Molecular and cellular mechanisms of heterotopic ossification.

abstract：:The acute and chronic effects of bombesin (BM) on the structure and function of rat adrenal cortex were investigated by morphometric and radioimmunological techniques. An intraperitoneal bolus injection of 2 micrograms/rat BM markedly raised plasma corticosterone (B) concentration (PBC). The intraperitoneal BM infusio...

journal_title：Histology and histopathology

authors： Malendowicz LK,Nussdorfer GG,Miskowiak B,Majchrzak M

更新日期：1995-01-01 00:00:00

abstract：:Mitochondrial transcription factor A (mtTFA) plays a crucial role in both the transcription and maintenance of mitochondrial DNA. A high expression of mtTFA has been demonstrated in several solid tumors, and is closely associated with cancer cell survival/apoptosis and growth. However, its expression pattern in pancre...

journal_title：Histology and histopathology

authors： Kimura T,Kitada S,Uramoto H,Zhi L,Kawatsu Y,Takeda T,Horie S,Nabeshima A,Noguchi H,Sasaguri Y,Izumi H,Kohno K,Yamada S

更新日期：2015-02-01 00:00:00

abstract：:Cerebral cavernous malformations (CCMs) are described as vascular lesions consisting of endothelial-lined dilated vessels embedded in a connective tissue sheath without intervening parenchyma between them. Their anatomical connections with the normal blood vessels are still enigmatic and the fine three-dimensional (3-...

journal_title：Histology and histopathology

authors： Toralba S,Landemore G,Coquemont M,Plancoulaine B,Chapon F

更新日期：2014-08-01 00:00:00

abstract：:Compliance with current regulations for the development of innovative medicines require the testing of candidate therapies in relevant translational animal models prior to human use. This poses a great challenge when the drug is composed of cells, not only because of the living nature of the active ingredient but also...

journal_title：Histology and histopathology

authors： Ramallo M,Carreras-Sánchez I,López-Fernández A,Vélez R,Aguirre M,Feldman S,Vives J

更新日期：2020-09-11 00:00:00

abstract：:Acetylcholinesterase (AchE)-positive afferent axons in the mucosa of the cat urinary bladder were examined in the present experiments. Small-sized dorsal root ganglion cells containing AchE enzyme activity were labelled by injection of retrograde tracer (wheat germ agglutinin conjugated to enzymatically inactive horse...

journal_title：Histology and histopathology

authors： Wakabayashi Y,Kojima Y,Makiura Y,Tomoyoshi T,Maeda T

更新日期：1995-07-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) and its receptor, TrkB, are broadly expressed in the developing and adult mammalian brain. BDNF/TrkB-stimulated intracellular signaling is critical for neuronal survival, morphogenesis, and plasticity. It is well known that binding of BDNF to TrkB elicits various intracellular ...

journal_title：Histology and histopathology

authors： Numakawa T,Suzuki S,Kumamaru E,Adachi N,Richards M,Kunugi H

更新日期：2010-02-01 00:00:00

abstract：:Recently, the characterization of mucinous tubular and spindle-cell carcinoma (MTSCC) has been established. MTSCC predominantly occurs in females. This tumor is histologically characterized by eosinophilic cytoplasm, elongated and anastomosing tubules, myxomatous stroma and low-grade nuclear cytology. Proliferation of...

journal_title：Histology and histopathology

authors： Kuroda N,Toi M,Hiroi M,Shuin T,Enzan H

更新日期：2005-01-01 00:00:00

abstract：:Epidemiologic studies have suggested that elderly patients who consumed diets rich in antioxidants throughout their lives are less likely to be afflicted with age-related macular degeneration (AMD). This led to the Age-Related Eye Disease Study, which showed that supplements containing antioxidant vitamins and zinc re...

journal_title：Histology and histopathology

authors： Shen JK,Dong A,Hackett SF,Bell WR,Green WR,Campochiaro PA

更新日期：2007-12-01 00:00:00

abstract：:The present study analyzed the temporal and spatial expression of TGF-beta isoforms and activated pSmad2 and p38MAPK during epithelial debridement wound repair, using chick cornea by immunohistochemistry. Normal corneas showed low-level TGF-betas staining. Following wounding, TGF-beta1 expression was strong in the Bow...

journal_title：Histology and histopathology

authors： Huh MI,Chang Y,Jung JC

更新日期：2009-11-01 00:00:00

abstract：:The resistance to airflow that develops in most obstructive processes takes place in the small airways. The aim of the present paper is to describe bronchial hysteresis morphometrically in a respiratory cycle model. As a working hypothesis, it is proposed that the changes that take place in the respiratory tract durin...

