Regulation and function of sphingosine kinase 2 in diseases.

abstract：:The proto-oncogene, ets-1, is a transcription factor known to control the expression of a number of genes and has been postulated to play a role in cell growth, differentiation and tumour invasion. We examined 137 cases of breast carcinoma by immunohistochemistry and compared the degree of Ets-1 expression among the d...

journal_title：Histology and histopathology

authors： Katayama S,Nakayama T,Ito M,Naito S,Sekine I

更新日期：2005-01-01 00:00:00

abstract：:We review here the 14 members of the Monocarboxylate transporter family (MCTs), their relationship based on sequence homology. The range of substrates transported by different members of this family extends from the standard monocarboxylate metabolites, lactic and pyruvic acids, to aromatic amino acids and thyroid hor...

journal_title：Histology and histopathology

authors： Merezhinskaya N,Fishbein WN

更新日期：2009-02-01 00:00:00

abstract：:Morphological and biochemical alterations have been described in neurons of the aged human brain. However, the cell death process associated with neuronal senescence remains to be elucidated. Apoptosis and autophagic degeneration, two modes of programmed cell death described in embryogenesis and tissue renewal in adul...

journal_title：Histology and histopathology

authors： Anglade P,Vyas S,Hirsch EC,Agid Y

更新日期：1997-07-01 00:00:00

abstract：:The aim of this study was to demonstrate the morphology and matrix synthesis of embryonic rat liver cells (day 18 of gestation) in organoid cultures (high density cultures) with electron microscopic and immunomorphological techniques. For this purpose the cells of embryonic rat livers were isolated enzymatically and g...

journal_title：Histology and histopathology

authors： Elkasaby A,Xu D,Schröter-Kermani C,Merker HJ

更新日期：1991-04-01 00:00:00

abstract：:HPV infection has been identified recently as the causative agent of a subset of squamous cell carcinomas arising in oropharyngeal tonsils. Factors influencing the susceptibility of tonsillar epithelium to HPV-induced oncogenesis are far from being elucidated. A 5-protein signature including cytokeratin (CK)7, anterio...

journal_title：Histology and histopathology

authors： Morbini P,Capello GL,Alberizzi P,Benazzo M,Paglino C,Comoli P,Pedrazzoli P

更新日期：2015-07-01 00:00:00

abstract：:TIMPs in the prostates of male and female gerbils and evaluated the effects of testosterone on the expression of these enzymes. Ventral prostates from male gerbils that were either intact or had been castrated for 7 or 21 days, along with prostates from female gerbils that were either intact or had been treated with t...

journal_title：Histology and histopathology

authors： Rochel-Maia SS,Santos FC,Vilamaior PS,Justulin LA Jr,Felisbino SL,Góes RM,Taboga SR

更新日期：2011-11-01 00:00:00

abstract：:Detailed characterization of the subdermal model is a significant tool for better understanding of calcification mechanisms occurring in heart valves. In previous ultrastructural investigation on six-week-implantated aortic valve leaflets, modified pre-embedding glutaraldehyde-cuprolinic-blue reactions (GA-CB) enabled...

journal_title：Histology and histopathology

authors： Ortolani F,Bonetti A,Tubaro F,Petrelli L,Contin M,Nori SL,Spina M,Marchini M

更新日期：2007-03-01 00:00:00

abstract：:In order to reveal modulation of the number of pulmonary neuroendocrine cells (PNEC) in interstitial lung diseases and to clarify significance of cell proliferation activity in occurrence of PNEC, we counted airway PNEC of the patients of idiopathic interstitial pneumonia, secondary interstitial pneumonia and control ...

journal_title：Histology and histopathology

authors： Ito T,Ogura T,Ogawa N,Udaka N,Hayashi H,Inayama Y,Yazawa T,Kitamura H

更新日期：2002-10-01 00:00:00

abstract：:Knee osteoarthritis (KOA) is the most common progressive joint disorder associated with disability in the world. As a chronic disease, KOA has multifactorial etiology. However, the poor self-healing ability of the articular cartilage due to its intrinsic tissue hypovascularity and hypocellularity seems to be directly ...

journal_title：Histology and histopathology

authors： Gu X,Li C,Yin F,Yang G

更新日期：2018-07-01 00:00:00

abstract：:Tumorigenesis correlates with hypermethylation of tumor suppressors and hypomethylation of oncogenes. DNA methyltransferases (DNMTs) catalyze DNA methylation, and mutations and aberrant expression in DNMT genes are found in multiple human tumors. The discovery of the DNA demethylation function of TET proteins has open...

