Abstract:
:Detailed histomorphometric analysis of human conjunctival biopsy specimens has convincingly demonstrated that tissue remodeling of the extracellular matrix (ECM) is an essential and dynamic process associated with conjunctival scarring in ocular cicatricial pemphigoid (OCP). The conjunctival scarring often eventually results in impaired vision and/or blindness. The molecular mechanisms of conjunctival scarring are not completely understood. Accumulating evidence indicates that the early phase of conjunctival fibrosis is linked with an immuno-inflammatory process mediated by cytokines released by activated conjunctival cells and/or by infiltrating cells. Fibrogenic cytokines secreted by inflammatory cells and fibroblasts might actively be involved in remodeling of the matrix within the conjunctival stroma, possibly by regulating the altered metabolism of matrix proteins.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Razzaque MS,Foster CS,Ahmed ARdoi
10.14670/HH-16.1203subject
Has Abstractpub_date
2001-10-01 00:00:00pages
1203-12issue
4eissn
0213-3911issn
1699-5848journal_volume
16pub_type
杂志文章,评审abstract::A method for the in vitro generation of granulomas and its use in the analysis of the human granulomatous response is summarized. As a target for the cellular response L3 larvae of Nippostrongylus brasiliensis are coincubated with human mononuclear blood cells, and within seven to fourteen days the development of bloo...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-16.645
更新日期:2001-04-01 00:00:00
abstract::A battery of horseradish peroxidase-conjugated lectins (Con A, WGA and DBA), as well as conventional histochemical techniques (PAS, saponification, Alcian Blue pH 0.1, 1, 2.5, chlorhydric hydrolisis, neuraminidase, Bromophenol blue, Tioglycollate reduction and Ferric-ferricyanide-FeIII) were used to study the content ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-13.727
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:Expression of hypoxia-related tissue factors in 1p-aberrant oligodendroglial neoplasms diminishes patient outcome. Differentiated embryo-chondrocyte expressed gene 1 (DEC1) has been described as novel hypoxia-related tissue factor. In our study, we assessed the expression of DEC1 in 1p aberrant oligodendrogl...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-20.1173
更新日期:2005-10-01 00:00:00
abstract::Peritumoral brain edema (PTBE) is considered to be one of the main biological behaviors of brain glioma. However, the histopathological features of PTBE remain imprecisely defined. We analyzed the histopathological characteristics in the PTBE area of 22 cases of glioma. Microscopically, the pre-existing basic structur...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-11-607
更新日期:2015-09-01 00:00:00
abstract::Neurodegenerative and muscle diseases bear both complex and multifactorial pathologies. An efficacious and robust therapeutic option to treat these diseases is yet to be elucidated. At such a time, mesenchymal stem cells have drawn significant attention due to their immunomodulatory and regenerative properties. Accumu...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-11-951
更新日期:2018-07-01 00:00:00
abstract::In this article we review immunocytochemical localization studies using a monoclonal antibody raised against the 31 kD subunit of bovine H(+)-ATPase, and indirect immunofluorescent staining. In the proximal tubules there is intense H(+)-ATPase staining along the brush borders of S1 and S2, and linear subvillar invagin...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:
更新日期:1997-07-01 00:00:00
abstract::Lymphatic vessels afferent to the popliteal nodes in young adult rats and guinea pigs were interrupted at the lowest edge of the popliteal fossa, and regressive changes in the nodes occurring 4 to 16 or 18 weeks after surgery were re-examined histologically. In the rat, some popliteal nodes were drained by lymphatic c...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1993-07-01 00:00:00
abstract::The main role of growth arrest and DNA damage-inducible (GADD) genes is to block proliferation at G1 and G2 checkpoints in response to DNA damage. The goal of this study was to examine the expression of GADD genes in primary melanomas with respect to prognosis. GADD34 was found in 73% of the primary melanomas investig...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-17.805
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Protein tyrosine kinase 7 (PTK7) is a member of receptor protein tyrosine kinase-like molecules, which is involved in tumorigenesis. However, the association between PTK7 expression and its pathological significance in survival prognosis remains under investigation. The purpose of this meta-analysis is to cl...
