Effect of chronic alcoholism on the human hippocampus.


:The effect of chronic alcoholism on the human hippocampus was studied in 21 patients, divided in 4 groups: Group A under 45 years, group B 46-59 years, group C 60-69, and Group D over 70 years; and compared with age-matched control patients who died without neurological complications. The gyrus dentatus and the ammonic fields CA1 through CA4 were analyzed by counting the number of neurons and the size of the nuclear area. Both parameters were evaluated statistically. The most important findings were a high neuronal loss in alcoholics in the first age group. In addition, the hippocampal neurons failed to display a vicarious reaction, since the nuclei did not show any increase in size despite the intense neuronal loss. Our results point out an early neuronal loss in the hippocampus of alcoholic patients higher than age-matched controls, as well as a lack of reaction to the neuronal insult.


Histol Histopathol


Bengochea O,Gonzalo LM


Has Abstract


1990-07-01 00:00:00












  • Immunohistochemical distribution of cocaine- and amphetamine-regulated transcript peptide - like immunoreactive (CART-LI) nerve fibers and various degree of co-localization with other neuronal factors in the circular muscle layer of human descending colon

    abstract::Cocaine- and amphetamine-regulated transcript peptide (CART) is a neuromediator and/or neuromodulator in nerve structures within the gastrointestinal tract, but knowledge about its distribution, functions and co-localisation with other neuronal factors, especially in humans, is very scarce. During the present investig...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Gonkowski S,Kamińska B,Landowski P,Całka J

    更新日期:2013-07-01 00:00:00

  • Regulation and function of sphingosine kinase 2 in diseases.

    abstract::Sphingosine kinase functions to phosphorylate sphingosine to sphingosine 1-phosphate (S1P) to keep balance in the metabolites of sphingolipids. There are two isoforms of sphingosine kinase, sphingosine kinase 1 (SphK1) and sphingosine kinase 2 (SphK2). Although SphK1 and SphK2 share high sequence similarity, SphK2 has...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Song DD,Zhou JH,Sheng R

    更新日期:2018-05-01 00:00:00

  • MYC and BCL-2 adjusted-International Prognostic Index (A-IPI) is a better predictor of outcome than the standard IPI for patients with diffuse large B-cell lymphoma treated with R-CHOP.

    abstract::The International Prognostic Index (IPI) has been the basis for determining prognosis in patients with diffuse large B-cell lymphoma (DLBCL) for the past 20 years. The utility of the IPI must be reassessed in the era of immunochemotherapy. Seven risk factors at diagnosis were identified, and a maximum of 7 points were...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Wang J,Zhou M,Xu JY,Yang YG,Zhang QG,Zhou RF,Chen B,Ouyang J,Li C

    更新日期:2016-03-01 00:00:00

  • Comparison of histological characteristics and expression of CD3 and CD79a among the hemal nodes, lymph nodes and spleens of yaks (Bos grunniens).

    abstract::This experiment compared the histological characteristics and distribution of CD3 and CD79a among yak lymph nodes, hemal nodes and spleen. The three organs from ten clinically healthy newborn and adult yaks were studied using histology and immunohistochemistry. The yak hemal nodes, which consisted of blood sinuses, ly...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Huang Y,Cui Y,Yu S,He J,He Y,Zhang Q,Liu P,Pu Y,Sun J,Kang X

    更新日期:2019-03-01 00:00:00

  • Tumor heterogeneity has important consequences for personalized medicine in ovarian cancer.

    abstract::Most patients with ovarian cancers relapse, and treatment failure has often been attributed to chemoresistance in tumor cells. Emerging evidence indicates that tumor heterogeneity may play an equally important role. Although the idea of tumor heterogeneity is not new, little attention has been focused on applying it t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Gui T,Cao D,Yang J,Shen K

    更新日期:2015-02-01 00:00:00

  • Microglia and prion disease: a review.

    abstract::Prion diseases are characterized by the accumulation of PrPSc, an altered isoform of a normal cellular protein, PrPc. The prion hypothesis holds that the process of conformational change from PrPc to PrPSc under the influence of PrPSc constitutes the basic infectious mechanism in prion diseases. It is still unknown wh...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Brown DR,Kretzschmar HA

