Expression of the Shwachman-Bodian-Diamond syndrome (SBDS) protein in human pancreatic cancer and chronic pancreatitis.

Abstract:

BACKGROUND:The Shwachman-Bodian-Diamond syndrome (SBDS) protein is a member of a highly conserved family which influences RNA activation and is associated with pancreatic, skeletal and bone marrow deficiencies, as well as hematological malignancies. METHODS:In this study, the expression and localization of SBDS were investigated in normal human pancreatic tissues, chronic pancreatitis (CP) tissues, primary and metastatic pancreatic ductal adenocarcinoma (PDAC) tissues, as well as in cultured pancreatic cancer cell lines by immunohistochemistry, immunoblotting and immunocytochemistry. RESULTS:In the normal pancreas, SBDS was localized in the cytoplasm of islet cells and ductal cells. In CP tissues, SBDS was found in the cytoplasm of ductal cells, tubular complexes, stromal fibroblasts and in PanIN1-2 lesions. In PDAC tissues, SBDS exhibited cytoplasmic and occasionally nuclear localization in tubular complexes, PanIN1-3 lesions, cancer cells, and stromal fibroblasts. Different levels of SBDS protein were detected in cultured pancreatic cancer cell lines. CONCLUSION:SBDS is expressed in normal, CP, and PDAC tissues, as well as in pancreatic cancer cell lines. The different expression and localization patterns suggest a role of SBDS in the pathogenesis of, or response to, inflammatory and neoplastic pancreatic diseases.

journal_name

Histol Histopathol

authors

Kayed H,Bekasi S,Keleg S,Welsch T,Esposito I,Shimamura A,Michalski CW,Friess H,Kleeff J

doi

10.14670/HH-23.819

subject

Has Abstract

pub_date

2008-07-01 00:00:00

pages

819-26

issue

7

eissn

0213-3911

issn

1699-5848

journal_volume

23

pub_type

杂志文章
  • Dental stem cells--characteristics and potential.

    abstract::Soft dental tissues have been identified as easily accessible sources of multipotent postnatal stem cells. Dental stem cells are mesenchymal stem cells (MSC) capable of differentiating into at least three distinct cell lineages: osteo/odontogenic, adipogenic and neurogenic. They express various markers including those...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-29.699

    authors: Bojic S,Volarevic V,Ljujic B,Stojkovic M

    更新日期:2014-06-01 00:00:00

  • Involvement of neuropeptides in the regulation of growth, structure and function of the adrenal cortex.

    abstract::Current data on the influence of neuropeptides on the growth, structure and function of cells comprising the hypothalamo-pituitary-adrenal axis were presented and discussed. The action of vasopressin, oxytocin, neurotensin, bombesin, neuropeptide Y, substance P and VIP have been evaluated. The hypothesis has been intr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:

    authors: Malendowicz LK

    更新日期:1993-01-01 00:00:00

  • Estimation and comparison of the contents of blood group B antigens in selected human tissues by microphotometric quantification of Griffonia simplicifolia agglutinin I-B4 staining with or without prior alpha-galactosidase digestion.

    abstract::Griffonia simplicifolia agglutinin I-B4 (GSAI-B4) has broader specificity for B antigen variants and can recognize the antigens in a wide variety of human tissues. Thus, the concentration range of GSAI-B4 required for staining and the susceptibility of staining to alpha-galactosidase digestion is presumed to correlate...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Ito N,Nagaike C,Morimura Y,Hatake H

    更新日期:1997-04-01 00:00:00

  • In vivo cellular uptake of bismuth ions from shotgun pellets.

    abstract::Shotgun pellets containing bismuth (Bi) are widely used and may cause a rather intense exposure of some wild animals to Bi. A Bi shotgun pellet was implanted intramuscularly in the triceps surae muscle of 18 adult male Wistar rats. Another group of 9 animals had a Bi shotgun pellet implanted intracranially in the neoc...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-18.781

    authors: Stoltenberg M,Locht L,Larsen A,Jensen D,Danscher G

    更新日期:2003-07-01 00:00:00

  • Thermotherapy for Harding-Passey melanoma: light and electron microscopic study.

    abstract::The changes of implanted Harding-Passey melanoma in C57Bl/6J mice following treatment with wholebody hyperthermia were studied. The treated tumours showed a progressive growth delay, cellular and architectural irregularities as well as cell injury characteristics. The presence of distended and irregular blood vessels,...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Vicente V,Gómez M,Gómez S,Calderon F,Canteras M,Cremades A