journal_title:Histology and histopathology
pub_type: 杂志文章,meta分析
doi:10.14670/HH-11-933
更新日期:2018-04-01 00:00:00
abstract::Smads are signal transducers for the members of the TGF-beta superfamily. Of these Smads, Smad4 is essential for TGF-beta signaling. The purpose of this study was to elucidate Smad4 expression and localization in 65 gastric adenomas, 49 intestinal-type and 39 diffuse type of gastric adenocarcinomas (including 12 cases...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-20.543
更新日期:2005-04-01 00:00:00
abstract::The presence of synaptophysin, a presynaptic Ca2+ binding glycoprotein, has been analyzed in the cochlear nucleus complex of the adult cat using an antisynaptophysin monoclonal antibody. Synaptophysin immunoreactivity was differently distributed between regions of cochlear nuclei. Terminal boutons contacting directly ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-13.415
更新日期:1998-04-01 00:00:00
abstract:AIMS:The prognostic application of YES1 in epithelial ovarian cancer (EOC) is currently unclear. We aimed to investigate the expression of YES1 and its correlation with survival outcome in patients with EOC. METHODS:A retrospective study of patients diagnosed with EOC at the Cancer Center, Sun Yat-Sen University, Guan...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-18-203
更新日期:2020-07-01 00:00:00
abstract::The corneas of nine pipefish, Corythoichthyes paxtoni (Syngnathidae, Teleostei), five freshly fixed and four museum specimens, were examined using light and electron microscopy. In transverse section, the surface of the corneal epithelium is covered by a complex series of ridges or microplicae which extends over the c...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1995-04-01 00:00:00
abstract::The population of the world grows every year, and life expectancy tends to increase. Thus, long-term preservation of teeth in aged individuals is an urgent issue. The main causes of tooth loss are well known to be periodontitis, caries, fractures, and orthodontic conditions. Although implant placement is a widely acce...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-29.1249
更新日期:2014-10-01 00:00:00
abstract::Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive cell loss confined mostly to dopaminergic neurons of the substantia nigra. Several factors, including oxidative stress, and decreased activity of complex I mitochondrial respiratory chain, are involved in the degenerative process. Ye...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::The mandible has a mixed embryological origin, and its growth is associated with the secondary cartilage of the condyle process (CP). In this area, growth depends on an array of intrinsic and extrinsic factors that influence protein metabolism. In the present study, we used an adolescent rat model to evaluate the grow...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-25.45
更新日期:2010-01-01 00:00:00
abstract::Melanocytes characterized by their tyrosinase activity, melanosomes and dendrites locate in the basal layer of epidermis and hair bulb in the skin of mice. Melanocytes differentiate from undifferentiated melanoblasts derived from embryonic neural crest. Melanocyte-stimulating hormone plays an important role in the reg...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:
更新日期:1995-01-01 00:00:00
abstract::Orexins A and B are two hypothalamic peptides, involved in the central regulation of feeding, which act through two receptor subtypes, named OX1R and OX2R. OX1R is selective for orexin-A, and OX2R binds both orexins. We have investigated the effects of three subcutaneous injections of 10 nmol/kg body weight of orexins...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-16.713
更新日期:2001-07-01 00:00:00
abstract::Vascular endothelial cells play a critical role in the maintenance of endometrial homeostasis. Indeed many pathological conditions causing abnormal endometrial bleeding including progestin only contraception, hormone replacement therapy, endometrial polyps, myomas, hyperplasia and cancer are associated with aberrant a...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-20.719
更新日期:2005-07-01 00:00:00
abstract::Neonatal hypoxic ischemia (HI) results in different extents of brain damage, and immature brain tissue is particularly sensitive to the stimulation of HI. Hypoxic-ischemic brain damage (HIBD) is a common and serious nervous system disease in neonates, for both full-term infants and preterm infants, and is one of the m...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-18-214
更新日期:2020-09-01 00:00:00
abstract::Ischemic heart disease is a widespread cause of death. During infarction, myocardial injury is mediated by release of several pro-inflammatory cytokines including multifunctional interleukin-1 (IL-1). In various tissues, IL-1-mediated deleterious effects are known to be attenuated via the over-expression of natural an...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-23.1093
更新日期:2008-09-01 00:00:00
abstract::During mammalian mitosis, a proofreading network called the spindle assembly checkpoint (SAC) is indispensable for ensuring the fidelity of chromosome segregation. An inhibitory SAC signal is deputed to inhibits mitotic cell-cycle progression in response to misaligned chromosomes until such imperfections are rectified...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-21.873
更新日期:2006-08-01 00:00:00
abstract::High mobility group box 1 protein (HMGB1) is a non-histone chromosomal protein which is highly conserved, ubiquitous, and widely distributed. HMGB1 has multiple functions in the nucleus, including the maintenance of nucleosome structure, the regulation of gene transcription, and involvement in DNA recombination. HMBG1...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-29.235
更新日期:2014-02-01 00:00:00
abstract::Autoimmune dry eye (Sjögren's syndrome, SS) is a chronic systemic disease characterized by salivary and lacrimal gland inflammation and tissue damage leading to keratoconjunctivitis sicca and xerostomia. In this review attention has been devoted to the cause of the development of oxidative injuries of the ocular surfa...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-24.1357
更新日期:2009-10-01 00:00:00
abstract::Phagocytosis is an important feature of innate immunity in which invading microorganisms are engulfed, killed and degraded - and in some immune cells, their antigens presented to adaptive immune system. A closely related process, efferocytosis, removes apoptotic cells, and is essential for the maintenance of homeostas...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-18-252
更新日期:2020-09-29 00:00:00
abstract::Sex steroid hormones are involved in regulation of skin development and functions as well as in some skin pathological events. To determine the sites of action of estrogens, androgens and progestins, studies have been performed during the recent years to accurately localize receptors for each steroid hormone in human ...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-19.629
更新日期:2004-04-01 00:00:00
abstract::Serotonin-producing pancreatic endocrine tumours are rare neoplasms which in most cases exhibit malignant biological behaviour. These tumours, in the majority of the well-documented cases, are composed of argyrophil- and argentaffin-positive cells which contain large pleomorphic neurosecretory granules. In contrast, a...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1990-07-01 00:00:00
abstract::The presence of Cajal-Retzius cells in the adult human prefrontal and visual cortices has been demonstrated with calcium binding protein immunocytochemistry and NADPH-diaphorase histochemistry. These cells expressed parvalbumin, calbindin and calretinin calcium binding proteins and displayed NADPH-diaphorase enzyme ac...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-14.487
更新日期:1999-04-01 00:00:00
abstract::Glucocorticoids play a major role in attenuation of the inflammatory response and they are useful in the primary combination chemotherapy of breast cancer, since in vitro studies have demonstrated an antiproliferative effect in human breast cancer cells. In contrast, it was recently shown that glucocorticoids protect ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-23.77
更新日期:2008-01-01 00:00:00
abstract::This study deals with myocardial preservation after 24 hours of continuous, hypothermic and oxygenated perfusion with Cape Town (CT) solution, focusing on the morphological changes produced by preservation and reperfusion, and their possible relationship to the composition of the solution and the immediate hemodynamic...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-13.21
更新日期:1998-01-01 00:00:00