Molecules of cell adhesion and extracellular matrix proteolysis in oral squamous cell carcinoma.

Abstract:

:Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity with a poor 5-year survival rate, due in large part to the presence of metastatic disease at initial diagnosis. In recent years, a number of studies have examined the oral tumor microenvironment to asses the potential dynamic balance between extracellular matrix deposition and proteolytic degradation as well as the cellular adhesion molecules that mediate adhesion to matrix and regulate tissue cohesion. The objective of this review is to provide a brief overview of the major matrix components, adhesion molecules and proteolytic enzymes in the oral tumor microenvironment and to summarize recent findings regarding the role of these complex molecular players in oral tumor progression.

journal_name

Histol Histopathol

authors

Shi Z,Stack MS

doi

10.14670/HH-25.917

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

917-32

issue

7

eissn

0213-3911

issn

1699-5848

journal_volume

25

pub_type

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