Zhang S




Has Abstract


2015-09-01 00:00:00














  • Molecular and morphological characterization of neural tube defects in embryos of diabetic Swiss Albino mice.

    abstract:BACKGROUND AND RESULTS:Embryos from diabetic mice exhibit several forms of neural tube defects, including non-closure of the neural tube. In the present study, embryos collected at embryonic day 11.5 from diabetic pregnancies displayed open neural tube with architectural disruption of the surrounding tissues. The perce...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Loh WT,Dheen ST,Jiang B,Kumar SD,Tay SS

    更新日期:2011-08-01 00:00:00

  • Chaperone-mediated autophagy in cancer: Advances from bench to bedside.

    abstract::Chaperone-mediated autophagy (CMA), a selective form of autophagy, where cellular proteins with KFERQ-like motif are targeted to the lysosome for degradation, is necessary to maintain cellular homeostasis. The role of CMA in neurodegenerative diseases has been extensively studied in the past decades, with defects in t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Hou T,Fan Y,Dan W,Liu B,Wang Z,Zeng J,Li L

    更新日期:2020-07-01 00:00:00

  • Effects of Helicobacter pylori on biological characteristics of gastric epithelial cells.

    abstract::Infection with Helicobacter pylori (H. pylori) strains is linked to an increased risk of inflammation and gastric cancer. To investigate the effects of H. pylori on biological characteristics of gastric epithelial cells SGC-7901, derived from human adenocarcinoma, morphological appearances of both the pathogen and the...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Wang P,Mei J,Tao J,Zhang N,Tian H,Fu GH

    更新日期:2012-08-01 00:00:00

  • Immunophenotypic characterization of primary and secondary lymphoid follicles.

    abstract::The need for an immunophenotypical referential framework relative to lymphoid follicle has led us to apply a panel of monoclonal and polyclonal antibodies, by means of a sensitive immunostaining method. Lymphoid follicle is an immunophenotypically complex structure made up of three lymphoid populations (B, being its b...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: de Luaces CP,Peral JI,García Tejeiro M,Aguirre C

    更新日期:1988-01-01 00:00:00

  • Unexpected presence of the neurotrophins NGF and BDNF and the neurotrophin receptor p75 in the tendon cells of the human Achilles tendon.

    abstract::Neurotrophins are substances that have been shown to be important in growth and remodelling phases in different types of tissue. There is no information concerning the possible occurrences of neurotrophins and their receptors in tendons. In this study, sections of both chronic painful (tendinosis) and pain-free (non-t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Bagge J,Lorentzon R,Alfredson H,Forsgren S

    更新日期:2009-07-01 00:00:00

  • Cavernomas of the human brainstem: 3-dimensional reconstruction from histological slides using computerized techniques.

    abstract::Cerebral cavernous malformations (CCMs) are described as vascular lesions consisting of endothelial-lined dilated vessels embedded in a connective tissue sheath without intervening parenchyma between them. Their anatomical connections with the normal blood vessels are still enigmatic and the fine three-dimensional (3-...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Toralba S,Landemore G,Coquemont M,Plancoulaine B,Chapon F

    更新日期:2014-08-01 00:00:00

  • Fine reconstruction of the pancreatic ductular system at the onset of pancreatitis.

    abstract::The three-dimensional structure of the pancreatic ductular system (from the intercalated duct to the intercellular secretory canaliculus) is controversial and unclear. The aim of this study is to reveal the three-dimensional structure of the pancreatic ductular sysytem at the onset of pancreatitis. One day following r...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Endo H,Ashizawa N,Niigaki M,Hamamoto N,Niigaki M,Kaji T,Katsube T,Watanabe M,Naora H,Otani H,Kinoshita Y

    更新日期:2002-01-01 00:00:00

  • Domestic microwave processing for rapid immunohistochemical diagnosis of bovine rabies.

