Abstract：
:The primary objective of this research project was to study the role of sex steroids in the pathogenesis of cholelithiasis using the Syrian hamster as a model. In addition to the morphological examination of the gallbladder epithelium, we thought it imperative to observe the changes induced in the biliary tract in response to the sex steroid treatment. This report focuses on the morphological changes induced in the liver. The hamsters were randomly divided into 4 groups, control (C), estrogen-treated (E), estrogen and medroxyprogesterone-treated (E+MP), and medroxyprogesterone-treated (MP) groups. The E group hepatocytes demonstrated proliferation of the smooth endoplasmic reticulum, lipofuscin-like granules, aggregates of glycogen rosettes, and dense bodies. Lipid droplets in the hepatocyte cytoplasm as well as the nuclei were detected in this group. E+MP combined treatment induced an exacerbation of all the changes observed in the E group, furthermore, there appeared to be a disruption of the hepatic parenchymal architecture. The MP-treated group also exhibited the architectural changes observed in the E+MP group, but also showed sinusoidal dilation. In response to MP alone, the fatty changes in the liver appeared to be accentuated. A striking feature induced in response to MP treatment, was a focal area suggestive of adenomatous changes.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Karkare S,Adamiec-Beyga E,Gilloteaux Jsubject
Has Abstractpub_date
1995-07-01 00:00:00pages
619-32issue
3eissn
0213-3911issn
1699-5848journal_volume
10pub_type
杂志文章abstract：:A quantitative study regarding the age-related changes occurring in the somatic organelles of the neocerebellar Purkinje cell is carried out, using female rats aged 2 to 24 months. Standard manual morphometric techniques are used to calculate the following parameters: somatic volume, volumetric fractions and absolute ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:There is scarce information on the possible effects of chronic exposure to mercury on skeletal muscle. Dental personnel are frequently exposed to inhalation of metallic mercury vapours. The skeletal muscle of five technicians and one dentist (females, age 36-55) was studied. All of them presented symptoms of chronic m...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-15.673
更新日期：2000-07-01 00:00:00
abstract：:Recently, the characterization of mucinous tubular and spindle-cell carcinoma (MTSCC) has been established. MTSCC predominantly occurs in females. This tumor is histologically characterized by eosinophilic cytoplasm, elongated and anastomosing tubules, myxomatous stroma and low-grade nuclear cytology. Proliferation of...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-20.221
更新日期：2005-01-01 00:00:00
abstract：:Endometriosis is a chronic pelvic inflammatory process. Local inflammation is known to play a role in pain and infertility associated with the disease, and may be extensively involved in molecular and cellular processes leading to endometriosis development. In this review, we focus on two inflammatory mediators clearl...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-26.1083
更新日期：2011-08-01 00:00:00
abstract：:The novel coronavirus disease 2019 (COVID-19) outbreak began in the city of Wuhan, whereupon it rapidly spread throughout China and subsequently across the world. Rapid transmission of COVID-19 has caused wide-spread panic. Many established medications have been used to treat the disease symptoms; however, no specific...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-18-223
更新日期：2020-10-01 00:00:00
abstract：:Processing adult human trabecular bone to obtain tissue sections suitable for research or diagnostic purposes has always been challenging, particularly in the preparation of adult bone specimens for advanced immunohistochemistry applications. In contrast to the majority of soft tissues, decalcified bone samples perfor...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-28.1605
更新日期：2013-12-01 00:00:00
abstract：:This study was conducted to determine the effects of extracts obtained from both normal and denervated muscles on different muscle types. Wistar rats were used and were divided into a control group and four experimental groups. Each experimental group was treated intraperitoneally during 10 consecutive days with a dif...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-11-776
更新日期：2016-12-01 00:00:00
abstract：:Human epithelium contains keratin, which is expressed during differentiation. Depending on the target cell type, different types of keratin are expressed, and their alterations seem to represent changes in cell properties. The basal cells of oral epithelium express keratin 5 (K5), K14, K15 and K19, but their alteratio...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-27.949
更新日期：2012-07-01 00:00:00
abstract：:Ductular hepatocytes are observed in the livers of both experimental animals and man under various conditions of severe toxin-, carcinogen- or viral-induced hepatic injury with prominent loss of parenchymal hepatocytes. These unique hepatic epithelial cells are characterized by phenotypic traits that are intermediate ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1995-04-01 00:00:00
abstract：BACKGROUND:Synaptotagmin 7 (SYT7) is a component of the synaptotagmin family, which is essential in many physiological and pathological processes. In this study, we aimed to investigate the role of SYT7 in osteosarcoma. METHODS:We defined the expression levels of SYT7 in osteosarcoma tissues and para-sarcoma tissues b...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-18-174
更新日期：2020-03-01 00:00:00
abstract：:In the present work a morphopathological study is carried out of the glomerular filtration barrier in 20 Large-White pigs weighing 20 kg, subjected to experimental intravenous inoculations of endotoxin from Salmonella enteritidis. The study is completed with the determination of protein plasmatic levels, through urine...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1989-10-01 00:00:00
abstract：:Spermatogenesis is under the control of a complex endocrine and paracrine system, including estrogen receptor (ER) signaling. In many target cells, ER promotes the transcription of c-fos and other proto-oncogenes to regulate cell growth and differentiation. Thus, in this study we evaluated the expression of the proto-...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-24.1515
更新日期：2009-12-01 00:00:00
abstract：:The anti-oxidant food additive, butylated hydroxytoluene (BHT), was fed to Sprague-Dawley rats at three concentrations: 0.2%, 0.4% and 0.8% for periods of 6, 12, 18 and 24 weeks, and the results were compared with corresponding groups treated with a potent carcinogen, 7,12-dimethylbenz[a]anthracene (DMBA) groups, with...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-14.391
