A functional circuit for the retrieval of remote cued fear memory.


:Although the retrosplenial cortex (RSC) is necessary for the retrieval of remotely acquired fear to a discrete auditory cue, it is not necessary for the retrieval of recently acquired cued-fear memories. Thus, the RSC's role in memory retrieval for discrete cues is time-dependent. The purpose of the current experiment was to identify the larger cortical circuit involved in the retrieval of remotely-acquired auditory fear memories. One candidate circuit involves the RSC and secondary auditory cortex; the secondary auditory cortex is also necessary for the retrieval of remotely acquired auditory fear memories (Sacco & Sacchetti, 2010), and sends direct projections to the RSC. To test this possibility, we assessed retrieval of remote memory following functional disconnection of the RSC and secondary auditory cortex. Complete disconnection of these regions produced a larger impairment in fear expression to a remotely acquired auditory cue compared to partial disconnection of these regions. These results are consistent with the notion that RSC and secondary auditory cortex form a functional circuit involved in the retrieval of remotely acquired fear to a discrete auditory cue. (PsycINFO Database Record (c) 2018 APA, all rights reserved).


Behav Neurosci


Behavioral neuroscience


Todd TP,Jiang MY,DeAngeli NE,Bucci DJ




Has Abstract


2018-10-01 00:00:00














  • Selective serotonin receptor stimulation of the medial nucleus accumbens causes differential effects on food intake and locomotion.

    abstract::Substantial evidence suggests that pharmacological manipulations of neural serotonin pathways influence ingestive behaviors. Despite the known role of the nucleus accumbens in directing appetitive and consummatory behavior, there has been little examination of the influences that serotonin receptors may play in modula...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Pratt WE,Blackstone K,Connolly ME,Skelly MJ

    更新日期:2009-10-01 00:00:00

  • Effects of ethanol and caffeine on behavior in C57BL/6 mice in the plus-maze discriminative avoidance task.

    abstract:INTRODUCTION:Caffeine is frequently consumed concurrent to or immediately following ethanol consumption. Identifying how caffeine and ethanol interact to modulate behavior is essential to understanding the co-use of these drugs. The plus-maze discriminative avoidance task (PMDAT) allows within-subject measurement of le...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Gulick D,Gould TJ

    更新日期:2009-12-01 00:00:00

  • Early postnatal handling alters glucocorticoid receptor concentrations in selected brain regions.

    abstract::Norway rat pups were either handled (H) or undisturbed (nonhandled, NH) in the period between birth and weaning on Day 21. Following weaning, half of the animals in each group were housed socially (Soc), and half were housed in isolation (Isol). At 120-150 days of age, all animals were sacrificed, and the following re...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Meaney MJ,Aitken DH,Bodnoff SR,Iny LJ,Tatarewicz JE,Sapolsky RM

    更新日期:1985-08-01 00:00:00

  • Mnemonic theories of hippocampal function.

    abstract::Although mnemonic interpretations of hippocampal function in people have been readily accepted for many years, similar interpretations of hippocampal function in animals have received a number of challenges. This article reviews two of these challenges, shows how they were resolved in favor of some kind of mnemonic in...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章,评审


    authors: Olton DS,Wible CG,Shapiro ML

    更新日期:1986-12-01 00:00:00

  • Role of instrumental learning in tolerance to cathinone hypophagia.

    abstract::The effects of dl-cathinone on milk intake and motor activity were investigated in bottle- and cannula-fed rats. Acute injections of cathinone produced dose-dependent increases in activity in both groups but only produced decreased intake in bottle-fed rats. With chronic injections, tolerance to the suppression of int...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Wolgin DL,Munoz JR

    更新日期:2006-04-01 00:00:00

  • Satiety-responsive neurons in the medial orbitofrontal cortex of the macaque.