journal_title：Histology and histopathology

authors： Escolar JD,Escolar MA,Guzmán J,Roqués M

更新日期：2003-01-01 00:00:00

abstract：:Nitric oxide (NO) is a biological messenger molecule produced by one of the essential amino acids L-arginine by the catalytic action of the enzyme NO synthase (NOS). The dual role of NO as a protective or toxic molecule is due to several factors, such as; the isoform of NOS involved, concentration of NO and the type o...

journal_title：Histology and histopathology

authors： Thippeswamy T,McKay JS,Quinn JP,Morris R

更新日期：2006-04-01 00:00:00

abstract：:The authors present a case of benign oncocytoma (oxyphil cell adenoma) of the nasal cavity in a young woman. This is the fifth case reported in that region. Immunohistochemical stains revealed positivity only for cytokeratin. ...

journal_title：Histology and histopathology

authors： Miracco C,Sensini I,Vessio G,Luzi P

更新日期：1986-01-01 00:00:00

abstract：:Much effort has been made by researchers to elucidate the complex biology of breast cancer stem cells (BCSCs), a small subset of breast tumor cells that display stem cell properties, drive tumor initiation, and growth. In recent years, it has been suggested that BCSCs could be responsible for the process of metastasis...

journal_title：Histology and histopathology

authors： Schwarz-Cruz Y Celis A,Espinosa M,Maldonado V,Melendez-Zajgla J

更新日期：2016-06-01 00:00:00

abstract：:Sulfur dioxide (SO₂) is a toxic gas and air pollutant. The toxic effects of SO₂ have been extensively studied. Oxidative damage due to SO₂ can occur in multiple organs. Inhaled SO₂ can also cause chromosomal aberrations, DNA damage and gene mutations in mammals. However, SO₂ can also be generated from the sulfur-conta...

journal_title：Histology and histopathology

authors： Wang XB,Cui H,Liu X,Du JB

更新日期：2017-12-01 00:00:00

abstract：:The terms construct or tissue equivalent refer to neotissue produced by tissue engineering techniques. The elements forming the construct are scaffolds on which cells are "recreated" to form an engineered-tissue sensitive to certain cell signals. The ability of the cells to expand and differentiate on the scaffold is ...

journal_title：Histology and histopathology

authors： Buján J,Pascual G,Corrales C,Gómez-Gil V,Rodríguez M,Bellón JM

更新日期：2005-07-01 00:00:00

abstract：:Sample preparation of dental tissues for quantitative electron microprobe analysis has not been critically examined because of the highly mineralized nature of these structures. The present study was designed to establish the most suitable method for the electron probe quantitative determination of calcium in human pe...

journal_title：Histology and histopathology

authors： Sánchez-Quevedo MC,Nieto-Albano OH,García JM,Gómez de Ferraris ME,Campos A

更新日期：1998-01-01 00:00:00

abstract：:The aim of the present work was to study the morphological implications between the elastin and the phenotypic expression of the vascular smooth muscle cells. For this purpose, sixty human tortuous arteries from different territories have been studied. We have measured the morphometric indexes Intimal Thickening Index...

journal_title：Histology and histopathology

authors： Ortiz PP,Sarrat R,Daret D,Whyte J,Torres A,Lamazière JM

更新日期：2000-01-01 00:00:00

abstract：:Close contacts between endocrine insular cells and exocrine acinar, centroacinar and ductular cells occur frequently in the rat pancreas as seen by both light and electron microscopy. Islets of Langerhans are surrounded incompletely by a thin connective tissue capsule or mantle but numerous exocrine-endocrine cell con...

journal_title：Histology and histopathology

authors： Leeson TS,Leeson R

更新日期：1986-01-01 00:00:00

abstract：:Vascular endothelial cells play a critical role in the maintenance of endometrial homeostasis. Indeed many pathological conditions causing abnormal endometrial bleeding including progestin only contraception, hormone replacement therapy, endometrial polyps, myomas, hyperplasia and cancer are associated with aberrant a...

journal_title：Histology and histopathology

authors： Krikun G,Mor G,Huang J,Schatz F,Lockwood CJ

更新日期：2005-07-01 00:00:00

abstract：:Neurotrophins are substances that have been shown to be important in growth and remodelling phases in different types of tissue. There is no information concerning the possible occurrences of neurotrophins and their receptors in tendons. In this study, sections of both chronic painful (tendinosis) and pain-free (non-t...

