Abstract:
:The present experiment was designed to determine whether infusions of naloxone into specific brain sites can block sexual reinforcement as evaluated with the conditioned place preference procedure. Methylnaloxonium (5 micrograms/cannula) was infused bilaterally either into the medial preoptic area (MPOA) or into the nucleus accumbens (NAC) of sexually experienced male rats. We chose the MPOA because it is important for sexual behavior, and several opioid peptides have been shown to modify sexual behavior when infused there. The NAC appears to be a critical structure for drug-induced reward. Methylnaloxonium blocked place preference produced by ejaculation after infusion into the MPOA without affecting sexual behavior. Infusion of the antagonist into the NAC did not reduce the reinforcing properties of ejaculation. These data suggest that the MPOA may be a site where sexual reward is produced.
journal_name
Behav Neuroscijournal_title
Behavioral neuroscienceauthors
Agmo A,Gómez Mdoi
10.1037//0735-7044.107.5.812subject
Has Abstractpub_date
1993-10-01 00:00:00pages
812-8issue
5eissn
0735-7044issn
1939-0084journal_volume
107pub_type
杂志文章abstract::The ability of men to identify popular word associations had earlier been shown to be affected by left-sided thalamic surgery for movement disorders; now, over a year later, the impairment has been observed with operations on both sides. In addition, upon testing at approximately the same time interval, men who had un...
journal_title:Behavioral neuroscience
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journal_title:Behavioral neuroscience
pub_type: 杂志文章
doi:10.1037//0735-7044.106.2.315
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