Reinnervation of the dentate gyrus and recovery of alternation behavior following entorhinal cortex lesions.

Abstract:

:Adult male rats were implanted with chronically indwelling recording electrodes in the dentate hilus of one hemisphere and bipolar stimulating electrodes in the contralateral entorhinal cortex (EC). Daily measurements were then made of the amplitude of responses, evoked through the crossed temporodentate (CTD) pathway, while the rats were unanesthetized and unrestrained. The implanted rats were also trained to alternate turns in a T-maze, with the use of a rewarded-alternation procedure. After reaching criterion performance in the alternation task, each rat was given a lesion of the EC ipsilateral to the recording electrode (n = 14) or a sham lesion (n = 5). Mean amplitudes of the evoked responses increased over Postlesion Days 4-11, probably due to reactive synaptogenesis in the CTD system, reaching a level that was significantly elevated above prelesion levels by Postlesion Day 6. Rats given EC lesions exhibited a transient impairment in alternation performance, with the mean alternation score significantly below prelesion levels on Postlesion Days 2-6. Although 2 EC-lesioned rats did not show a behavioral deficit, the electrophysiological increases and behavioral recovery were correlated in the remaining 12 cases (Pearson r = .73). These results are consistent with the interpretation that sprouting by the CTD system contributes to recovery of T-maze alternation performance following unilateral EC lesions.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Reeves TM,Smith DC

doi

10.1037//0735-7044.101.2.179

subject

Has Abstract

pub_date

1987-04-01 00:00:00

pages

179-86

issue

2

eissn

0735-7044

issn

1939-0084

journal_volume

101

pub_type

杂志文章
  • Behavioral sensitization to apomorphine in pigeons (Columba livia): blockade by the D1 dopamine antagonist SCH-23390.

    abstract::Repeated administration of apomorphine leads to a context-dependent pecking response sensitization. Previously sensitized pigeons (Columba livia) challenged with saline in the same context show a conditioned response (CR). The authors studied the effects of intrastriatal injections of the dopamine (D(1)) antagonist SC...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.118.5.1080

    authors: Acerbo MJ,Delius JD

    更新日期:2004-10-01 00:00:00

  • Aged rats with intact memory show distinctive recruitment in cortical regions relative to young adults in a cue mismatch task.

    abstract::Similar to elderly humans, aged Long-Evans rats exhibit individual differences in performance on tasks that critically depend on the medial temporal lobe memory system. Although reduced memory performance is common, close to half of aged rats in this outbred rodent population perform within the range of young subjects...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000332

    authors: Haberman RP,Monasterio A,Branch A,Gallagher M

    更新日期:2019-10-01 00:00:00

  • Dopaminergic activity modulation via aggression, status, and a visual social signal.

    abstract::Social interaction may elicit aggression, establish social rank, and be influenced by changes in central dopaminergic activity. In the lizard Anolis carolinensis, a sign stimulus (darkening of postorbital skin or eyespots) inhibits aggressive response from opponents, in part because it forms more rapidly in dominant m...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.120.1.93

    authors: Korzan WJ,Forster GL,Watt MJ,Summers CH

    更新日期:2006-02-01 00:00:00

  • Preferential use of the landmark navigational system by head direction cells in rats.

    abstract::Previous studies have identified a population of cells recorded in the postsubiculum and the anterior thalamic nucleus (ATN) that discharge as a function of an animal's head direction (HD) in the horizontal plane. The present experiments monitored HD cell activity when rats were confronted with a situation in which di...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.109.1.49

    authors: Goodridge JP,Taube JS

    更新日期:1995-02-01 00:00:00

  • Modification of the acoustic startle response in hearing-impaired C57BL/6J mice: prepulse augmentation and prolongation of prepulse inhibition.

    abstract::Modification of acoustic startle amplitude by a 10-ms tone prepulse (S1) was evaluated as a function of the interstimulus interval (ISI) between the onset of S1 and the onset of the startle-evoking stimulus (S2). Subjects were normal-hearing 1-month-old C57BL/6J (C57) mice and CBA/CaJ mice and 5-month-old C57 mice wit...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.109.3.396

    authors: Willott JF,Carlson S

    更新日期:1995-06-01 00:00:00

  • Anticipatory errors after unilateral lesions of the subthalamic nucleus in the rat: evidence for a failure of response inhibition.

