Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body.

abstract：:Sphingosine kinase functions to phosphorylate sphingosine to sphingosine 1-phosphate (S1P) to keep balance in the metabolites of sphingolipids. There are two isoforms of sphingosine kinase, sphingosine kinase 1 (SphK1) and sphingosine kinase 2 (SphK2). Although SphK1 and SphK2 share high sequence similarity, SphK2 has...

journal_title：Histology and histopathology

authors： Song DD,Zhou JH,Sheng R

更新日期：2018-05-01 00:00:00

abstract：:Multilocular cystic renal cell carcinoma (MCRCC) accounts for approximately 1 to 2% of all renal tumors. This tumor is currently classified as a subtype of clear cell RCC. Clinically, the majority of these tumors are incidentally found. Macroscopically, the tumor is well demarcated and consists of various-sized cysts....

journal_title：Histology and histopathology

authors： Kuroda N,Ohe C,Mikami S,Inoue K,Nagashima Y,Cohen RJ,Pan CC,Michal M,Hes O

更新日期：2012-08-01 00:00:00

abstract：:The morphology of the rat duodenum after chronic treatment with 15% (v/v) ethanol and 4% (v/v) pentanol was studied. Male Wistar rats of experimental groups were given ethanol and pentanol for 15 weeks with food and fluid freely available. Ethanol-15% and 4% pentanol-fed rats showed a significantly reduced fluid and f...

journal_title：Histology and histopathology

authors： Vaquera J,Vaquera A,Girbes T

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Protein tyrosine kinase 7 (PTK7) is a member of receptor protein tyrosine kinase-like molecules, which is involved in tumorigenesis. However, the association between PTK7 expression and its pathological significance in survival prognosis remains under investigation. The purpose of this meta-analysis is to cl...

journal_title：Histology and histopathology

authors： Chen G,Qi S,Yang X,Chen W

更新日期：2018-04-01 00:00:00

abstract：:The integrity of the thymus during early life is necessary for a proper maturation of the neuroendocrine system, including the adrenal axis. The thymic metallopeptide thymulin seems to be a central physiologic mediator of thymus-pituitary communication. Furthermore, neonatal thymulin gene therapy has been shown to pre...

journal_title：Histology and histopathology

authors： Martines E,Reggiani PC,Schwerdt JI,Goya RG,Cónsole G

更新日期：2011-04-01 00:00:00

abstract：:The ultrastructure of the atrial myocardium in the monkey (Macaca fascicularis) was studied after bilateral cervical vagotomy and survival times of 100, 175 and 367 days. Changes were observed in the nucleus and the cytoplasm of the myocyte. Sequestered within the nuclei of the affected myocytes were cytoplasmic organ...

journal_title：Histology and histopathology

authors： Wong WC,Yick TY,Ling EA

更新日期：1989-07-01 00:00:00

abstract：:Thymidine phosphorylase (TP), thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) have been indicated as possible predictive markers for epithelial malignancies. All these three enzymes are actively involved in 5-FU metabolism. In this report, we investigated mRNA expression of these factors with real-...

journal_title：Histology and histopathology

authors： Li H,Suo Z,Zhang Y,Risberg B,Karlsson MG,Villman K,Nesland JM

更新日期：2004-01-01 00:00:00

abstract：:Emperipolesis has recently been described as a constant feature of "biphasic squamoid" papillary renal cell carcinoma (BPRCC). We also noticed this in some high-grade (HG) RCC, which promoted the present study to estimate the incidence of emperipolesis in RCCs and to describe them in further detail. 14 cases of HGRCC ...

journal_title：Histology and histopathology

authors： Rotterova P,Martinek P,Alaghehbandan R,Prochazkova K,Damjanov I,Rogala J,Suster S,Perez-Montiel D,Alvarado-Cabrero I,Sperga M,Svajdler M,Michalova K,Pivovarcikova K,Daum O,Hora M,Dusek M,Ondic O,Stehlikova A,Michal M

更新日期：2018-03-01 00:00:00

abstract：:This study evidences the presence of primordial germ cells, in tissue squash preparations and sections from hematological malignancies. Primordial germ cells were identified by their morphology, the intense PAS, PAS-D reaction and presence of calcium-activated neutral proteinase. Primordial germ cells gave rise to nuc...

journal_title：Histology and histopathology

authors： Logothetou-Rella H

更新日期：1996-10-01 00:00:00

abstract：:Platelet-collagen interaction is a complex event that involves ligand-receptor interaction. There are many adhesive non-integrin receptors for platelets to interact with various types of collagens. These non-integrin receptors also serve as signal transducers both from the outside of platelets to the inside and possib...

