Abstract:
:The International Prognostic Index (IPI) has been the basis for determining prognosis in patients with diffuse large B-cell lymphoma (DLBCL) for the past 20 years. The utility of the IPI must be reassessed in the era of immunochemotherapy. Seven risk factors at diagnosis were identified, and a maximum of 7 points were assigned to each patient. Four risk groups were created: low (0-1), low-intermediate (2-3), high-intermediate (4), and high (5-7). Using MYC and BCL-2 clinical data from the Drum Tower Hospital collected during the rituximab era, we performed a retrospective analysis of patients with DLBCL treated with R-CHOP and built an biological markers adjusted IPI with the goal of improving risk stratification.Clinical features from 60 adults with de novo DLBCL diagnosed from 2008-2013 were assessed for their prognostic significance. The IPI remains predictive, but it cannot identify the high-risk subgroup. Compared with the IPI, the MYC and BCL-2 adjusted-IPI (A-IPI) better discriminated patients in the high-risk subgroup (4-year overall survival [OS]: 33.3%) than did the IPI (4 year OS: 48.0%). In the era of R-CHOP treatment, MYC and BCL-2 adjusted-IPI is more powerful than the IPI for helping guide treatment planning and interpretation of clinical trials.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Wang J,Zhou M,Xu JY,Yang YG,Zhang QG,Zhou RF,Chen B,Ouyang J,Li Cdoi
10.14670/HH-11-673subject
Has Abstractpub_date
2016-03-01 00:00:00pages
285-92issue
3eissn
0213-3911issn
1699-5848pii
HH-11-673journal_volume
31pub_type
杂志文章abstract::Nitric oxide (NO) is a biological messenger molecule produced by one of the essential amino acids L-arginine by the catalytic action of the enzyme NO synthase (NOS). The dual role of NO as a protective or toxic molecule is due to several factors, such as; the isoform of NOS involved, concentration of NO and the type o...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-21.445
更新日期:2006-04-01 00:00:00
abstract::Macrophages are important effector cells in cell-mediated immunity against intracellular infection. Among cytokines that macrophages are able to release are IL-12 and TNF alpha. IL-12 is a critical linker between the innate and adaptive cell-mediated immunity, capable of Th1 differentiation and IFN gamma release by T ...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-15.199
更新日期:2000-01-01 00:00:00
abstract:INTRODUCTION:It is difficult to prevent and treat intra- and peri-neural fibrosis after peripheral nerve surgery. Many authors have attempted to develop and verify the effectiveness of substances to decrease the formation of adherences in different tissues. MATERIAL AND METHODS:this study aimed to assess the effective...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-25.741
更新日期:2010-06-01 00:00:00
abstract::β-lapachone is a quinone of lapachol extracted from the bark of lapacho tree. Recent findings demonstrated that punched skin wounds of mice healed faster with β-lapachone treatment. The present study investigates the effects of β-lapachone on burn-wound skin of C57BL/6 mice injured by a 100 °C iron stick. Our results ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-26.905
更新日期:2011-07-01 00:00:00
abstract::Targeting essential cellular pathways that determine neuronal and vascular survival can foster a successful therapeutic platform for the treatment of a wide variety of degenerative disorders in the central nervous system. In particular, oxidative cellular injury can precipitate several nervous system disorders that ma...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-19.495
更新日期:2004-04-01 00:00:00
abstract::The salamanderfish, Lepidogalaxias salamandroides (Galaxiidae, Teleostei) is endemic to southwestern Australia and inhabits shallow, freshwater pools which evaporate during the hot summer months. Burrowing into the substrate in response to falling water levels allows these fish to aestivate for extended periods of tim...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-13.1037
更新日期:1998-10-01 00:00:00
abstract::Current data on the influence of neuropeptides on the growth, structure and function of cells comprising the hypothalamo-pituitary-adrenal axis were presented and discussed. The action of vasopressin, oxytocin, neurotensin, bombesin, neuropeptide Y, substance P and VIP have been evaluated. The hypothesis has been intr...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:
更新日期:1993-01-01 00:00:00
abstract::The S100 gene family, which is composed of at least 24 members carrying the Ca2+ binding EF-hand motif, has been implicated in both intracellular and extracellular functions, including enzyme activities, immune responses, cytoskeleton dynamics, Ca2+ homeostasis, cell growth and cell differentiation. Altered S100 prote...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-22.1025
更新日期:2007-09-01 00:00:00
abstract::The presence of intestinal metaplasia (IM) 11 years after selective proximal vagotomy (SPV), selective proximal vagotomy with pyloroplasty (SPV + PP) and selective vagotomy with pyloroplasty (SV + PP) was investigated in 38 consecutive patients. IM was significantly more frequent in SPV than in SV + PP, SPV + PP or in...
