Drug discrimination training during chronic drug treatment affects the development of tolerance.

abstract：:Female rats exhibit a conditioned place preference (CPP) for a context paired with mating. The present experiment tested the hypothesis that the activation of the pelvic nerve mediates the reinforcing effects of mating for female rats. Rats underwent bilateral pelvic nerve or sham transection and then received paced m...

journal_title：Behavioral neuroscience

authors： Meerts SH,Clark AS

更新日期：2009-06-01 00:00:00

abstract：:These studies were designed to determine the dose-response autonomic and behavioral thermoregulatory effects and the motor effects of dopamine (DA) and prostaglandin E1 (PGE1) injected into the lateral cerebral ventricles of rats. These studies were made possible with a computer-controlled thermocline that permits fre...

journal_title：Behavioral neuroscience

authors： Marques PR,Spencer RL,Burks TF,McDougal JN

更新日期：1984-10-01 00:00:00

abstract：:The behavior of fetal rats was examined on Day 19 of gestation with procedures that enabled chemical stimulation and direct observation of fetuses. Rat fetuses are sensitive to both tactile stroking and intraoral infusion of chemical solutions, but the pattern and amount of activity depend upon the modality of stimula...

journal_title：Behavioral neuroscience

authors： Smotherman WP,Robinson SR

更新日期：1988-02-01 00:00:00

abstract：:The ability to attend to appropriate stimuli, to plan actions and then alter those actions when environmental conditions change, is essential for an organism to thrive. There is increasing evidence that these executive control processes are mediated in part by N-methyl-D-aspartate receptors (NMDAR). NMDAR subunits con...

journal_title：Behavioral neuroscience

authors： Thompson SM,Josey M,Holmes A,Brigman JL

更新日期：2015-04-01 00:00:00

abstract：:In order to examine the development of tolerance to opioids, eight cynomolgus and two rhesus monkeys were trained to press a lever for food reinforcement and then were catheterized so that drugs could be infused. Three doses of hydromorphone and six different interdose intervals were studied. Hydromorphone infusions i...

journal_title：Behavioral neuroscience

authors： Ternes JW,Ehrman R,O'Brien CP

更新日期：1983-04-01 00:00:00

abstract：:This study reexamined Grigson's reward comparison hypothesis (1997), which claimed to have resolved the paradox of addictive, rewarding drugs manifesting an aversive effect in the conditioned taste aversion (CTA) paradigm. Here, the authors compared the conditioned suppression effects of lithium chloride (LiCl) and am...

journal_title：Behavioral neuroscience

authors： Huang AC,Hsiao S

更新日期：2008-12-01 00:00:00

abstract：:The authors measured food reinforcement, polymorphisms of the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes, and laboratory energy intake in 29 obese and 45 nonobese humans 18-40 years old. Food reinforcement was greater in obese than in nonobese individuals, especially in obese individuals with th...

journal_title：Behavioral neuroscience

authors： Epstein LH,Temple JL,Neaderhiser BJ,Salis RJ,Erbe RW,Leddy JJ

更新日期：2007-10-01 00:00:00

abstract：:Regulation of energy intake depends in part on both memory for prior food intake and internal signals of hunger and satiety. These functions are both mediated by the hippocampus, a brain structure that animal studies have shown to be impaired after maintenance on high fat and refined sugar (HFS) diets. Study 1, using ...

journal_title：Behavioral neuroscience

authors： Francis HM,Stevenson RJ

更新日期：2011-12-01 00:00:00

abstract：:Although mnemonic interpretations of hippocampal function in people have been readily accepted for many years, similar interpretations of hippocampal function in animals have received a number of challenges. This article reviews two of these challenges, shows how they were resolved in favor of some kind of mnemonic in...

journal_title：Behavioral neuroscience

authors： Olton DS,Wible CG,Shapiro ML

更新日期：1986-12-01 00:00:00

abstract：:The ability of men to identify popular word associations had earlier been shown to be affected by left-sided thalamic surgery for movement disorders; now, over a year later, the impairment has been observed with operations on both sides. In addition, upon testing at approximately the same time interval, men who had un...

journal_title：Behavioral neuroscience

authors： Lansdell H

更新日期：1989-08-01 00:00:00

abstract：:Previous results from our laboratory have demonstrated that 3-day-old rats given dopamine (DA)-depleting brain lesions are spared the severe behavioral dysfunctions seen after comparable brain damage in adults. This behavioral sparing is accompanied by a sprouting of serotonin (5-HT)-containing neurons in the striatum...