    abstract::Feeding-related gustatory, olfactory, and visual activation of the orbitofrontal cortex (OFC) decreases following satiety. Previous neurophysiological studies have concentrated on the caudolateral OFC (clOFC). We describe satiety-induced modulation of 23 gustatory, 5 water, and 15 control neurons in the medial OFC (mO...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Pritchard TC,Nedderman EN,Edwards EM,Petticoffer AC,Schwartz GJ,Scott TR

    更新日期:2008-02-01 00:00:00

  • Epinephrine-induced learning under anesthesia: retention performance at several training-testing intervals.

    abstract::While under deep barbiturate anesthesia, rats received a series of 10 classical conditioning trials in which white noise was paired with intramuscular shock. The anesthetized animals received either saline or epinephrine injections prior to the training trials. Independent sets of animals were tested for retention per...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Gold PE,Weinberger NM,Sternberg DB

    更新日期:1985-10-01 00:00:00

  • Milk-induced, opioid-mediated antinociception in rats at the time of cesarean delivery.

    abstract::Four experiments were conducted in rats within 2 hr of cesarean delivery to assess antinociception at birth and its possible opioid bases. Morphine antinociception was established in a dose-dependent fashion (0.0625-5.0 mg/kg bw). Analgesia was naloxone (1.0 mg/kg) reversible. In succeeding experiments, antinociceptio...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Blass EM,Jackson AM,Smotherman WP

    更新日期:1991-10-01 00:00:00

  • Behavioral spectral sensitivities of different retinal areas in pigeons.

    abstract::The spectral sensitivity of the red and the yellow retinal fields of head-fixed pigeons was separately measured for wavelengths between 340 and 640 nm by a behavioral perimetric technique. Within this spectral range the mean spectral sensitivity of both fields was found to be maximal at 584 nm and minimal at the lower...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Remy M,Emmerton J

    更新日期:1989-02-01 00:00:00

  • Hippocampectomy impairs the memory of recently, but not remotely, acquired trace eyeblink conditioned responses.

    abstract::New Zealand male rabbits (Oryctolagus cuniculus) were trained on a trace eyeblink conditioning paradigm using a 250-ms tone conditioned stimulus, a 100-ms airpuff unconditioned stimulus, and a 500-ms trace interval. Rabbits received bilateral hippocampal aspirations either 1 day or 1 month after learning. Controls con...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Kim JJ,Clark RE,Thompson RF

    更新日期:1995-04-01 00:00:00

  • Lack of task specificity and absence of posttraining effects of atropine on learning.

    abstract::Three experiments are reported whose purpose was to examine the effect of the cholinergic antagonist atropine on the acquisition of different learning tasks known to be sensitive or insensitive to impairment by hippocampal lesions; on the retention of performance acquired in the absence of the drug; and on memory cons...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Hagan JJ,Tweedie F,Morris RG

    更新日期:1986-08-01 00:00:00

  • Analysis of learning deficits in aged rats on the W-track continuous spatial alternation task.

    abstract::Young and aged animals were tested on a spatial alternation task that consisted of two interleaved components: (1) an "outbound" or alternation component (working memory) and (2) an "inbound" component, requiring the animal to remember to return to a central location in space (spatial memory). In the present study, ag...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Kapellusch AJ,Lester AW,Schwartz BA,Smith AC,Barnes CA

    更新日期:2018-12-01 00:00:00

  • Behavior of rat fetuses following chemical or tactile stimulation.

    abstract::The behavior of fetal rats was examined on Day 19 of gestation with procedures that enabled chemical stimulation and direct observation of fetuses. Rat fetuses are sensitive to both tactile stroking and intraoral infusion of chemical solutions, but the pattern and amount of activity depend upon the modality of stimula...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Smotherman WP,Robinson SR

    更新日期:1988-02-01 00:00:00

  • Anteromedial temporal lobe damage blocks startle modulation by fear and disgust.

    abstract::The acoustic startle reflex (ASR) is potentiated during negative emotion, but attenuated during positive emotional experience. The modulation of the ASR by fear depends critically on the amygdala. The authors investigated ASR modulation to fearful, disgusting, pleasant, and neutral stimuli in 12 patients with unilater...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Buchanan TW,Tranel D,Adolphs R

