Expression of the Shwachman-Bodian-Diamond syndrome (SBDS) protein in human pancreatic cancer and chronic pancreatitis.


BACKGROUND:The Shwachman-Bodian-Diamond syndrome (SBDS) protein is a member of a highly conserved family which influences RNA activation and is associated with pancreatic, skeletal and bone marrow deficiencies, as well as hematological malignancies. METHODS:In this study, the expression and localization of SBDS were investigated in normal human pancreatic tissues, chronic pancreatitis (CP) tissues, primary and metastatic pancreatic ductal adenocarcinoma (PDAC) tissues, as well as in cultured pancreatic cancer cell lines by immunohistochemistry, immunoblotting and immunocytochemistry. RESULTS:In the normal pancreas, SBDS was localized in the cytoplasm of islet cells and ductal cells. In CP tissues, SBDS was found in the cytoplasm of ductal cells, tubular complexes, stromal fibroblasts and in PanIN1-2 lesions. In PDAC tissues, SBDS exhibited cytoplasmic and occasionally nuclear localization in tubular complexes, PanIN1-3 lesions, cancer cells, and stromal fibroblasts. Different levels of SBDS protein were detected in cultured pancreatic cancer cell lines. CONCLUSION:SBDS is expressed in normal, CP, and PDAC tissues, as well as in pancreatic cancer cell lines. The different expression and localization patterns suggest a role of SBDS in the pathogenesis of, or response to, inflammatory and neoplastic pancreatic diseases.


Histol Histopathol


Kayed H,Bekasi S,Keleg S,Welsch T,Esposito I,Shimamura A,Michalski CW,Friess H,Kleeff J




Has Abstract


2008-07-01 00:00:00












  • An immunohistochemical study of NFE2L2, KEAP1 and 8-hydroxy-2'-deoxyguanosine and the EMT markers SNAI2, ZEB1 and TWIST1 in metastatic melanoma.

    abstract:BACKGROUND:Little is known regarding the role of redox balance regulators in metastatic melanomas, but there is some evidence for a link between epithelial-to-mesenchymal transition (EMT) and cellular redox status. METHODS:We compared the immunohistochemical expression of nuclear factor erythroid-2-related factor 2 (N...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Hintsala HR,Haapasaari KM,Soini Y,Karihtala P

    更新日期:2017-02-01 00:00:00

  • Bone morphogenetic proteins and their receptor signaling in prostate cancer.

    abstract::Bone morphogenetic proteins (BMPs) belong to the TGF-Beta superfamily and are vital bone inductive factors. BMPs also play important roles during embryonic development and the postnatal homeostasis of various organs and tissues, by controlling cellular differentiation, proliferation and apoptosis. Prostate cancer is t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Ye L,Lewis-Russell JM,Kyanaston HG,Jiang WG

    更新日期:2007-10-01 00:00:00

  • M1- and M2-macrophage polarization in thioacetamide (TAA)-induced rat liver lesions; a possible analysis for hepato-pathology.

    abstract::"Classically activated macrophages (M1)" and "alternatively activated macrophages (M2)", which appear in injured tissues, control either inflammation or remodeling. The mechanism remains unclear. To clarify the M1-/M2-macrophage polarization in acute liver injury, M1- and M2-related factors were analysed in F344 rats ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Wijesundera KK,Izawa T,Murakami H,Tennakoon AH,Golbar HM,Kato-Ichikawa C,Tanaka M,Kuwamura M,Yamate J

    更新日期:2014-04-01 00:00:00

  • Cadmium toxicity on cultured neonatal rat hepatocytes: biochemical and ultrastructural analyses.

    abstract::The effects of cadmium exposure on the protein secretory functions of cultured neonatal rat hepatocytes were analyzed by both two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) and electron microscopy. [35S]Methionine-labelled protein secretion was significantly depressed by cadmium exposure in a dose-depend...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Hirano T,Ueda H,Kawahara A,Fujimoto S

    更新日期:1991-01-01 00:00:00

  • Commonly used mesenchymal stem cell markers and tracking labels: Limitations and challenges.

    abstract::Early observations that cultured mesenchymal stem cells (MSCs) could be induced to exhibit certain characteristics of osteocytes and chondrocytes led to the proposal that they could be transplanted for tissue repair through cellular differentiation. Therefore, many subsequent preclinical studies with transplanted MSCs...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Lin CS,Xin ZC,Dai J,Lue TF

    更新日期:2013-09-01 00:00:00

  • Liver growth factor antifibrotic activity in vivo is associated with a decrease in activation of hepatic stellate cells.

