Abstract:
:The pathophysiologic mechanism by which chronic hypoxia causes pulmonary hypertension is unknown. If anti-platelet agents, or other pharmacologic interventions, altered the pulmonary vascular changes induced by hypoxia, information concerning the pathogenesis of the pulmonary hypertension or the potential therapeutic usefulness of the drugs might be obtained. In Study 1, rats exposed to chronic hypobaric hypoxia (PB = 520 mmHg) had a pulmonary arterial medial thickness of 6.7 +/- 0.6 mu compared to 4.1 +/- 0.2 mu* for control, normoxic rats (*p less than 0.05). Administration of dipyridamole (2mg/kg/day), or sulfinpyrazone (11 mg/kg/day) in the drinking water reduced the medial thickness to 5.0 +/- 0.3 mu* and 5.4 +/- 0.5 mu* respectively, thus suggesting the possible involvement of platelets in the response of the media to chronic hypoxia. In Study 2, hypoxic rats treated with the calcium blocker, flunarizine, were found to have less medial hypertrophy than a control group of hypoxic rats. This observation suggests that a decrease in transmembrane calcium flux may also reduce medial hypertrophy.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Keith IM,Will JA,Huxtable RJ,Weir Ksubject
Has Abstractpub_date
1987-04-01 00:00:00pages
203-6issue
2eissn
0213-3911issn
1699-5848journal_volume
2pub_type
杂志文章abstract::The terms construct or tissue equivalent refer to neotissue produced by tissue engineering techniques. The elements forming the construct are scaffolds on which cells are "recreated" to form an engineered-tissue sensitive to certain cell signals. The ability of the cells to expand and differentiate on the scaffold is ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-20.891
更新日期:2005-07-01 00:00:00
abstract::Using histopathological analysis of semi-thin sections stained with toluidine blue, we observed profound pathological changes in the islets of Langerhans of hamsters infected with the scrapie agent (strain 139H). These included cytoplasmic vesicles, nuclear swelling, and vacuolization in the islet cells. Two types of ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND AND RESULTS:Embryos from diabetic mice exhibit several forms of neural tube defects, including non-closure of the neural tube. In the present study, embryos collected at embryonic day 11.5 from diabetic pregnancies displayed open neural tube with architectural disruption of the surrounding tissues. The perce...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-26.965
更新日期:2011-08-01 00:00:00
abstract::Erythema dyschromicum perstans (EDP) and vitiligo are two cutaneous pigmentary dermatoses of unknown etiology. In the present study, the leukocyte infiltrates in the affected skin of EDP and vitiligo patients were studied using the avidin-biotin (ABC) immunoperoxidase technique and monoclonal antibodies which recognis...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1987-07-01 00:00:00
abstract::The purpose of this investigation was to clarify the mechanisms of amyloid fibril formation in human lymph nodes. In our present study, amyloid deposition was observed diffusely in all compartments of the lymph nodes. The deposition form showed extremely characteristic findings in its morphological features. Namely, a...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1986-07-01 00:00:00
abstract::Epidemiologic studies have suggested that elderly patients who consumed diets rich in antioxidants throughout their lives are less likely to be afflicted with age-related macular degeneration (AMD). This led to the Age-Related Eye Disease Study, which showed that supplements containing antioxidant vitamins and zinc re...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-22.1301
更新日期:2007-12-01 00:00:00
abstract::Strain injuries of tendons are the most common orthopedic injuries in athletic subjects, be they equine or human. When the tendon is suddenly damaged, an acute inflammatory phase occurs whereas its repetitive overloading may cause chronic injuries. Currently the criteria used for grading injuries are general and subje...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-11-601
更新日期:2015-08-01 00:00:00
abstract::The developing fetal brain is one of the most susceptible organs to irradiation insult. Prenatal irradiation-induced abnormalities in the cerebrum have been well examined in mouse fetuses. However, little information on abnormalities in the cerebellum caused by irradiation is available. Moreover, few reports have exam...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-23.953
更新日期:2008-08-01 00:00:00
abstract::A study was undertaken to analyze the spatio-temporal pattern of mesenchymal cell proliferation in the developing palate of quail. Quail embryos were grown in shell-less culture. The developing palates were labelled with 3H-thymidine between culture days 2-6 (which corresponded in vivo incubation days 5-9), and proces...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1995-07-01 00:00:00
abstract::Nitric oxide (NO) is a biological messenger molecule produced by one of the essential amino acids L-arginine by the catalytic action of the enzyme NO synthase (NOS). The dual role of NO as a protective or toxic molecule is due to several factors, such as; the isoform of NOS involved, concentration of NO and the type o...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-21.445
更新日期:2006-04-01 00:00:00
abstract::The presence of Cajal-Retzius cells in the adult human prefrontal and visual cortices has been demonstrated with calcium binding protein immunocytochemistry and NADPH-diaphorase histochemistry. These cells expressed parvalbumin, calbindin and calretinin calcium binding proteins and displayed NADPH-diaphorase enzyme ac...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-14.487
更新日期:1999-04-01 00:00:00
abstract::The International Prognostic Index (IPI) has been the basis for determining prognosis in patients with diffuse large B-cell lymphoma (DLBCL) for the past 20 years. The utility of the IPI must be reassessed in the era of immunochemotherapy. Seven risk factors at diagnosis were identified, and a maximum of 7 points were...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-11-673
更新日期:2016-03-01 00:00:00
abstract::Griffonia simplicifolia agglutinin I-B4 (GSAI-B4) has broader specificity for B antigen variants and can recognize the antigens in a wide variety of human tissues. Thus, the concentration range of GSAI-B4 required for staining and the susceptibility of staining to alpha-galactosidase digestion is presumed to correlate...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1997-04-01 00:00:00
