Thrombocytopenia in leukemia: Pathogenesis and prognosis.

Abstract:

:Leukemias, a heterogeneous group of hematological disorders, are characterized by ineffective hematopoiesis and morphologic abnormalities of hematopoietic cells. Thrombocytopenia is a common problem among leukemia types that can lead to hemorrhagic complications in patients. The purpose of this review article is to identify the conditions associated with the incidence of thrombocytopenia in leukemias. It can be stated that although translocations have been considered responsible for this complication in many studies, other factors such as bone marrow failure, genes polymorphism, a mutation in some transcription factors, and the adverse effects of treatment could be associated with pathogenesis and poor prognosis of thrombocytopenia in leukemias. Considering the importance of thrombocytopenia in leukemias, it is hoped that the recognition of risk factors increasing the incidence of this complication in leukemic patients would be useful for prevention and treatment of this disorder.

journal_name

Histol Histopathol

authors

Shahrabi S,Behzad MM,Jaseb K,Saki N

doi

10.14670/HH-11-976

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

895-908

issue

9

eissn

0213-3911

issn

1699-5848

pii

HH-11-976

journal_volume

33

pub_type

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