Cavernomas of the human brainstem: 3-dimensional reconstruction from histological slides using computerized techniques.

Abstract:

:Cerebral cavernous malformations (CCMs) are described as vascular lesions consisting of endothelial-lined dilated vessels embedded in a connective tissue sheath without intervening parenchyma between them. Their anatomical connections with the normal blood vessels are still enigmatic and the fine three-dimensional (3-D) organization of these vascular lesions remains to be established. Two stacks of serial histological slices, obtained from two brainstem CCM lesions (from the necropsy of a CCM2 male patient), were stained using Masson's trichrome method and then digitized. Stacks of regions of interest underwent quasi-automatic processing: 1) propagative registering using blockmatching algorithms and Brain Visa programs; 2) 3-D segmentation using Aphelion; 3) display with Anatomist or ImageVis3D. These first histological 3-D reconstructions show the external limits of the caverns defined as the external limit of their collagen sheath. These pictures not only reveal the gross spatial organization of the lesions, but due to their high resolution (4 μm) and with the help of simple anaglyphic 3-D rendering, they also allow the visualization of connections between caverns and very small blood vessels.

journal_name

Histol Histopathol

authors

Toralba S,Landemore G,Coquemont M,Plancoulaine B,Chapon F

doi

10.14670/HH-29.1071

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

1071-6

issue

8

eissn

0213-3911

issn

1699-5848

pii

HH-11-467

journal_volume

29

pub_type

杂志文章
  • Differential severity of LPS-induced lung injury in CD26/DPP4 positive and deficient F344 rats.

    abstract:BACKGROUND:Lipopolysaccharide (LPS) induced inflammation often leads to lung injury, in which pulmonary recruitment of neutrophils plays a pivotal role. Inflammatory processes are influenced by CD26/DPP4, highly expressed in lungs. Asthma induced CD26/DPP4 deficient (CD26/DPP4⁻) Fischer (F) 344 rats suffering from a tr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-18-117

    authors: Zientara A,Stephan M,von Hörsten S,Schmiedl A

    更新日期:2019-10-01 00:00:00

  • Multilocular cystic renal cell carcinoma with focus on clinical and pathobiological aspects.

    abstract::Multilocular cystic renal cell carcinoma (MCRCC) accounts for approximately 1 to 2% of all renal tumors. This tumor is currently classified as a subtype of clear cell RCC. Clinically, the majority of these tumors are incidentally found. Macroscopically, the tumor is well demarcated and consists of various-sized cysts....

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-27.969

    authors: Kuroda N,Ohe C,Mikami S,Inoue K,Nagashima Y,Cohen RJ,Pan CC,Michal M,Hes O

    更新日期:2012-08-01 00:00:00

  • Distribution and pathophysiologic role of molybdenum-containing enzymes.

    abstract::The importance of molybdenum-containing enzymes in the pathophysiology of a number of clinical disorders necessitates a comprehensive understanding of their histological localization and expression. The objectives of this review are to cover such enzymes so far reported and their enzyme- and immunohistochemical locali...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:

    authors: Moriwaki Y,Yamamoto T,Higashino K

    更新日期:1997-04-01 00:00:00

  • Histology of skeletal muscle reconstructed by means of the implantation of autologous adipose tissue: an experimental study.

    abstract::The purpose of this study was to determine the histological characteristics of a skeletal muscle reconstructed by means of the implantation of autologous adipose tissue following an experimentally-induced volumetric muscle loss. A cylindrical piece in the belly of the rat anterior tibial muscle was removed. In the hol...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-18-163

    authors: Leiva-Cepas F,Jimena I,Ruz-Caracuel I,Luque E,Villalba R,Peña-Amaro J

    更新日期:2020-05-01 00:00:00

  • Silencing of synaptotagmin 7 regulates osteosarcoma cell proliferation, apoptosis, and migration.

    abstract:BACKGROUND:Synaptotagmin 7 (SYT7) is a component of the synaptotagmin family, which is essential in many physiological and pathological processes. In this study, we aimed to investigate the role of SYT7 in osteosarcoma. METHODS:We defined the expression levels of SYT7 in osteosarcoma tissues and para-sarcoma tissues b...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-18-174

    authors: Wu Z,Sun Z,Huang R,Zang D,Wang C,Yan X,Yan W

    更新日期:2020-03-01 00:00:00

  • The induction of gut hyperplasia by phytohaemagglutinin in the diet and limitation of tumour growth.