更新日期：1999-04-01 00:00:00
abstract：:The effects of cadmium exposure on the protein secretory functions of cultured neonatal rat hepatocytes were analyzed by both two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) and electron microscopy. [35S]Methionine-labelled protein secretion was significantly depressed by cadmium exposure in a dose-depend...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:The antifibrotic activity of Liver Growth Factor (LGF), a liver mitogen, was previously demonstrated in several models of rat liver fibrosis and even in extrahepatic sites, such as carotid artery in hypertensive rats and rat CdCl2-induced lung fibrosis. In the present study, we have attempted to examine in depth its m...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-24.473
更新日期：2009-04-01 00:00:00
abstract：:The pineal organs of 14-week-old domestic geese were investigated with light and electron microscopy. The pineals consisted of a wide distal part and a narrow middle-proximal one. The glands were attached to the intercommissural region via the choroid plexus. The pineal parenchyma was formed by round or elongated foll...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-21.1075
更新日期：2006-10-01 00:00:00
abstract：:The purpose of this study is to visualize topographical changes of serum proteins, albumin and immunoglobulin, passing through mouse glomerular capillary loops and their reabsorption in renal proximal tubules by immunohistochemistry in combination with our "in vivo cryotechnique". The "in vivo cryotechnique" was perfo...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-20.807
更新日期：2005-07-01 00:00:00
abstract：:Chaperone-mediated autophagy (CMA), a selective form of autophagy, where cellular proteins with KFERQ-like motif are targeted to the lysosome for degradation, is necessary to maintain cellular homeostasis. The role of CMA in neurodegenerative diseases has been extensively studied in the past decades, with defects in t...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-18-202
更新日期：2020-07-01 00:00:00
abstract：:In this article we review immunocytochemical localization studies using a monoclonal antibody raised against the 31 kD subunit of bovine H(+)-ATPase, and indirect immunofluorescent staining. In the proximal tubules there is intense H(+)-ATPase staining along the brush borders of S1 and S2, and linear subvillar invagin...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1997-07-01 00:00:00
abstract：:Voltage-activated Ca2+ channels play an important role in synaptic transmission, signal processing and development. The immunohistochemical localization of Cav1.2 (alpha1C) and Cav2.3 (alpha1E) Ca2+ channels was studied in the developing and adult mouse organ of Corti using subunit-specific antibodies and fluorescent ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-18.1115
更新日期：2003-10-01 00:00:00
abstract：:Serotonin-producing pancreatic endocrine tumours are rare neoplasms which in most cases exhibit malignant biological behaviour. These tumours, in the majority of the well-documented cases, are composed of argyrophil- and argentaffin-positive cells which contain large pleomorphic neurosecretory granules. In contrast, a...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：:Circadian and seasonal variations were observed in the karyometric index of pinealocytes in the cortical and medullary regions of the distal pineal body. The study involved 70 Wistar rats over a 24-hour interval (0:6, 10:00, 14:00, 18:00, 22:00, 02:00, 06:00 h) during two natural photoluminous periods, i.e. late summe...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：:Tumorigenesis correlates with hypermethylation of tumor suppressors and hypomethylation of oncogenes. DNA methyltransferases (DNMTs) catalyze DNA methylation, and mutations and aberrant expression in DNMT genes are found in multiple human tumors. The discovery of the DNA demethylation function of TET proteins has open...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-29.991
更新日期：2014-08-01 00:00:00
abstract：:Hexachlorobenzene (HCB) is a fungicide and a pollutant of increasing concern in industrialized regions of the world. Reproductive failure is one of the effects of HCB upon mammals. Alteration of cell shape in the ovary surface epithelium (OSE) of Cynomolgus monkeys following oral administration of HCB was observed in ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
abstract：:The photoreceptors of the barred owl (Strix varia) consist of rods, single cones and unequal double cones present in a ratio of about 35:1:3. In the light-adapted condition the rods are of uniform diameter along their entire length and are therefore not felt to undergo photomechanical changes. The rod outer segment co...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:Although traditionally little attention has been paid to the interplay between neurotrophins and the cell cycle, a number of recent findings suggest an important role for these growth factors in the regulation of this aspect of the cellular physiology. In this article, we review the evidence from a number of studies t...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-17.1227
更新日期：2002-10-01 00:00:00
abstract：:The acute and chronic effects of bombesin (BM) on the structure and function of rat adrenal cortex were investigated by morphometric and radioimmunological techniques. An intraperitoneal bolus injection of 2 micrograms/rat BM markedly raised plasma corticosterone (B) concentration (PBC). The intraperitoneal BM infusio...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:The ultrastructure of four aldosterone secreting adenomas and of the adjacent zona glomerulosa has been described by the use of stereological techniques. Adenomatous cells (about 2800 microns 3 in volume) invariably displayed a striking abundance of lipid droplets, which occupied about 30% of the cytoplasm. Mitochondr...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1988-07-01 00:00:00
abstract：:Recent data challenge the relevance of the RB pathway to cancer based on RB inactivation, at least in breast tumors. To obtain information on the actual role of the components of the RB pathway in tumor progression we decided to investigate whether their quantitative changes were associated with variations in the leve...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-22.769
更新日期：2007-07-01 00:00:00
abstract：:Testis samples were taken from young (3 months), middle-aged (12 months) and aged (24 months) male rats, processed, stained and examined via a light microscope. There were no prominent abnormal germinal epithelium and interstitial tissue. However, the aging process promoted a significant decrease in the mean amount of...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1988-10-01 00:00:00
