Functional morphology of the equine pelvic flexure and its role in disease. A review.

Abstract:

:The hindgut is the major site in the horse for nutrient digestion and absorption. Most of this activity occurs in the large intestinal compartments, i.e., cecum, right and left ventral colon and left and right dorsal colon. The colonic pelvic flexure is a short and narrow loop connecting the left ventral and left dorsal colon. It is not significant directly in digestive and absorptive processes but plays an important functional role in regulating colonic aboral and retropropulsive transit of digesta through its motility pacemaker activity. The pelvic flexure also contributes to the pathophysiology of colic, the leading cause of death in horses. Its narrow lumen may contribute to colonic impaction, and malfunctions of the pacemaker may contribute to volvuli and colonic displacements. Neuronal and ganglion density of the myenteric plexus is increased at the pelvic flexure and adjacent left dorsal colon pacemaker region. Contractile activity, vasoactive intestinal peptide (VIP) and neurokinins-1 and -3 are all enhanced in the pelvic flexure. The mucosa histologically resembles that of the ventral and dorsal colon, with apically-granulated principal cells and goblet cells lining the luminal surface. Clustered intranuclear inclusions resembling the cytoplasmic granules are also observed by electron microscopy in the principal cells as elsewhere in the horse colon. Further neuroendocrine and morphologic investigation of the pelvic flexure is warranted due to the great importance of this localized region for normal function and pathophysiology.

journal_name

Histol Histopathol

authors

Lopes MA,Pfeiffer CJ

doi

10.14670/HH-15.983

subject

Has Abstract

pub_date

2000-07-01 00:00:00

pages

983-91

issue

3

eissn

0213-3911

issn

1699-5848

journal_volume

15

pub_type

杂志文章,评审
  • Changes of calcium/calmodulin-dependent protein kinase II expression in dorsal root ganglia during maturation in long-term diabetes.

    abstract::Calcium/calmodulin-dependent protein kinase II (CaMKII) is considered one of the key intracellular signaling proteins for development of neuropathy. We analyzed the expression of total CaMKII (tCaMKII) and its alpha, beta, gamma and delta isoforms in dorsal root ganglia (DRG) in a rat model of Diabetes mellitus type I...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-29.10.649

    authors: Ferhatovic L,Jelicic Kadic A,Boric M,Puljak L

    更新日期:2014-05-01 00:00:00

  • Histochemical study of skin and gills of Senegal sole, Solea senegalensis larvae and adults.

    abstract::A battery of horseradish peroxidase-conjugated lectins (Con A, WGA and DBA), as well as conventional histochemical techniques (PAS, saponification, Alcian Blue pH 0.1, 1, 2.5, chlorhydric hydrolisis, neuraminidase, Bromophenol blue, Tioglycollate reduction and Ferric-ferricyanide-FeIII) were used to study the content ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-13.727

    authors: Sarasquete C,González de Canales ML,Arellano J,Muñoz Cueto JA,Ribeiro L,Dinis MT

    更新日期:1998-07-01 00:00:00

  • Description of primordial germ cells, oogonia, oocytes and embryo-like growth in squash preparations of tissues from hematological malignancies.

    abstract::This study evidences the presence of primordial germ cells, in tissue squash preparations and sections from hematological malignancies. Primordial germ cells were identified by their morphology, the intense PAS, PAS-D reaction and presence of calcium-activated neutral proteinase. Primordial germ cells gave rise to nuc...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Logothetou-Rella H

    更新日期:1996-10-01 00:00:00

  • Might the Masson trichrome stain be considered a useful method for categorizing experimental tendon lesions?

    abstract::Strain injuries of tendons are the most common orthopedic injuries in athletic subjects, be they equine or human. When the tendon is suddenly damaged, an acute inflammatory phase occurs whereas its repetitive overloading may cause chronic injuries. Currently the criteria used for grading injuries are general and subje...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-11-601

    authors: Martinello T,Pascoli F,Caporale G,Perazzi A,Iacopetti I,Patruno M

    更新日期:2015-08-01 00:00:00

  • Defect of the cerebellar vermis induced by prenatal gamma-ray irradiation in radiosensitive BALB/c mice.

    abstract::The developing fetal brain is one of the most susceptible organs to irradiation insult. Prenatal irradiation-induced abnormalities in the cerebrum have been well examined in mouse fetuses. However, little information on abnormalities in the cerebellum caused by irradiation is available. Moreover, few reports have exam...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-23.953

    authors: Saito A,Yamauchi H,Ishida Y,Ohmachi Y,Nakayama H

    更新日期:2008-08-01 00:00:00

  • C-reactive protein levels are associated with the progression of atherosclerotic lesions in rabbits.

