The bed nucleus of the stria terminalis is critically involved in enhancing associative learning after stressful experience.

Abstract:

:Exposure to an acute stressful event enhances trace eyeblink conditioning in male rats, even when rats begin training days after the stressor (Shors, 2001). The authors examined whether the bed nucleus of the stria terminalis (BNST), an area involved in stress and anxiety, is critically involved in this effect and, if so, when. The authors found that excitotoxic lesions to the BNST prevented the enhanced conditioning after stressor exposure. In addition, temporary inactivation of the BNST during the stressor did not alter enhanced responding, whereas inactivation during training prevented the enhancement. These data indicate that stressful experience induces persistent changes in the BNST that are necessary for enhancing learning well after the stressful event has ceased.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Bangasser DA,Santollo J,Shors TJ

doi

10.1037/0735-7044.119.6.1459

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

1459-66

issue

6

eissn

0735-7044

issn

1939-0084

pii

2006-00645-004

journal_volume

119

pub_type

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