abstract::The sarcolemmal domain of rat duodenal smooth muscle cells includes caveolae and associated cytoskeletal or filamentous elements. We have used the quick-freezing, deep-etching method to examine the three dimensional relationships between these components. Replica membranes for separated strips of rat duodenal muscle l...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-15.1059
更新日期:2000-10-01 00:00:00
abstract::Macrophages play important roles in host defense mechanisms. In the brain, besides microglial cells, meningeal macrophages are present. However, the pathobiological characteristics of meningeal macrophages in rats remain to be investigated. In normal meninx, immunohistochemically, macrophages reacting to CD163 (macrop...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-24.13
更新日期:2009-01-01 00:00:00
abstract::Junctional complexes such as tight junctions, adherens junctions, and desmosomes play crucial roles in the structure and function of epithelial cells. These junctions are involved in increasing cell-cell contact and as well serve as signaling centers regulating multiple functions in epithelial cells. Carcinoma cell li...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-20.35
更新日期:2005-01-01 00:00:00
abstract::Close contacts between endocrine insular cells and exocrine acinar, centroacinar and ductular cells occur frequently in the rat pancreas as seen by both light and electron microscopy. Islets of Langerhans are surrounded incompletely by a thin connective tissue capsule or mantle but numerous exocrine-endocrine cell con...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract::Bone marrow features in stable-phase chronic myelogenous leukemia (CML) are characterized by a striking heterogeneity which is determinable by appropriate means including representative pre-treatment trephine biopsies, immunohistochemistry and morphometry. Cell lineages involved to a variable extent consist not only o...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-14.1241
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:Gastric Cardiac Cancer (GCC) has high incidence and poor prognosis requiring early screening of high-risk populations. Minichromosome maintenance (MCM) proteins are used as diagnostic-biomarkers in many cancers but not validated for GCC. We evaluate MCM protein 2 (MCM2), comparing it with the validated marke...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-28.481
更新日期:2013-04-01 00:00:00
abstract::Elevated plasma levels of C-reactive protein (CRP) are associated with increased risk of cardiovascular disease. CRP immunoreactive protein is also detected in the lesions of atherosclerosis. However, it is not known whether the CRP contents of atherosclerotic lesions are associated with the initiation and progression...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-27.529
更新日期:2012-04-01 00:00:00
abstract::Many surgical techniques are employed in the treatment of severe obesity. A main consequence of these techniques is the improvement of type 2 Diabetes mellitus. Ghrelin is a gut hormone released in the gastric fundus and corpus, which has been related to diabetic improvement as mentioned in these papers. Sleeve gastre...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-18-200
更新日期:2020-08-01 00:00:00
abstract::Tumor angiogenesis plays important roles in the pathogenesis and prognosis of lung cancer. Both vascular endothelial growth factor (VEGF) and Dll4/Notch pathways are critical for angiogenesis, whereas their relationship under hypoxia in lung cancer remains unknown. Thus, in the present study, we evaluated the expressi...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-28.277
更新日期:2013-02-01 00:00:00
abstract::This study concerns the results of penile biopsies in 50 patients aged 27 to 80, with secondary impotence removed with a biopty gun or during penile surgery. The biopty gun specimens were equally representative as the open biopsy ones. The cause and the degree of erectile dysfunction were determined by clinical and la...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract::Sialoderivatives expressed in the rabbit oviduct under hormonal treatment have been investigated in situ by lectin histochemistry with a view to specifying further regional and temporal specializations which enable ampulla and isthmus to play distinct roles in the reproductive events. Application of MAL II and SNA lec...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-19.1175
更新日期:2004-10-01 00:00:00
abstract::The corneal structure of three deep-sea species of teleosts (Gadiformes, Teleostei) from different depths (250-4000 m) and photic zones are examined at the level of the light and electron microscopes. Each species shows a similar but complex arrangement of layers with a cornea split into dermal and scleral components....
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-13.325
更新日期:1998-04-01 00:00:00
abstract::Anthracyclines are one of the most effective anticancer drugs ever developed, but their clinical use has been hampered by the risk of severe cardiotoxicity. In this study, we investigated whether rabbits exposed to a different cumulative dose of anthracycline suffer from immunohistochemically detectable vascular toxic...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-26.551
更新日期:2011-05-01 00:00:00
abstract::Processing adult human trabecular bone to obtain tissue sections suitable for research or diagnostic purposes has always been challenging, particularly in the preparation of adult bone specimens for advanced immunohistochemistry applications. In contrast to the majority of soft tissues, decalcified bone samples perfor...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-28.1605
更新日期:2013-12-01 00:00:00
abstract::Thymidine phosphorylase (TP), thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) have been indicated as possible predictive markers for epithelial malignancies. All these three enzymes are actively involved in 5-FU metabolism. In this report, we investigated mRNA expression of these factors with real-...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-19.129
更新日期:2004-01-01 00:00:00
abstract::Sphingosine kinase functions to phosphorylate sphingosine to sphingosine 1-phosphate (S1P) to keep balance in the metabolites of sphingolipids. There are two isoforms of sphingosine kinase, sphingosine kinase 1 (SphK1) and sphingosine kinase 2 (SphK2). Although SphK1 and SphK2 share high sequence similarity, SphK2 has...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-11-939
更新日期:2018-05-01 00:00:00
abstract::Glaucoma is a neurodegenerative disease characterized by progressive loss of retinal ganglion cell axons and their cell bodies in the retina. Elevated intraocular pressure (IOP) is considered to be the major risk factor associated with the development of this neuropathy. Randomized controlled clinical trials have demo...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-22.1399
更新日期:2007-12-01 00:00:00