    更新日期:1987-10-01 00:00:00

  • Collagen-platelet interaction: platelet non-integrin receptors.

    abstract::Platelet-collagen interaction is a complex event that involves ligand-receptor interaction. There are many adhesive non-integrin receptors for platelets to interact with various types of collagens. These non-integrin receptors also serve as signal transducers both from the outside of platelets to the inside and possib...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-14.579

    authors: Chiang TM

    更新日期:1999-04-01 00:00:00

  • The effect of somatostatin analog octreotide on diethylstilbestrol-induced prolactin secretion, cell proliferation and vascular changes in the rat anterior pituitary gland.

    abstract::The effects of diethylstilbestrol (DES) and of long-acting somatostatin analog, octreotide (SMS) on the rat anterior pituitary microvasculature have been studied by means of computer-assisted image analysis. Additionally, the effects of DES and SMS on prolactin secretion and anterior pituitary cell proliferation have ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Pawlikowski M,Kunert-Radek J,Grochal M,Zieliński K,Kulig A

    更新日期:1997-10-01 00:00:00

  • Facilitating tailored therapeutic strategies for glioblastoma through an orthotopic patient-derived xenograft platform.

    abstract::Despite years of research into its pathobiology and continuing clinical trials for novel therapies, the prognosis for patients with glioblastoma (GBM) remains dismal. An important obstacle against treatment efficacy may be a high degree of intra- and inter-tumoral heterogeneity within GBMs, which may be caused by the ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-11-695

    authors: Lee HW,Lee K,Kim DG,Yang H,Nam DH

    更新日期:2016-03-01 00:00:00

  • Benign mast cell hyperplasia and atypical mast cell infiltrates in penile lichen planus in adult men.

    abstract::Introduction. Lichen planus (LP) is a chronic cytokine-mediated disease of possible auto-immune etiology. 25% of men have anogenital manifestations. Erosive penile LP causes a scarring phimosis of the foreskin in uncircumcised men. Mast cells as potent immune modulators have been implicated in a number of autoimmune a...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-29.1017

    authors: Regauer S,Beham-Schmid C

    更新日期:2014-08-01 00:00:00

  • Might the Masson trichrome stain be considered a useful method for categorizing experimental tendon lesions?

    abstract::Strain injuries of tendons are the most common orthopedic injuries in athletic subjects, be they equine or human. When the tendon is suddenly damaged, an acute inflammatory phase occurs whereas its repetitive overloading may cause chronic injuries. Currently the criteria used for grading injuries are general and subje...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-11-601

    authors: Martinello T,Pascoli F,Caporale G,Perazzi A,Iacopetti I,Patruno M

    更新日期:2015-08-01 00:00:00

  • Cells with morphological and immunohistochemical features of hepatic stellate cells (Ito cells) form an extralittoral (extrasinusoidal) compartment in the cirrhotic rat liver.

    abstract::Systematic studies on hepatic stellate cells and myofibroblasts have so far mainly focused on cells located in the perisinusoidal space of Disse, the so-called littoral compartment. Here, these cells play a key role for intralobular fibrogenesis and sinusoidal capillarization. However, advanced hepatic fibrosis and ci...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-14.719

    authors: Zimmermann A,Zimmermann H,Fellay M,Reichen J

    更新日期:1999-07-01 00:00:00

  • Monoclonal antibody against histiocytosis X cells.

    abstract::Monoclonal antibody against histiocytosis X cells (HXCs) was established. The antigen was the cell membrane of HXCs from the submandibular lesion of a 63-year-old man who had been diagnosed as an adult type of histiocytosis X (HX) and whose HXCs had numerous Birbeck granules (BGs). The obtained monoclonal antibody, na...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Ishikawa M,Matsuda M,Imai Y

    更新日期:1992-07-01 00:00:00

  • Less gelatinases is associated with apolipoprotein E accumulation in glomerulosclerosis rats.

    abstract:BACKGROUND:Gelatinases include matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9). The abnormal expressions of gelatinases are implicated in the pathogenesis of extracellular matrix (ECM) accumulation. Apolipo-protein E (apoE) is an important plasma protein in cholesterol homeostasis and plays a ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-27.249

    authors: Zhou TB,Qin YH,Lei FY,Su LN,Zhao YJ,Huang WF

    更新日期:2012-02-01 00:00:00

  • Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

    abstract::Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive cell loss confined mostly to dopaminergic neurons of the substantia nigra. Several factors, including oxidative stress, and decreased activity of complex I mitochondrial respiratory chain, are involved in the degenerative process. Ye...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Anglade P,Vyas S,Javoy-Agid F,Herrero MT,Michel PP,Marquez J,Mouatt-Prigent A,Ruberg M,Hirsch EC,Agid Y