    abstract::The nature of anticipatory responding in rats with unilateral subthalamic nucleus lesions was examined. Rats were trained to respond toward visual targets that were preceded by 1 of 4 different cues. For normal rats, a cue invokes an involuntary attentional orienting that enhances processing of the target at the locat...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.114.1.150

    authors: Phillips JM,Brown VJ

    更新日期:2000-02-01 00:00:00

  • Behavioral thermoregulation, core temperature, and motor activity: simultaneous quantitative assessment in rats after dopamine and prostaglandin E1.

    abstract::These studies were designed to determine the dose-response autonomic and behavioral thermoregulatory effects and the motor effects of dopamine (DA) and prostaglandin E1 (PGE1) injected into the lateral cerebral ventricles of rats. These studies were made possible with a computer-controlled thermocline that permits fre...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.98.5.858

    authors: Marques PR,Spencer RL,Burks TF,McDougal JN

    更新日期:1984-10-01 00:00:00

  • Sex and sodium intake in the rat.

    abstract::Female rats drink more 3% NaCl solution than do males, both when they need sodium (need-induced sodium intake or sodium appetite) and when they do not (need-free sodium intake). The sexual dimorphism of sodium intake is a secondary sexual characteristic because after castration at 1 day of age male rats drank 3% NaCl ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.106.1.172

    authors: Chow SY,Sakai RR,Witcher JA,Adler NT,Epstein AN

    更新日期:1992-02-01 00:00:00

  • An abrupt developmental shift in callosal modulation of sleep-related spindle bursts coincides with the emergence of excitatory-inhibitory balance and a reduction of somatosensory cortical plasticity.

    abstract::Transecting the corpus callosum of postnatal day (P)1-6 rats disinhibits the production of spindle bursts (SBs) within primary somatosensory cortex (S1), most notably during periods of sleep-related myoclonic twitching. Here we investigated developmental changes in this callosally mediated disinhibition and its associ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0020774

    authors: Marcano-Reik AJ,Prasad T,Weiner JA,Blumberg MS

    更新日期:2010-10-01 00:00:00

  • Chronic citalopram treatment ameliorates depressive behavior associated with light at night.

    abstract::Chronic exposure to light at night (LAN) is a circadian disruptor and may be linked to various health risks, including mood disorders. We recently demonstrated that chronic exposure to dim (5 lux) LAN provokes depressive-like behaviors and reduced hippocampal CA1 dendritic spine density in female hamsters. Whether thi...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0029699

    authors: Bedrosian TA,Weil ZM,Nelson RJ

    更新日期:2012-10-01 00:00:00

  • Sensory gating impairments in heavy cannabis users are associated with altered neural oscillations.

    abstract::Central cannabinoid receptors mediate neural oscillations and are localized to networks implicated in auditory P50 sensory gating, including the hippocampus and neocortex. The current study examined whether neural oscillations evoked by the paired clicks (S1, S2) are associated with abnormal P50 gating reported in can...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0016328

    authors: Edwards CR,Skosnik PD,Steinmetz AB,O'Donnell BF,Hetrick WP

    更新日期:2009-08-01 00:00:00

  • Long-term replacement of estrogen in combination with medroxyprogesterone acetate improves acquisition of an alternation task in middle-aged female rats.

    abstract::Studies have shown that ovarian hormones protect against some of the cognitive deficits associated with aging. Although much of the literature in rodents has focused on hippocampal dependent tasks, studies suggest that tasks dependent on the prefrontal cortex are also influenced by ovarian hormones. The present study ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0026461

    authors: Chisholm NC,Juraska JM

    更新日期:2012-02-01 00:00:00

  • Dissociating the effects of dopamine D2 receptors on effort-based versus value-based decision making using a novel behavioral approach.

    abstract::Cost-benefit decision making is essential for organisms to adapt to their ever-changing environment. Most studies of cost-benefit decision making involve choice conditions in which effort and value are varied simultaneously. This prevents identification of the aspects of cost-benefit decision making that are affected ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000361

    authors: Bailey MR,Chun E,Schipani E,Balsam PD,Simpson EH

    更新日期:2020-04-01 00:00:00

  • Footshock-induced sensitization of electrically elicited startle reflexes.

