High prevalence of human papillomavirus 16 in penile carcinoma.


:In order to analyze the incidence and prevalence of Human Papillomavirus (HPV) in penile carcinoma, we studied 49 patients with penile carcinoma. Formalin-fixed, paraffin-embedded tissue samples were collected from 64 samples of penile carcinoma from the Hospital General Universitario (Albacete, Spain). Cases were histologically classified and the polymerase chain reaction (PCR) method was used to detect the presence of HPV. Two sets of consensus primers were used, the My09/My11, and the GP5+/GP6+. All positive cases were sequenced in order to establish the implicated genotype. Our results showed that 38 of the 49 cases were positive for HPV (77,5%). HPV16 appeared in 32 (84,2 %) of the 38 positive cases and HPV18 in 4 (10,5%). Our data demonstrate that the My09/My11 primers are more sensitive than GP5+/GP6+ primers, although the combination of the two sets of primers notably increased the total number of HPV positive cases detected.


Histol Histopathol


Pascual A,Pariente M,Godínez JM,Sánchez-Prieto R,Atienzar M,Segura M,Poblet E




Has Abstract


2007-02-01 00:00:00












  • Detection of platelet-derived growth factor-alpha (PDGF-A) protein in cells of Leydig lineage in the postnatal rat testis.

    abstract::Platelet-derived growth factor-A (PDGF-A) is a locally produced growth factor in the rat testis secreted by both Sertoli cells and Leydig cells. It has been suggested that PDGF-A may be involved in modulation of testosterone production and may be essential to Leydig cell differentiation, however it is not known at wha...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Fecteau KA,Mrkonjich L,Mason JI,Mendis-Handagama SM

    更新日期:2006-12-01 00:00:00

  • Macrophage populations and expressions of regulatory proinflammatory factors in the rat meninx under lipopolysaccharide treatment in vivo and in vitro.

    abstract::Macrophages play important roles in host defense mechanisms. In the brain, besides microglial cells, meningeal macrophages are present. However, the pathobiological characteristics of meningeal macrophages in rats remain to be investigated. In normal meninx, immunohistochemically, macrophages reacting to CD163 (macrop...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Yamate J,Ishimine S,Izawa T,Kumagai D,Kuwamura M

    更新日期:2009-01-01 00:00:00

  • The relationship between mucin phenotype and clinicopathological factors, proliferative activity and p53 expression in gastric hyperplastic polyps.

    abstract:AIMS:Gastric hyperplastic polyps (GHPs) are the most common polypoid lesion of the stomach, and their malignant potential has been demonstrated. In the present study, we evaluated the mucin phenotypes of GHPs and investigated the relationships among mucin phenotypes and clinical-pathological factors, proliferative acti...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Li J,Wu LH,Shi Y,Li HM,Song MY,Jiao YF

    更新日期:2014-03-01 00:00:00

  • Synergism of imatinib, vatalanib and everolimus in the prevention of chronic lung allograft rejection after lung transplantation (LTx) in rats.

    abstract::Chronic lung allograft dysfunction (CLAD) still remains a major drawback in the outcome following lung transplantation (LTx). New therapeutic strategies are warranted. Growth factors and their receptors like platelet-derived growth factor-receptor (PDGFR) and vascular endothelial growth factor-receptor (VEGFR), may pl...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Keil L,Schaub AL,Hirt SW,Schmid C,Lehle K,von Suesskind-Schwendi M

    更新日期:2019-07-01 00:00:00

  • Immunohistochemical characterisation of dorsal root ganglia neurons supplying the porcine mammary gland.

    abstract::The present study investigated the chemical coding of mammary gland-projecting dorsal root ganglia (DRG) neurons using double-labelling immunohistochemistry. Earlier investigations revealed the presence of Fast blue - positive (FB+) neurons in Th9-Th12 DRG after injection of the tracer into the second, right thoracic ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Franke-Radowiecka A

    更新日期:2011-12-01 00:00:00

  • Overexpression of YES1 is associated with favorable prognosis and increased platinum-sensitivity in patients with epithelial ovarian cancer.