    更新日期:1997-01-01 00:00:00

  • Pax genes in development and maturation of the vertebrate visual system: implications for optic nerve regeneration.

    abstract::Pax genes play a pivotal role in development of the vertebrate visual system. Pax6 is the master control gene for eye development: ectopic expression of Pax6 in Xenopus laevis and Drosphila melanogaster leads to the formation of differentiated eyes on the legs or wings. Pax6 is involved in formation of ganglion cells ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-16.239

    authors: Ziman MR,Rodger J,Chen P,Papadimitriou JM,Dunlop SA,Beazley LD

    更新日期:2001-01-01 00:00:00

  • Signaling pathways in diabetic nephropathy.

    abstract::Diabetic nephropathy (DN) is a major cause of end-stage renal disease (ESRD), however, specific treatment for DN has not yet been elucidated. Therefore, it is critically important to understand the molecular mechanism underlying DN to develop cause-related therapeutic strategy. To date, various factors such as hemodyn...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-11-777

    authors: Kawanami D,Matoba K,Utsunomiya K

    更新日期:2016-10-01 00:00:00

  • Macrophage populations and expressions of regulatory proinflammatory factors in the rat meninx under lipopolysaccharide treatment in vivo and in vitro.

    abstract::Macrophages play important roles in host defense mechanisms. In the brain, besides microglial cells, meningeal macrophages are present. However, the pathobiological characteristics of meningeal macrophages in rats remain to be investigated. In normal meninx, immunohistochemically, macrophages reacting to CD163 (macrop...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-24.13

    authors: Yamate J,Ishimine S,Izawa T,Kumagai D,Kuwamura M

    更新日期:2009-01-01 00:00:00

  • Oxidized regenerated cellulose does not prevent the formation of experimental postoperative perineural fibrosis assessed by digital analysis.

    abstract:INTRODUCTION:It is difficult to prevent and treat intra- and peri-neural fibrosis after peripheral nerve surgery. Many authors have attempted to develop and verify the effectiveness of substances to decrease the formation of adherences in different tissues. MATERIAL AND METHODS:this study aimed to assess the effective...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-25.741

    authors: Hernández-Cortés P,Peregrina M,Aneiros-Fernández J,Tassi M,Pajares-López M,Toledo M,O'Valle F

    更新日期:2010-06-01 00:00:00

  • Fhit protein is preferentially expressed in the nucleus of monocyte-derived cells and its possible biological significance.

    abstract::The FHIT gene encompassing the most active common human fragile region, FRA3B, has been proposed as a tumour suppressor gene for important common human carcinomas. The mechanism in which Fhit protein exerts its tumour suppressor activity is still obscure. To further understand the Fhit function associated with its int...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-21.915

    authors: Zhao P,Hou N,Lu Y

    更新日期:2006-09-01 00:00:00

  • Mononuclear cell subpopulations and infiltrating lymphocytes in erythema dyschromicum perstans and vitiligo.

    abstract::Erythema dyschromicum perstans (EDP) and vitiligo are two cutaneous pigmentary dermatoses of unknown etiology. In the present study, the leukocyte infiltrates in the affected skin of EDP and vitiligo patients were studied using the avidin-biotin (ABC) immunoperoxidase technique and monoclonal antibodies which recognis...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Gross A,Tapia FJ,Mosca W,Perez RM,Briceño L,Henriquez JJ,Convit J

    更新日期:1987-07-01 00:00:00

  • Synaptophysin immunoreactivity in the cat cochlear nuclei.

    abstract::The presence of synaptophysin, a presynaptic Ca2+ binding glycoprotein, has been analyzed in the cochlear nucleus complex of the adult cat using an antisynaptophysin monoclonal antibody. Synaptophysin immunoreactivity was differently distributed between regions of cochlear nuclei. Terminal boutons contacting directly ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-13.415

    authors: Gil-Loyzaga P,Bartolomé MV,Ibáñez A

    更新日期:1998-04-01 00:00:00

  • Microtubules regulate aortic endothelial cell actin microfilament reorganization in intact and repairing monolayers.

    abstract::To understand the role of microtubules and microfilaments in regulating endothelial monolayer integrity and repair, and since microtubules and microfilaments show some co-alignment in endothelial cells, we tested the hypothesis that microtubules organize microfilament distribution. Disruption of microtubules with colc...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-20.455

    authors: Lee JS,Gotlieb AI

    更新日期:2005-04-01 00:00:00

  • Comparative histopathological characteristics of highly pathogenic avian influenza (HPAI) in chickens and domestic ducks in 2008 Korea.