journal_title：Behavioral neuroscience

authors： Bruno JP,Jackson D,Zigmond MJ,Stricker EM

更新日期：1987-12-01 00:00:00

abstract：:Mice with genetically associated variations in the number and density of granule cells in the dentate gyrus were tested for open-field activity, spatial maze learning, and two-way avoidance conditioning. The number of granule cells was not associated with any behavior measured. Only avoidance conditioning was related ...

journal_title：Behavioral neuroscience

authors： Wimer C,Wimer RE,Wimer JS

更新日期：1983-12-01 00:00:00

abstract：:Substantial evidence suggests that pharmacological manipulations of neural serotonin pathways influence ingestive behaviors. Despite the known role of the nucleus accumbens in directing appetitive and consummatory behavior, there has been little examination of the influences that serotonin receptors may play in modula...

journal_title：Behavioral neuroscience

authors： Pratt WE,Blackstone K,Connolly ME,Skelly MJ

更新日期：2009-10-01 00:00:00

abstract：:Following spinal transection of the upper thoracic spinal cord, male Sprague-Dawley rats given legshock whenever a hindlimb is extended learn to maintain the leg in a flexed position. The region of the cord that mediates this instrumental learning was isolated using neuroanatomical tracing, localized infusion of lidoc...

journal_title：Behavioral neuroscience

authors： Liu GT,Ferguson AR,Crown ED,Bopp AC,Miranda RC,Grau JW

更新日期：2005-04-01 00:00:00

abstract：:The relation between testosterone and imprinting was investigated in domestic chicks. After hatching, chicks received either testosterone enanthate in oil or oil alone (controls). The chicks were then trained by exposing them to a rotating imprinting stimulus, either a red box or a stuffed jungle fowl. A preference sc...

journal_title：Behavioral neuroscience

authors： Bolhuis JJ,McCabe BJ,Horn G

更新日期：1986-02-01 00:00:00

abstract：:Spontaneous and drug-induced turning behavior and thigmotactic scanning were tested either acutely (4-6 hr) or chronically (9 days) after unilateral removal of vibrissae in rats. Rats that were tested acutely scanned more with the intact vibrissae side. This asymmetry was reduced in rats that were tested chronically, ...

journal_title：Behavioral neuroscience

authors： Milani H,Schwarting RK,Kumpf S,Steiner H,Huston JP

更新日期：1990-06-01 00:00:00

abstract：:Quipazine is a 5-HT2A-receptor agonist that has been used to induce motor activity and promote recovery of function after spinal cord injury in neonatal and adult rodents. Sensory stimulation also activates sensory and motor circuits and promotes recovery after spinal cord injury. In rats, tail pinching is an effectiv...

journal_title：Behavioral neuroscience

authors： Swann HE,Kauer SD,Allmond JT,Brumley MR

更新日期：2017-02-01 00:00:00

abstract：:This study uses an operant, behavioral model to assess the daily changes in the decay rate of short-term memory, motivation, and motor ability in rats exposed to chronic restraint. Restraint decreased reward-related motivation by 50% without altering memory decay rate or motor ability. Moreover, chronic restraint impa...

journal_title：Behavioral neuroscience

authors： Kleen JK,Sitomer MT,Killeen PR,Conrad CD

更新日期：2006-08-01 00:00:00

abstract：:These experiments examined the sufficiency of pairing an odor with either intrabulbar activation of noradrenergic beta-receptors or pharmacological stimulation of the locus coeruleus to support learned odor preferences in Postnatal Day 6-7 rat pups. The results showed that pups exposed to odor paired with beta-recepto...

journal_title：Behavioral neuroscience

authors： Sullivan RM,Stackenwalt G,Nasr F,Lemon C,Wilson DA

更新日期：2000-10-01 00:00:00

abstract：:Mild traumatic brain injuries are known to cause a host of symptoms, including headaches, nausea, and depression, that when persistent, are known as postconcussive syndrome. In addition to these overt symptomologies, individuals may experience changes in day-to-day behavior or temperament, which although not meeting c...

