Abstract：
:Recently ultraviolet light (UV) reaching the Earth's surface has been gradually increasing in amounts by the destruction of the ozone layers. Large parts of UV are absorbed in the cornea and lens, and only a few amounts reached the retina; however, the effect on the retina is not fully elucidated. 38 rats were irradiated 0.5-5.0 J/cm2 UV from 6 to 50 times every 24 hours, and immunohistochemically and immunochemically for superoxide dismutases (SOD). Morphologically, the destruction of rod outer segments (ROS) and dissociation of cell membranes between the pigment epithelial cells (PE) were already observed by 6 times 0.5 J/cm2 UV irradiations. As the doses of UV increased, heterochromatins and lipid droplets increased in the PE. In normal retina, Cu/Zn SOD were mainly distributed from the inner limiting membrane (ILM) to the ganglion cell layer, and the PE; however, after 6 times 0.5 J/cm2 UV irradiations, the distribution became widened from inner to outer plexiform layer (OPL). At that time, the concentrations of Cu/Zn and Mn SOD increased in the retina. The present study reveals that the morphological damage caused by UV irradiation is observed in the ROS and PE, where no immunoreactivities could be detected to Cu/Zn and Mn SOD. However, morphological damage was not from the ILM to OPL, where the immunoreactivities to both Cu/Zn and Mn SOD were observed.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Oguni M,Tamura H,Kato K,Setogawa Tsubject
Has Abstractpub_date
1996-07-01 00:00:00pages
695-702issue
3eissn
0213-3911issn
1699-5848journal_volume
11pub_type
杂志文章abstract：:Chronic liver diseases are commonly associated with tissue hypoxia that may cause inflammation, oxidative stress, liver cell injury and increased nuclear transcriptional regulation. The hepatic response to chronic hypoxia at the molecular level has not yet been clearly understood until now. The aim of this study is to...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：2013-04-01 00:00:00
abstract：:Sixty male Wistar rats were used for this experiment and assigned at random to the control group or to the stimulation method. Control rats show cerebral asymmetry with right bias at the frontal and occipital lobes. In the case of stimulated rats the differences from the occipital zone increase while those from the fr...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
abstract：:The coexistence of serotonin and cholecystokinin was studied in foetal sheep lungs at pseudoglandular stage of development by light microscopic immunohistochemistry. The coexistence was examined by staining consecutive sections with the different antibodies. Serotonin and cholecystokinin immunoreactivity was found wit...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:TNFalpha exerts apoptosis throughout an intracellular transduction pathway that involves the kinase proteins TRAF-2 (integration point of apoptotic and survival signals), ASK1 (pro-apoptotic protein), MEK-4 (p38 activator and metastasis suppressor gene), JNK (stress mitogen activated protein kinase) and the transcript...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-23.1279
更新日期：2008-10-01 00:00:00
abstract：:The effects of the administration of cyclophosphamide to male rats at doses of 400 mg/m2 for a period of 5 days and of 200 mg/m2 over two five-day cycles interrupted by a 21-day break reveal differences in the ultrastructural morphology of gonadotrophic cells between treated animals and normal controls. The ultrastruc...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
abstract：:Actin microfilaments and microtubules are important cytoskeletal proteins that regulate endothelial repair through alterations in cell shape and through regulation of cell migration following wounding of the endothelium. Upstream pathways have been identified in the regulation of actin and microtubule organization, es...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-18.879
更新日期：2003-07-01 00:00:00
abstract：:Chorioamnionitis and preeclampsia account for the majority of preterm births worldwide. Thus far, adequate methods for early detection or prevention of these diseases are lacking. In preeclampsia, accelerated villous maturation is believed to compensate placental insufficiency. However, little is known about the effec...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-18-205
更新日期：2020-08-01 00:00:00
abstract：:The response of the SON to various forms of stress is well documented. However, the effect of operative stress, which is a common and important clinical event requiring the mediation of vasopressin, has largely escaped attention. The present report describes the ultrastructural changes in the neurons of the caudal (re...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1988-04-01 00:00:00
abstract：BACKGROUND:Protein tyrosine kinase 7 (PTK7) is a member of receptor protein tyrosine kinase-like molecules, which is involved in tumorigenesis. However, the association between PTK7 expression and its pathological significance in survival prognosis remains under investigation. The purpose of this meta-analysis is to cl...
