Dissociation of conditioned locomotion and Fos induction in response to stimuli formerly paired with cocaine.


:A discrete stimulus (flashing light) was paired with cocaine (20 mg/kg) to induce conditioned locomotion. To identify brain regions activated during this response, Fos was measured with immunohistochemistry. Although paired subjects displayed robust conditioned locomotion, Fos was not increased in any limbic brain regions analyzed. In contrast, pairing of cocaine with generalized contextual cues (whole room) produced conditioned locomotion and Fos activation in the prelimbic portion of prefrontal cortex and the nucleus accumbens core. These results suggest that the pattern of neuronal activation during cocaine-conditioned activity differs depending on whether a discrete or contextual stimulus is used as a conditioned stimulus. The possibility that expectancy and frustrative nonreward contribute to Fos expression in rats conditioned to contextual cues is discussed.


Behav Neurosci


Behavioral neuroscience


Hotsenpiller G,Horak BT,Wolf ME


Has Abstract


2002-08-01 00:00:00












  • Interactions between cognition and circadian rhythms: attentional demands modify circadian entrainment.

    abstract::Animals and humans are able to predict and synchronize their daily activity to signals present in their environments. Environmental cues are most often associated with signaling the beginning or the end of a daily activity cycle, but they can also be used to time the presentation or availability of scarce resources. I...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Gritton HJ,Sutton BC,Martinez V,Sarter M,Lee TM

    更新日期:2009-10-01 00:00:00

  • Role of the anterior hypothalamus-preoptic area in the regulation of courtship behavior in the male Canadian red-sided garter snake (Thamnophis sirtalis parietalis): lesion experiments.

    abstract::Lesions of the medial preoptic area and/or the ventromedial hypothalamus resulted in an abrupt and immediate decline in courtship behavior in adult male Canadian red-sided garter snakes (Thamnophis sirtalis parietalis). Lesions of the more anterior portions of the preoptic area resulted in a more gradual, delayed decl...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Friedman D,Crews D

    更新日期:1985-10-01 00:00:00

  • A small amount of wheel running facilitates eating in nondeprived rats.

    abstract::A high level of dopaminergic activation such as that produced by a high dose of amphetamine suppresses eating, whereas a low level such as that produced by a low dose can have the opposite effect. Like a high dose of amphetamine, a high level of wheel running also suppresses eating. It was hypothesized that this suppr...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Lett BT,Grant VL,Gaborko LL

    更新日期:1996-12-01 00:00:00

  • Aged rats with intact memory show distinctive recruitment in cortical regions relative to young adults in a cue mismatch task.

    abstract::Similar to elderly humans, aged Long-Evans rats exhibit individual differences in performance on tasks that critically depend on the medial temporal lobe memory system. Although reduced memory performance is common, close to half of aged rats in this outbred rodent population perform within the range of young subjects...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Haberman RP,Monasterio A,Branch A,Gallagher M

    更新日期:2019-10-01 00:00:00

  • Effects of nicotine exposure and anxiety on motivation for reward and gambling-like cues under reward uncertainty.

    abstract::Reward uncertainty is a common characteristic of gambling and may powerfully enhance attraction to gambling-related cues, thus promoting maladaptive gambling behaviors in susceptible individuals. The co-occurrence of gambling disorder with tobacco use disorder (60.4%) suggests a common mechanism for their pathology, a...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Russell TI,Robinson MJF

    更新日期:2019-08-01 00:00:00

  • Processing of preconsciously acquired information measured by hemispheric asymmetry and selection accuracy.

    abstract::This study was conducted to investigate the effects of instruction types on hemispheric activation and accurate selection of spatial stimuli that had been previously presented at a subliminal level. Right-handed females randomly received either an "analytic" or a "holistic" instruction. Both groups first saw a series ...

    journal_title:Behavioral neuroscience

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Barchas PR,Perlaki KM

    更新日期:1986-06-01 00:00:00

  • Comparative potency of tactile, auditory, and visual stimulus repetition in eliciting activated forebrain EEG in the rabbit.

