Abstract:
:This experiment was conducted to determine whether the amount of preoperative training influences the effects, on retention, of amygdala lesions induced 30 days after escape training. Rats received 1 or 10 footshock-motivated escape training trials; 30 days later, sham or neurotoxic amygdala lesions were induced. Results of an inhibitory avoidance test performed 4 days after surgery indicated that amygdala lesions impaired retention performance; however, increased preoperative training partially attenuated the retention deficit. Increased preoperative training also attenuated the impairing effects of the lesions on retention assessed in a continuous multiple-trial inhibitory avoidance task given 36 days after the original escape training. The finding that amygdala-lesioned rats remembered the escape training suggests that the amygdala is not a critical locus of the changes underlying the long-term retention of footshock-motivated escape training.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Parent MB,West M,McGaugh JLdoi
10.1037//0735-7044.108.6.1080subject
Has Abstractpub_date
1994-12-01 00:00:00pages
1080-7issue
6eissn
0735-7044issn
1939-0084journal_volume
108pub_type
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