    abstract::The acoustic startle reflex can be facilitated by the presentation of a train of footshocks presented in rapid succession (footshock sensitization). Acoustic startle is a short-latency reflex mediated by a neural circuit consisting of the ventral cochlear nucleus (VCN), ventral nucleus of the lateral lemniscus (VLL), ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.103.3.504

    authors: Boulis NM,Davis M

    更新日期:1989-06-01 00:00:00

  • The development of a conditioned place preference to morphine: effects of lesions of various CNS sites.

    abstract::This study examined the neural substrates underlying the development of a conditioned place preference (CPP) to morphine (2 mg/kg x 3 pairings) by testing whether lesions of 7 different neural sites block a morphine-induced CPP. Lesions of the pedunculopontine tegmental nucleus (PPTg), the periaqueductal gray (PAG), o...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.111.6.1313

    authors: Olmstead MC,Franklin KB

    更新日期:1997-12-01 00:00:00

  • Rat prefrontal dopamine and cognitive control: impaired and enhanced conflict performance.

    abstract::It has been proposed that the cognitive dysfunction observed in patients with schizophrenia reflects a failure in cognitive control, in particular an inability to use task-relevant information to guide behavior. Using a prefrontal-dependent task designed to reflect aspects of cue and response conflict seen in human co...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0023572

    authors: Haddon JE,Killcross S

    更新日期:2011-06-01 00:00:00

  • Enkephalin hydrolysis in plasma is highly correlated with escape performance in the rat.

    abstract::A very high correlation was found in rats between latency to escape on the first trial of an active avoidance task and the rate at which [leu]enkephalin is hydrolyzed in plasma. In addition, the rate of [leu]enkephalin hydrolysis is significantly altered following the first training trial. The results suggest that a r...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.102.3.404

    authors: Martinez JL Jr,Weinberger SB

    更新日期:1988-06-01 00:00:00

  • Effects of hydrocortisone on false memory recognition in healthy men and women.

    abstract::Most of the studies focusing on the effect of stress on false memories by using psychosocial and physiological stressors yielded diverse results. In the present study, we systematically tested the effect of exogenous hydrocortisone using a false memory paradigm. In this placebo-controlled study, 37 healthy men and 38 ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/bne0000170

    authors: Duesenberg M,Weber J,Schaeuffele C,Fleischer J,Hellmann-Regen J,Roepke S,Moritz S,Otte C,Wingenfeld K

    更新日期:2016-12-01 00:00:00

  • Hippocampal lesions impair memory of short-delay conditioned eye blink in rabbits.

    abstract::Involvement of hippocampus in short-delay eye blink conditioning was reexamined during conditioned response (CR) consolidation. Rabbits received bilateral hippocampectomy, removal of overlying neocortex, or sham lesions and were trained with tone/puff pairings to early acquisition (consolidation) or well trained (over...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.103.5.935

    authors: Akase E,Alkon DL,Disterhoft JF

    更新日期:1989-10-01 00:00:00

  • Microinjection of morphine into the nucleus accumbens impairs contextual learning in rats.

    abstract::A unilateral microinjection of morphine into the amygdala impaired fear conditioning to both a conditioned stimulus (CS) paired with shock and the context where shock occurred, whereas a microinjection of morphine into the nucleus accumbens (NA) spared fear conditioning to the CS but impaired, in a dose-dependent and ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.111.5.996

    authors: Westbrook RF,Good AJ,Kiernan MJ

    更新日期:1997-10-01 00:00:00

  • Effects of regional striatal lesions on motor, motivational, and executive aspects of progressive-ratio performance in rats.

    abstract::The striatum is implicated in response selection and performance, the dorsal striatum in sensorimotor control and habit learning, and the ventral striatum in motivation and rewarded behaviors. Ventral striatal lesions produce performance changes on food-reinforced, progressive-ratio (PR) schedules, but the effects of ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.113.4.718

    authors: Eagle DM,Humby T,Dunnett SB,Robbins TW

    更新日期:1999-08-01 00:00:00

  • Rapid effects of 17β-estradiol on male copulatory behaviors are not elicited by the novel membrane active estrogenic compound STX.