    abstract::Elevated plasma levels of C-reactive protein (CRP) are associated with increased risk of cardiovascular disease. CRP immunoreactive protein is also detected in the lesions of atherosclerosis. However, it is not known whether the CRP contents of atherosclerotic lesions are associated with the initiation and progression...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-27.529

    authors: Yu Q,Li Y,Wang Y,Zhao S,Yang P,Chen Y,Fan J,Liu E

    更新日期:2012-04-01 00:00:00

  • Muscle fiber types in tetrapods. A comparative histochemical and morphometric study.

    abstract::A comparative histochemical and morphometric study in two groups of homologous muscles from different tetrapods (rat, pigeon, lizard and frog) was performed. On the basis of their fiber diameters and oxidative enzyme activities, an initial correlation between fiber types of all animals is observed, although in the liz...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Burgos Bretones JJ,Razquin Peralta B,Aguirre Urizar J,Rivera Pomar JM

    更新日期:1987-01-01 00:00:00

  • Pancreatic duct infiltration in the low-dose streptozocin-treated mouse.

    abstract::The pancreatic-duct system was observed during the initial stage of type 1 diabetes in C57BL/6J mice rendered diabetic with low doses of streptozocin. Light microscopy revealed that the ducts located in close proximity to islets (islet ducts) were involved in the infiltrating process: inflammatory cells extended from ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Papaccio G,Strate C,Linn T

    更新日期:1994-07-01 00:00:00

  • TNF-alpha/IL-1/NF-kappaB transduction pathway in human cancer prostate.

    abstract::TNFalpha exerts apoptosis throughout an intracellular transduction pathway that involves the kinase proteins TRAF-2 (integration point of apoptotic and survival signals), ASK1 (pro-apoptotic protein), MEK-4 (p38 activator and metastasis suppressor gene), JNK (stress mitogen activated protein kinase) and the transcript...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-23.1279

    authors: Royuela M,Rodríguez-Berriguete G,Fraile B,Paniagua R

    更新日期:2008-10-01 00:00:00

  • Primordial germ cell specification: the importance of being 'blimped'.

    abstract::In mouse embryos, the expression of Blimp1 has recently revealed a population of allocated primordial germ cell precursors 24 hours earlier than previously thought. Those 'blimped' precursors have been shown to give rise, by mitotic division, to germ cells only and no other cell lineages. Here, we try to understand th...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-23.1553

    authors: Chuva de Sousa Lopes SM,Roelen BA

    更新日期:2008-12-01 00:00:00

  • Effects of sex steroids on the Syrian hamster liver.

    abstract::The primary objective of this research project was to study the role of sex steroids in the pathogenesis of cholelithiasis using the Syrian hamster as a model. In addition to the morphological examination of the gallbladder epithelium, we thought it imperative to observe the changes induced in the biliary tract in res...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Karkare S,Adamiec-Beyga E,Gilloteaux J

    更新日期:1995-07-01 00:00:00

  • Nitric oxide synthase in the pineal gland.

    abstract::The recent discovery of nitric oxide (NO) as a biological messenger molecule with unique characteristics has opened a new field in pineal research. This free radical gas is synthesized by the enzyme nitric oxide synthase (NOS) from L-arginine. The activation of adrenoreceptors in the membrane of the pinealocytes media...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:

    authors: López-Figueroa MO,Møller M

    更新日期:1996-10-01 00:00:00

  • Effects of a non-selective beta-blocker on adult rat anterograde axonal transport and retinal ganglion layer after increased intraocular pressure.

    abstract::The aim of this study was to examine the effects of timolol in an experimental model of elevated intraocular pressure (IOP). Three episcleral veins of rats with normal IOP were cauterized. Three months later we examined the effects on anterograde axonal transport from the retinal ganglion cells (RGCs) to the superior ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-20.1077

    authors: Díaz F,Villena A,Moreno M,Vidal L,Parrado C,García-Campos J,de Vargas IP

    更新日期:2005-10-01 00:00:00

  • In vivo cellular uptake of bismuth ions from shotgun pellets.

