Adult stem and transit-amplifying cell location.


:Adult stem cells (ASC)--able to self renew and to intervene in maintaining the structural and functional integrity of their original tissue--can express greater plasticity than traditionally attributed to them, adopting functional phenotypes and expression profiles of cells from other tissues. Therefore, they could be useful to regenerative medicine and tissue engineering. Transit-amplifying cells (TAC) are committed progenitors among the ASC and their terminally differentiated daughter cells. The ASC reside in a specialized physical location named niche, which constitutes a three-dimensional microenviroment where ASC and TAC are protected and controlled in their self-renewing capacity and differentiation. The niche can be located near or far from the recruitment point, requiring a short or long-distance cellular migration, respectively. This paper briefly reviews the current status of research about ASC plasticity, transdifferentiation, fusion and functional adaptation mechanisms. Subsequently, ASC and TAC occurrence, characteristics and location have been considered in the skin, cornea, respiratory tract, teeth, gastrointestinal tract, liver, pancreas, salivary glands, kidney, breast, prostate, endometrium, mesenchyma, bone marrow, skeletal and cardiac muscle, nervous system and pituitary gland. Moreover, the role of cancer ASC has also been revised.


Histol Histopathol


Díaz-Flores L Jr,Madrid JF,Gutiérrez R,Varela H,Valladares F,Alvarez-Argüelles H,Díaz-Flores L




Has Abstract


2006-09-01 00:00:00












  • Expression of matrix metalloproteinase-9 (gelatinase B) in benign, premalignant and malignant laryngeal lesions.

    abstract::The matrix metalloproteinases (MMPs) are a family of proteolytic zinc-containing enzymes, which are responsible for the breakdown of the extracellular matrix components in pathological and physiological conditions. They are involved in basement membrane disruption, stroma and blood vessel penetration, metastasis and m...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Peschos D,Damala C,Stefanou D,Tsanou E,Assimakopoulos D,Vougiouklakis T,Charalabopoulos K,Agnantis NJ

    更新日期:2006-06-01 00:00:00

  • Skeletal muscle abnormalities associated with occupational exposure to mercury vapours.

    abstract::There is scarce information on the possible effects of chronic exposure to mercury on skeletal muscle. Dental personnel are frequently exposed to inhalation of metallic mercury vapours. The skeletal muscle of five technicians and one dentist (females, age 36-55) was studied. All of them presented symptoms of chronic m...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Nadorfy-López E,Torres SH,Finol H,Méndez M,Bello B

    更新日期:2000-07-01 00:00:00

  • Immunolocalization of interleukin-1 receptor antagonist in healthy and infarcted myocardium.

    abstract::Ischemic heart disease is a widespread cause of death. During infarction, myocardial injury is mediated by release of several pro-inflammatory cytokines including multifunctional interleukin-1 (IL-1). In various tissues, IL-1-mediated deleterious effects are known to be attenuated via the over-expression of natural an...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Bonetti A,Marchini M,Ortolani F

    更新日期:2008-09-01 00:00:00

  • Promoter methylation status of tumor suppressor and tumor-related genes in neoplastic and non-neoplastic gastric epithelia.

    abstract::A number of tumor suppressor and tumor-related genes exhibit promoter hypermethylation with resulting gene silencing in human cancers. In addition, several gene promoters have also been shown to become hypermethylated in non-neoplastic cells during aging. To assess the physiological consequence and clinical significan...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Tamura G

    更新日期:2004-01-01 00:00:00

  • Nitric oxide, a biological double-faced janus--is this good or bad?

    abstract::Nitric oxide (NO) is a biological messenger molecule produced by one of the essential amino acids L-arginine by the catalytic action of the enzyme NO synthase (NOS). The dual role of NO as a protective or toxic molecule is due to several factors, such as; the isoform of NOS involved, concentration of NO and the type o...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Thippeswamy T,McKay JS,Quinn JP,Morris R

    更新日期:2006-04-01 00:00:00

  • Nitric oxide and nitric oxide synthase: biology, pathology, localization.

    abstract::Nitric oxide (NO) has opened a new and vigorous field of biological and clinical experimentation as evidenced presently by about one hundred original publications every week. Being a biological signal under physiological conditions, NO may be to pathologically affected tissues. Major insights into the ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Wolf G

    更新日期:1997-01-01 00:00:00

  • Temporal and spatial distribution of TGF-beta isoforms and signaling intermediates in corneal regenerative wound repair.

