Abstract：
:Bone morphogenetic proteins (BMPs) belong to the TGF-Beta superfamily and are vital bone inductive factors. BMPs also play important roles during embryonic development and the postnatal homeostasis of various organs and tissues, by controlling cellular differentiation, proliferation and apoptosis. Prostate cancer is the most common cancer in men in Western countries, with a high incidence of bone metastasis. Once bony metastasis developed, the condition is incurable, and contributes significant disease specific morbidity and mortality. However, the mechanisms underlying the development of bone metastasis remain unclear. BMPs have been implicated in the development of both primary and secondary tumors, particularly skeletal metastasis. Aberrations in BMPs signaling have also been identified in various neoplasms. Recently studies have also suggested a pivotal role in bone metastasis for Noggin, which is a BMP antagonist. In this review, we discuss the current knowledge of BMPs signaling, abnormalities which have been identified and their involvement in tumour progression, and particularly in the development of bone metastasis in prostate cancer.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Ye L,Lewis-Russell JM,Kyanaston HG,Jiang WGdoi
10.14670/HH-22.1129subject
Has Abstractpub_date
2007-10-01 00:00:00pages
1129-47issue
10eissn
0213-3911issn
1699-5848journal_volume
22pub_type
杂志文章,评审abstract：:Ductular hepatocytes are observed in the livers of both experimental animals and man under various conditions of severe toxin-, carcinogen- or viral-induced hepatic injury with prominent loss of parenchymal hepatocytes. These unique hepatic epithelial cells are characterized by phenotypic traits that are intermediate ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1995-04-01 00:00:00
abstract：:This study evidences the presence of primordial germ cells, in tissue squash preparations and sections from hematological malignancies. Primordial germ cells were identified by their morphology, the intense PAS, PAS-D reaction and presence of calcium-activated neutral proteinase. Primordial germ cells gave rise to nuc...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
abstract：:The anti-oxidant food additive, butylated hydroxytoluene (BHT), was fed to Sprague-Dawley rats at three concentrations: 0.2%, 0.4% and 0.8% for periods of 6, 12, 18 and 24 weeks, and the results were compared with corresponding groups treated with a potent carcinogen, 7,12-dimethylbenz[a]anthracene (DMBA) groups, with...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-14.391
更新日期：1999-04-01 00:00:00
abstract：:Nitric oxide (NO) has opened a new and vigorous field of biological and clinical experimentation as evidenced presently by about one hundred original publications every week. Being a biological signal under physiological conditions, NO may be
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1997-01-01 00:00:00
abstract：:A quantitative study regarding the age-related changes occurring in the somatic organelles of the neocerebellar Purkinje cell is carried out, using female rats aged 2 to 24 months. Standard manual morphometric techniques are used to calculate the following parameters: somatic volume, volumetric fractions and absolute ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Targeting essential cellular pathways that determine neuronal and vascular survival can foster a successful therapeutic platform for the treatment of a wide variety of degenerative disorders in the central nervous system. In particular, oxidative cellular injury can precipitate several nervous system disorders that ma...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-19.495
更新日期：2004-04-01 00:00:00
abstract：:The International Prognostic Index (IPI) has been the basis for determining prognosis in patients with diffuse large B-cell lymphoma (DLBCL) for the past 20 years. The utility of the IPI must be reassessed in the era of immunochemotherapy. Seven risk factors at diagnosis were identified, and a maximum of 7 points were...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-11-673
更新日期：2016-03-01 00:00:00
abstract：:In Duchenne muscular dystrophy (DMD), the progressive loss of muscle and its ability to function is associated with significant fibrosis, representing the major disease complication in patients. Halofuginone, a halogenated analog of the naturally occurring febrifugine, has been shown to prevent fibrosis in various ani...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-18-083
更新日期：2019-07-01 00:00:00
abstract：:The effects of diethylstilbestrol (DES) and of long-acting somatostatin analog, octreotide (SMS) on the rat anterior pituitary microvasculature have been studied by means of computer-assisted image analysis. Additionally, the effects of DES and SMS on prolactin secretion and anterior pituitary cell proliferation have ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1997-10-01 00:00:00
abstract：:Melanopsin-expressing retinal ganglion cells (mRGCs) constitute a system in the mammalian retina used for irradiance detection, regulating non-image forming functions, such as photoentrainment of circadian rhythms, control of the pupillary light reflex, masking response, light-regulated melatonin secretion, and modula...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-18-138
更新日期：2019-12-01 00:00:00
abstract：:The population of the world grows every year, and life expectancy tends to increase. Thus, long-term preservation of teeth in aged individuals is an urgent issue. The main causes of tooth loss are well known to be periodontitis, caries, fractures, and orthodontic conditions. Although implant placement is a widely acce...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-29.1249
更新日期：2014-10-01 00:00:00
abstract：:The effects of cadmium exposure on the protein secretory functions of cultured neonatal rat hepatocytes were analyzed by both two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) and electron microscopy. [35S]Methionine-labelled protein secretion was significantly depressed by cadmium exposure in a dose-depend...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Adult stem cells (ASC)--able to self renew and to intervene in maintaining the structural and functional integrity of their original tissue--can express greater plasticity than traditionally attributed to them, adopting functional phenotypes and expression profiles of cells from other tissues. Therefore, they could be...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-21.995
更新日期：2006-09-01 00:00:00
