Heart mitochondria in rats submitted to chronic hypoxia.

Abstract:

:The effect of prolonged exposure to normobaric hypoxia on the mitochondria of myocard of rats exposed for several weeks to 8 and 7% O2 has been morphometrically evaluated. Twelve male Wistar rats housed in Nalgene cages (2 per cage) with a batch of six cages placed in plexiglass chambers were maintained in air/N2 mixtures containing different concentrations of O2. Six animals kept in similar cages under normoxia served as controls. When at day 60 the FIO2 was reduced to 8%, the weight increase stagnated and after the 81st test day, on which the hypoxic animals were subdivided into 8% and 7% groups the weight curve showed a decrease in the mean body weight for both groups. The arrest and the following loss of weight beyond the 85th day may be interpreted as the expression of a limit reached in the compensation capacity. In the 8%-group the shape of the mitochondria varied more markedly often with budding and furrowing of the surface. In the 7%-group bizarre shapes and wide variations in size with a decided shift towards larger mitochondria were noteworthy. While rats kept under 8% oxygen exhibited a numerical increase in myocardial mitochondria compared to controls, the mitochondria of the 7%-group were numerically reduced. The results suggest that hypoxia of 8% oxygen is compensatable, if only to some extent, by an increasing surface of mitochondrial membranes, and that further reduction of oxygen causes compensation mechanisms to fail as seen by the severe alterations of the mitochondrial population of the cardiomyocyte in the 7%-group.

journal_name

Histol Histopathol

authors

Cervós Navarro J,Kunas RC,Sampaolo S,Mansmann U

doi

10.14670/HH-14.1045

subject

Has Abstract

pub_date

1999-10-01 00:00:00

pages

1045-52

issue

4

eissn

0213-3911

issn

1699-5848

journal_volume

14

pub_type

杂志文章
  • Dental stem cells--characteristics and potential.

    abstract::Soft dental tissues have been identified as easily accessible sources of multipotent postnatal stem cells. Dental stem cells are mesenchymal stem cells (MSC) capable of differentiating into at least three distinct cell lineages: osteo/odontogenic, adipogenic and neurogenic. They express various markers including those...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-29.699

    authors: Bojic S,Volarevic V,Ljujic B,Stojkovic M

    更新日期:2014-06-01 00:00:00

  • Cape Town solution in prolonged myocardial preservation: structural and ultrastructural study.

    abstract::This study deals with myocardial preservation after 24 hours of continuous, hypothermic and oxygenated perfusion with Cape Town (CT) solution, focusing on the morphological changes produced by preservation and reperfusion, and their possible relationship to the composition of the solution and the immediate hemodynamic...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-13.21

    authors: García-Poblete E,Alvarez L,Fernández H,Escudero C,Torralba A

    更新日期:1998-01-01 00:00:00

  • Telocytes form networks in normal cardiac tissues.

    abstract::Telocytes (TC) are a class of interstitial cells present in heart. Their characteristic feature is the presence of extremely long and thin prolongations (called telopodes). Therefore, we were interested to see whether or not TCs form networks in normal cardiac tissues, as previously suggested. Autopsy samples of card...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-27.807

    authors: Rusu MC,Pop F,Hostiuc S,Curca GC,Jianu AM,Paduraru D

    更新日期:2012-06-01 00:00:00

  • Serotonin-producing pancreatic endocrine tumour. Histological, ultrastructural and immunohistochemical study of a case.

    abstract::Serotonin-producing pancreatic endocrine tumours are rare neoplasms which in most cases exhibit malignant biological behaviour. These tumours, in the majority of the well-documented cases, are composed of argyrophil- and argentaffin-positive cells which contain large pleomorphic neurosecretory granules. In contrast, a...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Kanavaros P,Hoang C,Le Bodic MF,Polivka M,Hautefeuille P

    更新日期:1990-07-01 00:00:00

  • Advances in the knowledge of breast cancer stem cells. A review.

    abstract::Much effort has been made by researchers to elucidate the complex biology of breast cancer stem cells (BCSCs), a small subset of breast tumor cells that display stem cell properties, drive tumor initiation, and growth. In recent years, it has been suggested that BCSCs could be responsible for the process of metastasis...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-11-718

    authors: Schwarz-Cruz Y Celis A,Espinosa M,Maldonado V,Melendez-Zajgla J

    更新日期:2016-06-01 00:00:00

  • Electron microscopic study on amyloid fibril formation in human lymph nodes.