    更新日期:1997-07-01 00:00:00

  • Time-dependent effects of maternal continuous propranolol on fetal lung development in rats.

    abstract::Previous studies have demonstrated a role for the beta-adrenergic system in the maturation of the fetal alveolar epithelium. Chronic blockade of beta-adrenergic binding sites has been shown to adversely effect physiologic and biochemical indices of fetal lung maturation. In the present study timed-pregnant female Spra...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Smith DM,Sommers SS

    更新日期:2002-04-01 00:00:00

  • Heart mitochondria in rats submitted to chronic hypoxia.

    abstract::The effect of prolonged exposure to normobaric hypoxia on the mitochondria of myocard of rats exposed for several weeks to 8 and 7% O2 has been morphometrically evaluated. Twelve male Wistar rats housed in Nalgene cages (2 per cage) with a batch of six cages placed in plexiglass chambers were maintained in air/N2 mixt...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Cervós Navarro J,Kunas RC,Sampaolo S,Mansmann U

    更新日期:1999-10-01 00:00:00

  • Immunolocalization of interleukin-1 receptor antagonist in healthy and infarcted myocardium.

    abstract::Ischemic heart disease is a widespread cause of death. During infarction, myocardial injury is mediated by release of several pro-inflammatory cytokines including multifunctional interleukin-1 (IL-1). In various tissues, IL-1-mediated deleterious effects are known to be attenuated via the over-expression of natural an...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Bonetti A,Marchini M,Ortolani F

    更新日期:2008-09-01 00:00:00

  • Regeneration of the periodontium for preservation of the damaged tooth.

    abstract::The population of the world grows every year, and life expectancy tends to increase. Thus, long-term preservation of teeth in aged individuals is an urgent issue. The main causes of tooth loss are well known to be periodontitis, caries, fractures, and orthodontic conditions. Although implant placement is a widely acce...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Maeda H,Tomokiyo A,Wada N,Koori K,Kawachi G,Akamine A

    更新日期:2014-10-01 00:00:00

  • Effect of irradiation on autogenous bone transplantation in rat parietal bone.

    abstract::To determine the appropriate time for bone reconstruction after irradiation, the healing process after autogenous iliac bone transplantation in the irradiated parietal bone was examined by scanning electron microscopy and light microscopy. Bone transplantation was carried out at the second and the fourth weeks after C...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Takekawa M,Matsuda M,Ohotubo S

    更新日期:2000-01-01 00:00:00

  • An ultrastructural stereologic study of aldosterone secreting adrenal adenomas and of adjacent zona glomerulosa.

    abstract::The ultrastructure of four aldosterone secreting adenomas and of the adjacent zona glomerulosa has been described by the use of stereological techniques. Adenomatous cells (about 2800 microns 3 in volume) invariably displayed a striking abundance of lipid droplets, which occupied about 30% of the cytoplasm. Mitochondr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Belloni AS,Mantero F,Rocco S,Gottardo G,Mazzocchi G,Nussdorfer GG

    更新日期:1988-07-01 00:00:00

  • Novel polyvinyl alcohol (PVA) based cryoprotection method that facilitates cutting frozen sections of decalcified human trabecular bone.

    abstract::Processing adult human trabecular bone to obtain tissue sections suitable for research or diagnostic purposes has always been challenging, particularly in the preparation of adult bone specimens for advanced immunohistochemistry applications. In contrast to the majority of soft tissues, decalcified bone samples perfor...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Maly IP,Rahner C,Nowakowski AM,Müller-Gerbl M

    更新日期:2013-12-01 00:00:00

  • Fine reconstruction of the pancreatic ductular system at the onset of pancreatitis.

    abstract::The three-dimensional structure of the pancreatic ductular system (from the intercalated duct to the intercellular secretory canaliculus) is controversial and unclear. The aim of this study is to reveal the three-dimensional structure of the pancreatic ductular sysytem at the onset of pancreatitis. One day following r...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Endo H,Ashizawa N,Niigaki M,Hamamoto N,Niigaki M,Kaji T,Katsube T,Watanabe M,Naora H,Otani H,Kinoshita Y

