Abstract:
:Glaucoma is a neurodegenerative disease characterized by progressive loss of retinal ganglion cell axons and their cell bodies in the retina. Elevated intraocular pressure (IOP) is considered to be the major risk factor associated with the development of this neuropathy. Randomized controlled clinical trials have demonstrated that in some patients the disease progresses, even after lowering the IOP. Several researchers have devised ways to induce elevated IOP in the rat eye with the aim of impeding the flow of aqueous humour out of the eye. Chronic ocular hypertension in rats induces morphofunctional changes in the optic nerve head and retina. Death of ganglion cells is thought to follow an apoptotic pathway. Changes have also been reported in neuronal and non-neuronal cells, levels of cyclooxygenase, and nitric oxide synthase, endothelin 1 and brain derived neurotrophic factor. Other mechanisms include intracellular electrolyte imbalance, microglial phagocytosis and elevated glutamate levels. Neuroprotection is the treatment strategy by preventing neuronal death. Hypotensive drugs (beta-blockers, alpha-agonists and prostaglandins), Ca++ channel blockers, NMDA antagonists and nitric oxide synthase inhibitors have been used as neuroprotective drugs in experimental models of glaucoma.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
García-Campos J,Villena A,Díaz F,Vidal L,Moreno M,Pérez de Vargas Idoi
10.14670/HH-22.1399subject
Has Abstractpub_date
2007-12-01 00:00:00pages
1399-411issue
12eissn
0213-3911issn
1699-5848journal_volume
22pub_type
杂志文章,评审abstract::Morphological and biochemical alterations have been described in neurons of the aged human brain. However, the cell death process associated with neuronal senescence remains to be elucidated. Apoptosis and autophagic degeneration, two modes of programmed cell death described in embryogenesis and tissue renewal in adul...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1997-07-01 00:00:00
abstract::Immunohistochemistry of the terminal complement complex (C5b-9) and fibronectin (FN) is useful to detect myocardial ischemia preceding necrosis in the postmortem diagnosis of sudden cardiac death. The present immunohistochemical study examined connexin43 (Cx43) and zonula occludens-1 (ZO-1) as markers of early myocard...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-29.767
更新日期:2014-06-01 00:00:00
abstract::Sialoderivatives expressed in the rabbit oviduct under hormonal treatment have been investigated in situ by lectin histochemistry with a view to specifying further regional and temporal specializations which enable ampulla and isthmus to play distinct roles in the reproductive events. Application of MAL II and SNA lec...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-19.1175
更新日期:2004-10-01 00:00:00
abstract::The renin-angiotensin system (RAS) and tubuloglomerular feedback (TGF) are central to the maintenance of blood pressure and body fluid composition. Renin, NO synthase-1 (NOS-1), and cyclooxygenase-2 (COX-2) are key regulators of the RAS and TGF. In the present study, to investigate species-specific differences in the ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-23.143
更新日期:2008-02-01 00:00:00
abstract::Thrombospondin-1 (TSP-1) is a matrix protein implicated in mechanisms of wound healing. TSP-1 contains the sequence cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG) that has been shown to function primarily as a cell adhesion domain. Our laboratory has isolated a novel receptor specific for the CSVTCG adhesi...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-13.967
更新日期:1998-10-01 00:00:00
abstract::Bone marrow features in stable-phase chronic myelogenous leukemia (CML) are characterized by a striking heterogeneity which is determinable by appropriate means including representative pre-treatment trephine biopsies, immunohistochemistry and morphometry. Cell lineages involved to a variable extent consist not only o...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-14.1241
更新日期:1999-10-01 00:00:00
abstract::The clinical presentation, histopathology and immunoelectron microscopic features of two cases of duodenal somatostatinoma are described, one of which is a hitherto unreported example of a collision tumour with a neurofibroma. Ultrastructural morphometric immunoelectron microscopy studies revealed the presence of four...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-21.1171
更新日期:2006-11-01 00:00:00