    abstract::The present study describes the use of a microwave processing protocol for the rapid histopathological and immunohistochemical diagnosis of bovine rabies. Immunohistochemistry has been used for rabies diagnosis in formalin-fixed tissue with satisfactory results, although the time to diagnosis is considerably longer th...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Abreu CC,Nakayama PA,Nogueira CI,Mesquita LP,Lopes PF,Varaschin MS,Seixas Jdo N,Ferreira E,Bezerra PS Jr

    更新日期:2012-09-01 00:00:00

  • A truncated isoform of the PP2A B56gamma regulatory subunit reduces irradiation-induced Mdm2 phosphorylation and could contribute to metastatic melanoma cell radioresistance.

    abstract::F10, a subline of the B16 mouse melanoma cell line, is itself the parent of the more metastatic BL6 line. BL6 cells differ from F10 cells by an alteration of the gene encoding the B56gamma regulatory subunit of protein phosphatase 2A (PP2A), which results in mRNA encoding a truncated variant of the subunit (deltagamma...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Koma YI,Ito A,Watabe K,Kimura SH,Kitamura Y

    更新日期:2004-04-01 00:00:00

  • Hydroxy group requirement for halofuginone-dependent inhibition of muscle fibrosis and improvement of histopathology in the mdx mouse model for Duchenne muscular dystrophy.

    abstract::In Duchenne muscular dystrophy (DMD), the progressive loss of muscle and its ability to function is associated with significant fibrosis, representing the major disease complication in patients. Halofuginone, a halogenated analog of the naturally occurring febrifugine, has been shown to prevent fibrosis in various ani...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Wellner G,Mordechay S,Evans P,Genin O,Pines M,Halevy O

    更新日期:2019-07-01 00:00:00

  • Histological approach to Bacillus subtilis colony-biofilm: evolving internal architecture and sporulation dynamics.

    abstract::Bacillus subtilis has been used as a classic model to study biofilm formation and sporulation process. Colonies of wild-type strains usually have a complex external morphology, but the details of their internal architecture are still undisclosed. Since bacterial biofilms fulfill the criteria to be considered tissues, ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Gómez-Aguado F,Corcuera MT,Gómez-Lus ML,de la Parte MA,Ramos C,García-Rey C,Alonso MJ,Prieto J

    更新日期:2013-10-01 00:00:00

  • Less gelatinases is associated with apolipoprotein E accumulation in glomerulosclerosis rats.

    abstract:BACKGROUND:Gelatinases include matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9). The abnormal expressions of gelatinases are implicated in the pathogenesis of extracellular matrix (ECM) accumulation. Apolipo-protein E (apoE) is an important plasma protein in cholesterol homeostasis and plays a ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Zhou TB,Qin YH,Lei FY,Su LN,Zhao YJ,Huang WF

    更新日期:2012-02-01 00:00:00

  • Localization of sex steroid receptors in human skin.

    abstract::Sex steroid hormones are involved in regulation of skin development and functions as well as in some skin pathological events. To determine the sites of action of estrogens, androgens and progestins, studies have been performed during the recent years to accurately localize receptors for each steroid hormone in human ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Pelletier G,Ren L

    更新日期:2004-04-01 00:00:00

  • Down-regulation of TSG101 by small interfering RNA inhibits the proliferation of breast cancer cells through the MAPK/ERK signal pathway.

    abstract::We designed to investigate the effects of down-regulating the tumor susceptibility gene 101 (TSG101) on the proliferation and apoptosis of the human breast cancer MCF-7 cell line, and the role of the MAPK/ERK signal pathway in this process. The siRNA against TSG101 was transfected into the breast cancer MCF-7 cell lin...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Zhang Y,Song M,Cui ZS,Li CY,Xue XX,Yu M,Lu Y,Zhang SY,Wang EH,Wen YY

    更新日期:2011-01-01 00:00:00

  • Advances in translational orthopaedic research with species-specific multipotent mesenchymal stromal cells derived from the umbilical cord.

