Abstract：
:There is now evidence that estrogens and androgens are exerting their effects in different tissues throughout the body. In order to determine the sites of action of these steroids, studies have been performed to identify at the cellular level the localization of androgen receptor (AR) and the two estrogen receptor (ER) subtypes, ERalpha and ERbeta, specially in the rat, monkey and human. In the prostate, AR was observed in the secretory and stromal cells. In the testis, Sertoli, Leydig and myoid cells were labelled. In the epididymis and seminal vesicles, both epithelial and stromal cells contained AR. In the ovary, AR was detected in granulosa and interstitial cells. In the uterus, epithelial, stromal and muscle cells were all immunopositive for AR. In the central nervous system, AR-containing neurons were found to be widely distributed throughout the brain. In the mammary gland, epithelial cells in acini and ducts and stromal cells were demonstrated to express AR. In the skin, AR was detected in keratinocytes, sebaceous and sweat glands, and hair follicles. In addition, AR was also found in anterior pituitary, thyroid, adrenal cortex, liver, kidney tubules, urinary bladder, cardiac and striated muscle, and bone. The ER subtypes are in general differentially expressed. While ERalpha has been predominantly found in anterior pituitary, uterus, vagina, testis, liver and kidney, ERbeta is predominant in thyroid, ovary, prostate, skin, bladder, lungs, gastro-intestinal tract, cartilage and bone. In tissues which contain both receptor subtypes, such as ovary, testis and various regions of the brain, a cell-specific localization for each ER subtype has been generally observed. Altogether, the recent results on the cellular localization of sex steroid receptors will certainly contribute to a better understanding of the specific role of these steroids in different target organs.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Pelletier Gdoi
10.14670/HH-15.1261subject
Has Abstractpub_date
2000-10-01 00:00:00pages
1261-70issue
4eissn
0213-3911issn
1699-5848journal_volume
15pub_type
杂志文章,评审abstract：:Oral squamous cell carcinoma is the most common head and neck malignancy, characterised by high invasive capacity, lymph node metastasis, and high recurrence rate. Among the morphological features of oral cancer, the tumour-associated tissue eosinophilia has gained growing interest in the last years. Eosinophils are a...
journal_title：Histology and histopathology
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journal_title：Histology and histopathology
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doi：10.14670/HH-15.1059
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journal_title：Histology and histopathology
pub_type： 杂志文章
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journal_title：Histology and histopathology
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journal_title：Histology and histopathology
pub_type： 杂志文章,评审
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abstract：:Ewing-like sarcomas (ELS) are a heterogenous group of tumors that frequently affect pediatric and young adult patients. Accurate classification and distinction from the Ewing sarcoma family of tumor (ESFT) is decisive in patient management. ELS share a significant morphologic, immunohistochemical and clinical overlap ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-11-792
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journal_title：Histology and histopathology
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更新日期：2001-07-01 00:00:00
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journal_title：Histology and histopathology
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doi：10.14670/HH-29.343
更新日期：2014-03-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-16.713
更新日期：2001-07-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-14.1045
更新日期：1999-10-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-11-601
更新日期：2015-08-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-29.1249
更新日期：2014-10-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-18.207
更新日期：2003-01-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-11-778
更新日期：2017-02-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-18.1219
更新日期：2003-10-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-24.141
更新日期：2009-02-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-24.1213
更新日期：2009-10-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章,评审
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更新日期：2012-04-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-22.177
更新日期：2007-02-01 00:00:00
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journal_title：Histology and histopathology
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doi：
更新日期：1990-07-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章,评审
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更新日期：2020-09-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
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更新日期：2018-09-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章,评审
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更新日期：2010-07-01 00:00:00
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journal_title：Histology and histopathology
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doi：
更新日期：1994-04-01 00:00:00
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journal_title：Histology and histopathology
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doi：10.14670/HH-28.61
更新日期：2013-01-01 00:00:00
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journal_title：Histology and histopathology
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更新日期：2010-04-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-11-673
更新日期：2016-03-01 00:00:00
abstract：:Osteoclasts are physiological polykaryons specialized in the resorption of calcified tissue. In the context of the clinical use of calcium-phosphate (CaP) ceramics as bone substitutes, this study used transmission electron microscopy to investigate the in vitro mechanisms of CaP ceramic degradation by osteoclastic cel...
journal_title：Histology and histopathology
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doi：10.14670/HH-16.37
更新日期：2001-01-01 00:00:00
