Abstract:
:The study investigated the link between the potentially nephrotoxic levels of aluminium ingested in the natural diet of eucalypt leaves by koalas in the Adelaide Hills, South Australia, and the high incidence of renal failure in koalas within this habitat. Routine histology of kidney specimens revealed no pathologies at the light microscopic level and contrasted sharply with the clinical signs of renal failure. However staining with solochrome azurine and Perl's Prussian blue showed aluminium was present in some proximal convoluted tubules in all specimens. Aluminium was also found in bone samples. The presence of aluminium in bone and kidney tissues was confirmed using electron dispersive x-ray analysis with transmission and scanning electron microscopy. Ultrastructural changes, including a decrease in lysosomal numbers, were seen in proximal convoluted tubules and these changes were shown to coincide with the presence of aluminium. No aluminium was found in koalas that died from causes other than renal failure. It was concluded that renal failure in the koalas of the Adelaide Hills is characterised by the presence of aluminium in the kidneys and bone and it is probably related to the high levels of aluminium in their restricted diet of eucalypt leaves. However, it is not known if the presence of aluminium is the cause or effect of the renal failure. The study is the first account where aluminium ingested as part of the natural diet of mammals has been shown to accumulate in the animal and be implicated with nephrotoxicity.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Haynes JI,Askew MJ,Leigh Cdoi
10.14670/HH-19.777subject
Has Abstractpub_date
2004-07-01 00:00:00pages
777-84issue
3eissn
0213-3911issn
1699-5848journal_volume
19pub_type
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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更新日期:2020-09-29 00:00:00
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journal_title:Histology and histopathology
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更新日期:1989-04-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-21.603
更新日期:2006-06-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1994-10-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-25.1181
更新日期:2010-09-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-23.1439
更新日期:2008-12-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-15.493
更新日期:2000-04-01 00:00:00
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journal_title:Histology and histopathology
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doi:10.14670/HH-11-811
更新日期:2017-05-01 00:00:00
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journal_title:Histology and histopathology
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doi:10.14670/HH-21.93
更新日期:2006-01-01 00:00:00
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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更新日期:2015-08-01 00:00:00
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journal_title:Histology and histopathology
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更新日期:2001-04-01 00:00:00
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journal_title:Histology and histopathology
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更新日期:2018-07-01 00:00:00
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journal_title:Histology and histopathology
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更新日期:1993-04-01 00:00:00
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journal_title:Histology and histopathology
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更新日期:2011-05-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-17.1121
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND AND RESULTS:Embryos from diabetic mice exhibit several forms of neural tube defects, including non-closure of the neural tube. In the present study, embryos collected at embryonic day 11.5 from diabetic pregnancies displayed open neural tube with architectural disruption of the surrounding tissues. The perce...
journal_title:Histology and histopathology
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更新日期:2011-08-01 00:00:00
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journal_title:Histology and histopathology
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更新日期:2010-06-01 00:00:00
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journal_title:Histology and histopathology
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更新日期:2002-01-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-29.10.497
更新日期:2014-04-01 00:00:00