    abstract::The growth of a transplantable murine non-Hodgkin lymphoma tumour, developing either intraperitoneally as an ascites tumour or subcutaneously as a solid tumour, has been shown to be markedly diminished by including phytohaemagglutinin (PHA), a lectin present in raw kidney bean (Phaseolus vulgaris) in the diet. In NMRI...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-13.575

    authors: Pryme IF,Pusztai A,Bardocz S,Ewen SW

    更新日期:1998-04-01 00:00:00

  • Pax genes in development and maturation of the vertebrate visual system: implications for optic nerve regeneration.

    abstract::Pax genes play a pivotal role in development of the vertebrate visual system. Pax6 is the master control gene for eye development: ectopic expression of Pax6 in Xenopus laevis and Drosphila melanogaster leads to the formation of differentiated eyes on the legs or wings. Pax6 is involved in formation of ganglion cells ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-16.239

    authors: Ziman MR,Rodger J,Chen P,Papadimitriou JM,Dunlop SA,Beazley LD

    更新日期:2001-01-01 00:00:00

  • Liver growth factor antifibrotic activity in vivo is associated with a decrease in activation of hepatic stellate cells.

    abstract::The antifibrotic activity of Liver Growth Factor (LGF), a liver mitogen, was previously demonstrated in several models of rat liver fibrosis and even in extrahepatic sites, such as carotid artery in hypertensive rats and rat CdCl2-induced lung fibrosis. In the present study, we have attempted to examine in depth its m...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-24.473

    authors: Díaz-Gil JJ,García-Monzón C,Rúa C,Martín-Sanz P,Cereceda RM,Miquilena-Colina ME,Machín C,Fernández-Martínez A,García-Cañero R

    更新日期:2009-04-01 00:00:00

  • Review of mucinous tubular and spindle-cell carcinoma of the kidney with a focus on clinical and pathobiological aspects.

    abstract::Recently, the characterization of mucinous tubular and spindle-cell carcinoma (MTSCC) has been established. MTSCC predominantly occurs in females. This tumor is histologically characterized by eosinophilic cytoplasm, elongated and anastomosing tubules, myxomatous stroma and low-grade nuclear cytology. Proliferation of...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-20.221

    authors: Kuroda N,Toi M,Hiroi M,Shuin T,Enzan H

    更新日期:2005-01-01 00:00:00

  • Ultrastructural substrates for increased lung water content in experimental pulmonary edema.

    abstract::We examined the relationship between the incidence of ultrastructural changes in the alveolar septum and the extravascular lung water content. Pulmonary edema was induced in 18 mongrel dogs by either dextran (n = 12) or alloxan (n = 6) administration. Six other dogs served as controls. Extravascular lung water content...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Oda H,Arakawa M,Kambara K,Nakahara K,Segawa T,Ando F,Kawada T,Hirakawa S,Shoumura S,Isono H

    更新日期:1993-01-01 00:00:00

  • Adipose-derived stem cells in articular cartilage regeneration: current concepts and optimization strategies.

    abstract::Knee osteoarthritis (KOA) is the most common progressive joint disorder associated with disability in the world. As a chronic disease, KOA has multifactorial etiology. However, the poor self-healing ability of the articular cartilage due to its intrinsic tissue hypovascularity and hypocellularity seems to be directly ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-11-955

    authors: Gu X,Li C,Yin F,Yang G

    更新日期:2018-07-01 00:00:00

  • Mononuclear cell subpopulations and infiltrating lymphocytes in erythema dyschromicum perstans and vitiligo.

    abstract::Erythema dyschromicum perstans (EDP) and vitiligo are two cutaneous pigmentary dermatoses of unknown etiology. In the present study, the leukocyte infiltrates in the affected skin of EDP and vitiligo patients were studied using the avidin-biotin (ABC) immunoperoxidase technique and monoclonal antibodies which recognis...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Gross A,Tapia FJ,Mosca W,Perez RM,Briceño L,Henriquez JJ,Convit J

    更新日期:1987-07-01 00:00:00

  • Clinical significance of Src expression and activity in human neoplasia.

    abstract::Src, a 60 kDa non-receptor tyrosine kinase, is the product of normal c-src of the human genome and member of the Src protein tyrosine kinases family (SFK). As described by Martin and Rous, a genetic recombination between c-src and the RSV oncogene of Rous sarcoma virus results in a modified Src protein, with increased...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-27.677

    authors: Chatzizacharias NA,Kouraklis GP,Giaginis CT,Theocharis SE

    更新日期:2012-06-01 00:00:00

  • Localization of androgen and estrogen receptors in rat and primate tissues.

