Abstract：
:This paper reports the histopathological findings in the eyes of a 26-year-old female patient diagnosed with systemic lupus erythematosus (SLE) with peripheral neuropathy. The patient had no significant ocular problems. She died of pneumonia after two years of suffering. The eyeballs were procured at autopsy and the retina, choroid and optic nerve processed for light and electron microscopy, and immunohistochemistry for immunoglobulin G (IgG), glial fibrillary acidic protein (GFAP), calbindin and parvalbumin. Histologically, there was haemorrhaging in the retinal nerve fibre layer. Ultrastructurally, the axons of this layer were swollen, and contained an unusual accumulation of microtubules and smooth endoplasmic reticulum. There were degenerative changes in the pericytes and smooth muscle cells of blood vessels. The capillary lumen was partially obliterated, and contained IgG, which was also detected throughout the choroid and wall of choroidal arterioles. The latter and Bruch's membrane showed fibrin deposits. The optic nerve showed infiltrated mononuclear cells near the degenerated axons, these axons lacked immunoreactivity to calbindin and parvalbumin. Compared to the control, the connective tissue sheaths of the central retinal vessels possessed a vast number of proliferated fibroblast cells, and trichrome staining showed transmural vessel scarring. Dense GFAP immunoreactivity was observed surrounding the vessel wall. These pathological changes are due to impaired blood circulation caused by haemorrhaging and vasculitis, and vessel occlusion by fibrin. The nature of the changes observed tends to indicate that a regular, thorough ophthalmic examination should be conducted even in the absence of significant ocular symptoms in SLE.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Nag TC,Wadhwa Sdoi
10.14670/HH-20.373subject
Has Abstractpub_date
2005-04-01 00:00:00pages
373-82issue
2eissn
0213-3911issn
1699-5848journal_volume
20pub_type
杂志文章abstract：:The aim of this study was to examine the effects of timolol in an experimental model of elevated intraocular pressure (IOP). Three episcleral veins of rats with normal IOP were cauterized. Three months later we examined the effects on anterograde axonal transport from the retinal ganglion cells (RGCs) to the superior ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-20.1077
更新日期：2005-10-01 00:00:00
abstract：:HNK-1 positive (HNK-1+) cells in human peripheral blood and lymph nodes were comparatively analysed by means of immunohistochemistry and immunoelectron microscopy. In peripheral blood, the HNK-1+ cells were grouped into large granular lymphocytes (LGLs), small lymphocytes and intermediate forms, all of which had many ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1989-04-01 00:00:00
abstract：:The salamanderfish, Lepidogalaxias salamandroides (Galaxiidae, Teleostei) is endemic to southwestern Australia and inhabits shallow, freshwater pools which evaporate during the hot summer months. Burrowing into the substrate in response to falling water levels allows these fish to aestivate for extended periods of tim...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-13.1037
更新日期：1998-10-01 00:00:00
abstract：:Factor H (FH) is the predominant soluble inhibitor of the complement system. With a concentration of 200-800 microg/ml in human and rat plasma it acts as a cofactor for the soluble factor I (FI)-mediated cleavage of the component C3b to iC3b. Furthermore it competes with factor B for binding to C3b and C3(H2O) and pro...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-21.93
更新日期：2006-01-01 00:00:00
abstract：:Recent data challenge the relevance of the RB pathway to cancer based on RB inactivation, at least in breast tumors. To obtain information on the actual role of the components of the RB pathway in tumor progression we decided to investigate whether their quantitative changes were associated with variations in the leve...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-22.769
更新日期：2007-07-01 00:00:00
abstract：:The distribution of peptidergic nerves in canine mammary tissues was studied by immunohistochemical techniques. In addition, the general and the noradrenergic innervations were demonstrated using protein gene product 9.5 and tyrosine hydroxylase immunoreactivities as markers, respectively. Tissue specimens from the ca...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-22.1175
更新日期：2007-11-01 00:00:00