    更新日期:2004-04-01 00:00:00

  • Neonatal chorda tympani transection alters adult preference for ammonium chloride in the rat.

    abstract::The immature gustatory system of the neonatal rat is characterized by sensitivity to disruption by early interventions such as receptor or nerve damage. The present studies examined the effect of chorda tympani transection (neoCTX) of neonates on adult preference for salt and nonsalt stimuli. NeoCTX at 10 days of age ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Sollars SI,Bernstein IL

    更新日期:1996-06-01 00:00:00

  • Supplemental choline during the periweaning period protects against trace conditioning impairments attributable to post-training ethanol exposure in adolescent rats.

    abstract::Supplemental choline during early stages of development can result in long-lasting improvements to memory function. In addition, pre- or postnatal choline has been shown to be protective against some of the adverse effects of early alcohol exposure. The present experiment examined whether supplemental choline given to...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Hunt PS

    更新日期:2012-08-01 00:00:00

  • Medial prefrontal lesions impair performance in an operant delayed nonmatch to sample working memory task.

    abstract::Cognitive functions, such as working memory, are disrupted in most psychiatric disorders. Many of these processes are believed to depend on the medial prefrontal cortex (mPFC). Traditionally, maze-based behavioral tasks, which have a strong exploratory component, have been used to study the role of the mPFC in working...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Benoit LJ,Holt ES,Teboul E,Taliaferro JP,Kellendonk C,Canetta S

    更新日期:2020-06-01 00:00:00

  • Sexual behavior regulated (paced) by the female induces conditioned place preference.

    abstract::The possibility that female-paced coital behavior induces a reward state of sufficient intensity and duration to induce conditioning was evaluated by the conditioned-place-preference paradigm. Ovariectomized female rats, treated with estradiol benzoate and progesterone, regulated (paced) their coital interactions with...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Paredes RG,Alonso A

    更新日期:1997-02-01 00:00:00

  • Re-examination of amphetamine-induced conditioned suppression of tastant intake in rats: the task-dependent drug effects hypothesis.

    abstract::This study reexamined Grigson's reward comparison hypothesis (1997), which claimed to have resolved the paradox of addictive, rewarding drugs manifesting an aversive effect in the conditioned taste aversion (CTA) paradigm. Here, the authors compared the conditioned suppression effects of lithium chloride (LiCl) and am...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Huang AC,Hsiao S

    更新日期:2008-12-01 00:00:00

  • Perinatal stress effects on later anxiety and hormone secretion in male mandarin voles.

    abstract::The estradiol (E2), estrogen receptor-α (ERα), testosterone (T), and androgen receptor (AR) can contribute to anxiety, but whether they are associated with the reversion of prenatal adverse outcomes remains unclear. Here, we tested the interactive effects of prenatal maternal restraint stress and early postnatal short...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: He FQ,Fang G,Wang B,Guo XJ,Guo CL

    更新日期:2015-12-01 00:00:00

  • Effects of parturition and maternal experience on noradrenaline and acetylcholine release in the olfactory bulb of sheep.

    abstract::Acetylcholine (ACh) and noradrenaline (NA) release in the olfactory bulb (OB) of ewes was monitored using microdialysis. Both ACh and NA release increased at parturition in multiparous but not in primiparous ewes. However, vaginocervical stimulation performed 6 hr postpartum induced an increase of ACh and NA release i...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Lévy F,Guevara-Guzman R,Hinton MR,Kendrick KM,Keverne EB

    更新日期:1993-08-01 00:00:00

  • The lasting effects of spike insoles on postural control in the elderly.

    abstract::The purpose of the present study was to explore the lasting effects of a tactile sensitivity enhancement induced by spike insoles on the control of stance in the elderly. Healthy elderly subjects (n = 19, mean age = 68.8) and young adults (n = 17, mean age = 24.3) were instructed to stand or to walk for 5 minutes with...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Palluel E,Olivier I,Nougier V

