Alteration of primate ovary surface epithelium by exposure to hexachlorobenzene: a quantitative study.

Abstract:

:Hexachlorobenzene (HCB) is a fungicide and a pollutant of increasing concern in industrialized regions of the world. Reproductive failure is one of the effects of HCB upon mammals. Alteration of cell shape in the ovary surface epithelium (OSE) of Cynomolgus monkeys following oral administration of HCB was observed in this study. At the lowest dose used, 0.1 mg/kg body weight, a dosage that is associated with follicular degeneration, HCB caused quantifiable changes in length-to-width ratios of OSE. Measurement of cell shape by light microscopy offers a reliable indication of OSE changes induced by HCB.

journal_name

Histol Histopathol

authors

Sims DE,Singh A,Donald A,Jarrell J,Villeneuve DC

subject

Has Abstract

pub_date

1991-10-01 00:00:00

pages

525-9

issue

4

eissn

0213-3911

issn

1699-5848

journal_volume

6

pub_type

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