Abstract：
:The effect of chronic alcoholism on the human hippocampus was studied in 21 patients, divided in 4 groups: Group A under 45 years, group B 46-59 years, group C 60-69, and Group D over 70 years; and compared with age-matched control patients who died without neurological complications. The gyrus dentatus and the ammonic fields CA1 through CA4 were analyzed by counting the number of neurons and the size of the nuclear area. Both parameters were evaluated statistically. The most important findings were a high neuronal loss in alcoholics in the first age group. In addition, the hippocampal neurons failed to display a vicarious reaction, since the nuclei did not show any increase in size despite the intense neuronal loss. Our results point out an early neuronal loss in the hippocampus of alcoholic patients higher than age-matched controls, as well as a lack of reaction to the neuronal insult.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Bengochea O,Gonzalo LMsubject
Has Abstractpub_date
1990-07-01 00:00:00pages
349-57issue
3eissn
0213-3911issn
1699-5848journal_volume
5pub_type
杂志文章abstract：:Studies with scanning electron microscopy in the normal human sulcular epithelium are scarce, and no precise information exists about cell surface patterns along the epithelium, the frequencies of these patterns, or possible regional differences within the mouth. In five periodontal biopsy specimens each from the ante...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:The aims of the present study were to apply the AMG technique for localization of mercury at the light and electron microscopic level in the ovary of crucian carp after exposure to mercuric chloride and to find out if this heavy metal induces expression of caspase-3. Depending on the stage of ovarian follicle developm...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-24.141
更新日期：2009-02-01 00:00:00
abstract：:Chronic liver diseases are commonly associated with tissue hypoxia that may cause inflammation, oxidative stress, liver cell injury and increased nuclear transcriptional regulation. The hepatic response to chronic hypoxia at the molecular level has not yet been clearly understood until now. The aim of this study is to...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：2013-04-01 00:00:00
abstract：:Various microscopic methods have been used to analyze the morphology and molecular distribution of cells and tissues. Using conventional procedures, however, ischemic or anoxic artifacts are inevitably caused by tissue-resection or perfusion-fixation. The in vivo cryotechnique (IVCT) was developed to overcome these pr...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-22.1281
更新日期：2007-11-01 00:00:00
abstract：:Endometriosis is a chronic pelvic inflammatory process. Local inflammation is known to play a role in pain and infertility associated with the disease, and may be extensively involved in molecular and cellular processes leading to endometriosis development. In this review, we focus on two inflammatory mediators clearl...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-26.1083
更新日期：2011-08-01 00:00:00
abstract：:We review here the 14 members of the Monocarboxylate transporter family (MCTs), their relationship based on sequence homology. The range of substrates transported by different members of this family extends from the standard monocarboxylate metabolites, lactic and pyruvic acids, to aromatic amino acids and thyroid hor...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-24.243
更新日期：2009-02-01 00:00:00
abstract：:Neurotrophins are substances that have been shown to be important in growth and remodelling phases in different types of tissue. There is no information concerning the possible occurrences of neurotrophins and their receptors in tendons. In this study, sections of both chronic painful (tendinosis) and pain-free (non-t...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-24.839
更新日期：2009-07-01 00:00:00
abstract：:Calcium/calmodulin-dependent protein kinase II (CaMKII) is considered one of the key intracellular signaling proteins for development of neuropathy. We analyzed the expression of total CaMKII (tCaMKII) and its alpha, beta, gamma and delta isoforms in dorsal root ganglia (DRG) in a rat model of Diabetes mellitus type I...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-29.10.649
更新日期：2014-05-01 00:00:00
abstract：:A battery of horseradish peroxidase-conjugated lectins (Con A, WGA and DBA), as well as conventional histochemical techniques (PAS, saponification, Alcian Blue pH 0.1, 1, 2.5, chlorhydric hydrolisis, neuraminidase, Bromophenol blue, Tioglycollate reduction and Ferric-ferricyanide-FeIII) were used to study the content ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-13.727
更新日期：1998-07-01 00:00:00
abstract：:The pineal organs of 14-week-old domestic geese were investigated with light and electron microscopy. The pineals consisted of a wide distal part and a narrow middle-proximal one. The glands were attached to the intercommissural region via the choroid plexus. The pineal parenchyma was formed by round or elongated foll...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-21.1075
更新日期：2006-10-01 00:00:00
abstract：:Chronic lung allograft dysfunction (CLAD) still remains a major drawback in the outcome following lung transplantation (LTx). New therapeutic strategies are warranted. Growth factors and their receptors like platelet-derived growth factor-receptor (PDGFR) and vascular endothelial growth factor-receptor (VEGFR), may pl...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-18-088
更新日期：2019-07-01 00:00:00
abstract：:The endocrine cells in the gastrointestinal tract of the musk shrew were studied immunohistochemically. Eleven kinds of endocrine cells, immunoreactive for serotonin, somatostatin, gastrin, cholecistokinin, gastric inhibitory polypeptide, motilin, secretin, neurotensin, pancreatic glucagon, enteroglucagon and bovine p...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Many surgical techniques are employed in the treatment of severe obesity. A main consequence of these techniques is the improvement of type 2 Diabetes mellitus. Ghrelin is a gut hormone released in the gastric fundus and corpus, which has been related to diabetic improvement as mentioned in these papers. Sleeve gastre...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-18-200
更新日期：2020-08-01 00:00:00
abstract：:During endotoxic shock, the liver exerts a lipopolysaccharide (LPS) clearance function with the participation of both parenchymal and sinusoidal cells. Liver damage could be caused by LPS direct action, hypoxia and/or inflammatory mediators released by Kupffer cells. The aim of this study is to establish an experiment...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1996-07-01 00:00:00
