Understanding the role of the cytoskeleton in the complex regulation of the endothelial repair.

Abstract:

:Actin microfilaments and microtubules are important cytoskeletal proteins that regulate endothelial repair through alterations in cell shape and through regulation of cell migration following wounding of the endothelium. Upstream pathways have been identified in the regulation of actin and microtubule organization, especially small GTPases. Recently, there have been numerous proteins suggested to be capable of regulating interaction between microtubules and microfilaments to mediate microtubule regulation of endothelial repair, an important process in limiting injury to the artery wall and in reducing the extent of arterial disease. If disrupted, a rapid repair mechanism is important in reestablishing the integrity of the endothelium in order to reestablish its function as a macromolecular barrier, a thromboresistant surface, and a biologically active tissue. Strategies to improve repair should alter the pathobiology of the atherosclerotic plaque and thus improve the prognosis of patients with atherosclerosis.

journal_name

Histol Histopathol

authors

Lee JS,Gotlieb AI

doi

10.14670/HH-18.879

subject

Has Abstract

pub_date

2003-07-01 00:00:00

pages

879-87

issue

3

eissn

0213-3911

issn

1699-5848

journal_volume

18

pub_type

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