    更新日期:2002-01-01 00:00:00

  • Antioxidant enzymes in renal cell carcinoma.

    abstract::The aim of the study was to estimate the significance of oxidative/nitrosative damage and expression of antioxidant enzymes in renal cell carcinomas (RCC). For this we investigated immunohistochemically six antioxidant enzymes (AOEs) including MnSOD, ECSOD, thioredoxin, thioredoxin reductase, and gammaglutamyl cystein...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Soini Y,Kallio JP,Hirvikoski P,Helin H,Kellokumpu-Lehtinen P,Tammela TL,Peltoniemi M,Martikainen PM,Kinnula LV

    更新日期:2006-02-01 00:00:00

  • Close association of centroacinar/ductular and insular cells in the rat pancreas.

    abstract::Close contacts between endocrine insular cells and exocrine acinar, centroacinar and ductular cells occur frequently in the rat pancreas as seen by both light and electron microscopy. Islets of Langerhans are surrounded incompletely by a thin connective tissue capsule or mantle but numerous exocrine-endocrine cell con...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Leeson TS,Leeson R

    更新日期:1986-01-01 00:00:00

  • Thrombocytopenia in leukemia: Pathogenesis and prognosis.

    abstract::Leukemias, a heterogeneous group of hematological disorders, are characterized by ineffective hematopoiesis and morphologic abnormalities of hematopoietic cells. Thrombocytopenia is a common problem among leukemia types that can lead to hemorrhagic complications in patients. The purpose of this review article is to id...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Shahrabi S,Behzad MM,Jaseb K,Saki N

    更新日期:2018-09-01 00:00:00

  • Adult stem and transit-amplifying cell location.

    abstract::Adult stem cells (ASC)--able to self renew and to intervene in maintaining the structural and functional integrity of their original tissue--can express greater plasticity than traditionally attributed to them, adopting functional phenotypes and expression profiles of cells from other tissues. Therefore, they could be...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Díaz-Flores L Jr,Madrid JF,Gutiérrez R,Varela H,Valladares F,Alvarez-Argüelles H,Díaz-Flores L

    更新日期:2006-09-01 00:00:00

  • The induction of gut hyperplasia by phytohaemagglutinin in the diet and limitation of tumour growth.

    abstract::The growth of a transplantable murine non-Hodgkin lymphoma tumour, developing either intraperitoneally as an ascites tumour or subcutaneously as a solid tumour, has been shown to be markedly diminished by including phytohaemagglutinin (PHA), a lectin present in raw kidney bean (Phaseolus vulgaris) in the diet. In NMRI...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Pryme IF,Pusztai A,Bardocz S,Ewen SW

    更新日期:1998-04-01 00:00:00

  • Oncocytic adenoma of the nasal cavity. A case report.

    abstract::The authors present a case of benign oncocytoma (oxyphil cell adenoma) of the nasal cavity in a young woman. This is the fifth case reported in that region. Immunohistochemical stains revealed positivity only for cytokeratin. ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Miracco C,Sensini I,Vessio G,Luzi P

    更新日期:1986-01-01 00:00:00

  • Antigen retrieval on epoxy sections based on tissue infiltration with a moderately increased amount of accelerator to detect immune complex deposits in glomerular tissue.

    abstract::We wanted to examine the effect of antigen retrieval on epoxy sections where the tissue had been infiltrated by resin containing moderately increased amounts of accelerator. The concentration of accelerator DMP-30 (Tri(Dimethyl Amino Methyl) Phenol) was varied in the range of 0% to 4% in the infiltration step of the t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Brorson SH,Andersen T,Haug S,Kristiansen I,Risstubben A,Tchou H,Ulstein J

    更新日期:1999-01-01 00:00:00

  • The thyroid gland of Callithrix jacchus in organ culture.

    abstract::Thyroid glands from 7 marmosets (Callithrix jacchus) of different age groups (newborn, 2 weeks, 2, 7, 8 and 11 months, and 8 years) were grown as organ culture according to Trowell at the medium/air interphase for 3 to 30 days. The morphology of thyroid tissue was well preserved until the end of the culture period. Ne...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Maile S,Merker HJ