journal_title:Histology and histopathology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1993-04-01 00:00:00
abstract::Lewis(y) (Le(y)), also designated CD174, represents a carbohydrate blood group antigen which is strongly expressed in neoplastic gastrointestinal tissues. Previous reports indicated an association between Le(y) expression and apoptosis. Therefore, we tried to elucidate its clinicopathological relevance in a series of ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-21.503
更新日期:2006-05-01 00:00:00
abstract::TNFalpha exerts apoptosis throughout an intracellular transduction pathway that involves the kinase proteins TRAF-2 (integration point of apoptotic and survival signals), ASK1 (pro-apoptotic protein), MEK-4 (p38 activator and metastasis suppressor gene), JNK (stress mitogen activated protein kinase) and the transcript...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-23.1279
更新日期:2008-10-01 00:00:00
abstract::We used antisera to pure atrial natriuretic peptide to localise this peptide by immunocytochemistry in rat and human tissue. We showed that both rat and human atrial cardiocytes gave a positive reaction while ventricular cardiocytes were consistently negative. Peripheral islet cells in rat but not in human pancreas al...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1986-04-01 00:00:00
abstract:AIMS:Gastric hyperplastic polyps (GHPs) are the most common polypoid lesion of the stomach, and their malignant potential has been demonstrated. In the present study, we evaluated the mucin phenotypes of GHPs and investigated the relationships among mucin phenotypes and clinical-pathological factors, proliferative acti...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-29.343
更新日期:2014-03-01 00:00:00
abstract::Pneumadin (PNM) is a biologically active decapeptide, which has previously been found to enhanced rat adrenal growth; the mechanism is indirect and probably involves the stimulation of both arginine-vasopressin (AVP) and ACTH release. The effects of 2- and 6-day PNM administration on the atrophic adrenal cortices of r...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:Protein tyrosine kinase 7 (PTK7) is a member of receptor protein tyrosine kinase-like molecules, which is involved in tumorigenesis. However, the association between PTK7 expression and its pathological significance in survival prognosis remains under investigation. The purpose of this meta-analysis is to cl...
journal_title:Histology and histopathology
pub_type: 杂志文章,meta分析
doi:10.14670/HH-11-933
更新日期:2018-04-01 00:00:00
abstract::Terminal dendrites of cone horizontal cells (HCs) in teleost retinas show numerous spine-like protrusions named spinules, which are invaginated into the cone pedicles during light-adaptation, but retracted during dark-adaptation. Somata of HC show nematosomes whose size decreases as the number of spinules increases. M...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-17.721
更新日期:2002-01-01 00:00:00
abstract::Calcium/calmodulin-dependent protein kinase II (CaMKII) is considered one of the key intracellular signaling proteins for development of neuropathy. We analyzed the expression of total CaMKII (tCaMKII) and its alpha, beta, gamma and delta isoforms in dorsal root ganglia (DRG) in a rat model of Diabetes mellitus type I...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-29.10.649
更新日期:2014-05-01 00:00:00
abstract::Ductular hepatocytes are observed in the livers of both experimental animals and man under various conditions of severe toxin-, carcinogen- or viral-induced hepatic injury with prominent loss of parenchymal hepatocytes. These unique hepatic epithelial cells are characterized by phenotypic traits that are intermediate ...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:
更新日期:1995-04-01 00:00:00
abstract::Thyroid glands from 7 marmosets (Callithrix jacchus) of different age groups (newborn, 2 weeks, 2, 7, 8 and 11 months, and 8 years) were grown as organ culture according to Trowell at the medium/air interphase for 3 to 30 days. The morphology of thyroid tissue was well preserved until the end of the culture period. Ne...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1995-10-01 00:00:00