    abstract::The present study analyzed the temporal and spatial expression of TGF-beta isoforms and activated pSmad2 and p38MAPK during epithelial debridement wound repair, using chick cornea by immunohistochemistry. Normal corneas showed low-level TGF-betas staining. Following wounding, TGF-beta1 expression was strong in the Bow...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Huh MI,Chang Y,Jung JC

    更新日期:2009-11-01 00:00:00

  • Use of a fibroblastic matrix improves the results of mesothelial-cell seeding on vascular prostheses of polytetrafluoroethylene.

    abstract::Mesothelial cells (MC) obtained from the human omentum are a good alternative to the use of endothelial cells (EC) as a covering for vascular prostheses of polytetrafluoroethylene (PTFE), given the antithrombogenic properties and good behavior in vitro of mesothelial cells. We studied the behaviour of mesothelial cell...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Buján J,García-Honduvilla N,Hernando A,Bellón JM

    更新日期:1995-10-01 00:00:00

  • Morphological changes in the rat exocrine pancreas after pancreatic duct ligation.

    abstract::In the present study, morphological changes of the exocrine pancreas in rats after pancreatic duct ligation were examined with light microscopy (hematoxylin-eosin, TUNEL, and PCNA staining) and scanning electron microscopy in order to elucidate the effects of increased pancreatic duct pressure. On the fifth day after ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Hamamoto N,Ashizawa N,Niigaki M,Kaji T,Katsube T,Endoh H,Watanabe M,Sumi S,Kinoshita Y

    更新日期:2002-10-01 00:00:00

  • Regional differences in cell surface patterns in normal human sulcular epithelium.

    abstract::Studies with scanning electron microscopy in the normal human sulcular epithelium are scarce, and no precise information exists about cell surface patterns along the epithelium, the frequencies of these patterns, or possible regional differences within the mouth. In five periodontal biopsy specimens each from the ante...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Sánchez-Quevedo MC,Moreu G,Campos A,García JM,González-Jaranay M

    更新日期:1994-01-01 00:00:00

  • MgSO4 treatment preserves the ischemia-induced reduction in S-100 protein without modification of the expression of endothelial tight junction molecules.

    abstract:UNLABELLED:The aim of this work was to evaluate the effect of magnesium sulphate (MgSO4) administration on blood-brain barrier (BBB) permeabilization after cerebral hypoxia-ischemia (HI) induced by partial occlusion of the umbilical cord of premature fetal lambs. We also characterized BBB dysfunction in terms of the le...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Goñi-de-Cerio F,Alvarez A,Alvarez FJ,Rey-Santano MC,Alonso-Alconada D,Mielgo VE,Gastiasoro E,Hilario E

    更新日期:2009-09-01 00:00:00

  • TNF-alpha/IL-1/NF-kappaB transduction pathway in human cancer prostate.

    abstract::TNFalpha exerts apoptosis throughout an intracellular transduction pathway that involves the kinase proteins TRAF-2 (integration point of apoptotic and survival signals), ASK1 (pro-apoptotic protein), MEK-4 (p38 activator and metastasis suppressor gene), JNK (stress mitogen activated protein kinase) and the transcript...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Royuela M,Rodríguez-Berriguete G,Fraile B,Paniagua R

    更新日期:2008-10-01 00:00:00

  • Abnormal distribution of CD45 isoforms expressed by CD4+ and CD8+ T cells in rheumatoid arthritis.

    abstract::CD45RO+ T cells are referred to as memory or helper-inducer while CD45RA+ T cells are regarded as naive or suppressor-inducer T cells. The former population predominates in the peripheral blood and even more in the synovial fluid of patients with rheumatoid arthritis, to the expense of the latter population. Within th...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Mamoune A,Durand V,Le Goff P,Pennec YL,Youinou P,Le Corre R

    更新日期:2000-04-01 00:00:00

  • Comparative in vivo and in vitro models to approach the cellular basis of endotoxic shock. The role of sinusoidal liver cells.

    abstract::During endotoxic shock, the liver exerts a lipopolysaccharide (LPS) clearance function with the participation of both parenchymal and sinusoidal cells. Liver damage could be caused by LPS direct action, hypoxia and/or inflammatory mediators released by Kupffer cells. The aim of this study is to establish an experiment...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Pagani R,Portolés MT,Arahuetes R,Ainaga MJ,Machín C,Rua C