    abstract::The experiments addressed the question of whether certain modalities of stimulation are more effective in eliciting immobility-related, atropine-sensitive neocortical low-voltage fast activity and hippocampal rhythmical slow activity from the rabbit. More pronounced activation and less pronounced habituation followed ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Whishaw IQ,Dyck R

    更新日期:1984-04-01 00:00:00

  • Amphetamine-induced sensitization and reward uncertainty similarly enhance incentive salience for conditioned cues.

    abstract::Amphetamine and stress can sensitize mesolimbic dopamine-related systems. In Pavlovian autoshaping, repeated exposure to uncertainty of reward prediction can enhance motivated sign-tracking or attraction to a discrete reward-predicting cue (lever-conditioned stimulus; CS+), as well as produce cross-sensitization to am...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Robinson MJ,Anselme P,Suchomel K,Berridge KC

    更新日期:2015-08-01 00:00:00

  • Conditioned brain-stimulation reward attenuates the acoustic startle reflex in rats.

    abstract::The acoustic startle reflex (ASR) in rats is attenuated by a light paired with food or, in humans, by "pleasant" pictures. Rats were trained to barpress for lateral hypothalamus (LH) stimulation. ASR amplitudes were then measured at 4 intensities, with or without a light. Control rats that did not receive brain-stimul...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Steidl S,Li L,Yeomans JS

    更新日期:2001-06-01 00:00:00

  • Amygdalo-striatal interaction in the enhancement of stimulus salience in associative learning.

    abstract::Function of the central nucleus of the amygdala (CeA) is critical to 2 aspects of attention in associative learning: the conditioning of orienting responses (ORs) to cues paired with food, and the enhancement of cue salience by the surprising omission of expected events. Such salience enhancements have been found to d...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Esber GR,Torres-Tristani K,Holland PC

    更新日期:2015-04-01 00:00:00

  • Sexual behavior regulated (paced) by the female induces conditioned place preference.

    abstract::The possibility that female-paced coital behavior induces a reward state of sufficient intensity and duration to induce conditioning was evaluated by the conditioned-place-preference paradigm. Ovariectomized female rats, treated with estradiol benzoate and progesterone, regulated (paced) their coital interactions with...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Paredes RG,Alonso A

    更新日期:1997-02-01 00:00:00

  • The NO/sGC/PKG signaling pathway in the NAc shell is necessary for the acquisition of morphine-induced place preference.

    abstract::There is evidence that the nitric oxide (NO)/soluble guanylyl cyclase (sGC)/cGMP-dependent protein kinase (PKG) signaling pathway in the basal lateral amygdala and hippocampus plays a key role in memory processing, but it is not known if this NO signaling pathway in the nucleus accumbens (Gomes et al., 2006), a known ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Shen F,Wang N,Qi C,Li YJ,Cui CL

    更新日期:2014-08-01 00:00:00

  • Differential sensitivity to the wake-promoting actions of norepinephrine within the medial preoptic area and the substantia innominata.

    abstract::Mapping studies were conducted to delineate the site(s) of action for the arousal-enhancing actions of norepinephrine (NE) within the basal forebrain region encompassing the medial preoptic area (MPOA) and the substantia innominata (SI). Varying doses of NE, the beta-agonist, isoproterenol, or the alpha1-agonist, phen...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Berridge CW,O'Neill J

    更新日期:2001-02-01 00:00:00

  • Peripeduncular nucleus lesions in the rat: I. Effects on maternal aggression, lactation, and maternal behavior during pre- and postpartum periods.

    abstract::Bilateral peripeduncular (PPN) lesions made on the seventh postpartum day (L7) with either radiofrequency (RF) current or N-methyl-d,l-aspartic acid (NMDA)/phosphate buffered saline (PBS) reduced maternal aggression (MA) and partially inhibited lactation without producing significant deficits in other items of materna...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Factor EM,Mayer AD,Rosenblatt JS

    更新日期:1993-02-01 00:00:00

  • Consequences of serial cortical, hippocampal, and thalamic lesions and of different lengths of overtraining on the acquisition and retention of learning tasks.

