A functional circuit for the retrieval of remote cued fear memory.

Abstract:

:Although the retrosplenial cortex (RSC) is necessary for the retrieval of remotely acquired fear to a discrete auditory cue, it is not necessary for the retrieval of recently acquired cued-fear memories. Thus, the RSC's role in memory retrieval for discrete cues is time-dependent. The purpose of the current experiment was to identify the larger cortical circuit involved in the retrieval of remotely-acquired auditory fear memories. One candidate circuit involves the RSC and secondary auditory cortex; the secondary auditory cortex is also necessary for the retrieval of remotely acquired auditory fear memories (Sacco & Sacchetti, 2010), and sends direct projections to the RSC. To test this possibility, we assessed retrieval of remote memory following functional disconnection of the RSC and secondary auditory cortex. Complete disconnection of these regions produced a larger impairment in fear expression to a remotely acquired auditory cue compared to partial disconnection of these regions. These results are consistent with the notion that RSC and secondary auditory cortex form a functional circuit involved in the retrieval of remotely acquired fear to a discrete auditory cue. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Todd TP,Jiang MY,DeAngeli NE,Bucci DJ

doi

10.1037/bne0000237

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

403-408

issue

5

eissn

0735-7044

issn

1939-0084

pii

2018-25962-001

journal_volume

132

pub_type

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