abstract::The purpose of this study was to determine the histological characteristics of a skeletal muscle reconstructed by means of the implantation of autologous adipose tissue following an experimentally-induced volumetric muscle loss. A cylindrical piece in the belly of the rat anterior tibial muscle was removed. In the hol...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-18-163
更新日期:2020-05-01 00:00:00
abstract:AIMS:The expression patterns of TGFB signaling proteins, such as TGFB1/2, TGFBR1(ALK5), TGFBR2, SMAD1/2/3, SMAD2/3, SMAD4, SMAD7, and of downstream targets of TGFB signaling, CDKN1A (p21CIP1), CDKN1B (p27KIP1), MYC, CDC25A, TP53, and RELA (p65NF-kB) were investigated in gastric carcinomas and other gastric lesions. ME...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-23.1439
更新日期:2008-12-01 00:00:00
abstract::Knee osteoarthritis (KOA) is the most common progressive joint disorder associated with disability in the world. As a chronic disease, KOA has multifactorial etiology. However, the poor self-healing ability of the articular cartilage due to its intrinsic tissue hypovascularity and hypocellularity seems to be directly ...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-11-955
更新日期:2018-07-01 00:00:00
abstract::Snake-like chromatin (SLC) is a nuclear alteration occurring under various pathological conditions and in different tissues. The aim of this study was the morphological and immunocytochemical characterization of SLC-positive conjunctival epithelial cells from keratoconjunctivitis sicca (KCS) patients. Impression cytol...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-21.355
更新日期:2006-04-01 00:00:00
abstract::Bone morphogenetic proteins (BMPs) belong to the TGF-Beta superfamily and are vital bone inductive factors. BMPs also play important roles during embryonic development and the postnatal homeostasis of various organs and tissues, by controlling cellular differentiation, proliferation and apoptosis. Prostate cancer is t...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-22.1129
更新日期:2007-10-01 00:00:00
abstract::An electron microscopic study of the myoepithelial cells in the chicken Harderian gland provides evidence that these cells can be transformed into myofibroblasts. After the application of a Brucella ovis suspension in sterile saline onto the eyeball, every 5 minutes for half an hour, myoepithelial cells gradually deve...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1991-07-01 00:00:00
abstract::A rat IgG2a monoclonal antibody against a stage-specific fetal glycoprotein with a molecular mass of 68 kDa (FGP68) was produced and applied to paraffin sections. This monoclonal antibody was used to compare the expression of FGP68 with that of both alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) in 75 hepa...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-19.701
更新日期:2004-07-01 00:00:00
abstract::The repair of articular cartilage defects is increasingly moving into the focus of experimental and clinical investigations. Histological analysis is the gold standard for a valid and objective evaluation of cartilaginous repair tissue and predominantly relies on the use of established scoring systems. In the past thr...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-11-620
更新日期:2015-08-01 00:00:00
abstract::To determine the appropriate time for bone reconstruction after irradiation, the healing process after autogenous iliac bone transplantation in the irradiated parietal bone was examined by scanning electron microscopy and light microscopy. Bone transplantation was carried out at the second and the fourth weeks after C...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-15.7
更新日期:2000-01-01 00:00:00
abstract::Experimental Doxorubicin-exposure in utero is correlated with foetal oesophageal atresia, tracheo-oesophageal fistula, axial alterations. While gastrointestinal and respiratory defects have been largely investigated, only sporadic data have been published to date on notochordal and vertebral defects. The aim of this w...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-17.31
更新日期:2002-01-01 00:00:00
abstract::In the last years, it has been reported that bone marrow stromal cells (BMSC) are able to differentiate towards a neuronal phenotype, in vitro as well as in vivo, and consequently, the possible use of these cells for the treatment of neurological diseases has acquired enormous importance. The objective of this review ...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-24.107
更新日期:2009-01-01 00:00:00
abstract::There is scarce information on the possible effects of chronic exposure to mercury on skeletal muscle. Dental personnel are frequently exposed to inhalation of metallic mercury vapours. The skeletal muscle of five technicians and one dentist (females, age 36-55) was studied. All of them presented symptoms of chronic m...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-15.673