    abstract::We compared characteristic lesions occurring in chickens and domestic ducks naturally infected with H5N1 HPAI virus in April and May 2008. Infected chickens generally exhibited pale-green, watery diarrhoea, depression, neurological signs and cyanosis of wattles and combs, and infected ducks generally exhibited neurolo...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-26.167

    authors: Woo GH,Kim HY,Bae YC,Jean YH,Bak EJ,Kim MJ,Hwang EK,Joo YS

    更新日期:2011-02-01 00:00:00

  • Detection of platelet-derived growth factor-alpha (PDGF-A) protein in cells of Leydig lineage in the postnatal rat testis.

    abstract::Platelet-derived growth factor-A (PDGF-A) is a locally produced growth factor in the rat testis secreted by both Sertoli cells and Leydig cells. It has been suggested that PDGF-A may be involved in modulation of testosterone production and may be essential to Leydig cell differentiation, however it is not known at wha...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-21.1295

    authors: Fecteau KA,Mrkonjich L,Mason JI,Mendis-Handagama SM

    更新日期:2006-12-01 00:00:00

  • Regional differences in cell surface patterns in normal human sulcular epithelium.

    abstract::Studies with scanning electron microscopy in the normal human sulcular epithelium are scarce, and no precise information exists about cell surface patterns along the epithelium, the frequencies of these patterns, or possible regional differences within the mouth. In five periodontal biopsy specimens each from the ante...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Sánchez-Quevedo MC,Moreu G,Campos A,García JM,González-Jaranay M

    更新日期:1994-01-01 00:00:00

  • Frequent expression of haemopoietic and non-haemopoietic antigens by reactive plasma cells: an immunohistochemical study using formalin-fixed, paraffin-embedded tissue.

    abstract::Unlike other B cells, plasma cells (PC) react with only a few antibodies against haemopoietic antigens. We investigated 36 specimens exhibiting a reactive increase in PC numbers (i.e. plasmacytosis, PC hyperplasia) with a broad panel of antibodies suitable for use on formalin-fixed, paraffin-embedded tissue, and compa...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-14.805

    authors: Beschorner R,Horny HP,Petruch UR,Kaiserling E

    更新日期:1999-07-01 00:00:00

  • Muscle fiber types in tetrapods. A comparative histochemical and morphometric study.

    abstract::A comparative histochemical and morphometric study in two groups of homologous muscles from different tetrapods (rat, pigeon, lizard and frog) was performed. On the basis of their fiber diameters and oxidative enzyme activities, an initial correlation between fiber types of all animals is observed, although in the liz...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Burgos Bretones JJ,Razquin Peralta B,Aguirre Urizar J,Rivera Pomar JM

    更新日期:1987-01-01 00:00:00

  • Hepatic response to chronic hypoxia in experimental rat model through HIF-1 alpha, activator protein-1 and NF-kappa B.

    abstract::Chronic liver diseases are commonly associated with tissue hypoxia that may cause inflammation, oxidative stress, liver cell injury and increased nuclear transcriptional regulation. The hepatic response to chronic hypoxia at the molecular level has not yet been clearly understood until now. The aim of this study is to...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Lau TY,Xiao J,Liong EC,Liao L,Leung TM,Nanji AA,Fung ML,Tipoe GL

    更新日期:2013-04-01 00:00:00

  • Anti-platelet agents reduce morphological changes of chronic hypoxic pulmonary hypertension.

    abstract::The pathophysiologic mechanism by which chronic hypoxia causes pulmonary hypertension is unknown. If anti-platelet agents, or other pharmacologic interventions, altered the pulmonary vascular changes induced by hypoxia, information concerning the pathogenesis of the pulmonary hypertension or the potential therapeutic ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Keith IM,Will JA,Huxtable RJ,Weir K

    更新日期:1987-04-01 00:00:00

  • Induction system of neural and muscle lineage cells from bone marrow stromal cells; a new strategy for tissue reconstruction in degenerative diseases.

    abstract::Since bone marrow stromal cells (MSCs) are easily accessible both from healthy donors and patients, and can be expanded on a therapeutic scale, they have attracted attention for cell-based therapy. MSCs contribute to the protection of host tissue after transplantation by Immune modulation and trophic effect. They also...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-24.631

    authors: Kitada M,Dezawa M

    更新日期:2009-05-01 00:00:00