journal_title：Behavioral neuroscience

authors： Hazari A,Salberg S,Griep Y,Yamakawa GR,Mychasiuk R

更新日期：2020-10-01 00:00:00

abstract：:The effects of exogenous and endogenous steroids on components of female sexual behavior of neonatal male and female rats were investigated. In Experiment 1, 4-day-old rats were treated with 0, 0.1, 1.0, 10, or 100 micrograms/10 g body weight estradiol benzoate (EB) and were tested 44 hr later. In Experiment 2, male r...

journal_title：Behavioral neuroscience

authors： Williams CL

更新日期：1987-10-01 00:00:00

abstract：:Vasopressin-immunoreactive (AVP-ir) cells in the bed nucleus of the stria terminalis (BST) and medial amygdaloid nucleus (MA) and their AVP-ir projections to the lateral septum were studied in monogamous prairie voles (Microtus ochrogaster) and promiscuous meadow voles (M. pennsylvanicus). A sexually dimorphic AVP-ir ...

journal_title：Behavioral neuroscience

authors： Wang Z

更新日期：1995-04-01 00:00:00

abstract：:Sniffing, a behavior that enhances detection and localization of odorants, is typically assumed to require behavioral arousal. In an effort to determine whether sniffing and arousal are dissociable, dimethyl disulfide (DMDS) was presented to 8-day-old rats while respiration and behavioral state were monitored. Pups sn...

journal_title：Behavioral neuroscience

authors： Seelke AM,Blumberg MS

更新日期：2004-04-01 00:00:00

abstract：:Female ovariectomized (OVX) and sham-OVX rats were trained in a task designed to assess sustained attention. After achieving asymptotic performance, OVX rats did not exhibit the impairment in performance over blocks of trials (i.e., the vigilance decrement) observed in sham-OVX rats. Furthermore, OVX rats' performance...

journal_title：Behavioral neuroscience

authors： McGaughy J,Sarter M

更新日期：1999-12-01 00:00:00

abstract：:Effects of the ingestion of protein and carbohydrate conditioned a preference for one size of chow particle over another, which was triggered by need for a specific nutrient. This learned elicitation of nutrient-specific dietary selection was not changed by injection of dl-fenfluramine HCl (2.5 mg/kg). This indicates ...

journal_title：Behavioral neuroscience

authors： Booth DA,Baker BJ

更新日期：1990-02-01 00:00:00

abstract：:This study was prompted by reports of functionally normal humans with micrencephaly or cortical hypoplasia. Methylazoxymethanol acetate (MAM) treatment, which induces micrencephaly in rats, was administered by injection (20 mg/kg) on gestational day 14. Prior to weaning and into adulthood, offspring were assessed on m...

journal_title：Behavioral neuroscience

authors： Ferguson SA,Racey FD,Paule MG,Holson RR

更新日期：1993-12-01 00:00:00

abstract：:Central cannabinoid receptors mediate neural oscillations and are localized to networks implicated in auditory P50 sensory gating, including the hippocampus and neocortex. The current study examined whether neural oscillations evoked by the paired clicks (S1, S2) are associated with abnormal P50 gating reported in can...

journal_title：Behavioral neuroscience

authors： Edwards CR,Skosnik PD,Steinmetz AB,O'Donnell BF,Hetrick WP

更新日期：2009-08-01 00:00:00

abstract：:Two groups of rats were trained on operant discriminations in which the discriminanda were two different sound pressure levels of a 4-kHz tone. The discriminanda were chosen so that the loudness difference between stimuli was equivalent for each group when calculated from a power function with an exponent of .35. Half...

journal_title：Behavioral neuroscience

authors： Raslear TG,Pierrel-Sorrentino R,Rudnick F

更新日期：1983-06-01 00:00:00

abstract：:Adult male rats were implanted with chronically indwelling recording electrodes in the dentate hilus of one hemisphere and bipolar stimulating electrodes in the contralateral entorhinal cortex (EC). Daily measurements were then made of the amplitude of responses, evoked through the crossed temporodentate (CTD) pathway...

journal_title：Behavioral neuroscience

authors： Reeves TM,Smith DC

更新日期：1987-04-01 00:00:00

abstract：:Environmental cues associated with drug administration elicit neural activation in circuits involved in cognitive processes and emotional regulation. An important question is whether the neural activation observed is specific to the drug-paired environment or is due to a generalized activation induced by previous drug...

journal_title：Behavioral neuroscience

authors： Schroeder BE,Kelley AE

更新日期：2002-08-01 00:00:00