abstract：:The possibility of resuscitating livers after warm ischaemia has been recently suggested. The aim of the present investigation was to analyse the effects of anoxia on the morphology of hepatic cells, to determine whether these effects are reversible after providing a resuscitation period between warm ischaemia (WI) an...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:The aim of our study was to document whether relationships existed among bone morphogenetic proteins (BMPs), peripheral nerve and neoplastic lesions of nerve sheath tumors. The mRNA transcriptions of BMP-2, 3, 4 and 5 in 10 cases of schwannoma, three cases of malignant schwannoma and two cases of trigeminal neuralgia ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-16.1013
更新日期：2001-10-01 00:00:00
abstract：:Ductular hepatocytes are observed in the livers of both experimental animals and man under various conditions of severe toxin-, carcinogen- or viral-induced hepatic injury with prominent loss of parenchymal hepatocytes. These unique hepatic epithelial cells are characterized by phenotypic traits that are intermediate ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1995-04-01 00:00:00
abstract：:The rapid Golgi method, combined with current optical and electronmicroscopical techniques, was used in three central gangliogliomas and in one dysplastic gangliocytoma of the cerebellum to study the morphology of ganglionic cells. Gangliogliomas were composed of bipolar, fusiform and radiate cells with dense core and...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：:Dimethylnitrosamine (DMN) induced liver injury in rats with cell necrosis, inflammation, hemorrhages, increased collagen type III synthesis and basement membrane component laminin and collagen IV localization in perisinusoidal sites. Malotilate ingestion during DMN treatment abolished inflammation and decreased inters...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Chaperone-mediated autophagy (CMA), a selective form of autophagy, where cellular proteins with KFERQ-like motif are targeted to the lysosome for degradation, is necessary to maintain cellular homeostasis. The role of CMA in neurodegenerative diseases has been extensively studied in the past decades, with defects in t...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-18-202
更新日期：2020-07-01 00:00:00
abstract：:Histochemical distribution of glycoproteins, carbohydrates and proteins rich in different amino acids were studied using histological and histochemical procedures, in Senegal sole, Solea senegalensis (Kaup, 1858) larvae from hatching until day 15. Glycogen, proteins and glycoproteins were detected in the yolk-sac of t...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
abstract：:Glomerular alterations of experimental diabetes mellitus are observed in animals submitted to a reduction in renal mass, suggesting that some mechanisms responsible for the progression of renal disease are common. The aim of this study was to investigate the effect of nephrectomy on the renal function and morphology o...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-19.1085
更新日期：2004-10-01 00:00:00
abstract：:Erythema dyschromicum perstans (EDP) and vitiligo are two cutaneous pigmentary dermatoses of unknown etiology. In the present study, the leukocyte infiltrates in the affected skin of EDP and vitiligo patients were studied using the avidin-biotin (ABC) immunoperoxidase technique and monoclonal antibodies which recognis...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1987-07-01 00:00:00
abstract：:In this article we review immunocytochemical localization studies using a monoclonal antibody raised against the 31 kD subunit of bovine H(+)-ATPase, and indirect immunofluorescent staining. In the proximal tubules there is intense H(+)-ATPase staining along the brush borders of S1 and S2, and linear subvillar invagin...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1997-07-01 00:00:00
abstract：:The developing fetal brain is one of the most susceptible organs to irradiation insult. Prenatal irradiation-induced abnormalities in the cerebrum have been well examined in mouse fetuses. However, little information on abnormalities in the cerebellum caused by irradiation is available. Moreover, few reports have exam...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-23.953
更新日期：2008-08-01 00:00:00
abstract：:The hindgut is the major site in the horse for nutrient digestion and absorption. Most of this activity occurs in the large intestinal compartments, i.e., cecum, right and left ventral colon and left and right dorsal colon. The colonic pelvic flexure is a short and narrow loop connecting the left ventral and left dors...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-15.983
更新日期：2000-07-01 00:00:00
abstract：:The anti-oxidant food additive, butylated hydroxytoluene (BHT), was fed to Sprague-Dawley rats at three concentrations: 0.2%, 0.4% and 0.8% for periods of 6, 12, 18 and 24 weeks, and the results were compared with corresponding groups treated with a potent carcinogen, 7,12-dimethylbenz[a]anthracene (DMBA) groups, with...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-14.391