更新日期:2000-07-01 00:00:00
abstract::Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity with a poor 5-year survival rate, due in large part to the presence of metastatic disease at initial diagnosis. In recent years, a number of studies have examined the oral tumor microenvironment to asses the potential dynamic balance ...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-25.917
更新日期:2010-07-01 00:00:00
abstract::Sample preparation of dental tissues for quantitative electron microprobe analysis has not been critically examined because of the highly mineralized nature of these structures. The present study was designed to establish the most suitable method for the electron probe quantitative determination of calcium in human pe...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-13.109
更新日期:1998-01-01 00:00:00
abstract::We designed to investigate the effects of down-regulating the tumor susceptibility gene 101 (TSG101) on the proliferation and apoptosis of the human breast cancer MCF-7 cell line, and the role of the MAPK/ERK signal pathway in this process. The siRNA against TSG101 was transfected into the breast cancer MCF-7 cell lin...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-26.87
更新日期:2011-01-01 00:00:00
abstract::Previous studies have demonstrated a role for the beta-adrenergic system in the maturation of the fetal alveolar epithelium. Chronic blockade of beta-adrenergic binding sites has been shown to adversely effect physiologic and biochemical indices of fetal lung maturation. In the present study timed-pregnant female Spra...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-17.365
更新日期:2002-04-01 00:00:00
abstract::Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the purpose of anti-inflammation, antipyretic, and analgesia. For this aim, they are used for the alleviation of pain, fever, and inflammation associated with rheumatoid arthritis, sports injuries, and temporary pain. However, treatment with NSAIDs may ...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-27.417
更新日期:2012-04-01 00:00:00
abstract::The aim of our study was to evaluate corneal cell proliferation and apoptosis in cases of granular, macular and lattice dystrophy, and to provide evidence which may help to clarify whether apoptosis is a pathogenic factor in any of these dystrophies. The study group comprised 39 eyes (from 33 patients) which had under...
journal_title:Histology and histopathology
pub_type: 杂志文章,多中心研究
doi:10.14670/HH-22.837
更新日期:2007-08-01 00:00:00
abstract::The present review examines various aspects of the developmental expression of neuropeptides and of their receptors in mammalian retinas, emphasizing their possible roles in retinal maturation. Different peptidergic systems have been investigated with some detail during retinal development, including substance P (SP),...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-18.1219
更新日期:2003-10-01 00:00:00
abstract::To investigate the matrix metalloproteinase (MMP)-9, (MMP)-13, E-Cadherin and Ki-67 expressions in road pavers' skin chronically exposed to bitumen products in order to contribute to a better understanding of the earlier tissue alteration. Skin punch biopsies from 16 daily exposed workers and a control group were stud...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-18-116
更新日期:2019-10-01 00:00:00
abstract::Laminin (LAM) and fibronectin (FI) are regarded as major components of the glomerular extracellular matrix. The aim of this study was to define the distribution of LAM and FI in primary glomerulonephritis (GN) and GN of systemic lupus erythematosus (SLE) and to correlate the type of glomerular disorders with possible ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1993-07-01 00:00:00
abstract::Hexachlorobenzene (HCB) is a fungicide and a pollutant of increasing concern in industrialized regions of the world. Reproductive failure is one of the effects of HCB upon mammals. Alteration of cell shape in the ovary surface epithelium (OSE) of Cynomolgus monkeys following oral administration of HCB was observed in ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1991-10-01 00:00:00
abstract::Nitric oxide (NO) has opened a new and vigorous field of biological and clinical experimentation as evidenced presently by about one hundred original publications every week. Being a biological signal under physiological conditions, NO may be
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:
更新日期:1997-01-01 00:00:00