    abstract::The ability of the rat brain to acquire or to retain specific learning tasks was tested under conditions of multiple lesions and widely different amounts of practice. Lesion targets were (a) the medial prefrontal and cingulate cortex, (b) the anterior and mediodorsal thalamus, and (c) the dorsal and ventral hippocampu...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Markowitsch HJ,Kessler J,Streicher M

    更新日期:1985-04-01 00:00:00

  • Mapping the substrate for brain stimulation reward by means of current-number trade-off functions.

    abstract::In previous studies using moveable electrodes to map the substrate for brain stimulation reward, reward effectiveness was estimated by varying either the current or the number of pulses per train. The resulting relationship between reward effectiveness and stimulation site is independent of the fixed parameter only if...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Forgie ML,Shizgal P

    更新日期:1993-06-01 00:00:00

  • Higher reported saturated fat and refined sugar intake is associated with reduced hippocampal-dependent memory and sensitivity to interoceptive signals.

    abstract::Regulation of energy intake depends in part on both memory for prior food intake and internal signals of hunger and satiety. These functions are both mediated by the hippocampus, a brain structure that animal studies have shown to be impaired after maintenance on high fat and refined sugar (HFS) diets. Study 1, using ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Francis HM,Stevenson RJ

    更新日期:2011-12-01 00:00:00

  • HemiParkinson analogue rats display active support in good limbs versus passive support in bad limbs on a skilled reaching task of variable height.

    abstract::Rats with unilateral dopamine (DA) depletion (hemiParkinson analogue rats) are impaired in using the contralateral (bad) limbs for skilled movements and for postural adjustments and compensate by using their good limbs in novel ways. The present study consisted of a reaching task in which compensatory adjustments usin...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Miklyaeva EI,Whishaw IQ

    更新日期:1996-02-01 00:00:00

  • Differential behavioral response to dopamine D2 agonists by sexually naive, sexually active, and sexually inactive male rats.

    abstract::This study was performed with male rats categorized as sexually naive (SN), sexually active (SA), or sexually inactive (SI). In a first experiment the effects of dopamine (DA) D2 agonist SND 919 (0.05, 1, and 10 mg/kg) on the copulatory behavior of SN, SA and SI rats were assessed. In a second experiment the DA D2 ago...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Giuliani D,Ferrari F

    更新日期:1996-08-01 00:00:00

  • Exposure to enriched environment improves spatial learning performances and enhances cell density but not choline acetyltransferase activity in the hippocampus of ventral subicular-lesioned rats.

    abstract::The authors demonstrated the efficacy of enriched housing conditions in promoting the behavioral recovery and neuronal survival following subicular lesion in rats. Chemical lesioning of the ventral subiculum impaired the spatial learning performances in rats. The lesion also induced a significant degree of neurodegene...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Dhanushkodi A,Bindu B,Raju TR,Kutty BM

    更新日期:2007-06-01 00:00:00

  • Modification of the acoustic startle response in hearing-impaired C57BL/6J mice: prepulse augmentation and prolongation of prepulse inhibition.

    abstract::Modification of acoustic startle amplitude by a 10-ms tone prepulse (S1) was evaluated as a function of the interstimulus interval (ISI) between the onset of S1 and the onset of the startle-evoking stimulus (S2). Subjects were normal-hearing 1-month-old C57BL/6J (C57) mice and CBA/CaJ mice and 5-month-old C57 mice wit...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Willott JF,Carlson S

    更新日期:1995-06-01 00:00:00

  • Cholinergic mechanisms of the context preexposure facilitation effect in adolescent rats.

    abstract::The context preexposure facilitation effect (CPFE) is a variant of contextual fear conditioning in which context learning, context-shock association, and expression of context conditioning occur in 3 separate phases-preexposure, training, and testing. During the preexposure phase, the CPFE is disrupted by hippocampal ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Robinson-Drummer PA,Dokovna LB,Heroux NA,Stanton ME

    更新日期:2016-04-01 00:00:00

  • Impaired trace eyeblink conditioning in bilateral, medial-temporal lobe amnesia.

