Sex versus sweet: opposite effects of opioid drugs on the reward of sucrose and sexual pheromones.

Abstract:

:Endogenous opioids mediate some reward processes involving both natural (food, sweet taste) and artificial (morphine, heroin) rewards. In contrast, sexual behavior (which is also reinforcing) is generally inhibited by opioids. To establish the role of endogenous opioids for a newly described natural reinforcer, namely male sexual pheromones for female mice, we checked the effects of systemic injections of the general opioid antagonist naloxone (1-10 mg/kg) and the agonist fentanyl (0.1- 0.5 mg/kg) in a number of behavioral tests. Naloxone affected neither the innate preference for male-soiled bedding (vs. female-soiled bedding) in 2-choice tests nor the induction of place conditioning using male pheromones as rewarding stimuli, although it effectively blocked the preference for consuming a sucrose solution. In contrast, fentanyl inhibited the preference for male chemosignals without altering sucrose preference. These results suggest that, in macrosmatic animals such as rodents, opioidergic inhibition of sexual behavior might be due, at least partially, to an impaired processing of pheromonal cues and that the hedonic value of sweet-tasting solutions and sexual pheromones are under different opioid modulation.

journal_name

Behav Neurosci

journal_title

Behavioral neuroscience

authors

Agustín-Pavón C,Martínez-Ricós J,Martínez-García F,Lanuza E

doi

10.1037/0735-7044.122.2.416

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

416-25

issue

2

eissn

0735-7044

issn

1939-0084

pii

2008-03769-016

journal_volume

122

pub_type

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