    abstract::The antifibrotic activity of Liver Growth Factor (LGF), a liver mitogen, was previously demonstrated in several models of rat liver fibrosis and even in extrahepatic sites, such as carotid artery in hypertensive rats and rat CdCl2-induced lung fibrosis. In the present study, we have attempted to examine in depth its m...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Díaz-Gil JJ,García-Monzón C,Rúa C,Martín-Sanz P,Cereceda RM,Miquilena-Colina ME,Machín C,Fernández-Martínez A,García-Cañero R

    更新日期:2009-04-01 00:00:00

  • Adipose-derived stem cells in articular cartilage regeneration: current concepts and optimization strategies.

    abstract::Knee osteoarthritis (KOA) is the most common progressive joint disorder associated with disability in the world. As a chronic disease, KOA has multifactorial etiology. However, the poor self-healing ability of the articular cartilage due to its intrinsic tissue hypovascularity and hypocellularity seems to be directly ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Gu X,Li C,Yin F,Yang G

    更新日期:2018-07-01 00:00:00

  • Efficient uptake of mannosylated proteins by a human Schwann cell line.

    abstract::Complex carbohydrate structures are essential molecules of infectious microbes and host cells, and are involved in cell signaling associated with inflammatory and immune responses. The uptake of mannose-tailed glycans is usually carried out by macrophages, dendritic cells (DCs), and other professional phagocytes to tr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Baetas-da-Cruz W,Alves L,Guimarães EV,Santos-Silva A,Pessolani MC,Barbosa HS,Corte-Real S,Cavalcante LA

    更新日期:2009-08-01 00:00:00

  • Abnormal distribution of CD45 isoforms expressed by CD4+ and CD8+ T cells in rheumatoid arthritis.

    abstract::CD45RO+ T cells are referred to as memory or helper-inducer while CD45RA+ T cells are regarded as naive or suppressor-inducer T cells. The former population predominates in the peripheral blood and even more in the synovial fluid of patients with rheumatoid arthritis, to the expense of the latter population. Within th...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Mamoune A,Durand V,Le Goff P,Pennec YL,Youinou P,Le Corre R

    更新日期:2000-04-01 00:00:00

  • TNF-alpha/IL-1/NF-kappaB transduction pathway in human cancer prostate.

    abstract::TNFalpha exerts apoptosis throughout an intracellular transduction pathway that involves the kinase proteins TRAF-2 (integration point of apoptotic and survival signals), ASK1 (pro-apoptotic protein), MEK-4 (p38 activator and metastasis suppressor gene), JNK (stress mitogen activated protein kinase) and the transcript...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Royuela M,Rodríguez-Berriguete G,Fraile B,Paniagua R

    更新日期:2008-10-01 00:00:00

  • The dynamic stem cell microenvironment is orchestrated by microvesicle-mediated transfer of genetic information.

    abstract::It has been commonly supposed that adult stem cells co-localize with supporting cells within specific regions or specialized microenvironment in each tissue/organ, called stem cell niche. This concept was based on the assumption that stem cells are intrinsically hierarchical in nature. However, recent data indicate th...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Deregibus MC,Tetta C,Camussi G

    更新日期:2010-03-01 00:00:00

  • Potential therapeutic effect of SO₂ on fibrosis.

    abstract::Fibrosis is a pathological feature of most chronic diseases and leads to the dysfunction of various organs. However, there is currently no effective method for treating fibrosis. In recent years, a small gas, sulfur dioxide (SO₂), which can be generated endogenously in mammals, has been found to have vasorelaxation ac...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Wang XB,Cui H,Du JB

    更新日期:2019-12-01 00:00:00

  • Antigen retrieval on epoxy sections based on tissue infiltration with a moderately increased amount of accelerator to detect immune complex deposits in glomerular tissue.

    abstract::We wanted to examine the effect of antigen retrieval on epoxy sections where the tissue had been infiltrated by resin containing moderately increased amounts of accelerator. The concentration of accelerator DMP-30 (Tri(Dimethyl Amino Methyl) Phenol) was varied in the range of 0% to 4% in the infiltration step of the t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Brorson SH,Andersen T,Haug S,Kristiansen I,Risstubben A,Tchou H,Ulstein J

    更新日期:1999-01-01 00:00:00

  • Oncocytic adenoma of the nasal cavity. A case report.