    abstract::There is now evidence that estrogens and androgens are exerting their effects in different tissues throughout the body. In order to determine the sites of action of these steroids, studies have been performed to identify at the cellular level the localization of androgen receptor (AR) and the two estrogen receptor (ER...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-15.1261

    authors: Pelletier G

    更新日期:2000-10-01 00:00:00

  • Three-dimensional architecture of the connective tissue core and surface structures of the lingual papillae in the rabbit.

    abstract::Three-dimensional characteristics of the epithelial cell layer and connective tissue interface of the tongue were studied using scanning electron microscopy. In this study, the fragments of tongue were fixed in modified Karnovsky's fixative solution. Subsequently, the specimens were treated with 10% NaOH solution for ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-17.455

    authors: Silva MC,Watanabe I,Kronka MC

    更新日期:2002-04-01 00:00:00

  • Fhit protein is preferentially expressed in the nucleus of monocyte-derived cells and its possible biological significance.

    abstract::The FHIT gene encompassing the most active common human fragile region, FRA3B, has been proposed as a tumour suppressor gene for important common human carcinomas. The mechanism in which Fhit protein exerts its tumour suppressor activity is still obscure. To further understand the Fhit function associated with its int...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-21.915

    authors: Zhao P,Hou N,Lu Y

    更新日期:2006-09-01 00:00:00

  • A truncated isoform of the PP2A B56gamma regulatory subunit reduces irradiation-induced Mdm2 phosphorylation and could contribute to metastatic melanoma cell radioresistance.

    abstract::F10, a subline of the B16 mouse melanoma cell line, is itself the parent of the more metastatic BL6 line. BL6 cells differ from F10 cells by an alteration of the gene encoding the B56gamma regulatory subunit of protein phosphatase 2A (PP2A), which results in mRNA encoding a truncated variant of the subunit (deltagamma...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-19.391

    authors: Koma YI,Ito A,Watabe K,Kimura SH,Kitamura Y

    更新日期:2004-04-01 00:00:00

  • Molecular biology of glioma tumorigenesis.

    abstract::Gliomas are the most common intracranial malignant tumors in humans, and high-grade gliomas in particular pose a unique challenge due to their propensity for proliferation and tissue invasion. Our understanding of glioma oncogenesis, proliferation, and invasion has been greatly advanced in the past 10 years as researc...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-18.207

    authors: Ware ML,Berger MS,Binder DK

    更新日期:2003-01-01 00:00:00

  • Immunohistochemistry of connexin43 and zonula occludens-1 in the myocardium as markers of early ischemia in autopsy material.

    abstract::Immunohistochemistry of the terminal complement complex (C5b-9) and fibronectin (FN) is useful to detect myocardial ischemia preceding necrosis in the postmortem diagnosis of sudden cardiac death. The present immunohistochemical study examined connexin43 (Cx43) and zonula occludens-1 (ZO-1) as markers of early myocard...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-29.767

    authors: Kawamoto O,Michiue T,Ishikawa T,Maeda H

    更新日期:2014-06-01 00:00:00

  • Histopathological features of endometritis eosinophilica in mares.

    abstract::Equine endometritis eosinophilica (EE) is rarely described and its diagnostic criteria are not defined. The aim of this study was to characterize histological features of EE. A data base (1995-2013) was searched for biopsies with increased eosinophils. This study included all biopsies with this diagnosis and represent...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-11-872

    authors: Grimm AL,Schoon HA,Schöniger S

    更新日期:2017-11-01 00:00:00

  • Less gelatinases is associated with apolipoprotein E accumulation in glomerulosclerosis rats.

    abstract:BACKGROUND:Gelatinases include matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9). The abnormal expressions of gelatinases are implicated in the pathogenesis of extracellular matrix (ECM) accumulation. Apolipo-protein E (apoE) is an important plasma protein in cholesterol homeostasis and plays a ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-27.249

    authors: Zhou TB,Qin YH,Lei FY,Su LN,Zhao YJ,Huang WF

    更新日期:2012-02-01 00:00:00

  • Control of the cell cycle by neurotrophins: lessons from the p75 neurotrophin receptor.

    abstract::Although traditionally little attention has been paid to the interplay between neurotrophins and the cell cycle, a number of recent findings suggest an important role for these growth factors in the regulation of this aspect of the cellular physiology. In this article, we review the evidence from a number of studies t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-17.1227

    authors: López-Sánchez N,Frade JM

    更新日期:2002-10-01 00:00:00

  • Hydroxy group requirement for halofuginone-dependent inhibition of muscle fibrosis and improvement of histopathology in the mdx mouse model for Duchenne muscular dystrophy.