更新日期：1999-04-01 00:00:00
abstract：:The effects induced by different concentrations (50, 75, 100 microM) of the cytostatic drug cisplatin (cDDP) in NIH/3T3 cells were analyzed. Sub-confluent cultures of this mouse fibroblast line, obtained after serum deprivation, showed the presence of aneuploid/polyploid cells with ploidy values ranging from 4c to 24c...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-23.717
更新日期：2008-06-01 00:00:00
abstract：:Recently ultraviolet light (UV) reaching the Earth's surface has been gradually increasing in amounts by the destruction of the ozone layers. Large parts of UV are absorbed in the cornea and lens, and only a few amounts reached the retina; however, the effect on the retina is not fully elucidated. 38 rats were irradia...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1996-07-01 00:00:00
abstract：:Testis samples were taken from young (3 months), middle-aged (12 months) and aged (24 months) male rats, processed, stained and examined via a light microscope. There were no prominent abnormal germinal epithelium and interstitial tissue. However, the aging process promoted a significant decrease in the mean amount of...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1988-10-01 00:00:00
abstract：:Since endometriosis is a proliferative disease we evaluated the presence of anti-apoptotic factor (Bcl-2) and pro-apoptotic factor (Bax) in deep pelvic endometriosis. A Cross-sectional observational study was performed at Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil. Forty women aged 26 to 46 years with ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-29.1129
更新日期：2014-09-01 00:00:00
abstract：:Spinal cord injury (SCI) is one of the most destructive traumatic diseases in human beings. The balance of inflammation in the microenvironment is crucial to the repair process of spinal cord injury. Inflammatory cytokines are direct mediators of local lesion inflammation and affect the prognosis of spinal cord injury...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-18-262
更新日期：2020-10-01 00:00:00
abstract：:Sixty male Wistar rats were used for this experiment and assigned at random to the control group or to the stimulation method. Control rats show cerebral asymmetry with right bias at the frontal and occipital lobes. In the case of stimulated rats the differences from the occipital zone increase while those from the fr...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
abstract：:The population of the world grows every year, and life expectancy tends to increase. Thus, long-term preservation of teeth in aged individuals is an urgent issue. The main causes of tooth loss are well known to be periodontitis, caries, fractures, and orthodontic conditions. Although implant placement is a widely acce...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-29.1249
更新日期：2014-10-01 00:00:00
abstract：:Ebulin f is a ribosome-inactivating protein (RIP) present in green fruits of the dwarf elder (Sambucus ebulus L). Since dwarf elder fruits are used for food and as a medicine, we assessed the study of toxicological effects and safety of ebulin f in elderly mice, comparing these results with those reported in young ani...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-11-992
更新日期：2018-09-01 00:00:00
abstract：:To investigate the matrix metalloproteinase (MMP)-9, (MMP)-13, E-Cadherin and Ki-67 expressions in road pavers' skin chronically exposed to bitumen products in order to contribute to a better understanding of the earlier tissue alteration. Skin punch biopsies from 16 daily exposed workers and a control group were stud...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-18-116
更新日期：2019-10-01 00:00:00
abstract：:Since bone marrow stromal cells (MSCs) are easily accessible both from healthy donors and patients, and can be expanded on a therapeutic scale, they have attracted attention for cell-based therapy. MSCs contribute to the protection of host tissue after transplantation by Immune modulation and trophic effect. They also...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-24.631
更新日期：2009-05-01 00:00:00
abstract：:To determine the appropriate time for bone reconstruction after irradiation, the healing process after autogenous iliac bone transplantation in the irradiated parietal bone was examined by scanning electron microscopy and light microscopy. Bone transplantation was carried out at the second and the fourth weeks after C...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-15.7
更新日期：2000-01-01 00:00:00