    abstract::The authors present a case of benign oncocytoma (oxyphil cell adenoma) of the nasal cavity in a young woman. This is the fifth case reported in that region. Immunohistochemical stains revealed positivity only for cytokeratin. ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Miracco C,Sensini I,Vessio G,Luzi P

    更新日期:1986-01-01 00:00:00

  • REG IV overexpression in an early stage of colorectal carcinogenesis: an immunohistochemical study.

    abstract::To clarify the role of REG IV, a new member of the regenerating gene (REG) family, in tumorigenesis and progression of colorectal carcinoma (CRC), 320 CRC specimens, 123 corresponding adjacent non-cancerous mucosa (ANCMs), 46 corresponding non-adjacent non-cancerous mucosa (NANCMs) and 86 adenomas were investigated im...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Li XH,Zheng Y,Zheng HC,Takahashi H,Yang XH,Masuda S,Takano Y

    更新日期:2010-04-01 00:00:00

  • DEC1 expression in 1p-aberrant oligodendroglial neoplasms.

    abstract:BACKGROUND:Expression of hypoxia-related tissue factors in 1p-aberrant oligodendroglial neoplasms diminishes patient outcome. Differentiated embryo-chondrocyte expressed gene 1 (DEC1) has been described as novel hypoxia-related tissue factor. In our study, we assessed the expression of DEC1 in 1p aberrant oligodendrogl...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Preusser M,Birner P,Ambros IM,Ambros PF,Budka H,Harris AL,Hainfellner JA

    更新日期:2005-10-01 00:00:00

  • Control of the cell cycle by neurotrophins: lessons from the p75 neurotrophin receptor.

    abstract::Although traditionally little attention has been paid to the interplay between neurotrophins and the cell cycle, a number of recent findings suggest an important role for these growth factors in the regulation of this aspect of the cellular physiology. In this article, we review the evidence from a number of studies t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: López-Sánchez N,Frade JM

    更新日期:2002-10-01 00:00:00

  • Histochemical aspects of the yolk-sac and digestive tract of larvae of the Senegal sole, Solea senegalensis (Kaup, 1858).

    abstract::Histochemical distribution of glycoproteins, carbohydrates and proteins rich in different amino acids were studied using histological and histochemical procedures, in Senegal sole, Solea senegalensis (Kaup, 1858) larvae from hatching until day 15. Glycogen, proteins and glycoproteins were detected in the yolk-sac of t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Sarasquete C,González de Canales ML,Arellano JM,Muñoz-Cueto JA,Ribeiro L,Dinis MT

    更新日期:1996-10-01 00:00:00

  • Validation of an original incubator set-up for the exposure of human astrocyte cells to X-band microwaves in a GTEM-chamber.

    abstract::A current concern about the biological effects of electromagnetic fields (EMF) is increasing with the wide spread use of X-band microwaves (MW, 8-10 GHz range). Gigahertz transverse electromagnetic (GTEM) field flat transmission lines are currently being used for experimental exposure of biological samples to high fre...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Pérez-Bruzón RN,Del Moral A,Pérez-Castejón C,Llorente M,Vera A,Azanza MJ

    更新日期:2011-09-01 00:00:00

  • Immunohistochemical characterisation of dorsal root ganglia neurons supplying the porcine mammary gland.

    abstract::The present study investigated the chemical coding of mammary gland-projecting dorsal root ganglia (DRG) neurons using double-labelling immunohistochemistry. Earlier investigations revealed the presence of Fast blue - positive (FB+) neurons in Th9-Th12 DRG after injection of the tracer into the second, right thoracic ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Franke-Radowiecka A

    更新日期:2011-12-01 00:00:00

  • Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors.

    abstract::The aim of our study was to document whether relationships existed among bone morphogenetic proteins (BMPs), peripheral nerve and neoplastic lesions of nerve sheath tumors. The mRNA transcriptions of BMP-2, 3, 4 and 5 in 10 cases of schwannoma, three cases of malignant schwannoma and two cases of trigeminal neuralgia ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Jin Y,Lu HB,Liong E,Lau TY,Tipoe GL

    更新日期:2001-10-01 00:00:00

  • In vitro and in vivo characterization of neural stem cells.

    abstract::Neural stem cells are defined as clonogenic cells with self-renewal capacity and the ability to generate all neural lineages (multipotentiality). Cells with these characteristics have been isolated from the embryonic and adult central nervous system. Under specific conditions, these cells can differentiate into neuron...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Bazán E,Alonso FJ,Redondo C,López-Toledano MA,Alfaro JM,Reimers D,Herranz AS,Paíno CL,Serrano AB,Cobacho N,Caso E,Lobo MV