    更新日期:2009-10-01 00:00:00

  • Transient inactivation of the thalamic nucleus reuniens and rhomboid nucleus produces deficits of a working-memory dependent tactile-visual conditional discrimination task.

    abstract::Working memory depends on communication between the hippocampus and the prefrontal cortex (PFC); however, the neural circuitry that mediates interactions between these brain areas has not been well characterized. Two candidate structures are the thalamic reuniens (RE) and rhomboid (Rh) nuclei, which are reciprocally c...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Hallock HL,Wang A,Shaw CL,Griffin AL

    更新日期:2013-12-01 00:00:00

  • Neonatal hind-paw injury disrupts acquisition of an instrumental response in adult spinal rats.

    abstract::The present study was designed to evaluate the impact of neonatal injury on adult spinal plasticity in rats. Subjects were randomly assigned to 1 of 4 experimental conditions: (a) hind-paw injury at Postnatal Day (PD) 2, (b) hind-paw injury at PD 5, (c) anesthesia exposure only on PD 2, or (d) anesthesia exposure only...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Young EE,Baumbauer KM,Elliot A,Joynes RL

    更新日期:2007-10-01 00:00:00

  • The union of the state: myoclonic twitching is coupled with nuchal muscle atonia in infant rats.

    abstract::Active sleep (AS), as measured by the occurrence of myoclonic twitching (MT), is the most prevalent behavioral state in newborn rats. Historically, AS has been considered a developmental precursor of REM sleep, but recently this idea has been questioned. In the present study, the authors assess, in 2-, 5-, and 8-day-o...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Karlsson KA,Blumberg MS

    更新日期:2002-10-01 00:00:00

  • Conditioned cyclosporine effects but not conditioned taste aversion in immunized rats.

    abstract::In 2 experiments, the development of adjuvant arthritis (an experimental autoimmune disease) was inhibited by exposing rats to a flavored solution that had previously been paired with injections of cyclosporine (an immunodepressive drug) compared with rats with the same history but exposed to a flavored solution that ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Klosterhalfen S,Klosterhalfen W

    更新日期:1990-10-01 00:00:00

  • Modulation of nicotine but not ethanol preference by the mouse Chrna4 A529T polymorphism.

    abstract::Available evidence indicates that common genes influence alcohol and tobacco abuse in humans. The studies reported here used mouse models to evaluate the hypothesis that genetically determined variability in the alpha4beta2* nicotinic receptor modulates genetically determined variability in the intake of both nicotine...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Butt CM,King NM,Hutton SR,Collins AC,Stitzel JA

    更新日期:2005-02-01 00:00:00

  • Memory impairment on a delayed non-matching-to-position task after lesions of the perirhinal cortex in the rat.

    abstract::Previous research conducted in monkeys and rats has established that the perirhinal cortex is critically involved in object- or stimulus-recognition memory, whereas other research suggests this region may contribute to memory for object discriminations. These findings do not rule out the possibility that the perirhina...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Wiig KA,Burwell RD

    更新日期:1998-08-01 00:00:00

  • Stress and adenosine: II. Adenosine analogs mimic the effect of inescapable shock on shuttle-escape performance in rats.

    abstract::In 3 experiments, the authors examined the role of adenosine regulation in escape deficits produced by earlier exposure to inescapable shock in rats (learned helplessness). Adenosine analogs injected before escape testing mimicked the effect of earlier inescapable shock, with the magnitude of the deficit varying with ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Minor TR,Winslow JL,Chang WC

    更新日期:1994-04-01 00:00:00

  • Fimbria-fornix transections disrupt the ontogeny of delayed alternation but not position discrimination in the rat.

    abstract::In Experiment 1, Long-Evans rat pups received fimbria-fornix transections or sham surgery on Postnatal Day 10 (PND10) and were then trained on PND23 to perform either a discrete-trials delayed alternation (DA) or a simple position discrimination (PD) task in a T maze. Rat pups in both surgical conditions learned the P...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Freeman JH Jr,Stanton ME

    更新日期:1991-06-01 00:00:00