journal_title：Histology and histopathology
pub_type： 杂志文章,meta分析
doi：10.14670/HH-11-933
更新日期：2018-04-01 00:00:00
abstract：:To understand the role of microtubules and microfilaments in regulating endothelial monolayer integrity and repair, and since microtubules and microfilaments show some co-alignment in endothelial cells, we tested the hypothesis that microtubules organize microfilament distribution. Disruption of microtubules with colc...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-20.455
更新日期：2005-04-01 00:00:00
abstract：:The purpose of this study was to determine the histological characteristics of a skeletal muscle reconstructed by means of the implantation of autologous adipose tissue following an experimentally-induced volumetric muscle loss. A cylindrical piece in the belly of the rat anterior tibial muscle was removed. In the hol...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-18-163
更新日期：2020-05-01 00:00:00
abstract：:Although traditionally little attention has been paid to the interplay between neurotrophins and the cell cycle, a number of recent findings suggest an important role for these growth factors in the regulation of this aspect of the cellular physiology. In this article, we review the evidence from a number of studies t...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-17.1227
更新日期：2002-10-01 00:00:00
abstract：:Nitric oxide (NO) is a widely recognized mediator of physiological and pathophysiological signal transmission. Its generation through L-arginine metabolism is relevant in the mesangium of the kidney where NO is produced by constitutive and inducible NO-synthase isoenzymes. Signaling is achieved through target interact...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-15.1151
更新日期：2000-10-01 00:00:00
abstract：:The main objective of this ultrastructural study was to gain a better understanding of the involvement of brain vasculature in clearance of proteins from edematous fluid. For this purpose, both native and modified (cationized, glucosylated, and mannosylated) bovine serum albumin-gold complexes (BSA-G, catBSA-G, glucBS...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-13.647
更新日期：1998-07-01 00:00:00
abstract：:Sex steroid hormones are involved in regulation of skin development and functions as well as in some skin pathological events. To determine the sites of action of estrogens, androgens and progestins, studies have been performed during the recent years to accurately localize receptors for each steroid hormone in human ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-19.629
更新日期：2004-04-01 00:00:00
abstract：:The primary objective of this research project was to study the role of sex steroids in the pathogenesis of cholelithiasis using the Syrian hamster as a model. In addition to the morphological examination of the gallbladder epithelium, we thought it imperative to observe the changes induced in the biliary tract in res...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1995-07-01 00:00:00
abstract：:Detailed characterization of the subdermal model is a significant tool for better understanding of calcification mechanisms occurring in heart valves. In previous ultrastructural investigation on six-week-implantated aortic valve leaflets, modified pre-embedding glutaraldehyde-cuprolinic-blue reactions (GA-CB) enabled...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-22.261
更新日期：2007-03-01 00:00:00
abstract：:Soft dental tissues have been identified as easily accessible sources of multipotent postnatal stem cells. Dental stem cells are mesenchymal stem cells (MSC) capable of differentiating into at least three distinct cell lineages: osteo/odontogenic, adipogenic and neurogenic. They express various markers including those...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-29.699
更新日期：2014-06-01 00:00:00
abstract：:STAT and SMAD often exert opposite biological effects on diverse cellular functions. Recent studies have shown that STAT can interface with SMAD at molecular level and that some novel molecules, such as SOCS (also called CIS) and APRO6 (also called TOB), modulate this signaling. A cofactor p300/CBP might act as a brid...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-17.887
更新日期：2002-01-01 00:00:00
abstract：:Vascular endothelial cells play a critical role in the maintenance of endometrial homeostasis. Indeed many pathological conditions causing abnormal endometrial bleeding including progestin only contraception, hormone replacement therapy, endometrial polyps, myomas, hyperplasia and cancer are associated with aberrant a...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-20.719
更新日期：2005-07-01 00:00:00
abstract：:Versican, a large extracellular matrix proteoglycan accumulates in tumor stroma and plays a key role in both malignant transformation and tumor progression. Increased versican expression has been observed in a wide range of malignant tumors, and has been associated with both cancer relapse and poor patient outcomes in...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-28.701
更新日期：2013-06-01 00:00:00
abstract：:Dimethylnitrosamine (DMN) induced liver injury in rats with cell necrosis, inflammation, hemorrhages, increased collagen type III synthesis and basement membrane component laminin and collagen IV localization in perisinusoidal sites. Malotilate ingestion during DMN treatment abolished inflammation and decreased inters...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:The possible involvement of endogenous vasoactive intestinal peptide (VIP), cholecystokinin (CCK) and neurotensin (NT) in the control of thymocyte proliferation has been investigated in vivo in the immature rat. For this task, we have studied the effects of the administration of selective antagonists of the receptors ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-16.155
更新日期：2001-01-01 00:00:00
abstract：:Immunocytochemical demonstration of metallothionein (MT) has been reported as a useful prognostic tool in human breast cancer. The aim of this study was to determine the immunohistochemical location of MT in canine mammary tumours and its possible correlation with the morphologic characteristics of these tumours. Surg...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-14.51
更新日期：1999-01-01 00:00:00
abstract：:Ductular hepatocytes are observed in the livers of both experimental animals and man under various conditions of severe toxin-, carcinogen- or viral-induced hepatic injury with prominent loss of parenchymal hepatocytes. These unique hepatic epithelial cells are characterized by phenotypic traits that are intermediate ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1995-04-01 00:00:00
abstract：:Emperipolesis has recently been described as a constant feature of "biphasic squamoid" papillary renal cell carcinoma (BPRCC). We also noticed this in some high-grade (HG) RCC, which promoted the present study to estimate the incidence of emperipolesis in RCCs and to describe them in further detail. 14 cases of HGRCC ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-11-925
更新日期：2018-03-01 00:00:00
abstract：:The rapid Golgi method, combined with current optical and electronmicroscopical techniques, was used in three central gangliogliomas and in one dysplastic gangliocytoma of the cerebellum to study the morphology of ganglionic cells. Gangliogliomas were composed of bipolar, fusiform and radiate cells with dense core and...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：:Elevated plasma levels of C-reactive protein (CRP) are associated with increased risk of cardiovascular disease. CRP immunoreactive protein is also detected in the lesions of atherosclerosis. However, it is not known whether the CRP contents of atherosclerotic lesions are associated with the initiation and progression...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-27.529
更新日期：2012-04-01 00:00:00
abstract：:Platelet-collagen interaction is a complex event that involves ligand-receptor interaction. There are many adhesive non-integrin receptors for platelets to interact with various types of collagens. These non-integrin receptors also serve as signal transducers both from the outside of platelets to the inside and possib...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-14.579
更新日期：1999-04-01 00:00:00
abstract：:Serotonin-producing pancreatic endocrine tumours are rare neoplasms which in most cases exhibit malignant biological behaviour. These tumours, in the majority of the well-documented cases, are composed of argyrophil- and argentaffin-positive cells which contain large pleomorphic neurosecretory granules. In contrast, a...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