    更新日期:2004-10-01 00:00:00

  • Neuropeptide Y-related peptides and hypothalamo-pituitary-adrenal axis function.

    abstract::Current data on the localization of neuropeptide Y-related peptides in the hypothalamo-pituitary-adrenal gland (HPA) axis as well as the effects of these peptides on the function of cells comprising HPA axis are presented and discussed. The action of neuropeptide Y, peptide YY, and pancreatic polypeptide on HPA axis a...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Malendowicz LK,Markowska A,Zabel M

    更新日期:1996-04-01 00:00:00

  • Cape Town solution in prolonged myocardial preservation: structural and ultrastructural study.

    abstract::This study deals with myocardial preservation after 24 hours of continuous, hypothermic and oxygenated perfusion with Cape Town (CT) solution, focusing on the morphological changes produced by preservation and reperfusion, and their possible relationship to the composition of the solution and the immediate hemodynamic...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: García-Poblete E,Alvarez L,Fernández H,Escudero C,Torralba A

    更新日期:1998-01-01 00:00:00

  • Reduced expression of the membrane skeleton protein beta1-spectrin (SPTBN1) is associated with worsened prognosis in pancreatic cancer.

    abstract::Spectrins are members of the superfamily of F-actin cross linking proteins that are important as scaffolding proteins for protein sorting, cell adhesion, and migration. In addition, spectrins have been implicated in TGF-beta signaling. The aim of the present study was to analyze the expression and localization of beta...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Jiang X,Gillen S,Esposito I,Giese NA,Michalski CW,Friess H,Kleeff J

    更新日期:2010-12-01 00:00:00

  • Pineal gland in rats with 7,12-dimethylbenz(a)anthracene-induced mammary tumors subjected to manipulations known as enhancers of pineal actions.

    abstract::The ultrastructure of pinealocytes was studied in rats with 7,12-dimethylbenz(a)anthracene-induced mammary tumors which were subjected to experimental manipulations known as enhancers of pineal actions (anosmia, underfeeding or cold exposure). In these animals we found: (I)--more nuclei with deep nuclear invaginations...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Cos S,Bardasano JL,Mediavilla MD,Sánchez Barceló EJ

    更新日期:1989-04-01 00:00:00

  • Description of primordial germ cells, oogonia, oocytes and embryo-like growth in squash preparations of tissues from hematological malignancies.

    abstract::This study evidences the presence of primordial germ cells, in tissue squash preparations and sections from hematological malignancies. Primordial germ cells were identified by their morphology, the intense PAS, PAS-D reaction and presence of calcium-activated neutral proteinase. Primordial germ cells gave rise to nuc...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Logothetou-Rella H

    更新日期:1996-10-01 00:00:00

  • Defect of the cerebellar vermis induced by prenatal gamma-ray irradiation in radiosensitive BALB/c mice.

    abstract::The developing fetal brain is one of the most susceptible organs to irradiation insult. Prenatal irradiation-induced abnormalities in the cerebrum have been well examined in mouse fetuses. However, little information on abnormalities in the cerebellum caused by irradiation is available. Moreover, few reports have exam...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Saito A,Yamauchi H,Ishida Y,Ohmachi Y,Nakayama H

    更新日期:2008-08-01 00:00:00

  • MYC and BCL-2 adjusted-International Prognostic Index (A-IPI) is a better predictor of outcome than the standard IPI for patients with diffuse large B-cell lymphoma treated with R-CHOP.

    abstract::The International Prognostic Index (IPI) has been the basis for determining prognosis in patients with diffuse large B-cell lymphoma (DLBCL) for the past 20 years. The utility of the IPI must be reassessed in the era of immunochemotherapy. Seven risk factors at diagnosis were identified, and a maximum of 7 points were...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Wang J,Zhou M,Xu JY,Yang YG,Zhang QG,Zhou RF,Chen B,Ouyang J,Li C

    更新日期:2016-03-01 00:00:00

  • Morphometric study on the interhemispheric asymmetries in the Wistar rat and the effects of early experience.

    abstract::Sixty male Wistar rats were used for this experiment and assigned at random to the control group or to the stimulation method. Control rats show cerebral asymmetry with right bias at the frontal and occipital lobes. In the case of stimulated rats the differences from the occipital zone increase while those from the fr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Isasa Chueca JA,Lahoz Gimeno M,Redondo Marco JA

    更新日期:1992-07-01 00:00:00