abstract：:Diabetic nephropathy (DN) is a major cause of end-stage renal disease (ESRD), however, specific treatment for DN has not yet been elucidated. Therefore, it is critically important to understand the molecular mechanism underlying DN to develop cause-related therapeutic strategy. To date, various factors such as hemodyn...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-11-777
更新日期：2016-10-01 00:00:00
abstract：:Sphingosine kinase functions to phosphorylate sphingosine to sphingosine 1-phosphate (S1P) to keep balance in the metabolites of sphingolipids. There are two isoforms of sphingosine kinase, sphingosine kinase 1 (SphK1) and sphingosine kinase 2 (SphK2). Although SphK1 and SphK2 share high sequence similarity, SphK2 has...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-11-939
更新日期：2018-05-01 00:00:00
abstract：:Cerebral cavernous malformations (CCMs) are described as vascular lesions consisting of endothelial-lined dilated vessels embedded in a connective tissue sheath without intervening parenchyma between them. Their anatomical connections with the normal blood vessels are still enigmatic and the fine three-dimensional (3-...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-29.1071
更新日期：2014-08-01 00:00:00
abstract：:Neurons of the substantia nigra show severe morphological changes in Parkinson's disease. Pathological alterations of cell bodies have been described, whereas those of neuronal processes have hardly been investigated. Golgi impregnation has been the chosen method for demonstrating neuronal processes and dendritic and ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
abstract：:Takeda-G-protein-receptor-5 (TGR5) is a receptor for bile acids and its expression has been described in a variety of tissues and species. Characterization of TGR5 distribution and function has been investigated in drug discovery for the treatment of metabolic diseases in humans. Because dogs are one of the species us...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-18-025
更新日期：2019-01-01 00:00:00
abstract：:Ebulin f is a ribosome-inactivating protein (RIP) present in green fruits of the dwarf elder (Sambucus ebulus L). Since dwarf elder fruits are used for food and as a medicine, we assessed the study of toxicological effects and safety of ebulin f in elderly mice, comparing these results with those reported in young ani...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-11-992
更新日期：2018-09-01 00:00:00
abstract：:Hexachlorobenzene (HCB) is a fungicide and a pollutant of increasing concern in industrialized regions of the world. Reproductive failure is one of the effects of HCB upon mammals. Alteration of cell shape in the ovary surface epithelium (OSE) of Cynomolgus monkeys following oral administration of HCB was observed in ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
abstract：:CD45RO+ T cells are referred to as memory or helper-inducer while CD45RA+ T cells are regarded as naive or suppressor-inducer T cells. The former population predominates in the peripheral blood and even more in the synovial fluid of patients with rheumatoid arthritis, to the expense of the latter population. Within th...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-15.587
更新日期：2000-04-01 00:00:00
abstract：:Gliomas are the most common intracranial malignant tumors in humans, and high-grade gliomas in particular pose a unique challenge due to their propensity for proliferation and tissue invasion. Our understanding of glioma oncogenesis, proliferation, and invasion has been greatly advanced in the past 10 years as researc...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-18.207
更新日期：2003-01-01 00:00:00
abstract：:Thymidine phosphorylase (TP), thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) have been indicated as possible predictive markers for epithelial malignancies. All these three enzymes are actively involved in 5-FU metabolism. In this report, we investigated mRNA expression of these factors with real-...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-19.129
更新日期：2004-01-01 00:00:00
abstract：:To investigate the matrix metalloproteinase (MMP)-9, (MMP)-13, E-Cadherin and Ki-67 expressions in road pavers' skin chronically exposed to bitumen products in order to contribute to a better understanding of the earlier tissue alteration. Skin punch biopsies from 16 daily exposed workers and a control group were stud...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-18-116
更新日期：2019-10-01 00:00:00
abstract：:Membranous glomerulonephritis caused in Barbus graellsi by myxosporidian infections have been studied by electron microscopy and immunoelectron microscopy techniques. This study indicates that Myxosporidian infection produces a chronic severe aggression. Spores reach the spleen, the kidney and the liver, where they ar...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1993-10-01 00:00:00
abstract：:The need for an immunophenotypical referential framework relative to lymphoid follicle has led us to apply a panel of monoclonal and polyclonal antibodies, by means of a sensitive immunostaining method. Lymphoid follicle is an immunophenotypically complex structure made up of three lymphoid populations (B, being its b...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:This study was conducted to determine the effects of extracts obtained from both normal and denervated muscles on different muscle types. Wistar rats were used and were divided into a control group and four experimental groups. Each experimental group was treated intraperitoneally during 10 consecutive days with a dif...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-11-776
更新日期：2016-12-01 00:00:00
abstract：:The present study investigated the chemical coding of mammary gland-projecting dorsal root ganglia (DRG) neurons using double-labelling immunohistochemistry. Earlier investigations revealed the presence of Fast blue - positive (FB+) neurons in Th9-Th12 DRG after injection of the tracer into the second, right thoracic ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-26.1509
更新日期：2011-12-01 00:00:00
abstract：:We examined morphological characteristics of the carotid body of spontaneously hypertensive rats (SHR), those of age-matched normotensive Wistar rats (NWR), and age-matched genetically comparable Wistar Kyoto rats (WKY). We examined the distribution and abundance of four different regulatory neuropeptides: substance P...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-26.369
更新日期：2011-03-01 00:00:00
abstract：:Renal oncocytosis is a recently established disease entity characterized by numerous oncocytic tumors and diffuse involvement of oncocytic changes in renal parenchymal epithelia. In this article, we review this disease with a focus on its clinical and pathobiological aspects. Clinically, renal oncocytosis may occur in...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-27.1407
更新日期：2012-11-01 00:00:00