    abstract::Trace eyeblink classical conditioning was assessed in patients with bilateral medial-temporal amnesia and matched control participants who had previously shown equivalent delay eyeblink conditioning (J. D. E. Gabrieli et al., 1995). The silent trace interval varied for durations of 500, 750, or 1,000 ms in successive ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: McGlinchey-Berroth R,Carrillo MC,Gabrieli JD,Brawn CM,Disterhoft JF

    更新日期:1997-10-01 00:00:00

  • Hippocampal growth and maintenance depend on food-caching experience in juvenile mountain chickadees (Poecile gambeli).

    abstract::This experiment investigated the development of caching behavior and the hippocampus (HF) in postfledging mountain chickadees (Poecile gambeli). From Days 35 to 53, the number of seeds stored increased but the proportion recovered did not. Birds that stored and recovered during 3 or more trials had significantly enlar...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Clayton NS

    更新日期:2001-06-01 00:00:00

  • Influence of opioid peptides on learning and memory processes in the chick.

    abstract::Several experiments were conducted to examine the effects of intracranial injection of opioid peptides and antagonists on learning and memory in the chick. Pretraining injection of [leu5]enkephalin and the selective delta receptor agonist [D-Pen2,L-Pen5]enkephalin (DPLPE) into the intermediate medial hyperstriatum ven...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Patterson TA,Schulteis G,Alvarado MC,Martinez JL Jr,Bennett EL,Rosenzweig MR,Hruby VJ

    更新日期:1989-04-01 00:00:00

  • Hippocampal lesions impair contextual fear conditioning in two strains of mice.

    abstract::Two different strains of mice, C57BL/6J and BALB/c, with hippocampal, cortical, or sham lesions, underwent contextual fear conditioning. In both strains, contextual fear, as measured by the freezing response, was significantly impaired in hippocampus-lesioned animals compared with sham control animals. Fear conditioni...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Chen C,Kim JJ,Thompson RF,Tonegawa S

    更新日期:1996-10-01 00:00:00

  • Differential effects of neurokinin-1 receptor activation in subregions of the periaqueductal gray matter on conditional and unconditional fear behaviors in rats.

    abstract::Central neurokinin-1 (NK-1) receptors are thought to modulate aversion, whereas the periaqueductal gray matter (PAG) is a common pathway for the integration of fear behaviors. The authors determined whether injection of an NK-1 agonist (GR73632) into subregions of the PAG would alter fear-related behaviors. Behavioral...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Mongeau R,De Oca BM,Fanselow MS,Marsden CA

    更新日期:1998-10-01 00:00:00

  • Fovea and foveation in Parkinson's disease.

    abstract::Nondemented Parkinson's disease (PD) patients report problems on nonmotor tasks that depend on visual or visuospatial abilities. In PD, foveal vision is impaired. Experimental studies in humans and monkeys established that foveal processing and visuospatial attention may be linked through saccadic eye movements. Sacca...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章,评审


    authors: Bodis-Wollner I,Glazman S,Yerram S

    更新日期:2013-04-01 00:00:00

  • Motherhood and nursing stimulate c-FOS expression in the rabbit forebrain.

    abstract::Mother rabbits nurse once daily with circadian periodicity. The authors investigated brain structures involved in regulating this activity by quantifying c-FOS-immunoreactive (IR) cells in the forebrain of: (1) mothers killed on postpartum Day 1 (PPD 1) after nursing (Group 1) or not given pups (Group 2); (2) mothers ...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: González-Mariscal G,Jiménez A,Chirino R,Beyer C

    更新日期:2009-08-01 00:00:00

  • Long-term memory facilitation in rats by posttraining epinephrine.

    abstract::Effects of posttraining epinephrine (EPI) on retention of a massed (1 session, 30 trials) 2-way active avoidance task in rats were studied. The rats received an injection (ip) of 0.05 mg/kg EPI, 0.01 mg/kg EPI, or distilled water immediately after the training session. EPI did not improve retention 24 hr after the tra...

    journal_title:Behavioral neuroscience

    pub_type: 杂志文章


    authors: Costa-Miserachs D,Portell-Cortés I,Aldavert-Vera L,Torras-García M,Morgado-Bernal I

    更新日期:1994-06-01 00:00:00