Neonatal handling reduces the number of cells in the locus coeruleus of rats.

Abstract:

:Neonatal handling induces long-lasting effects on behaviors and stress responses. The objective of the present study was to analyze the effects of neonatal handling (from the 1st to the 10th day after delivery) on the number of cells and volume of locus coeruleus (LC) nucleus in male and female rats at 4 different ages: 11, 26, 35, and 90 days. Results showed significant reductions in the number of cells and the volume of the LC nucleus in neonatally handled males and females compared with nonhandled rats. Environmental stimulation early in life induced a stable structural change in a central noradrenergic nucleus, which could be one of the causal factors for the behavioral and hormonal alterations observed in adulthood.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Lucion AB,Pereira FM,Winkelman EC,Sanvitto GL,Anselmo-Franci JA

doi

10.1037/0735-7044.117.5.894

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

894-903

issue

5

eissn

0735-7044

issn

1939-0084

pii

2003-08567-002

journal_volume

117

pub_type

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