    abstract::Shotgun pellets containing bismuth (Bi) are widely used and may cause a rather intense exposure of some wild animals to Bi. A Bi shotgun pellet was implanted intramuscularly in the triceps surae muscle of 18 adult male Wistar rats. Another group of 9 animals had a Bi shotgun pellet implanted intracranially in the neoc...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-18.781

    authors: Stoltenberg M,Locht L,Larsen A,Jensen D,Danscher G

    更新日期:2003-07-01 00:00:00

  • Time-dependent effects of maternal continuous propranolol on fetal lung development in rats.

    abstract::Previous studies have demonstrated a role for the beta-adrenergic system in the maturation of the fetal alveolar epithelium. Chronic blockade of beta-adrenergic binding sites has been shown to adversely effect physiologic and biochemical indices of fetal lung maturation. In the present study timed-pregnant female Spra...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-17.365

    authors: Smith DM,Sommers SS

    更新日期:2002-04-01 00:00:00

  • Presence and distribution of 5HT-, VIP-, NPY-, and SP-immunoreactive structures in adult mouse lung.

    abstract::A large number of biologically active substances have been identified and characterised in the respiratory tract of several mammals. These substances (amines and peptides) exert important regulatory influences on respiratory functions, and they act as neurotransmitters/neuromodulators, both being released from nerve t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Verástegui C,Fernández-Vivero J,Prada A,Rodríguez F,Romero A,González-Moreno M,de Castro JM

    更新日期:1997-10-01 00:00:00

  • Ewing sarcoma and the new emerging Ewing-like sarcomas: (CIC and BCOR-rearranged-sarcomas). A systematic review.

    abstract::Ewing-like sarcomas (ELS) are a heterogenous group of tumors that frequently affect pediatric and young adult patients. Accurate classification and distinction from the Ewing sarcoma family of tumor (ESFT) is decisive in patient management. ELS share a significant morphologic, immunohistochemical and clinical overlap ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-11-792

    authors: Machado I,Navarro S,Llombart-Bosch A

    更新日期:2016-11-01 00:00:00

  • The effect of somatostatin analog octreotide on diethylstilbestrol-induced prolactin secretion, cell proliferation and vascular changes in the rat anterior pituitary gland.

    abstract::The effects of diethylstilbestrol (DES) and of long-acting somatostatin analog, octreotide (SMS) on the rat anterior pituitary microvasculature have been studied by means of computer-assisted image analysis. Additionally, the effects of DES and SMS on prolactin secretion and anterior pituitary cell proliferation have ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Pawlikowski M,Kunert-Radek J,Grochal M,Zieliński K,Kulig A

    更新日期:1997-10-01 00:00:00

  • Telocytes form networks in normal cardiac tissues.

    abstract::Telocytes (TC) are a class of interstitial cells present in heart. Their characteristic feature is the presence of extremely long and thin prolongations (called telopodes). Therefore, we were interested to see whether or not TCs form networks in normal cardiac tissues, as previously suggested. Autopsy samples of card...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-27.807

    authors: Rusu MC,Pop F,Hostiuc S,Curca GC,Jianu AM,Paduraru D

    更新日期:2012-06-01 00:00:00

  • The role of TET family proteins and 5-hydroxymethylcytosine in human tumors.

    abstract::Tumorigenesis correlates with hypermethylation of tumor suppressors and hypomethylation of oncogenes. DNA methyltransferases (DNMTs) catalyze DNA methylation, and mutations and aberrant expression in DNMT genes are found in multiple human tumors. The discovery of the DNA demethylation function of TET proteins has open...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-29.991

    authors: Wu YC,Ling ZQ

    更新日期:2014-08-01 00:00:00

  • Melanopsin-expressing retinal ganglion cells in aging and disease.

    abstract::Melanopsin-expressing retinal ganglion cells (mRGCs) constitute a system in the mammalian retina used for irradiance detection, regulating non-image forming functions, such as photoentrainment of circadian rhythms, control of the pupillary light reflex, masking response, light-regulated melatonin secretion, and modula...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-18-138

    authors: Esquiva G,Hannibal J

    更新日期:2019-12-01 00:00:00

  • Alterations induced by E-cadherin and beta-catenin antibodies during the development of Bufo arenarum (Anura-Bufonidae).

    abstract::E(epithelial)-cadherin is a member of a calcium-dependent family of cell surface glycoproteins involved in cell-cell adhesion and morphogenesis. Catenins are a large family of proteins that connect the cadherins to the cytoskeleton. They are important for cadherin function and for transducing signals involved in speci...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-16.1097

    authors: Izaguirre MF,Adur JF,Soler AP,Casco VH

    更新日期:2001-10-01 00:00:00

  • Hepatic response to chronic hypoxia in experimental rat model through HIF-1 alpha, activator protein-1 and NF-kappa B.