    更新日期:1995-10-01 00:00:00

  • Extensive alteration in the expression profiles of TGFB pathway signaling components and TP53 is observed along the gastric dysplasia-carcinoma sequence.

    abstract:AIMS:The expression patterns of TGFB signaling proteins, such as TGFB1/2, TGFBR1(ALK5), TGFBR2, SMAD1/2/3, SMAD2/3, SMAD4, SMAD7, and of downstream targets of TGFB signaling, CDKN1A (p21CIP1), CDKN1B (p27KIP1), MYC, CDC25A, TP53, and RELA (p65NF-kB) were investigated in gastric carcinomas and other gastric lesions. ME...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Kim SH,Lee SH,Choi YL,Wang LH,Park CK,Shin YK

    更新日期:2008-12-01 00:00:00

  • Daunorubicin does not induce immunohistochemically detectable endothelial dysfunction in rabbit aorta and femoral artery.

    abstract::Anthracyclines are one of the most effective anticancer drugs ever developed, but their clinical use has been hampered by the risk of severe cardiotoxicity. In this study, we investigated whether rabbits exposed to a different cumulative dose of anthracycline suffer from immunohistochemically detectable vascular toxic...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Nachtigal P,Sterba M,Popelová O,Večeřová L,Kudláčková Z,Jirkovský E,Geršl V

    更新日期:2011-05-01 00:00:00

  • Cyclosporin A-induced changes of the thymic microenvironment. A review of morphological studies.

    abstract::Cyclosporin A is an immunosuppressive drug, which disrupts the activation of peripheral T-lymphocyte pool and blocks the maturation of thymocytes within the thymus. Normally, thymic nonlymphoid cells provide the optimal inductive microenvironment for development of T-lymphocytes. After application of cyclosporin A the...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Milićević NM,Milićević Z

    更新日期:1998-10-01 00:00:00

  • A human in vitro granuloma model for the investigation of multinucleated giant cell and granuloma formation.

    abstract::A method for the in vitro generation of granulomas and its use in the analysis of the human granulomatous response is summarized. As a target for the cellular response L3 larvae of Nippostrongylus brasiliensis are coincubated with human mononuclear blood cells, and within seven to fourteen days the development of bloo...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Seitzer U,Haas H,Gerdes J

    更新日期:2001-04-01 00:00:00

  • Microvascular changes in relation to inflammation and epidermal hyperplasia in chronic cutaneous lesions of psoriasis vulgaris.

    abstract::Epidermal proliferation, inflammatory changes and microvascular augmentation are prominent features of chronic cutaneous psoriatic lesions. The objective of this study was the investigation of blood and lymphatic microvascular changes in relation to epidermal changes and inflammatory infiltration in dermis. Immunohist...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Výbohová D,Adamicová K,Mellová Y,Hešková G

    更新日期:2017-05-01 00:00:00

  • Histology and ultrastructure of the pineal organ in the domestic goose.

    abstract::The pineal organs of 14-week-old domestic geese were investigated with light and electron microscopy. The pineals consisted of a wide distal part and a narrow middle-proximal one. The glands were attached to the intercommissural region via the choroid plexus. The pineal parenchyma was formed by round or elongated foll...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Prusik M,Lewczuk B,Nowicki M,Przybylska-Gornowicz B

    更新日期:2006-10-01 00:00:00

  • Distribution and pathophysiologic role of molybdenum-containing enzymes.

    abstract::The importance of molybdenum-containing enzymes in the pathophysiology of a number of clinical disorders necessitates a comprehensive understanding of their histological localization and expression. The objectives of this review are to cover such enzymes so far reported and their enzyme- and immunohistochemical locali...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Moriwaki Y,Yamamoto T,Higashino K

    更新日期:1997-04-01 00:00:00

  • Nitric oxide, a biological double-faced janus--is this good or bad?

    abstract::Nitric oxide (NO) is a biological messenger molecule produced by one of the essential amino acids L-arginine by the catalytic action of the enzyme NO synthase (NOS). The dual role of NO as a protective or toxic molecule is due to several factors, such as; the isoform of NOS involved, concentration of NO and the type o...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Thippeswamy T,McKay JS,Quinn JP,Morris R

    更新日期:2006-04-01 00:00:00