Abstract:
:This study was conducted to determine the effects of extracts obtained from both normal and denervated muscles on different muscle types. Wistar rats were used and were divided into a control group and four experimental groups. Each experimental group was treated intraperitoneally during 10 consecutive days with a different extract. These extracts were obtained from normal soleus muscle, denervated soleus, normal extensor digitorum longus, and denervated extensor digitorum longus. Following treatment, the soleus and extensor digitorum longus muscles were obtained for study under optic and transmission electron microscope; morphometric parameters and myogenic responses were also analyzed. The results demonstrated that the treatment with normal soleus muscle and denervated soleus muscle extracts provoked hypertrophy and increased myogenic activity. In contrast, treatment with extracts from the normal and denervated EDL had a different effect depending on the muscle analyzed. In the soleus muscle it provoked hypertrophy of type I fibers and increased myogenic activity, while in the extensor digitorum longus atrophy of the type II fibers was observed without changes in myogenic activity. This suggests that the muscular responses of atrophy and hypertrophy may depend on different factors related to the muscle type which could be related to innervation.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Agüera E,Castilla S,Luque E,Jimena I,Leiva-Cepas F,Ruz-Caracuel I,Peña Jdoi
10.14670/HH-11-776subject
Has Abstractpub_date
2016-12-01 00:00:00pages
1367-79issue
12eissn
0213-3911issn
1699-5848pii
HH-11-776journal_volume
31pub_type
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