    abstract:AIMS:The prognostic application of YES1 in epithelial ovarian cancer (EOC) is currently unclear. We aimed to investigate the expression of YES1 and its correlation with survival outcome in patients with EOC. METHODS:A retrospective study of patients diagnosed with EOC at the Cancer Center, Sun Yat-Sen University, Guan...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Zhou Y,Chen P,Huang Q,Wan T,Jiang Y,Jiang S,Yan S,Zheng M

    更新日期:2020-07-01 00:00:00

  • Odontogenic jaw cysts: light and electron microscopical investigations.

    abstract::Light and electron microscopy were used to analyze the epithelial lining of odontogenic cysts excised from edentulous regions of the jaws. Clinically, three cases were identified as keratocysts, and 21 cases as cysts other than keratocysts ("non-keratocysts"). The epithelium of the former was found to achieve keratini...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Domenici-Lombardo L,Amunni F,Bergamini M,Romagnoli P

    更新日期:1996-04-01 00:00:00

  • Coexistence of serotonin and cholecystokinin in paraneurons of the foetal sheep lung.

    abstract::The coexistence of serotonin and cholecystokinin was studied in foetal sheep lungs at pseudoglandular stage of development by light microscopic immunohistochemistry. The coexistence was examined by staining consecutive sections with the different antibodies. Serotonin and cholecystokinin immunoreactivity was found wit...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Balaguer L,Romano J,Ruiz-Pesini P

    更新日期:1994-01-01 00:00:00

  • Microvascular changes in relation to inflammation and epidermal hyperplasia in chronic cutaneous lesions of psoriasis vulgaris.

    abstract::Epidermal proliferation, inflammatory changes and microvascular augmentation are prominent features of chronic cutaneous psoriatic lesions. The objective of this study was the investigation of blood and lymphatic microvascular changes in relation to epidermal changes and inflammatory infiltration in dermis. Immunohist...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Výbohová D,Adamicová K,Mellová Y,Hešková G

    更新日期:2017-05-01 00:00:00

  • Atrial natriuretic peptide in the heart and pancreas.

    abstract::We used antisera to pure atrial natriuretic peptide to localise this peptide by immunocytochemistry in rat and human tissue. We showed that both rat and human atrial cardiocytes gave a positive reaction while ventricular cardiocytes were consistently negative. Peripheral islet cells in rat but not in human pancreas al...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Lindop GB,Mallon EA,MacIntyre G

    更新日期:1986-04-01 00:00:00

  • Intraepidermal free nerve fiber endings in the hairless skin of the rat as revealed by the zinc iodide-osmium tetroxide technique.

    abstract::The nerve fiber distribution in the epidermis of the hairless rat skin was studied light microscopically by means of zinc iodide-osmium tetroxide staining. Two different morphological types of free nerve fiber endings could be detected: clusters of relatively thick nerve fibers stretched up through the spinous layer u...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Müller T

    更新日期:2000-04-01 00:00:00

  • Structural and ultrastructural hepatic changes in experimental canine leishmaniasis.

    abstract::Six 4 month-old beagles were inoculated with Leishmania donovani infantum, three of them intraperitoneally (Group A) and the other three intravenously (Group B). The animals from Group A were killed 109, 433 and 592 days after inoculation and animals from Group B 109, 171 and 334 after inoculation. The liver of each o...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: González JL,Rollán E,Novoa C,Castaño M

    更新日期:1988-10-01 00:00:00

  • Adult stem and transit-amplifying cell location.

    abstract::Adult stem cells (ASC)--able to self renew and to intervene in maintaining the structural and functional integrity of their original tissue--can express greater plasticity than traditionally attributed to them, adopting functional phenotypes and expression profiles of cells from other tissues. Therefore, they could be...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Díaz-Flores L Jr,Madrid JF,Gutiérrez R,Varela H,Valladares F,Alvarez-Argüelles H,Díaz-Flores L

    更新日期:2006-09-01 00:00:00

  • Presence and distribution of 5HT-, VIP-, NPY-, and SP-immunoreactive structures in adult mouse lung.

