Microinjection of morphine into the nucleus accumbens impairs contextual learning in rats.

Abstract:

:A unilateral microinjection of morphine into the amygdala impaired fear conditioning to both a conditioned stimulus (CS) paired with shock and the context where shock occurred, whereas a microinjection of morphine into the nucleus accumbens (NA) spared fear conditioning to the CS but impaired, in a dose-dependent and receptor-specific manner, fear conditioning to the context. Morphine in the NA also spared extinction and latent inhibition of a CS but abolished the context specificity of these effects and eliminated the increase in discriminability that results from preexposure to a to-be-shocked context. The results identify a role for the NA in the processes by which rats learn about a context and are discussed in terms of an opioid disruption of either within-context associations or of attentional processes that contribute to such associations.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Westbrook RF,Good AJ,Kiernan MJ

doi

10.1037//0735-7044.111.5.996

subject

Has Abstract

pub_date

1997-10-01 00:00:00

pages

996-1013

issue

5

eissn

0735-7044

issn

1939-0084

journal_volume

111

pub_type

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