journal_title：Histology and histopathology

authors： Wu YC,Ling ZQ

更新日期：2014-08-01 00:00:00

abstract：:The acute and chronic effects of bombesin (BM) on the structure and function of rat adrenal cortex were investigated by morphometric and radioimmunological techniques. An intraperitoneal bolus injection of 2 micrograms/rat BM markedly raised plasma corticosterone (B) concentration (PBC). The intraperitoneal BM infusio...

journal_title：Histology and histopathology

authors： Malendowicz LK,Nussdorfer GG,Miskowiak B,Majchrzak M

更新日期：1995-01-01 00:00:00

abstract：:Neutrophil extracellular traps (NETs) are innate immune systems against invading pathogens. NETs are characterized as released DNA mixed with cytoplasmic antimicrobial proteins such as myeloperoxidase, proteinase3 and neutrophil elastase. While NETs are thought to have an important role in host defense, recent work ha...

journal_title：Histology and histopathology

authors： Nakazawa D,Kumar S,Desai J,Anders HJ

更新日期：2017-03-01 00:00:00

abstract：:The importance of molybdenum-containing enzymes in the pathophysiology of a number of clinical disorders necessitates a comprehensive understanding of their histological localization and expression. The objectives of this review are to cover such enzymes so far reported and their enzyme- and immunohistochemical locali...

journal_title：Histology and histopathology

authors： Moriwaki Y,Yamamoto T,Higashino K

更新日期：1997-04-01 00:00:00

abstract：:Mesothelial cells (MC) obtained from the human omentum are a good alternative to the use of endothelial cells (EC) as a covering for vascular prostheses of polytetrafluoroethylene (PTFE), given the antithrombogenic properties and good behavior in vitro of mesothelial cells. We studied the behaviour of mesothelial cell...

journal_title：Histology and histopathology

authors： Buján J,García-Honduvilla N,Hernando A,Bellón JM

更新日期：1995-10-01 00:00:00

abstract：:The histological and ultrastructural features, as well as the immunoreactivity of one case of uncommon primary papillary and psammomatous adenocarcinoma of the umbilicus are studied in the present work. The observations have been undertaken in a nine-year follow-up, and have included the primitive tumour, two local re...

journal_title：Histology and histopathology

authors： Hernández N,Medina V,Alvarez-Arguelles H,Gutiérrez R,Pérez-Palma J,Díaz-Flores L

更新日期：1993-10-01 00:00:00

abstract：:To date, no detailed knowledge from animal experiments is available on the kind and extent of osseous and mineral metabolic disorders in genetically determined, insulin-dependent Type I diabetes. The purpose of this study was to examine the influence of the diabetic metabolic state in spontaneously diabetic BB/O(ttawa...

journal_title：Histology and histopathology

authors： Follak N,Klöting I,Ganzer D,Merk H

更新日期：2003-01-01 00:00:00

abstract：:The liver represents a site of expression of neurotrophins and their receptors. We have characterized the expression and intracellular localization of the nerve growth factor (NGF) receptor, Trk-A, in liver cells in vivo and in vitro. In both normal and fibrotic liver tissue, Trk-A immunostaining was present in differ...

journal_title：Histology and histopathology

authors： Bonacchi A,Taddei ML,Petrai I,Efsen E,Defranco R,Nosi D,Torcia M,Rosini P,Formigli L,Rombouts K,Zecchi S,Milani S,Pinzani M,Laffi G,Marra F

更新日期：2008-03-01 00:00:00

abstract：:The International Prognostic Index (IPI) has been the basis for determining prognosis in patients with diffuse large B-cell lymphoma (DLBCL) for the past 20 years. The utility of the IPI must be reassessed in the era of immunochemotherapy. Seven risk factors at diagnosis were identified, and a maximum of 7 points were...

journal_title：Histology and histopathology

authors： Wang J,Zhou M,Xu JY,Yang YG,Zhang QG,Zhou RF,Chen B,Ouyang J,Li C

更新日期：2016-03-01 00:00:00

abstract：:Terminal dendrites of cone horizontal cells (HCs) in teleost retinas show numerous spine-like protrusions named spinules, which are invaginated into the cone pedicles during light-adaptation, but retracted during dark-adaptation. Somata of HC show nematosomes whose size decreases as the number of spinules increases. M...

journal_title：Histology and histopathology

authors： García M,Grzywacz NM,De Juan J

更新日期：2002-01-01 00:00:00

abstract：:Ductular hepatocytes are observed in the livers of both experimental animals and man under various conditions of severe toxin-, carcinogen- or viral-induced hepatic injury with prominent loss of parenchymal hepatocytes. These unique hepatic epithelial cells are characterized by phenotypic traits that are intermediate ...