journal_title：Histology and histopathology

authors： Chiang TM

更新日期：1999-04-01 00:00:00

abstract：:Endometriosis is a chronic pelvic inflammatory process. Local inflammation is known to play a role in pain and infertility associated with the disease, and may be extensively involved in molecular and cellular processes leading to endometriosis development. In this review, we focus on two inflammatory mediators clearl...

journal_title：Histology and histopathology

authors： Defrère S,González-Ramos R,Lousse JC,Colette S,Donnez O,Donnez J,Van Langendonckt A

更新日期：2011-08-01 00:00:00

abstract：:The FHIT gene encompassing the most active common human fragile region, FRA3B, has been proposed as a tumour suppressor gene for important common human carcinomas. The mechanism in which Fhit protein exerts its tumour suppressor activity is still obscure. To further understand the Fhit function associated with its int...

journal_title：Histology and histopathology

authors： Zhao P,Hou N,Lu Y

更新日期：2006-09-01 00:00:00

abstract：:Peritumoral brain edema (PTBE) is considered to be one of the main biological behaviors of brain glioma. However, the histopathological features of PTBE remain imprecisely defined. We analyzed the histopathological characteristics in the PTBE area of 22 cases of glioma. Microscopically, the pre-existing basic structur...

journal_title：Histology and histopathology

authors： Wang X,Liu X,Chen Y,Lin G,Mei W,Chen J,Liu Y,Lin Z,Zhang S

更新日期：2015-09-01 00:00:00

abstract：:Circadian and seasonal variations were observed in the karyometric index of pinealocytes in the cortical and medullary regions of the distal pineal body. The study involved 70 Wistar rats over a 24-hour interval (0:6, 10:00, 14:00, 18:00, 22:00, 02:00, 06:00 h) during two natural photoluminous periods, i.e. late summe...

journal_title：Histology and histopathology

authors： Cimas García C,Martínez Soriano F,Ruiz Torner A

更新日期：1992-10-01 00:00:00

abstract：:Infection with Helicobacter pylori (H. pylori) strains is linked to an increased risk of inflammation and gastric cancer. To investigate the effects of H. pylori on biological characteristics of gastric epithelial cells SGC-7901, derived from human adenocarcinoma, morphological appearances of both the pathogen and the...

journal_title：Histology and histopathology

authors： Wang P,Mei J,Tao J,Zhang N,Tian H,Fu GH

更新日期：2012-08-01 00:00:00

abstract：:Lewis(y) (Le(y)), also designated CD174, represents a carbohydrate blood group antigen which is strongly expressed in neoplastic gastrointestinal tissues. Previous reports indicated an association between Le(y) expression and apoptosis. Therefore, we tried to elucidate its clinicopathological relevance in a series of ...

journal_title：Histology and histopathology

authors： Baldus SE,Mönig SP,Zirbes TK,Thakran J,Köthe D,Köppel M,Hanisch FG,Thiele J,Schneider PM,Hölscher AH,Dienes HP

更新日期：2006-05-01 00:00:00

abstract：:Various microscopic methods have been used to analyze the morphology and molecular distribution of cells and tissues. Using conventional procedures, however, ischemic or anoxic artifacts are inevitably caused by tissue-resection or perfusion-fixation. The in vivo cryotechnique (IVCT) was developed to overcome these pr...

journal_title：Histology and histopathology

authors： Ohno N,Terada N,Saitoh S,Zhou H,Fujii Y,Ohno S

更新日期：2007-11-01 00:00:00

abstract：:In order to analyze the incidence and prevalence of Human Papillomavirus (HPV) in penile carcinoma, we studied 49 patients with penile carcinoma. Formalin-fixed, paraffin-embedded tissue samples were collected from 64 samples of penile carcinoma from the Hospital General Universitario (Albacete, Spain). Cases were his...

journal_title：Histology and histopathology

authors： Pascual A,Pariente M,Godínez JM,Sánchez-Prieto R,Atienzar M,Segura M,Poblet E

更新日期：2007-02-01 00:00:00

abstract：:Spinal cord injury (SCI) is one of the most destructive traumatic diseases in human beings. The balance of inflammation in the microenvironment is crucial to the repair process of spinal cord injury. Inflammatory cytokines are direct mediators of local lesion inflammation and affect the prognosis of spinal cord injury...

journal_title：Histology and histopathology

authors： Lin S,Xu C,Lin J,Hu H,Zhang C,Mei X

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Gastric Cardiac Cancer (GCC) has high incidence and poor prognosis requiring early screening of high-risk populations. Minichromosome maintenance (MCM) proteins are used as diagnostic-biomarkers in many cancers but not validated for GCC. We evaluate MCM protein 2 (MCM2), comparing it with the validated marke...