    abstract::Compliance with current regulations for the development of innovative medicines require the testing of candidate therapies in relevant translational animal models prior to human use. This poses a great challenge when the drug is composed of cells, not only because of the living nature of the active ingredient but also...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Ramallo M,Carreras-Sánchez I,López-Fernández A,Vélez R,Aguirre M,Feldman S,Vives J

    更新日期:2020-09-11 00:00:00

  • Tissue and molecular events in human conjunctival scarring in ocular cicatricial pemphigoid.

    abstract::Detailed histomorphometric analysis of human conjunctival biopsy specimens has convincingly demonstrated that tissue remodeling of the extracellular matrix (ECM) is an essential and dynamic process associated with conjunctival scarring in ocular cicatricial pemphigoid (OCP). The conjunctival scarring often eventually ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Razzaque MS,Foster CS,Ahmed AR

    更新日期:2001-10-01 00:00:00

  • Ultrastructural observation on the rat supraoptic neurons following acute operative stress.

    abstract::The response of the SON to various forms of stress is well documented. However, the effect of operative stress, which is a common and important clinical event requiring the mediation of vasopressin, has largely escaped attention. The present report describes the ultrastructural changes in the neurons of the caudal (re...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Ray PK,Choudhury SR

    更新日期:1988-04-01 00:00:00

  • Coexistence of serotonin and cholecystokinin in paraneurons of the foetal sheep lung.

    abstract::The coexistence of serotonin and cholecystokinin was studied in foetal sheep lungs at pseudoglandular stage of development by light microscopic immunohistochemistry. The coexistence was examined by staining consecutive sections with the different antibodies. Serotonin and cholecystokinin immunoreactivity was found wit...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Balaguer L,Romano J,Ruiz-Pesini P

    更新日期:1994-01-01 00:00:00

  • Analysis of cell proliferation kinetics during the secondary palate development in quail.

    abstract::A study was undertaken to analyze the spatio-temporal pattern of mesenchymal cell proliferation in the developing palate of quail. Quail embryos were grown in shell-less culture. The developing palates were labelled with 3H-thymidine between culture days 2-6 (which corresponded in vivo incubation days 5-9), and proces...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Hehn BM,Young AV,Shah RM

    更新日期:1995-07-01 00:00:00

  • Review of papillary renal cell carcinoma with focus on clinical and pathobiological aspects.

    abstract::Recent studies have shown that papillary renal cell carcinoma (RCC) is clinically and genotypically a distinct entity. Papillary RCCs account for about 10-15% of renal parenchymal neoplasms. Macroscopically, the cut surface is yellow or brown in color and large tumors frequently show cystic change. Hemorrhage and necr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Kuroda N,Toi M,Hiroi M,Enzan H

    更新日期:2003-04-01 00:00:00

  • Ewing sarcoma and the new emerging Ewing-like sarcomas: (CIC and BCOR-rearranged-sarcomas). A systematic review.

    abstract::Ewing-like sarcomas (ELS) are a heterogenous group of tumors that frequently affect pediatric and young adult patients. Accurate classification and distinction from the Ewing sarcoma family of tumor (ESFT) is decisive in patient management. ELS share a significant morphologic, immunohistochemical and clinical overlap ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Machado I,Navarro S,Llombart-Bosch A

    更新日期:2016-11-01 00:00:00

  • Alterations induced by E-cadherin and beta-catenin antibodies during the development of Bufo arenarum (Anura-Bufonidae).

    abstract::E(epithelial)-cadherin is a member of a calcium-dependent family of cell surface glycoproteins involved in cell-cell adhesion and morphogenesis. Catenins are a large family of proteins that connect the cadherins to the cytoskeleton. They are important for cadherin function and for transducing signals involved in speci...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Izaguirre MF,Adur JF,Soler AP,Casco VH

    更新日期:2001-10-01 00:00:00

  • Post translational activation of latent transforming growth factor beta (L-TGF-beta): clinical implications.