    abstract::In Duchenne muscular dystrophy (DMD), the progressive loss of muscle and its ability to function is associated with significant fibrosis, representing the major disease complication in patients. Halofuginone, a halogenated analog of the naturally occurring febrifugine, has been shown to prevent fibrosis in various ani...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-18-083

    authors: Wellner G,Mordechay S,Evans P,Genin O,Pines M,Halevy O

    更新日期:2019-07-01 00:00:00

  • The dynamic stem cell microenvironment is orchestrated by microvesicle-mediated transfer of genetic information.

    abstract::It has been commonly supposed that adult stem cells co-localize with supporting cells within specific regions or specialized microenvironment in each tissue/organ, called stem cell niche. This concept was based on the assumption that stem cells are intrinsically hierarchical in nature. However, recent data indicate th...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-25.397

    authors: Deregibus MC,Tetta C,Camussi G

    更新日期:2010-03-01 00:00:00

  • The relative effects of severe burn injury and pre- and post-natal protein deprivation on mandibular condyle morphology.

    abstract::The mandible has a mixed embryological origin, and its growth is associated with the secondary cartilage of the condyle process (CP). In this area, growth depends on an array of intrinsic and extrinsic factors that influence protein metabolism. In the present study, we used an adolescent rat model to evaluate the grow...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-25.45

    authors: de Oliveira BC,de Oliveira F,Martini DT,Prisco CR,da Silva Riguetti MM,Liberti EA,de Campos Boldrini S

    更新日期:2010-01-01 00:00:00

  • Muscular hypertrophy and atrophy in normal rats provoked by the administration of normal and denervated muscle extracts.

    abstract::This study was conducted to determine the effects of extracts obtained from both normal and denervated muscles on different muscle types. Wistar rats were used and were divided into a control group and four experimental groups. Each experimental group was treated intraperitoneally during 10 consecutive days with a dif...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-11-776

    authors: Agüera E,Castilla S,Luque E,Jimena I,Leiva-Cepas F,Ruz-Caracuel I,Peña J

    更新日期:2016-12-01 00:00:00

  • Chaperone-mediated autophagy in cancer: Advances from bench to bedside.

    abstract::Chaperone-mediated autophagy (CMA), a selective form of autophagy, where cellular proteins with KFERQ-like motif are targeted to the lysosome for degradation, is necessary to maintain cellular homeostasis. The role of CMA in neurodegenerative diseases has been extensively studied in the past decades, with defects in t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-18-202

    authors: Hou T,Fan Y,Dan W,Liu B,Wang Z,Zeng J,Li L

    更新日期:2020-07-01 00:00:00

  • Thrombocytopenia in leukemia: Pathogenesis and prognosis.

    abstract::Leukemias, a heterogeneous group of hematological disorders, are characterized by ineffective hematopoiesis and morphologic abnormalities of hematopoietic cells. Thrombocytopenia is a common problem among leukemia types that can lead to hemorrhagic complications in patients. The purpose of this review article is to id...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-11-976

    authors: Shahrabi S,Behzad MM,Jaseb K,Saki N

    更新日期:2018-09-01 00:00:00

  • Gli-similar (Glis) Krüppel-like zinc finger proteins: insights into their physiological functions and critical roles in neonatal diabetes and cystic renal disease.

    abstract::GLI-similar (Glis) 1-3 proteins constitute a subfamily of the Krüppel-like zinc finger transcription factors that are closely related to the Gli family. Glis1-3 play critical roles in the regulation of a number of physiological processes and have been implicated in several pathologies. Mutations in GLIS2 have been lin...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-25.1481

    authors: Kang HS,ZeRuth G,Lichti-Kaiser K,Vasanth S,Yin Z,Kim YS,Jetten AM

    更新日期:2010-11-01 00:00:00

  • Pancreas is a preeminent source of ghrelin after sleeve gastrectomy in Wistar rats.

    abstract::Many surgical techniques are employed in the treatment of severe obesity. A main consequence of these techniques is the improvement of type 2 Diabetes mellitus. Ghrelin is a gut hormone released in the gastric fundus and corpus, which has been related to diabetic improvement as mentioned in these papers. Sleeve gastre...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-18-200

    authors: Camacho-Ramírez A,Mayo-Ossorio MÁ,Pacheco-García JM,Almorza-Gomar D,Ribelles-García A,Belmonte-Núñez A,Prada-Oliveira JA,Pérez-Arana GM

    更新日期:2020-08-01 00:00:00