journal_title：Histology and histopathology

authors： Liu M,Li JS,Tian DP,Huang B,Rosqvist S,Su M

更新日期：2013-04-01 00:00:00

abstract：:The anabolic androgenic steroid nandrolone decanoate has minimal androgenic effects and, thus, is widely used to induce muscle hypertrophy in both patients and athletes. Although increases in satellite cell numbers and satellite cells giving rise to new myonuclei are associated with hypertrophy in many experimental mo...

journal_title：Histology and histopathology

authors： Allouh MZ,Rosser BW

更新日期：2010-02-01 00:00:00

abstract：:The hindgut is the major site in the horse for nutrient digestion and absorption. Most of this activity occurs in the large intestinal compartments, i.e., cecum, right and left ventral colon and left and right dorsal colon. The colonic pelvic flexure is a short and narrow loop connecting the left ventral and left dors...

journal_title：Histology and histopathology

authors： Lopes MA,Pfeiffer CJ

更新日期：2000-07-01 00:00:00

abstract：:Morphological, histochemical and ultrastructural investigations on epiphyseal apparatus of Rana Esculenta were made. The most important findings were the following: 1) metaphyseal cartilage is localized inside proximal diaphyseal compact bone as a plug; 2) metaphyseal cartilage do not reduce in thickness during ageing...

journal_title：Histology and histopathology

authors： Dell'Orbo C,Gioglio L,Quacci D

更新日期：1992-04-01 00:00:00

abstract：:Spermatogenesis is under the control of a complex endocrine and paracrine system, including estrogen receptor (ER) signaling. In many target cells, ER promotes the transcription of c-fos and other proto-oncogenes to regulate cell growth and differentiation. Thus, in this study we evaluated the expression of the proto-...

journal_title：Histology and histopathology

authors： Araújo FC,Oliveira CA,Reis AB,Del Puerto HL,Martins AS,Reis FM

更新日期：2009-12-01 00:00:00

abstract：:Adult stem cells (ASC)--able to self renew and to intervene in maintaining the structural and functional integrity of their original tissue--can express greater plasticity than traditionally attributed to them, adopting functional phenotypes and expression profiles of cells from other tissues. Therefore, they could be...

journal_title：Histology and histopathology

authors： Díaz-Flores L Jr,Madrid JF,Gutiérrez R,Varela H,Valladares F,Alvarez-Argüelles H,Díaz-Flores L

更新日期：2006-09-01 00:00:00

abstract：:We compared characteristic lesions occurring in chickens and domestic ducks naturally infected with H5N1 HPAI virus in April and May 2008. Infected chickens generally exhibited pale-green, watery diarrhoea, depression, neurological signs and cyanosis of wattles and combs, and infected ducks generally exhibited neurolo...

journal_title：Histology and histopathology

authors： Woo GH,Kim HY,Bae YC,Jean YH,Bak EJ,Kim MJ,Hwang EK,Joo YS

更新日期：2011-02-01 00:00:00

abstract：:During endotoxic shock, the liver exerts a lipopolysaccharide (LPS) clearance function with the participation of both parenchymal and sinusoidal cells. Liver damage could be caused by LPS direct action, hypoxia and/or inflammatory mediators released by Kupffer cells. The aim of this study is to establish an experiment...

journal_title：Histology and histopathology

authors： Pagani R,Portolés MT,Arahuetes R,Ainaga MJ,Machín C,Rua C

更新日期：1996-07-01 00:00:00

abstract：:Fluoxetine shows controversial lung effects as it prevents pulmonary hypertension in adult rats but exposure during gestation causes pulmonary hypertension in neonatal rats. In the present study, we tested the null hypothesis that the antidepressant drug fluoxetine does not modify the development of bronchopulmonary d...

journal_title：Histology and histopathology

authors： Porzionato A,Zaramella P,Macchi V,Grisafi D,Salmaso R,Baraldi M,Fornaro E,Tassone E,Masola V,Onisto M,Chiandetti L,De Caro R

更新日期：2012-12-01 00:00:00

abstract：:Takeda-G-protein-receptor-5 (TGR5) is a receptor for bile acids and its expression has been described in a variety of tissues and species. Characterization of TGR5 distribution and function has been investigated in drug discovery for the treatment of metabolic diseases in humans. Because dogs are one of the species us...

journal_title：Histology and histopathology

authors： Giaretta PR,Suchodolski JS,Blick AK,Steiner JM,Lidbury JA,Rech RR

更新日期：2019-01-01 00:00:00

abstract：:We describe a new technique, decalcification by perfusion, for the softening of bony tissue. The blood circulatory system was perfused in 16 rats via a cannula through the left heart ventricle with a fixative followed by New Decalc (an acidic demineralizer) for 30-240 minutes. Perfusion decalcification for 120 minutes...

journal_title：Histology and histopathology

authors： Nilsson M,Hellström S,Albiin N

更新日期：1991-07-01 00:00:00