abstract：:Macrophages are important effector cells in cell-mediated immunity against intracellular infection. Among cytokines that macrophages are able to release are IL-12 and TNF alpha. IL-12 is a critical linker between the innate and adaptive cell-mediated immunity, capable of Th1 differentiation and IFN gamma release by T ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-15.199
更新日期：2000-01-01 00:00:00
abstract：:Heterotopic ossification (HO) is a debilitating condition in which cartilage and bone forms in soft tissues such as muscle, tendon, and ligament causing immobility. This process is induced by inflammation associated with traumatic injury. In an extremely rare genetic disorder called fibrodysplasia ossificans progessiv...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-29.1281
更新日期：2014-10-01 00:00:00
abstract：:The effect of prolonged exposure to normobaric hypoxia on the mitochondria of myocard of rats exposed for several weeks to 8 and 7% O2 has been morphometrically evaluated. Twelve male Wistar rats housed in Nalgene cages (2 per cage) with a batch of six cages placed in plexiglass chambers were maintained in air/N2 mixt...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-14.1045
更新日期：1999-10-01 00:00:00
abstract：:The histological and ultrastructural features, as well as the immunoreactivity of one case of uncommon primary papillary and psammomatous adenocarcinoma of the umbilicus are studied in the present work. The observations have been undertaken in a nine-year follow-up, and have included the primitive tumour, two local re...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1993-10-01 00:00:00
abstract：:CD24 is known to be an important diagnostic and prognostic marker of several major cancers affecting females. We aimed to determine CD24 expression in normal, hyperplastic, and carcinomatous endometrium and its correlation with estrogen and progesterone receptor expression. A total of 271 cases including 62 normal/atr...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-24.309
更新日期：2009-03-01 00:00:00
abstract：:The photoreceptors of the barred owl (Strix varia) consist of rods, single cones and unequal double cones present in a ratio of about 35:1:3. In the light-adapted condition the rods are of uniform diameter along their entire length and are therefore not felt to undergo photomechanical changes. The rod outer segment co...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:E(epithelial)-cadherin is a member of a calcium-dependent family of cell surface glycoproteins involved in cell-cell adhesion and morphogenesis. Catenins are a large family of proteins that connect the cadherins to the cytoskeleton. They are important for cadherin function and for transducing signals involved in speci...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-16.1097
更新日期：2001-10-01 00:00:00
abstract：:Fatty acid binding proteins (FABPs) are 15-kDa proteins responsible for the transport of fatty acids both intracellularly and extracellularly. Consisting of 12 different isoforms, some of the proteins have been found to be released in the serum and to be correlated with various diseases including cancer. Differential ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-18-014
更新日期：2019-01-01 00:00:00
abstract：:We have studied the occurrence and specific features of liver cell dysplasia (LCD) in Chinese patients showing liver cirrhosis with or without hepatocellular carcinoma (HCC). Three types of LCD (SLCD, LLCDo, LLCDe) were morphologically defined, and these types were further analyzed using karyometry, estimation of nucl...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:Differentiating nonspecific interstitial pneumonia (NSIP) from usual interstitial pneumonia (UIP) is important for the determination of both treatment and prognosis. Using two-dimensional fluorescence difference gel electrophoresis (2D-DIGE), we examined 8 UIPs, 8 NSIPs, and 30 normal lung tissues. Comparisons with co...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-29.377
更新日期：2014-03-01 00:00:00
abstract：:Junctional complexes such as tight junctions, adherens junctions, and desmosomes play crucial roles in the structure and function of epithelial cells. These junctions are involved in increasing cell-cell contact and as well serve as signaling centers regulating multiple functions in epithelial cells. Carcinoma cell li...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-20.35
更新日期：2005-01-01 00:00:00
abstract：:In the present study we examined prognostic value of immunohistochemical estimation of topoisomerase 1A (TOP 1A) and HER-2/neu expression in ovarian cancers treated with platinum-based drugs but not with topotecan and the relation between expression of these proteins on the one hand and intensity of proliferation (Ki6...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-21.713
更新日期：2006-07-01 00:00:00
abstract：:Equine endometritis eosinophilica (EE) is rarely described and its diagnostic criteria are not defined. The aim of this study was to characterize histological features of EE. A data base (1995-2013) was searched for biopsies with increased eosinophils. This study included all biopsies with this diagnosis and represent...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-11-872
更新日期：2017-11-01 00:00:00
abstract：:An inadequate balance between oxidant species and antioxidant mechanisms may constitute the primary mechanisms of a number of pathologies. The liver plays a central role in this balance: parenchymal hepatic cells contain and export especially high levels of the antioxidant glutathione and activated Kupffer cells relea...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-22.399
更新日期：2007-04-01 00:00:00
abstract：:In this paper we report the first complete mapping of the pituitary in a tuna species. The various different adenohypophysis cell types of the bluefin tuna, Thunnus thynnus L. have been identified and located using different antisera against mammalian and piscine hormones and various histochemical techniques: PAS, Alc...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-16.443
更新日期：2001-04-01 00:00:00
abstract：:Histochemical distribution of glycoproteins, carbohydrates and proteins rich in different amino acids were studied using histological and histochemical procedures, in Senegal sole, Solea senegalensis (Kaup, 1858) larvae from hatching until day 15. Glycogen, proteins and glycoproteins were detected in the yolk-sac of t...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