    abstract::A large number of biologically active substances have been identified and characterised in the respiratory tract of several mammals. These substances (amines and peptides) exert important regulatory influences on respiratory functions, and they act as neurotransmitters/neuromodulators, both being released from nerve t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Verástegui C,Fernández-Vivero J,Prada A,Rodríguez F,Romero A,González-Moreno M,de Castro JM

    更新日期:1997-10-01 00:00:00

  • Effects of bombesin on the morphology and function of the rat adrenal cortex: comparison of the acute and chronic responses.

    abstract::The acute and chronic effects of bombesin (BM) on the structure and function of rat adrenal cortex were investigated by morphometric and radioimmunological techniques. An intraperitoneal bolus injection of 2 micrograms/rat BM markedly raised plasma corticosterone (B) concentration (PBC). The intraperitoneal BM infusio...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Malendowicz LK,Nussdorfer GG,Miskowiak B,Majchrzak M

    更新日期:1995-01-01 00:00:00

  • Recent development of in vivo cryotechnique to cryobiopsy for living animals.

    abstract::Various microscopic methods have been used to analyze the morphology and molecular distribution of cells and tissues. Using conventional procedures, however, ischemic or anoxic artifacts are inevitably caused by tissue-resection or perfusion-fixation. The in vivo cryotechnique (IVCT) was developed to overcome these pr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Ohno N,Terada N,Saitoh S,Zhou H,Fujii Y,Ohno S

    更新日期:2007-11-01 00:00:00

  • Ultrastructural observation on the rat supraoptic neurons following acute operative stress.

    abstract::The response of the SON to various forms of stress is well documented. However, the effect of operative stress, which is a common and important clinical event requiring the mediation of vasopressin, has largely escaped attention. The present report describes the ultrastructural changes in the neurons of the caudal (re...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Ray PK,Choudhury SR

    更新日期:1988-04-01 00:00:00

  • Epithelial integrity, cell death and cell loss in mammalian small intestine.

    abstract::In recent years, the different mechanisms of epithelial cell loss which occur in mammalian and avian small intestine have been re-investigated. Information is now available for a variety of mammalian types and mechanisms can be divided into two major classes: [i] those preserving epithelial integrity by maintaining in...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Mayhew TM,Myklebust R,Whybrow A,Jenkins R

    更新日期:1999-01-01 00:00:00

  • Immunohistochemistry of connexin43 and zonula occludens-1 in the myocardium as markers of early ischemia in autopsy material.

    abstract::Immunohistochemistry of the terminal complement complex (C5b-9) and fibronectin (FN) is useful to detect myocardial ischemia preceding necrosis in the postmortem diagnosis of sudden cardiac death. The present immunohistochemical study examined connexin43 (Cx43) and zonula occludens-1 (ZO-1) as markers of early myocard...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Kawamoto O,Michiue T,Ishikawa T,Maeda H

    更新日期:2014-06-01 00:00:00

  • Current understanding of macrophage type 1 cytokine responses during intracellular infections.

    abstract::Macrophages are important effector cells in cell-mediated immunity against intracellular infection. Among cytokines that macrophages are able to release are IL-12 and TNF alpha. IL-12 is a critical linker between the innate and adaptive cell-mediated immunity, capable of Th1 differentiation and IFN gamma release by T ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Xing Z

    更新日期:2000-01-01 00:00:00

  • Monocarboxylate transporters: past, present, and future.

    abstract::We review here the 14 members of the Monocarboxylate transporter family (MCTs), their relationship based on sequence homology. The range of substrates transported by different members of this family extends from the standard monocarboxylate metabolites, lactic and pyruvic acids, to aromatic amino acids and thyroid hor...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Merezhinskaya N,Fishbein WN

    更新日期:2009-02-01 00:00:00

  • Somatostatinoma: collision with neurofibroma and ultrastructural features.

    abstract::The clinical presentation, histopathology and immunoelectron microscopic features of two cases of duodenal somatostatinoma are described, one of which is a hitherto unreported example of a collision tumour with a neurofibroma. Ultrastructural morphometric immunoelectron microscopy studies revealed the presence of four...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Varikatt W,Yong JL,Killingsworth MC

    更新日期:2006-11-01 00:00:00

  • Molecular pathogenesis of hereditary hemochromatosis.

