Abstract:
:A discrete stimulus (flashing light) was paired with cocaine (20 mg/kg) to induce conditioned locomotion. To identify brain regions activated during this response, Fos was measured with immunohistochemistry. Although paired subjects displayed robust conditioned locomotion, Fos was not increased in any limbic brain regions analyzed. In contrast, pairing of cocaine with generalized contextual cues (whole room) produced conditioned locomotion and Fos activation in the prelimbic portion of prefrontal cortex and the nucleus accumbens core. These results suggest that the pattern of neuronal activation during cocaine-conditioned activity differs depending on whether a discrete or contextual stimulus is used as a conditioned stimulus. The possibility that expectancy and frustrative nonreward contribute to Fos expression in rats conditioned to contextual cues is discussed.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Hotsenpiller G,Horak BT,Wolf MEsubject
Has Abstractpub_date
2002-08-01 00:00:00pages
634-45issue
4eissn
0735-7044issn
1939-0084journal_volume
116pub_type
杂志文章abstract::The ability of the rat brain to acquire or to retain specific learning tasks was tested under conditions of multiple lesions and widely different amounts of practice. Lesion targets were (a) the medial prefrontal and cingulate cortex, (b) the anterior and mediodorsal thalamus, and (c) the dorsal and ventral hippocampu...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:
更新日期:1985-04-01 00:00:00
abstract::Effects of posttraining epinephrine (EPI) on retention of a massed (1 session, 30 trials) 2-way active avoidance task in rats were studied. The rats received an injection (ip) of 0.05 mg/kg EPI, 0.01 mg/kg EPI, or distilled water immediately after the training session. EPI did not improve retention 24 hr after the tra...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.108.3.469
更新日期:1994-06-01 00:00:00
abstract::Infusing conscious unrestrained rats with either 0.5 M NaCl-CSF or 0.7 M sucrose-CSF into the lateral cerebral ventricle (IVT) at 38 microliters/hr for 4 hr induced drinking. Although the infusates were nearly equiosmotic, water drinking during the 0.5 M NaCl-CSF was greater than during 0.7 M sucrose-CSF. However, IVT...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.101.3.371
更新日期:1987-06-01 00:00:00
abstract::Rats emit aversive taste reactivity (TR) behavior (i.e., gapes) following intraoral delivery of a cocaine-paired taste cue and greater conditioned aversive TR at the end of training predicts greater drug-seeking and taking. Here, we examined the development of this conditioned aversive TR behavior on a trial-by-trial ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0036264
更新日期:2014-04-01 00:00:00
abstract::Conditioned inhibition (CI) of the rat eyeblink response and the neuronal correlates of CI in the cerebellar interpositus nucleus were examined in the present study. In Experiment 1, CI was established with a novel, 3-group design. In Experiment 2, neuronal activity in the anterior interpositus nucleus was recorded du...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:
更新日期:2002-02-01 00:00:00
abstract::Aggressive tendencies may be linked to the psychopharmacology of cocaine, yet few experimental approaches have been brought to bear on understanding the neurobiological implications of cocaine exposure during the developmentally sensitive period of adolescence. In this issue, Melloni and coauthors (L. A. Ricci, J. M. ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章,评审
doi:10.1037/0735-7044.118.5.1143
更新日期:2004-10-01 00:00:00
abstract:INTRODUCTION:Caffeine is frequently consumed concurrent to or immediately following ethanol consumption. Identifying how caffeine and ethanol interact to modulate behavior is essential to understanding the co-use of these drugs. The plus-maze discriminative avoidance task (PMDAT) allows within-subject measurement of le...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0017610
更新日期:2009-12-01 00:00:00
abstract::Endogenous opioids mediate some reward processes involving both natural (food, sweet taste) and artificial (morphine, heroin) rewards. In contrast, sexual behavior (which is also reinforcing) is generally inhibited by opioids. To establish the role of endogenous opioids for a newly described natural reinforcer, namely...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.122.2.416
更新日期:2008-04-01 00:00:00
abstract::The purpose of this study was to characterize the ontogeny of the acoustic startle response (ASR) and response sensitization to background noise in preweanling rats. Animals were tested daily from 11 to 21 days of age using one of four sets of background white noise levels [45-80 dB(A)]. With constant low-level (45 dB...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.102.5.706
更新日期:1988-10-01 00:00:00
abstract::Rats with perirhinal cortex lesions were sequentially trained in a rectangular water tank on a series of 3 visual discriminations, each between mirror-imaged stimuli. When these same discriminations were tested concurrently, the rats were forced to use a configural strategy to solve the problems effectively. There was...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/a0018320
更新日期:2010-02-01 00:00:00
abstract::Relations between sleep and memory were examined as a function of aging in rats. Sleep (24 hr), passive avoidance retention, and choline acetyltransferase (CAT) activity were assessed in 3 age-groups (6, 15, and 24 months old). Age-related alterations were evident in sleep, memory, and cortical and striatal CAT activi...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.103.4.755
更新日期:1989-08-01 00:00:00
abstract::Theories of habituation have included an increase in postsynaptic inhibition as one possible mechanism underlying response decrement following repetitive stimulus presentation. In this study, the glycine antagonist strychnine (1.0 mg/kg, ip, 10 min pretreatment) was used to investigate the involvement of glycinergic n...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.98.6.955
更新日期:1984-12-01 00:00:00
abstract::The addition of extra light-alone or rotation-alone presentations to sequences of light-rotation pairings reduced the associative suppression of phototaxic behavior for the nudibranch Hermissenda. Training-induced changes in Type B photoreceptor light responses were found to parallel the training-induced behavioral ch...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.101.1.13
更新日期:1987-02-01 00:00:00
abstract::The present study tested the prediction that D-cycloserine (DCS), a partial N-methyl-D-aspartate agonist, would facilitate extinction of conditioned freezing in male Sprague-Dawley rats. Rats received 5 light-shock pairings (conditioning). The following day, rats received 6 light-alone presentations (extinction traini...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.117.2.341