journal_title：Histology and histopathology

authors： Bagge J,Lorentzon R,Alfredson H,Forsgren S

更新日期：2009-07-01 00:00:00

abstract：:Extracellular matrix of meningiomas was studied by light and electron microscopy with the aid of immunohistochemical techniques. Special attention was paid to the distribution of type I, III, IV, V collagens and laminin with a comparison between meningothelial and fibroblastic types. Connective tissue fibers and basem...

journal_title：Histology and histopathology

authors： Nitta H,Yamashima T,Yamashita J,Kubota T

更新日期：1990-07-01 00:00:00

abstract：:Nitric oxide (NO) is a widely recognized mediator of physiological and pathophysiological signal transmission. Its generation through L-arginine metabolism is relevant in the mesangium of the kidney where NO is produced by constitutive and inducible NO-synthase isoenzymes. Signaling is achieved through target interact...

journal_title：Histology and histopathology

authors： Sandau KB,Brüne B

更新日期：2000-10-01 00:00:00

abstract：:PML is a tumour suppressor inactivated in Acute Promyelocytic Leukaemia (APL). PML is the essential component of a subnuclear structure called the PML nuclear body (PML-NB), which is disrupted in APL. By targeting different cellular proteins to this structure, PML can either hamper or potentiate their functions. The P...

journal_title：Histology and histopathology

authors： Salomoni P,Bellodi C

更新日期：2007-08-01 00:00:00

abstract：:The photoreceptors of the barred owl (Strix varia) consist of rods, single cones and unequal double cones present in a ratio of about 35:1:3. In the light-adapted condition the rods are of uniform diameter along their entire length and are therefore not felt to undergo photomechanical changes. The rod outer segment co...

journal_title：Histology and histopathology

authors： Braekevelt CR,Smith SA,Smith BJ

更新日期：1996-01-01 00:00:00

abstract：:The Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily of ligand-activated transcription factors, which plays crucial role in bile acid, cholesterol, lipid and glucose metabolism, as well as in the development of atherosclerosis, intestinal bacterial growth and liver regeneration. FXR is also i...

journal_title：Histology and histopathology

authors： Koutsounas I,Giaginis C,Theocharis S

更新日期：2012-07-01 00:00:00

abstract：:The aim of this study was to demonstrate the morphology and matrix synthesis of embryonic rat liver cells (day 18 of gestation) in organoid cultures (high density cultures) with electron microscopic and immunomorphological techniques. For this purpose the cells of embryonic rat livers were isolated enzymatically and g...

journal_title：Histology and histopathology

authors： Elkasaby A,Xu D,Schröter-Kermani C,Merker HJ

更新日期：1991-04-01 00:00:00

abstract：:Chronic lung allograft dysfunction (CLAD) still remains a major drawback in the outcome following lung transplantation (LTx). New therapeutic strategies are warranted. Growth factors and their receptors like platelet-derived growth factor-receptor (PDGFR) and vascular endothelial growth factor-receptor (VEGFR), may pl...

journal_title：Histology and histopathology

authors： Keil L,Schaub AL,Hirt SW,Schmid C,Lehle K,von Suesskind-Schwendi M

更新日期：2019-07-01 00:00:00

abstract：:The corneal structure of three deep-sea species of teleosts (Gadiformes, Teleostei) from different depths (250-4000 m) and photic zones are examined at the level of the light and electron microscopes. Each species shows a similar but complex arrangement of layers with a cornea split into dermal and scleral components....

journal_title：Histology and histopathology

authors： Collin SP,Collin HB

更新日期：1998-04-01 00:00:00

abstract：:In mouse embryos, the expression of Blimp1 has recently revealed a population of allocated primordial germ cell precursors 24 hours earlier than previously thought. Those 'blimped' precursors have been shown to give rise, by mitotic division, to germ cells only and no other cell lineages. Here, we try to understand th...

journal_title：Histology and histopathology

authors： Chuva de Sousa Lopes SM,Roelen BA

更新日期：2008-12-01 00:00:00

abstract：:Adult stem cells (ASC)--able to self renew and to intervene in maintaining the structural and functional integrity of their original tissue--can express greater plasticity than traditionally attributed to them, adopting functional phenotypes and expression profiles of cells from other tissues. Therefore, they could be...

journal_title：Histology and histopathology

authors： Díaz-Flores L Jr,Madrid JF,Gutiérrez R,Varela H,Valladares F,Alvarez-Argüelles H,Díaz-Flores L

更新日期：2006-09-01 00:00:00