    更新日期:1996-07-01 00:00:00

  • Physiopathologic dynamics of vesicle traffic in astrocytes.

    abstract::The view of how astrocytes, a type of glial cells, contribute to the functioning of the central nervous system (CNS) has changed greatly in the last decade. Although glial cells outnumber neurons in the mammalian brain, it was considered for over a century that they played a subservient role to neurons. This view chan...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Potokar M,Stenovec M,Kreft M,Gabrijel M,Zorec R

    更新日期:2011-02-01 00:00:00

  • Ultrastructural observation on the rat supraoptic neurons following acute operative stress.

    abstract::The response of the SON to various forms of stress is well documented. However, the effect of operative stress, which is a common and important clinical event requiring the mediation of vasopressin, has largely escaped attention. The present report describes the ultrastructural changes in the neurons of the caudal (re...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Ray PK,Choudhury SR

    更新日期:1988-04-01 00:00:00

  • Retinal and lenticular ultrastructure in the aestivating salamanderfish, Lepidogalaxias salamandroides (Galaxiidae, Teleostei) with special reference to a new type of photoreceptor mosaic.

    abstract::The salamanderfish, Lepidogalaxias salamandroides (Galaxiidae, Teleostei) is endemic to southwestern Australia and inhabits shallow, freshwater pools which evaporate during the hot summer months. Burrowing into the substrate in response to falling water levels allows these fish to aestivate for extended periods of tim...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Collin SP,Collin HB

    更新日期:1998-10-01 00:00:00

  • CD34+ stromal cells/fibroblasts/fibrocytes/telocytes as a tissue reserve and a principal source of mesenchymal cells. Location, morphology, function and role in pathology.

    abstract::We review the morphofunctional characteristics of CD34+ stromal fibroblastic/fibrocytic cells (CD34+ SFCs) and report our observations. We consider the following aspects of CD34+ SFCs: A) The confusing terms applied to this cell type, often combining the prefix CD34 with numerous names, including fibroblasts, fibrocyt...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Díaz-Flores L,Gutiérrez R,García MP,Sáez FJ,Díaz-Flores L Jr,Valladares F,Madrid JF

    更新日期:2014-07-01 00:00:00

  • Immunoexpression of gelatinase (MMP-2 and MMP-9) in the seminal vesicles and ventral prostate of Libyan jird (Meriones libycus) during the seasonal cycle of reproduction.

    abstract::An immunohistochemical study of matrix metalloproteinases (MMP-2 and MMP-9) or gelatinase (gelatinase A and gelatinase B) was performed on the seminal vesicles and ventral prostate of the Libyan jird (Meriones libycus) collected in the Beni-Abbes area during breeding period (spring and early summer), during resting ph...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Belhocine M,Gernigon-Spychalowicz T,Jacob MP,Benazzoug Y,Exbrayat JM

    更新日期:2010-05-01 00:00:00

  • Expression pattern of the endoplasmic reticulum stress protein gp96 in monophasic and chronic relapsing form of experimental autoimmune encephalomyelitis in rats.

    abstract::Gp96 is the endoplasmic reticulum (ER)-resident molecular chaperone, which is involved in the correction of unfolded proteins, in the activation of proteasome-dependent ER-associated degradation of the misfolded proteins, and in activation of the protein translation that modulates polypeptide traffic into the ER. Furt...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Jakovac H,Grebic D,Barac-Latas V,Mrakovcic I,Radosevic-Stasic B

    更新日期:2013-01-01 00:00:00

  • Immunohistochemistry of connexin43 and zonula occludens-1 in the myocardium as markers of early ischemia in autopsy material.

    abstract::Immunohistochemistry of the terminal complement complex (C5b-9) and fibronectin (FN) is useful to detect myocardial ischemia preceding necrosis in the postmortem diagnosis of sudden cardiac death. The present immunohistochemical study examined connexin43 (Cx43) and zonula occludens-1 (ZO-1) as markers of early myocard...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Kawamoto O,Michiue T,Ishikawa T,Maeda H

    更新日期:2014-06-01 00:00:00

  • The combined effect of honey and olive oil against methotrexate mediated hepatotoxicity in rats: A biochemical, histological and immunohistological study.