journal_title：Histology and histopathology

authors： Sirica AE

更新日期：1995-04-01 00:00:00

abstract：:To investigate the matrix metalloproteinase (MMP)-9, (MMP)-13, E-Cadherin and Ki-67 expressions in road pavers' skin chronically exposed to bitumen products in order to contribute to a better understanding of the earlier tissue alteration. Skin punch biopsies from 16 daily exposed workers and a control group were stud...

journal_title：Histology and histopathology

authors： Loreto C,Lombardo C,Caltabiano R,Filetti V,Vitale E,Seminara D,Castorina S,Fenga C,Ledda C,Rapisarda V

更新日期：2019-10-01 00:00:00

abstract：:The distribution of peptidergic nerves in canine mammary tissues was studied by immunohistochemical techniques. In addition, the general and the noradrenergic innervations were demonstrated using protein gene product 9.5 and tyrosine hydroxylase immunoreactivities as markers, respectively. Tissue specimens from the ca...

journal_title：Histology and histopathology

authors： Pinho MS,Gulbenkian S

更新日期：2007-11-01 00:00:00

abstract：:During endotoxic shock, the liver exerts a lipopolysaccharide (LPS) clearance function with the participation of both parenchymal and sinusoidal cells. Liver damage could be caused by LPS direct action, hypoxia and/or inflammatory mediators released by Kupffer cells. The aim of this study is to establish an experiment...

journal_title：Histology and histopathology

authors： Pagani R,Portolés MT,Arahuetes R,Ainaga MJ,Machín C,Rua C

更新日期：1996-07-01 00:00:00

abstract：:Thyroid glands from 7 marmosets (Callithrix jacchus) of different age groups (newborn, 2 weeks, 2, 7, 8 and 11 months, and 8 years) were grown as organ culture according to Trowell at the medium/air interphase for 3 to 30 days. The morphology of thyroid tissue was well preserved until the end of the culture period. Ne...

journal_title：Histology and histopathology

authors： Maile S,Merker HJ

更新日期：1995-10-01 00:00:00

abstract：:Our previous study on human skeletal muscle undergoing ischemia and reperfusion has revealed that granulocytes, which infiltrate the muscle tissue in large numbers, play an important role in mediating fibre injuries by producing superoxide anion (O2-) which is responsible for membrane lipid peroxidation. In the curren...

journal_title：Histology and histopathology

authors： Adembri C,Domenici LL,Formigli L,Brunelleschi S,Ferrari E,Novelli GP

更新日期：1994-10-01 00:00:00

abstract：:Aluminium (Al) is a neurotoxic metal and Al exposure may be a factor in the aetiology of various neurodegenerative diseases such as Alzheimer's disease (AD). The major pathohistological findings in the AD brain are the presence of neuritic plaques containing beta-amyloid (Abeta) which may interfere with neuronal commu...

journal_title：Histology and histopathology

authors： Rodella LF,Ricci F,Borsani E,Stacchiotti A,Foglio E,Favero G,Rezzani R,Mariani C,Bianchi R

更新日期：2008-04-01 00:00:00

abstract：:The aim of our study was to evaluate corneal cell proliferation and apoptosis in cases of granular, macular and lattice dystrophy, and to provide evidence which may help to clarify whether apoptosis is a pathogenic factor in any of these dystrophies. The study group comprised 39 eyes (from 33 patients) which had under...

journal_title：Histology and histopathology

authors： Szentmáry N,Takács L,Berta A,Szende B,Süveges I,Módis L

更新日期：2007-08-01 00:00:00

abstract：:A study was undertaken to analyze the spatio-temporal pattern of mesenchymal cell proliferation in the developing palate of quail. Quail embryos were grown in shell-less culture. The developing palates were labelled with 3H-thymidine between culture days 2-6 (which corresponded in vivo incubation days 5-9), and proces...

journal_title：Histology and histopathology

authors： Hehn BM,Young AV,Shah RM

更新日期：1995-07-01 00:00:00

abstract：:The novel coronavirus disease 2019 (COVID-19) outbreak began in the city of Wuhan, whereupon it rapidly spread throughout China and subsequently across the world. Rapid transmission of COVID-19 has caused wide-spread panic. Many established medications have been used to treat the disease symptoms; however, no specific...

journal_title：Histology and histopathology

authors： Zhou H,Liu LP,Fang M,Li YM,Zheng YW

更新日期：2020-10-01 00:00:00

abstract：:In the last years, it has been reported that bone marrow stromal cells (BMSC) are able to differentiate towards a neuronal phenotype, in vitro as well as in vivo, and consequently, the possible use of these cells for the treatment of neurological diseases has acquired enormous importance. The objective of this review ...

journal_title：Histology and histopathology

authors： Vaquero J,Zurita M

更新日期：2009-01-01 00:00:00