Abstract:
:Anthracyclines are one of the most effective anticancer drugs ever developed, but their clinical use has been hampered by the risk of severe cardiotoxicity. In this study, we investigated whether rabbits exposed to a different cumulative dose of anthracycline suffer from immunohistochemically detectable vascular toxicity and endothelial dysfunction. Daunorubicin (3 mg/kg, i.e. 50 mg/m²) was administered i.v. to rabbits once weekly for 1-10 weeks to reach different cumulative doses of the drug (50-500 mg/m²), while control rabbits received saline. The rabbits were sacrificed either 24 hours or 7 days after reaching each particular cumulative dose, and aortas and right femoral arteries were collected for immunohistochemical analysis. Immunohistochemical analysis showed ICAM-1 staining in many aortas from both saline and daunorubicin-treated rabbits without any relationship to the anthracycline treatment. On the contrary, unlike in the lipopolysaccharide-treated or hypercholesterolemic rabbits, no distinct immunoreactivity for other markers of inflammation, oxidative and nitrosative stress (VCAM-1, 4-HNE, iNOS and nitrotyrosine) were detected in aortas and femoral arteries from either control or daunorubicin-treated animals. No relationship to the cumulative dose of the drug or post-expose set up of harvesting was found. In this study, we have demonstrated that daunorubicin does not induce gross histopathological changes in the studied arteries and it fails to induce immunohistochemically detectable endothelial dysfunction. Thus, we propose that endothelial cells are much less susceptible to anthracycline toxicity than cardiac myocytes. In addition, our data suggest that vascular toxicity of anthracyclines plays rather a minor role in the cardiovascular complications of anthracycline chemotherapy.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Nachtigal P,Sterba M,Popelová O,Večeřová L,Kudláčková Z,Jirkovský E,Geršl Vdoi
10.14670/HH-26.551subject
Has Abstractpub_date
2011-05-01 00:00:00pages
551-62issue
5eissn
0213-3911issn
1699-5848journal_volume
26pub_type
杂志文章abstract::Melanopsin-expressing retinal ganglion cells (mRGCs) constitute a system in the mammalian retina used for irradiance detection, regulating non-image forming functions, such as photoentrainment of circadian rhythms, control of the pupillary light reflex, masking response, light-regulated melatonin secretion, and modula...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-18-138
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-26.1187
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journal_title:Histology and histopathology
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doi:10.14670/HH-26.369
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journal_title:Histology and histopathology
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doi:10.14670/HH-29.1017
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journal_title:Histology and histopathology
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doi:10.14670/HH-27.949
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-25.1371
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-24.473
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
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更新日期:2015-02-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
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journal_title:Histology and histopathology
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doi:
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-25.237
更新日期:2010-02-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1986-10-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-11-627
更新日期:2015-11-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1987-04-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-15.673
更新日期:2000-07-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-21.1171
更新日期:2006-11-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-29.699
更新日期:2014-06-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-18.487
更新日期:2003-04-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-25.995
更新日期:2010-08-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
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journal_title:Histology and histopathology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1993-04-01 00:00:00
abstract::TNFalpha exerts apoptosis throughout an intracellular transduction pathway that involves the kinase proteins TRAF-2 (integration point of apoptotic and survival signals), ASK1 (pro-apoptotic protein), MEK-4 (p38 activator and metastasis suppressor gene), JNK (stress mitogen activated protein kinase) and the transcript...
journal_title:Histology and histopathology
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更新日期:2008-10-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-23.1439
更新日期:2008-12-01 00:00:00
abstract::Prion diseases are characterized by the accumulation of PrPSc, an altered isoform of a normal cellular protein, PrPc. The prion hypothesis holds that the process of conformational change from PrPc to PrPSc under the influence of PrPSc constitutes the basic infectious mechanism in prion diseases. It is still unknown wh...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:
更新日期:1997-07-01 00:00:00
abstract::The view of how astrocytes, a type of glial cells, contribute to the functioning of the central nervous system (CNS) has changed greatly in the last decade. Although glial cells outnumber neurons in the mammalian brain, it was considered for over a century that they played a subservient role to neurons. This view chan...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-26.277
更新日期:2011-02-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:
更新日期:1993-01-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-13.647
更新日期:1998-07-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-11-778
更新日期:2017-02-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-16.713
更新日期:2001-07-01 00:00:00
abstract::The aim of this study was to examine the effects of timolol in an experimental model of elevated intraocular pressure (IOP). Three episcleral veins of rats with normal IOP were cauterized. Three months later we examined the effects on anterograde axonal transport from the retinal ganglion cells (RGCs) to the superior ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-20.1077
更新日期:2005-10-01 00:00:00