    abstract::Estrogens have been shown to rapidly promote male copulatory behaviors with a time-course that suggests rapid signaling events are involved. The present study tested the hypothesis that estrogen acts through a novel Gq protein-coupled membrane estrogen receptor (ER). Thus, either estradiol (E2), STX (a diphenylacrylam...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/a0032950

    authors: Kaufman KR,Kelly MJ,Roselli CE

    更新日期:2013-08-01 00:00:00

  • Interactive contributions of intracellular calcium and protein phosphatases to massed-trials learning deficits in Hermissenda.

    abstract::Using Hermissenda as subjects, massed-trials training deficits were examined. Associative pairings of light and rotation induced a progressively greater conditioned foot contraction in response to light as the intertrial interval (ITI) was extended (up to 8 min). In contrast, a short ITI (30 s) produced no evidence of...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.113.1.103

    authors: Muzzio IA,Ramirez RR,Talk AC,Matzel LD

    更新日期:1999-02-01 00:00:00

  • Pairings of a drug or place conditioned stimulus with lithium chloride produce conditioned sickness, not antisickness.

    abstract::In different experiments, pairings of a drug (pentobarbital or morphine) or place as the conditioned stimulus (CS) with lithium-induced sickness as the unconditioned stimulus (US) were given to rats to produce Pavlovian conditioning. Control rats received unpaired exposures. In the test, each rat was exposed to the CS...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.106.1.106

    authors: Lett BT

    更新日期:1992-02-01 00:00:00

  • Sex differences in brain and personality correlates of the ability to identify popular word associations.

    abstract::The ability of men to identify popular word associations had earlier been shown to be affected by left-sided thalamic surgery for movement disorders; now, over a year later, the impairment has been observed with operations on both sides. In addition, upon testing at approximately the same time interval, men who had un...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.103.4.893

    authors: Lansdell H

    更新日期:1989-08-01 00:00:00

  • Behavioral control, aversive stimulus frequency, and pituitary-adrenal response.

    abstract::Six females rats were trained to lever press under a free operant shock-postponement schedule. Each subject had a yoked control which received shock whenever the subject did. The shock-postponement interval (R-S) was varied from 5, 10, 20, 40, to 80 s over blocks of sessions. Corticosteroid levels were taken prior to ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.98.6.1094

    authors: Herrmann TF,Hurwitz HM,Levine S

    更新日期:1984-12-01 00:00:00

  • Cardiac startle and orienting responses in the great apes.

    abstract::Cardiac patterns of startle and orienting in response to auditory and vibrotactile stimuli were investigated in the infant chimpanzee and gorilla. Results revealed a notable cardiac acceleration in response to the initial presentations of stimuli of either modality. This acceleratory response appeared to reflect the c...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.98.5.914

    authors: Berntson GG,Boysen ST

    更新日期:1984-10-01 00:00:00

  • Light-dark differences in behavioral sensitivity to oxytocin.

    abstract::Ovariectomized female rats treated with estradiol benzoate (EB) and progesterone (P) were infused intracerebroventricularly with a low (200 ng) or high (1 microgram) dose of oxytocin (OT). The low dose of OT facilitated lordosis behavior only during the dark phase of the light-dark cycle in females that were pretreate...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.105.3.487

    authors: Schumacher M,Coirini H,Pfaff DW,McEwen BS

    更新日期:1991-06-01 00:00:00

  • Odors can induce feeding motor responses in the terrestrial mollusc Limax maximus.

    abstract::Highly developed odor learning was shown in the terrestrial slug Limax maximus. In addition, several key cellular elements of the neural network that controls ingestive feeding have been identified. The results of 3 experiments demonstrate an interaction between odor input and ingestive feeding in that olfactory stimu...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037//0735-7044.106.3.563

    authors: Sahley CL,Martin KA,Gelperin A

    更新日期:1992-06-01 00:00:00

  • Memory of social defeat is facilitated by cAMP response element-binding protein overexpression in the amygdala.

    abstract::The cAMP-responsive element binding protein (CREB) is a transcription factor that regulates synaptic plasticity and memory formation. Studies that have used conditioned fear models have established that CREB is important for the acquisition and consolidation of fear learning. The authors demonstrate that overexpressio...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章

    doi:10.1037/0735-7044.119.4.1125

    authors: Jasnow AM,Shi C,Israel JE,Davis M,Huhman KL

    更新日期:2005-08-01 00:00:00