    abstract::Chronic liver diseases are commonly associated with tissue hypoxia that may cause inflammation, oxidative stress, liver cell injury and increased nuclear transcriptional regulation. The hepatic response to chronic hypoxia at the molecular level has not yet been clearly understood until now. The aim of this study is to...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Lau TY,Xiao J,Liong EC,Liao L,Leung TM,Nanji AA,Fung ML,Tipoe GL

    更新日期:2013-04-01 00:00:00

  • Tracing the accumulation and effects of mercury uptake in the previtellogenic ovary of crucian carp, Carassius auratus gibelio by autometallography and caspase-3 immunohistochemistry.

    abstract::The aims of the present study were to apply the AMG technique for localization of mercury at the light and electron microscopic level in the ovary of crucian carp after exposure to mercuric chloride and to find out if this heavy metal induces expression of caspase-3. Depending on the stage of ovarian follicle developm...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-24.141

    authors: Zarnescu O

    更新日期:2009-02-01 00:00:00

  • Oxidized regenerated cellulose does not prevent the formation of experimental postoperative perineural fibrosis assessed by digital analysis.

    abstract:INTRODUCTION:It is difficult to prevent and treat intra- and peri-neural fibrosis after peripheral nerve surgery. Many authors have attempted to develop and verify the effectiveness of substances to decrease the formation of adherences in different tissues. MATERIAL AND METHODS:this study aimed to assess the effective...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-25.741

    authors: Hernández-Cortés P,Peregrina M,Aneiros-Fernández J,Tassi M,Pajares-López M,Toledo M,O'Valle F

    更新日期:2010-06-01 00:00:00

  • Vacuolar-type proton pump ATPases: roles of subunit isoforms in physiology and pathology.

    abstract::The vacuolar-type H(+)-ATPases (V-ATPases) are a family of multi-subunit ATP-dependent proton pumps involved in diverse cellular processes, including acid/base homeostasis, receptor-mediated endocytosis, processing of proteins and signaling molecules, targeting of lysosomal enzymes, and activation of various degradati...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-25.1611

    authors: Sun-Wada GH,Wada Y

    更新日期:2010-12-01 00:00:00

  • Immunocytohistochemical characterization of pituitary cells of the bluefin tuna, Thunnus thynnus L.

    abstract::In this paper we report the first complete mapping of the pituitary in a tuna species. The various different adenohypophysis cell types of the bluefin tuna, Thunnus thynnus L. have been identified and located using different antisera against mammalian and piscine hormones and various histochemical techniques: PAS, Alc...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-16.443

    authors: Rodríguez-Gómez FJ,Rendón-Unceta MC,Piñuela C,Muñoz-Cueto JA,Jiménez-Tenorio N,Sarasquete C

    更新日期:2001-04-01 00:00:00

  • Studies on the involvement of endogenous neuropeptides in the control of thymocyte proliferation in the rat.

    abstract::The possible involvement of endogenous vasoactive intestinal peptide (VIP), cholecystokinin (CCK) and neurotensin (NT) in the control of thymocyte proliferation has been investigated in vivo in the immature rat. For this task, we have studied the effects of the administration of selective antagonists of the receptors ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-16.155

    authors: Trejter M,Warchol JB,de Caro R,Brelinska R,Nussdorfer GG,Malendowicz LK

    更新日期:2001-01-01 00:00:00

  • New models towards assessing anti-cancer therapeutics.

    abstract::Cancer is the subject of intense research around the world, but many questions about how the disease works remain unanswered. How exactly does cancer start and how do tumours grow? In fact, at present there are ten times more anticancer drugs being tested in clinical trials than there were 15 years ago. However, many ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-27.157

    authors: Romero-Camarero I,Barajas-Diego M,Castellanos-Martín A,García-Martín Á,Varela G,Abad M,Ludeña MD,Pérez-Losada J,Sánchez-García I

    更新日期:2012-02-01 00:00:00

  • Molecular and cellular mechanisms of heterotopic ossification.

    abstract::Heterotopic ossification (HO) is a debilitating condition in which cartilage and bone forms in soft tissues such as muscle, tendon, and ligament causing immobility. This process is induced by inflammation associated with traumatic injury. In an extremely rare genetic disorder called fibrodysplasia ossificans progessiv...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-29.1281

    authors: Ramirez DM,Ramirez MR,Reginato AM,Medici D

    更新日期:2014-10-01 00:00:00