    abstract:BACKGROUND:Honey and olive oil are natural products that have high nutritional values, and therapeutic properties. Cytotoxic drugs, like methotrexate (MTX) are used to treat malignancies in tumour cells; however, these drugs also have serious side effects that could threaten the patient's life. AIM:To evaluate the pot...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Alturkistani HA,Abuzinadah OAH,Kelany AM,Abd El-Aziz GS,Alrafiah AR

    更新日期:2019-12-01 00:00:00

  • Effects of chronic administration of either ethanol or pentanol on rat duodenum morphology.

    abstract::The morphology of the rat duodenum after chronic treatment with 15% (v/v) ethanol and 4% (v/v) pentanol was studied. Male Wistar rats of experimental groups were given ethanol and pentanol for 15 weeks with food and fluid freely available. Ethanol-15% and 4% pentanol-fed rats showed a significantly reduced fluid and f...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Vaquera J,Vaquera A,Girbes T

    更新日期:2002-01-01 00:00:00

  • Fine reconstruction of the pancreatic ductular system at the onset of pancreatitis.

    abstract::The three-dimensional structure of the pancreatic ductular system (from the intercalated duct to the intercellular secretory canaliculus) is controversial and unclear. The aim of this study is to reveal the three-dimensional structure of the pancreatic ductular sysytem at the onset of pancreatitis. One day following r...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Endo H,Ashizawa N,Niigaki M,Hamamoto N,Niigaki M,Kaji T,Katsube T,Watanabe M,Naora H,Otani H,Kinoshita Y

    更新日期:2002-01-01 00:00:00

  • Morphology, differentiation and matrix production of liver cells in organoid cultures (high density cultures) of fetal rat livers.

    abstract::The aim of this study was to demonstrate the morphology and matrix synthesis of embryonic rat liver cells (day 18 of gestation) in organoid cultures (high density cultures) with electron microscopic and immunomorphological techniques. For this purpose the cells of embryonic rat livers were isolated enzymatically and g...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Elkasaby A,Xu D,Schröter-Kermani C,Merker HJ

    更新日期:1991-04-01 00:00:00

  • Muscular hypertrophy and atrophy in normal rats provoked by the administration of normal and denervated muscle extracts.

    abstract::This study was conducted to determine the effects of extracts obtained from both normal and denervated muscles on different muscle types. Wistar rats were used and were divided into a control group and four experimental groups. Each experimental group was treated intraperitoneally during 10 consecutive days with a dif...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Agüera E,Castilla S,Luque E,Jimena I,Leiva-Cepas F,Ruz-Caracuel I,Peña J

    更新日期:2016-12-01 00:00:00

  • Subcutaneous fat necrosis of newborn children.

    abstract::We report a case of subcutaneous fat necrosis of a newborn child which appeared 9 days after birth and was cured without any complications. We propose the reclassification of the etiological factors accompanying this lesion by classifying them in a plurietiological syndrome with some basic or essential factors and oth...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Salas Valién JS,Ribas Ariño MT,Egido Romo M,Palau Benavides MT

    更新日期:1990-01-01 00:00:00

  • Histology of skeletal muscle reconstructed by means of the implantation of autologous adipose tissue: an experimental study.

    abstract::The purpose of this study was to determine the histological characteristics of a skeletal muscle reconstructed by means of the implantation of autologous adipose tissue following an experimentally-induced volumetric muscle loss. A cylindrical piece in the belly of the rat anterior tibial muscle was removed. In the hol...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Leiva-Cepas F,Jimena I,Ruz-Caracuel I,Luque E,Villalba R,Peña-Amaro J

    更新日期:2020-05-01 00:00:00

  • Adhesion-dependent signalling and the initiation of haemostasis and thrombosis.

    abstract::Cell-cell and cell-extracellular matrix adhesion are critical aspects of platelet function, regulating interactions between circulating platelets in the bloodstream with the blood vessel wall. In haemostasis, platelets adhere to the subendothelial matrix of a damaged vessel, spread over the surface and recruit additio...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Andrews RK,Berndt MC

    更新日期:1998-07-01 00:00:00

  • How galectins have become multifunctional proteins.

    abstract::Having identified glycans of cellular glycoconjugates as versatile molecular messages, their recognition by sugar receptors (lectins) is a fundamental mechanism within the flow of biological information. This type of molecular interplay is increasingly revealed to be involved in a wide range of (patho)physiological pr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: García Caballero G,Kaltner H,Kutzner TJ,Ludwig AK,Manning JC,Schmidt S,Sinowatz F,Gabius HJ

    更新日期:2020-06-01 00:00:00