更新日期:2003-04-01 00:00:00
abstract::The rat's willingness to ingest glucose after an initial intraoral intake test was probed by beginning a 2nd intraoral intake test at variable durations (1-120 min). In Experiment 1, after an initial meal of 12.5% glucose solution averaging 26.9 +/- 1.7 ml (SEM, n = 10), the size of the 2nd (probe) meal of the same st...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
abstract::Covert shifts of visual attention in space have been quantified by measuring the effects of visual cues on the detection of visual targets in humans and monkeys maintaining visual fixation. These observations of "covert orienting" have provided important information regarding the neurobiology of visual attention in pr...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.109.6.1095
更新日期:1995-12-01 00:00:00
abstract::In 3 experiments, the authors examined the role of adenosine regulation in escape deficits produced by earlier exposure to inescapable shock in rats (learned helplessness). Adenosine analogs injected before escape testing mimicked the effect of earlier inescapable shock, with the magnitude of the deficit varying with ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.108.2.265
更新日期:1994-04-01 00:00:00
abstract::Appetitive behaviors of rats were monitored in a runway situation following central infusions of neuroactive substances into brain areas implicated in electrical self-stimulation. Microinjections of the dopamine antagonist cis-flupentixol or the cholinergic antagonist atropine into the nucleus accumbens (Acb) severely...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.110.2.331
更新日期:1996-04-01 00:00:00
abstract::Following spinal transection of the upper thoracic spinal cord, male Sprague-Dawley rats given legshock whenever a hindlimb is extended learn to maintain the leg in a flexed position. The region of the cord that mediates this instrumental learning was isolated using neuroanatomical tracing, localized infusion of lidoc...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.119.2.538
更新日期:2005-04-01 00:00:00
abstract::Three experiments are reported whose purpose was to examine the effect of the cholinergic antagonist atropine on the acquisition of different learning tasks known to be sensitive or insensitive to impairment by hippocampal lesions; on the retention of performance acquired in the absence of the drug; and on memory cons...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.100.4.483
更新日期:1986-08-01 00:00:00
abstract::To explore the role of the cerebellum in sustained attention, the authors tested lurcher, wildtype, and lurcher chimeric mice with zero, normal, and variable numbers of Purkinje cells, respectively, in a previously validated task of sustained attention. Results indicate that lurcher mice had a deficit in performance l...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.120.2.477
更新日期:2006-04-01 00:00:00
abstract::The purpose of this experiment was to evaluate the extent to which continued drug discrimination training during chronic drug treatment affects the development of tolerance. Rats were trained to discriminate distilled water from 0.75 mg/kg amphetamine in a two-lever drug discrimination task. Two groups were then given...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.103.2.373
更新日期:1989-04-01 00:00:00
abstract::The addition of a dual runway configuration did not disrupt the successful performance of normal animals, nor did it improve the deficit of septal rats on the Maier three-table spatial integration task. Both groups of animals displayed a preference for the outside runway configuration during exploration. During testin...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.99.4.631
更新日期:1985-08-01 00:00:00
abstract::Circadian rhythms in most mammals are synchronized to local time by phase and period resetting actions of daily light-dark cycles on a retino-recipient, light-entrainable circadian pacemaker, the suprachiasmatic nucleus (SCN). The SCN receives input from other brain regions, some of which mediate the phase and period ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章,评审
doi:10.1037/a0035885
更新日期:2014-06-01 00:00:00
abstract::Preadolescent mice have been shown to be differentially susceptible to the effects of both acute and chronic nicotine exposure on contextual fear learning relative to adults. For this study, we tested the effects of chronic nicotine exposure in preadolescence on adulthood extinction and spontaneous recovery of fear me...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/bne0000247
更新日期:2018-08-01 00:00:00
abstract::Down-regulation of negative emotions has been shown to reliably inhibit the emotion-modulated startle reflex, but it remains unclear whether the timing of the startle probe influences the quantification of emotion regulation with this measure. Moreover, it is not known whether the degree of startle inhibition correspo...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/bne0000271
更新日期:2018-12-01 00:00:00
abstract::The spontaneously hypertensive rat (SHR) has been suggested as a possible animal model of attention-deficit/hyperactivity disorder (ADHD). Reductions in the volume of the cerebellum and impairments in cerebellar-dependent eyeblink conditioning have been observed in ADHD, prompting investigation into whether SHRs also ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.122.1.63
更新日期:2008-02-01 00:00:00
abstract::Exposure to 3 moderately intense (1-mA) tailshocks has been shown to lower vocalization thresholds to both heat and shock. Previous shock exposure also facilitates the acquisition of conditioned fear as measured by freezing. These observations suggest that shock induces hyperalgesia (enhanced pain). This study explore...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.113.3.539
更新日期:1999-06-01 00:00:00
abstract::In four experiments we reexamined the recent report by Labbe, Firl, Mufson, and Stein (1983) that fetal cortical tissue transplanted to an aspirative prefrontal cortical cavity in rats can ameliorate the learning impairments induced by the aspirative lesions. Healthy surviving grafts from young (E16) embryonic donors ...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.101.4.489
更新日期:1987-08-01 00:00:00
abstract::The shy-bold continuum is a fundamental behavioral trait conserved across human and nonhuman animals. Individual differences along the shy-bold continuum are presumed to arise from, and are maintained by, differences in the excitability of forebrain limbic areas involved in the evaluation of stimulus saliency. To test...
journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037/0735-7044.122.3.704
更新日期:2008-06-01 00:00:00