Abstract：
:The hindgut is the major site in the horse for nutrient digestion and absorption. Most of this activity occurs in the large intestinal compartments, i.e., cecum, right and left ventral colon and left and right dorsal colon. The colonic pelvic flexure is a short and narrow loop connecting the left ventral and left dorsal colon. It is not significant directly in digestive and absorptive processes but plays an important functional role in regulating colonic aboral and retropropulsive transit of digesta through its motility pacemaker activity. The pelvic flexure also contributes to the pathophysiology of colic, the leading cause of death in horses. Its narrow lumen may contribute to colonic impaction, and malfunctions of the pacemaker may contribute to volvuli and colonic displacements. Neuronal and ganglion density of the myenteric plexus is increased at the pelvic flexure and adjacent left dorsal colon pacemaker region. Contractile activity, vasoactive intestinal peptide (VIP) and neurokinins-1 and -3 are all enhanced in the pelvic flexure. The mucosa histologically resembles that of the ventral and dorsal colon, with apically-granulated principal cells and goblet cells lining the luminal surface. Clustered intranuclear inclusions resembling the cytoplasmic granules are also observed by electron microscopy in the principal cells as elsewhere in the horse colon. Further neuroendocrine and morphologic investigation of the pelvic flexure is warranted due to the great importance of this localized region for normal function and pathophysiology.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Lopes MA,Pfeiffer CJdoi
10.14670/HH-15.983subject
Has Abstractpub_date
2000-07-01 00:00:00pages
983-91issue
3eissn
0213-3911issn
1699-5848journal_volume
15pub_type
杂志文章,评审abstract：:Chorioamnionitis and preeclampsia account for the majority of preterm births worldwide. Thus far, adequate methods for early detection or prevention of these diseases are lacking. In preeclampsia, accelerated villous maturation is believed to compensate placental insufficiency. However, little is known about the effec...
journal_title：Histology and histopathology
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journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
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abstract：:The pancreatic-duct system was observed during the initial stage of type 1 diabetes in C57BL/6J mice rendered diabetic with low doses of streptozocin. Light microscopy revealed that the ducts located in close proximity to islets (islet ducts) were involved in the infiltrating process: inflammatory cells extended from ...
journal_title：Histology and histopathology
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journal_title：Histology and histopathology
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doi：10.14670/HH-29.1017
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更新日期：2011-06-01 00:00:00
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journal_title：Histology and histopathology
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更新日期：1996-10-01 00:00:00
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journal_title：Histology and histopathology
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更新日期：1991-07-01 00:00:00
