Abstract:
:This series of experiments investigated the role of a prefrontal cortical-dorsal striatal circuit in attention, using a continuous performance task of sustained and spatially divided visual attention. A unilateral excitotoxic lesion of the medial prefrontal cortex and a contralateral lesion of the medial caudate-putamen were used to "disconnect" the circuit. Control groups of rats with unilateral lesions of either structure were tested in the same task. Behavioral controls included testing the effects of the disconnection lesion on Pavlovian discriminated approach behavior. The disconnection lesion produced a significant reduction in the accuracy of performance in the attentional task but did not impair Pavlovian approach behavior or affect locomotor or motivational variables, providing evidence for the involvement of this medial prefrontal corticostriatal system in aspects of visual attentional function.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Christakou A,Robbins TW,Everitt BJdoi
10.1037//0735-7044.115.4.812subject
Has Abstractpub_date
2001-08-01 00:00:00pages
812-25issue
4eissn
0735-7044issn
1939-0084journal_volume
115pub_type
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