abstract::Actin microfilaments and microtubules are important cytoskeletal proteins that regulate endothelial repair through alterations in cell shape and through regulation of cell migration following wounding of the endothelium. Upstream pathways have been identified in the regulation of actin and microtubule organization, es...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-18.879
更新日期:2003-07-01 00:00:00
abstract::Many surgical techniques are employed in the treatment of severe obesity. A main consequence of these techniques is the improvement of type 2 Diabetes mellitus. Ghrelin is a gut hormone released in the gastric fundus and corpus, which has been related to diabetic improvement as mentioned in these papers. Sleeve gastre...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-18-200
更新日期:2020-08-01 00:00:00
abstract::This report presents preliminary observations on the distribution of an epithelial surface antigen in human trophoblastic cells studied with the monoclonal antibody Ber-EP4 by means of an immunoperoxidase technique. Three cases of gestational choriocarcinoma and 20 cases of both villous and extravillous trophoblast, i...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1993-04-01 00:00:00
abstract::Infection with Helicobacter pylori (H. pylori) strains is linked to an increased risk of inflammation and gastric cancer. To investigate the effects of H. pylori on biological characteristics of gastric epithelial cells SGC-7901, derived from human adenocarcinoma, morphological appearances of both the pathogen and the...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-27.1079
更新日期:2012-08-01 00:00:00
abstract::Cyclin A, cyclin E, BUBR1, MAD2 and Aurora A are all cell-cycle regulatory proteins and have been proven to play crucial roles in carcinogenesis. However, their expression patterns in invasive ductal breast carcinoma (IDBC) are controversial and unclear. In this study, we examined the expression status of these candid...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-26.761
更新日期:2011-06-01 00:00:00
abstract::It has been commonly supposed that adult stem cells co-localize with supporting cells within specific regions or specialized microenvironment in each tissue/organ, called stem cell niche. This concept was based on the assumption that stem cells are intrinsically hierarchical in nature. However, recent data indicate th...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-25.397
更新日期:2010-03-01 00:00:00
abstract::The epicardium is the outer mesothelial layer of the heart. It covers the myocardium and plays important roles in both heart development and regeneration. It is derived from the proepicardium (PE), groups of cells that emerges at early developmental stages from the dorsal pericardial layer (DP) close to the atrio-vent...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-18-238
更新日期:2020-09-01 00:00:00
abstract::There is now evidence that estrogens and androgens are exerting their effects in different tissues throughout the body. In order to determine the sites of action of these steroids, studies have been performed to identify at the cellular level the localization of androgen receptor (AR) and the two estrogen receptor (ER...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-15.1261
更新日期:2000-10-01 00:00:00
abstract::Amyloidosis is a group of diseases characterized by the extracellular deposition of protein that contains non-branching, straight fibrils on electron microscopy (amyloid fibrils) that have a high content of beta-pleated sheet conformation. Various biochemically distinct proteins can undergo transformation into amyloid...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-20.1295
更新日期:2005-10-01 00:00:00
abstract::The view of how astrocytes, a type of glial cells, contribute to the functioning of the central nervous system (CNS) has changed greatly in the last decade. Although glial cells outnumber neurons in the mammalian brain, it was considered for over a century that they played a subservient role to neurons. This view chan...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-26.277
更新日期:2011-02-01 00:00:00
abstract::HtrA1 is a secreted protein which behaves as a molecular chaperone at low temperatures and as a serine protease at high temperatures. When the placenta escapes the normal growth control mechanisms, which are present during normal pregnancy, it may develop trophoblastic diseases, such as hydatidiform mole and choriocar...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-24.1213
更新日期:2009-10-01 00:00:00