    abstract::The purpose of this investigation was to clarify the mechanisms of amyloid fibril formation in human lymph nodes. In our present study, amyloid deposition was observed diffusely in all compartments of the lymph nodes. The deposition form showed extremely characteristic findings in its morphological features. Namely, a...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Dobashi M,Yuda F,Masuda A,Terashima K,Imai Y

    更新日期:1986-07-01 00:00:00

  • Tissue and molecular events in human conjunctival scarring in ocular cicatricial pemphigoid.

    abstract::Detailed histomorphometric analysis of human conjunctival biopsy specimens has convincingly demonstrated that tissue remodeling of the extracellular matrix (ECM) is an essential and dynamic process associated with conjunctival scarring in ocular cicatricial pemphigoid (OCP). The conjunctival scarring often eventually ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-16.1203

    authors: Razzaque MS,Foster CS,Ahmed AR

    更新日期:2001-10-01 00:00:00

  • Elastin variations implicating in vascular smooth muscle cells phenotype in human tortuous arteries.

    abstract::The aim of the present work was to study the morphological implications between the elastin and the phenotypic expression of the vascular smooth muscle cells. For this purpose, sixty human tortuous arteries from different territories have been studied. We have measured the morphometric indexes Intimal Thickening Index...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-15.95

    authors: Ortiz PP,Sarrat R,Daret D,Whyte J,Torres A,Lamazière JM

    更新日期:2000-01-01 00:00:00

  • Aberrant expression of a fetal glycoprotein 68 in hepatocellular carcinoma: a comparative study on the expression of alpha-fetoprotein and carcinoembryonic antigen.

    abstract::A rat IgG2a monoclonal antibody against a stage-specific fetal glycoprotein with a molecular mass of 68 kDa (FGP68) was produced and applied to paraffin sections. This monoclonal antibody was used to compare the expression of FGP68 with that of both alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) in 75 hepa...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-19.701

    authors: Kato M,Shinozawa T,Kato S,Terada T

    更新日期:2004-07-01 00:00:00

  • Keratins in the human trophoblast.

    abstract::Besides microfilaments and microtubules, intermediate filaments are major components of the cytoskeleton. In epithelial cells intermediate filaments are formed by heterodimers of specific keratins, whose expression pattern highly depends on the type of epithelium and differentiation degree of the cell. During the proc...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-28.817

    authors: Gauster M,Blaschitz A,Siwetz M,Huppertz B

    更新日期:2013-07-01 00:00:00

  • Histopathological findings in the peritumoral edema area of human glioma.

    abstract::Peritumoral brain edema (PTBE) is considered to be one of the main biological behaviors of brain glioma. However, the histopathological features of PTBE remain imprecisely defined. We analyzed the histopathological characteristics in the PTBE area of 22 cases of glioma. Microscopically, the pre-existing basic structur...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-11-607

    authors: Wang X,Liu X,Chen Y,Lin G,Mei W,Chen J,Liu Y,Lin Z,Zhang S

    更新日期:2015-09-01 00:00:00

  • Microvascular changes in relation to inflammation and epidermal hyperplasia in chronic cutaneous lesions of psoriasis vulgaris.

    abstract::Epidermal proliferation, inflammatory changes and microvascular augmentation are prominent features of chronic cutaneous psoriatic lesions. The objective of this study was the investigation of blood and lymphatic microvascular changes in relation to epidermal changes and inflammatory infiltration in dermis. Immunohist...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-11-811

    authors: Výbohová D,Adamicová K,Mellová Y,Hešková G

    更新日期:2017-05-01 00:00:00

  • The thyroid gland of Callithrix jacchus in organ culture.

    abstract::Thyroid glands from 7 marmosets (Callithrix jacchus) of different age groups (newborn, 2 weeks, 2, 7, 8 and 11 months, and 8 years) were grown as organ culture according to Trowell at the medium/air interphase for 3 to 30 days. The morphology of thyroid tissue was well preserved until the end of the culture period. Ne...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Maile S,Merker HJ

    更新日期:1995-10-01 00:00:00

  • Paracrine role for TGF-β-induced CTGF and VEGF in mesangial matrix expansion in progressive glomerular disease.

    abstract::Transforming growth factor-β (TGF-β) is a key regulator of extracellular matrix (ECM), and may mediate the development of glomerulosclerosis with accumulation of mesangial matrix. Mesangial cells secrete TGF-β in response to common in vitro fibrogenic stimuli. Yet mesangial immunostaining for active TGF-β1 is frequent...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-27.1131

    authors: Lee HS

    更新日期:2012-09-01 00:00:00

  • Markers of squamocolumnar junction cells in normal tonsils and oropharyngeal cancer with and without HPV infection.

