Abstract:
:Sex steroid hormones are involved in regulation of skin development and functions as well as in some skin pathological events. To determine the sites of action of estrogens, androgens and progestins, studies have been performed during the recent years to accurately localize receptors for each steroid hormone in human skin. Androgen receptors (AR) have been localized in most keratinocytes in epidermis. In the dermis, AR was detected in about 10% of fibroblasts. In sebaceous glands, AR was observed in both basal cells and sebocytes. In hair follicles, AR expression was restricted to dermal papillar cells. In eccrine sweat glands, only few secretory cells were observed to express AR. Estrogen receptor (ER) alpha was poorly expressing, being restricted to sebocytes. In contrast, ERbeta was found to be highly expressed in the epidermis, sebaceous glands (basal cells and sebocytes) and eccrine sweat glands. In the hair follicle, ERbeta is widely expressed with strong nuclear staining in dermal papilla cells, inner sheath cells, matrix cells and outer sheath cells including the buldge region. Progesterone receptors (PR) staining was found in nuclei of some keratinocytes and in nuclei of basal cells and sebocytes in sebaceous glands. PR nuclear staining was also observed in dermal papilla cells of hair follicles and in eccrine sweat glands. This information on the differential localization of sex steroid receptors in human skin should be of great help for future investigation on the specific role of each steroid on skin and its appendages.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Pelletier G,Ren Ldoi
10.14670/HH-19.629subject
Has Abstractpub_date
2004-04-01 00:00:00pages
629-36issue
2eissn
0213-3911issn
1699-5848journal_volume
19pub_type
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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doi:10.14670/HH-22.1175
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1990-07-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
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更新日期:2001-01-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
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更新日期:2011-05-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1992-10-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-11-601
更新日期:2015-08-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-18.487
更新日期:2003-04-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-21.285
更新日期:2006-03-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-14.51
更新日期:1999-01-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-27.677
更新日期:2012-06-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-16.1203
更新日期:2001-10-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
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更新日期:2007-06-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-13.109
更新日期:1998-01-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-28.155
更新日期:2013-02-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
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更新日期:2003-10-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
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更新日期:2001-07-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-27.89
更新日期:2012-01-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
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更新日期:2004-04-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
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更新日期:2009-01-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1987-07-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1992-07-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
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更新日期:2003-10-01 00:00:00