    abstract::Transforming growth factor-betas (TGF-betas) are multifunctional cytokines that exist in 3 isoforms in mammals. The TGF-betas are ubiquitously expressed and all isoforms are secreted as biologically inactive precursors called latent TGF-beta (L-TGF-beta). L-TGF-betas are generally not effective molecules because they ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Khalil N

    更新日期:2001-04-01 00:00:00

  • Abnormal distribution of CD45 isoforms expressed by CD4+ and CD8+ T cells in rheumatoid arthritis.

    abstract::CD45RO+ T cells are referred to as memory or helper-inducer while CD45RA+ T cells are regarded as naive or suppressor-inducer T cells. The former population predominates in the peripheral blood and even more in the synovial fluid of patients with rheumatoid arthritis, to the expense of the latter population. Within th...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Mamoune A,Durand V,Le Goff P,Pennec YL,Youinou P,Le Corre R

    更新日期:2000-04-01 00:00:00

  • Mad2 and spindle assembly checkpoint function during meiosis I in mammalian oocytes.

    abstract::During mammalian mitosis, a proofreading network called the spindle assembly checkpoint (SAC) is indispensable for ensuring the fidelity of chromosome segregation. An inhibitory SAC signal is deputed to inhibits mitotic cell-cycle progression in response to misaligned chromosomes until such imperfections are rectified...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Homer HA

    更新日期:2006-08-01 00:00:00

  • Induction system of neural and muscle lineage cells from bone marrow stromal cells; a new strategy for tissue reconstruction in degenerative diseases.

    abstract::Since bone marrow stromal cells (MSCs) are easily accessible both from healthy donors and patients, and can be expanded on a therapeutic scale, they have attracted attention for cell-based therapy. MSCs contribute to the protection of host tissue after transplantation by Immune modulation and trophic effect. They also...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Kitada M,Dezawa M

    更新日期:2009-05-01 00:00:00

  • Electron probe microanalysis of permanent human enamel and dentine. A methodological and quantitative study.

    abstract::Sample preparation of dental tissues for quantitative electron microprobe analysis has not been critically examined because of the highly mineralized nature of these structures. The present study was designed to establish the most suitable method for the electron probe quantitative determination of calcium in human pe...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Sánchez-Quevedo MC,Nieto-Albano OH,García JM,Gómez de Ferraris ME,Campos A

    更新日期:1998-01-01 00:00:00

  • Morphological and functional changes in experimental ocular hypertension and role of neuroprotective drugs.

    abstract::Glaucoma is a neurodegenerative disease characterized by progressive loss of retinal ganglion cell axons and their cell bodies in the retina. Elevated intraocular pressure (IOP) is considered to be the major risk factor associated with the development of this neuropathy. Randomized controlled clinical trials have demo...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: García-Campos J,Villena A,Díaz F,Vidal L,Moreno M,Pérez de Vargas I

    更新日期:2007-12-01 00:00:00

  • Ecophysiological responses of the seminal vesicle of Libyan jird (Meriones libycus) to the Saharan conditions: histological, morphometric and immunohistochemical analysis.

    abstract::The Libyan jird (Meriones libycus) is a nocturnal Saharan Rodent submitted to a seasonal cycle of reproduction characterized by a short active period during spring and beginning of summer, and a long phase of sexual quiescence from the end of summer until the end of winter. During this cycle, the male reproductive org...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Belhocine M,Gernigon-Spychalowicz T,Robert AM,Schoevaert D,Bennazzoug Y,Exbrayat JM

    更新日期:2007-06-01 00:00:00

  • Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors.

    abstract::The aim of our study was to document whether relationships existed among bone morphogenetic proteins (BMPs), peripheral nerve and neoplastic lesions of nerve sheath tumors. The mRNA transcriptions of BMP-2, 3, 4 and 5 in 10 cases of schwannoma, three cases of malignant schwannoma and two cases of trigeminal neuralgia ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Jin Y,Lu HB,Liong E,Lau TY,Tipoe GL

    更新日期:2001-10-01 00:00:00