    abstract::HPV infection has been identified recently as the causative agent of a subset of squamous cell carcinomas arising in oropharyngeal tonsils. Factors influencing the susceptibility of tonsillar epithelium to HPV-induced oncogenesis are far from being elucidated. A 5-protein signature including cytokeratin (CK)7, anterio...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-11-590

    authors: Morbini P,Capello GL,Alberizzi P,Benazzo M,Paglino C,Comoli P,Pedrazzoli P

    更新日期:2015-07-01 00:00:00

  • A rapid intraoperative estimation of the proliferative activity in brain tumors.

    abstract::A technique for staining the nucleolar organizer regions (NORs) in tumor cells applied to smears from brain tumor biopsy specimens is described. This technique provides a rapid intraoperative evaluation of the proliferative activity in cerebral neoplasms and is a valuable complement to hematoxylineosin stained smears,...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Vaquero J,Martínez R,Arias A,Oya S

    更新日期:1991-10-01 00:00:00

  • Detection of platelet-derived growth factor-alpha (PDGF-A) protein in cells of Leydig lineage in the postnatal rat testis.

    abstract::Platelet-derived growth factor-A (PDGF-A) is a locally produced growth factor in the rat testis secreted by both Sertoli cells and Leydig cells. It has been suggested that PDGF-A may be involved in modulation of testosterone production and may be essential to Leydig cell differentiation, however it is not known at wha...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-21.1295

    authors: Fecteau KA,Mrkonjich L,Mason JI,Mendis-Handagama SM

    更新日期:2006-12-01 00:00:00

  • Ultrastructure and organisation of the cornea, lens and iris in the pipefish, Corythoichthyes paxtoni (Syngnathidae, Teleostei).

    abstract::The corneas of nine pipefish, Corythoichthyes paxtoni (Syngnathidae, Teleostei), five freshly fixed and four museum specimens, were examined using light and electron microscopy. In transverse section, the surface of the corneal epithelium is covered by a complex series of ridges or microplicae which extends over the c...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Collin HB,Collin SP

    更新日期:1995-04-01 00:00:00

  • Control of the cell cycle by neurotrophins: lessons from the p75 neurotrophin receptor.

    abstract::Although traditionally little attention has been paid to the interplay between neurotrophins and the cell cycle, a number of recent findings suggest an important role for these growth factors in the regulation of this aspect of the cellular physiology. In this article, we review the evidence from a number of studies t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-17.1227

    authors: López-Sánchez N,Frade JM

    更新日期:2002-10-01 00:00:00

  • The contribution of cavernous body biopsy in the diagnosis and treatment of male impotence.

    abstract::This study concerns the results of penile biopsies in 50 patients aged 27 to 80, with secondary impotence removed with a biopty gun or during penile surgery. The biopty gun specimens were equally representative as the open biopsy ones. The cause and the degree of erectile dysfunction were determined by clinical and la...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Malovrouvas D,Petraki C,Constantinidis E,Petraki K,Antoniadis G,Constantinidis C,Kranidis A

    更新日期:1994-07-01 00:00:00

  • High expression of PKM2 as a poor prognosis indicator is associated with radiation resistance in cervical cancer.

    abstract::Our study aimed to investigate the association of Pyruvate Kinase isozyme type M2 (PKM2) with radiation resistance in locally advanced cervical squamous cell carcinoma (LACSCC). We retrospectively reviewed 132 female patients who received primary radiation therapy to treat LACSCC at Federation Internationale of Gyneco...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-11-627

    authors: Zhao Y,Shen L,Chen X,Qian Y,Zhou Q,Wang Y,Li K,Liu M,Zhang S,Huang X

    更新日期:2015-11-01 00:00:00

  • Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeys.

    abstract::In the present work we analyze the cerebellum of chronic parkinsonian monkeys in order to clarify whether chronic mesencephalic depletion is associated with long term activation of the cerebellar neurons in chronic Parkinsonism. In our study, we observed a persistent activation of Purkinje cells in the cerebellum of c...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-27.89

    authors: Heman P,Barcia C,Gómez A,Ros CM,Ros-Bernal F,Yuste JE,de Pablos V,Fernandez-Villalba E,Toledo-Cárdenas MR,Herrero MT

    更新日期:2012-01-01 00:00:00

  • The combination of strong immunohistochemical mtTFA expression and a high survivin index predicts a shorter disease-specific survival in pancreatic ductal adenocarcinoma.