    abstract::Hereditary hemochromatosis (HH) is an inherited iron overload disorder characterized by normal iron-driven erythropoiesis and abnormal iron metabolism, leading to excess iron deposited in parenchymal cells of liver, heart, and endocrine glands. Iron hormone, hepcidin, plays a critical role in iron homeostasis through ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Liu J,Pu C,Lang L,Qiao L,Abdullahi MA,Jiang C

    更新日期:2016-08-01 00:00:00

  • Morphological, immunohistochemical and ultrastructural changes in dimethylnitrosamine [correction of dimenthylnitrosamine] induced liver injury. Effect of malotilate.

    abstract::Dimethylnitrosamine (DMN) induced liver injury in rats with cell necrosis, inflammation, hemorrhages, increased collagen type III synthesis and basement membrane component laminin and collagen IV localization in perisinusoidal sites. Malotilate ingestion during DMN treatment abolished inflammation and decreased inters...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Stenbäck F,Ala-Kokko L,Ryhänen L

    更新日期:1989-01-01 00:00:00

  • The deep-sea teleost cornea: a comparative study of gadiform fishes.

    abstract::The corneal structure of three deep-sea species of teleosts (Gadiformes, Teleostei) from different depths (250-4000 m) and photic zones are examined at the level of the light and electron microscopes. Each species shows a similar but complex arrangement of layers with a cornea split into dermal and scleral components....

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Collin SP,Collin HB

    更新日期:1998-04-01 00:00:00

  • Nitric oxide and nitric oxide synthase: biology, pathology, localization.

    abstract::Nitric oxide (NO) has opened a new and vigorous field of biological and clinical experimentation as evidenced presently by about one hundred original publications every week. Being a biological signal under physiological conditions, NO may be to pathologically affected tissues. Major insights into the ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Wolf G

    更新日期:1997-01-01 00:00:00

  • Prognostic significance of metallothionein expression in correlation with Ki-67 expression in adenocarcinomas of large intestine.

    abstract::The study aimed at determining levels of metallothionein (MT) and Ki-67 antigen expression in adenocarcinomas of large intestine and examining relation of the expression levels with various clinical and pathological variables. The studies were performed on 81 cases of large intestine adenocarcinoma. Using immunocytoch...

    journal_title:Histology and histopathology

    pub_type: 临床试验,杂志文章


    authors: Dziegiel P,Forgacz J,Suder E,Surowiak P,Kornafel J,Zabel M

    更新日期:2003-04-01 00:00:00

  • MCM2 expression levels predict diagnosis and prognosis in gastric cardiac cancer.

    abstract:BACKGROUND:Gastric Cardiac Cancer (GCC) has high incidence and poor prognosis requiring early screening of high-risk populations. Minichromosome maintenance (MCM) proteins are used as diagnostic-biomarkers in many cancers but not validated for GCC. We evaluate MCM protein 2 (MCM2), comparing it with the validated marke...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Liu M,Li JS,Tian DP,Huang B,Rosqvist S,Su M

    更新日期:2013-04-01 00:00:00

  • Reduced expression of the membrane skeleton protein beta1-spectrin (SPTBN1) is associated with worsened prognosis in pancreatic cancer.

    abstract::Spectrins are members of the superfamily of F-actin cross linking proteins that are important as scaffolding proteins for protein sorting, cell adhesion, and migration. In addition, spectrins have been implicated in TGF-beta signaling. The aim of the present study was to analyze the expression and localization of beta...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Jiang X,Gillen S,Esposito I,Giese NA,Michalski CW,Friess H,Kleeff J

    更新日期:2010-12-01 00:00:00

  • Rab GTPases in the differential processing of phagocytosed pathogens versus efferocytosed apoptotic cells.

    abstract::Phagocytosis is an important feature of innate immunity in which invading microorganisms are engulfed, killed and degraded - and in some immune cells, their antigens presented to adaptive immune system. A closely related process, efferocytosis, removes apoptotic cells, and is essential for the maintenance of homeostas...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Taefehshokr N,Yin C,Heit B

    更新日期:2020-09-29 00:00:00