    abstract::Mitochondrial transcription factor A (mtTFA) plays a crucial role in both the transcription and maintenance of mitochondrial DNA. A high expression of mtTFA has been demonstrated in several solid tumors, and is closely associated with cancer cell survival/apoptosis and growth. However, its expression pattern in pancre...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-30.193

    authors: Kimura T,Kitada S,Uramoto H,Zhi L,Kawatsu Y,Takeda T,Horie S,Nabeshima A,Noguchi H,Sasaguri Y,Izumi H,Kohno K,Yamada S

    更新日期:2015-02-01 00:00:00

  • Unexpected presence of the neurotrophins NGF and BDNF and the neurotrophin receptor p75 in the tendon cells of the human Achilles tendon.

    abstract::Neurotrophins are substances that have been shown to be important in growth and remodelling phases in different types of tissue. There is no information concerning the possible occurrences of neurotrophins and their receptors in tendons. In this study, sections of both chronic painful (tendinosis) and pain-free (non-t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-24.839

    authors: Bagge J,Lorentzon R,Alfredson H,Forsgren S

    更新日期:2009-07-01 00:00:00

  • Pineal gland in rats with 7,12-dimethylbenz(a)anthracene-induced mammary tumors subjected to manipulations known as enhancers of pineal actions.

    abstract::The ultrastructure of pinealocytes was studied in rats with 7,12-dimethylbenz(a)anthracene-induced mammary tumors which were subjected to experimental manipulations known as enhancers of pineal actions (anosmia, underfeeding or cold exposure). In these animals we found: (I)--more nuclei with deep nuclear invaginations...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Cos S,Bardasano JL,Mediavilla MD,Sánchez Barceló EJ

    更新日期:1989-04-01 00:00:00

  • Physiopathologic dynamics of vesicle traffic in astrocytes.

    abstract::The view of how astrocytes, a type of glial cells, contribute to the functioning of the central nervous system (CNS) has changed greatly in the last decade. Although glial cells outnumber neurons in the mammalian brain, it was considered for over a century that they played a subservient role to neurons. This view chan...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-26.277

    authors: Potokar M,Stenovec M,Kreft M,Gabrijel M,Zorec R

    更新日期:2011-02-01 00:00:00

  • BDNF function and intracellular signaling in neurons.

    abstract::Brain-derived neurotrophic factor (BDNF) and its receptor, TrkB, are broadly expressed in the developing and adult mammalian brain. BDNF/TrkB-stimulated intracellular signaling is critical for neuronal survival, morphogenesis, and plasticity. It is well known that binding of BDNF to TrkB elicits various intracellular ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-25.237

    authors: Numakawa T,Suzuki S,Kumamaru E,Adachi N,Richards M,Kunugi H

    更新日期:2010-02-01 00:00:00

  • Hepatotoxicity induced by the anti-oxidant food additive, butylated hydroxytoluene (BHT), in rats: an electron microscopical study.

    abstract::The anti-oxidant food additive, butylated hydroxytoluene (BHT), was fed to Sprague-Dawley rats at three concentrations: 0.2%, 0.4% and 0.8% for periods of 6, 12, 18 and 24 weeks, and the results were compared with corresponding groups treated with a potent carcinogen, 7,12-dimethylbenz[a]anthracene (DMBA) groups, with...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-14.391

    authors: Safer AM,al-Nughamish AJ

    更新日期:1999-04-01 00:00:00

  • Ewing sarcoma and the new emerging Ewing-like sarcomas: (CIC and BCOR-rearranged-sarcomas). A systematic review.

    abstract::Ewing-like sarcomas (ELS) are a heterogenous group of tumors that frequently affect pediatric and young adult patients. Accurate classification and distinction from the Ewing sarcoma family of tumor (ESFT) is decisive in patient management. ELS share a significant morphologic, immunohistochemical and clinical overlap ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-11-792

    authors: Machado I,Navarro S,Llombart-Bosch A

    更新日期:2016-11-01 00:00:00

  • Immune complex-mediated glomerulopathy in Barbus graellsi infected with Myxobolus spp.

    abstract::Membranous glomerulonephritis caused in Barbus graellsi by myxosporidian infections have been studied by electron microscopy and immunoelectron microscopy techniques. This study indicates that Myxosporidian infection produces a chronic severe aggression. Spores reach the spleen, the kidney and the liver, where they ar...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Peribañez MA,del Cacho E,Castillo JA,Arnal MC

    更新日期:1993-10-01 00:00:00